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P16015

- CAH3_MOUSE

UniProt

P16015 - CAH3_MOUSE

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Protein

Carbonic anhydrase 3

Gene
Ca3, Car3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zinc By similarity.

Enzyme regulationi

Inhibited by acetazolamide By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Zinc; catalytic
Metal bindingi96 – 961Zinc; catalytic
Metal bindingi119 – 1191Zinc; catalytic
Active sitei127 – 1271 By similarity

GO - Molecular functioni

  1. carbonate dehydratase activity Source: UniProtKB-EC
  2. nickel cation binding Source: MGI
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. one-carbon metabolic process Source: InterPro
  2. response to ethanol Source: Ensembl
  3. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_199096. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 3 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase III
Carbonic anhydrase III
Short name:
CA-III
Gene namesi
Name:Ca3
Synonyms:Car3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88270. Car3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 260259Carbonic anhydrase 3PRO_0000077427Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei182 – 1821S-glutathionyl cysteine By similarity
Modified residuei187 – 1871S-glutathionyl cysteine By similarity

Post-translational modificationi

S-glutathionylated in hepatocytes under oxidative stress By similarity.

Keywords - PTMi

Acetylation, Glutathionylation

Proteomic databases

MaxQBiP16015.
PaxDbiP16015.
PRIDEiP16015.

2D gel databases

SWISS-2DPAGEP16015.

PTM databases

PhosphoSiteiP16015.

Expressioni

Tissue specificityi

Expressed at lower levels in adipose tissue from animals that were either genetically obese or had experimentally induced obesity.1 Publication

Gene expression databases

BgeeiP16015.
CleanExiMM_CAR3.
GenevestigatoriP16015.

Interactioni

Protein-protein interaction databases

BioGridi198484. 1 interaction.
IntActiP16015. 4 interactions.
MINTiMINT-1869657.
STRINGi10090.ENSMUSP00000029076.

Structurei

3D structure databases

ProteinModelPortaliP16015.
SMRiP16015. Positions 2-260.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 674Involved in proton transfer By similarity
Regioni198 – 1992Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3338.
GeneTreeiENSGT00750000117305.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP16015.
KOiK01672.
OMAiEAPFTHF.
OrthoDBiEOG7WMCK7.
PhylomeDBiP16015.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018441. Carbonic_anhydrase_CA3.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF96. PTHR18952:SF96. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P16015-1 [UniParc]FASTAAdd to Basket

« Hide

MAKEWGYASH NGPDHWHELY PIAKGDNQSP IELHTKDIKH DPSLQPWSAS    50
YDPGSAKTIL NNGKTCRVVF DDTYDRSMLR GGPLSGPYRL RQFHLHWGSS 100
DDHGSEHTVD GVKYAAELHL VHWNPKYNTF GEALKQPDGI AVVGIFLKIG 150
REKGEFQILL DALDKIKTKG KEAPFTHFDP SCLFPACRDY WTYHGSFTTP 200
PCEECIVWLL LKEPMTVSSD QMAKLRSLFS SAENEPPVPL VGNWRPPQPV 250
KGRVVRASFK 260
Length:260
Mass (Da):29,366
Last modified:January 23, 2007 - v3
Checksum:iF4E9FE69A3C324BB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91S → R in AAA37355. 1 Publication
Sequence conflicti86 – 861G → R in AAA37355. 1 Publication
Sequence conflicti126 – 1261K → R in AAA37355. 1 Publication
Sequence conflicti146 – 1461F → L in AAA37355. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27796 mRNA. Translation: AAA37355.1.
AF294988
, AF294983, AF294984, AF294985, AF294986, AF294987 Genomic DNA. Translation: AAG22029.1.
BC011129 mRNA. Translation: AAH11129.1.
CCDSiCCDS17250.1.
PIRiA43641.
RefSeqiNP_031632.2. NM_007606.3.
UniGeneiMm.300.

Genome annotation databases

EnsembliENSMUST00000029076; ENSMUSP00000029076; ENSMUSG00000027559.
GeneIDi12350.
KEGGimmu:12350.
UCSCiuc008oqs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27796 mRNA. Translation: AAA37355.1 .
AF294988
, AF294983 , AF294984 , AF294985 , AF294986 , AF294987 Genomic DNA. Translation: AAG22029.1 .
BC011129 mRNA. Translation: AAH11129.1 .
CCDSi CCDS17250.1.
PIRi A43641.
RefSeqi NP_031632.2. NM_007606.3.
UniGenei Mm.300.

3D structure databases

ProteinModelPortali P16015.
SMRi P16015. Positions 2-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198484. 1 interaction.
IntActi P16015. 4 interactions.
MINTi MINT-1869657.
STRINGi 10090.ENSMUSP00000029076.

PTM databases

PhosphoSitei P16015.

2D gel databases

SWISS-2DPAGE P16015.

Proteomic databases

MaxQBi P16015.
PaxDbi P16015.
PRIDEi P16015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029076 ; ENSMUSP00000029076 ; ENSMUSG00000027559 .
GeneIDi 12350.
KEGGi mmu:12350.
UCSCi uc008oqs.1. mouse.

Organism-specific databases

CTDi 12350.
MGIi MGI:88270. Car3.

Phylogenomic databases

eggNOGi COG3338.
GeneTreei ENSGT00750000117305.
HOGENOMi HOG000112637.
HOVERGENi HBG002837.
InParanoidi P16015.
KOi K01672.
OMAi EAPFTHF.
OrthoDBi EOG7WMCK7.
PhylomeDBi P16015.
TreeFami TF316425.

Enzyme and pathway databases

Reactomei REACT_199096. Reversible hydration of carbon dioxide.

Miscellaneous databases

ChiTaRSi CA3. mouse.
NextBioi 281000.
PROi P16015.
SOURCEi Search...

Gene expression databases

Bgeei P16015.
CleanExi MM_CAR3.
Genevestigatori P16015.

Family and domain databases

Gene3Di 3.10.200.10. 1 hit.
InterProi IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018441. Carbonic_anhydrase_CA3.
[Graphical view ]
PANTHERi PTHR18952. PTHR18952. 1 hit.
PTHR18952:SF96. PTHR18952:SF96. 1 hit.
Pfami PF00194. Carb_anhydrase. 1 hit.
[Graphical view ]
SMARTi SM01057. Carb_anhydrase. 1 hit.
[Graphical view ]
SUPFAMi SSF51069. SSF51069. 1 hit.
PROSITEi PS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse carbonic anhydrase III: nucleotide sequence and expression studies."
    Tweedie S., Edwards Y.
    Biochem. Genet. 27:17-30(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nucleotide sequence and structure of the mouse carbonic anhydrase III gene."
    Kim G., Lee T.-H., Wynshaw-Boris A., Levine R.L.
    Gene 265:37-44(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. Cited for: PROTEIN SEQUENCE OF 79-96, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCAH3_MOUSE
AccessioniPrimary (citable) accession number: P16015
Secondary accession number(s): Q9ERN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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