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Reviewed, UniProtKB/Swiss-Prot P16009 (VG05_BPT4)

Last modified June 16, 2009. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Tail-associated lysozyme
    EC=3.2.1.17
Alternative name(s):
    Protein Gp5
Gene names
Name: 5
OrganismEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifier10665 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Caudovirales › Myoviridae › T4-like viruses
Virus hostEscherichia coli [TaxID: 562]

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Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Tail-associated lysozyme.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sequence similarities

Belongs to the glycosyl hydrolase 24 family.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

27P171722EBI-1032754,EBI-1032762

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 575575Tail-associated lysozyme
PRO_0000218111

Sites

Active site1841Proton donor By similarity
Active site1931Nucleophile By similarity

Secondary structure

1 .......................................................................................................... 575
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P16009-1 [UniParc].

Last modified August 1, 1990. Version 2.
Checksum: 6CC2D04E05155CF5

FASTA57563,116
        10         20         30         40         50         60 
MEMISNNLNW FVGVVEDRMD PLKLGRVRVR VVGLHPPQRA QGDVMGIPTE KLPWMSVIQP 

        70         80         90        100        110        120 
ITSAAMSGIG GSVTGPVEGT RVYGHFLDKW KTNGIVLGTY GGIVREKPNR LEGFSDPTGQ 

       130        140        150        160        170        180 
YPRRLGNDTN VLNQGGEVGY DSSSNVIQDS NLDTAINPDD RPLSEIPTDD NPNMSMAEML 

       190        200        210        220        230        240 
RRDEGLRLKV YWDTEGYPTI GIGHLIMKQP VRDMAQINKV LSKQVGREIT GNPGSITMEE 

       250        260        270        280        290        300 
ATTLFERDLA DMQRDIKSHS KVGPVWQAVN RSRQMALENM AFQMGVGGVA KFNTMLTAML 

       310        320        330        340        350        360 
AGDWEKAYKA GRDSLWYQQT KGRASRVTMI ILTGNLESYG VEVKTPARSL SAMAATVAKS 

       370        380        390        400        410        420 
SDPADPPIPN DSRILFKEPV SSYKGEYPYV HTMETESGHI QEFDDTPGQE RYRLVHPTGT 

       430        440        450        460        470        480 
YEEVSPSGRR TRKTVDNLYD ITNADGNFLV AGDKKTNVGG SEIYYNMDNR LHQIDGSNTI 

       490        500        510        520        530        540 
FVRGDETKTV EGNGTILVKG NVTIIVEGNA DITVKGDATT LVEGNQTNTV NGNLSWKVAG 

       550        560        570 
TVDWDVGGDW TEKMASMSSI SSGQYTIDGS RIDIG

« Hide

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References

« Hide 'large scale' references
[1]"Functional relationships and structural determinants of two bacteriophage T4 lysozymes: a soluble (gene e) and a baseplate-associated (gene 5) protein."
Mosig G., Lin G.W., Franklin J., Fan W.H.
New Biol. 1:171-179(1989) [PubMed: 2488704] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mosig G.
Submitted (MAR-1990) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Bacteriophage T4 genome."
Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.
Microbiol. Mol. Biol. Rev. 67:86-156(2003) [PubMed: 12626685] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Sequencing, cloning and overexpression of genes of bacteriophage T4 between map positions 74.325 and 77.184."
Koch T., Lamm N., Rueger W.
Nucleic Acids Res. 17:4392-4392(1989) [PubMed: 2740234] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X15728 Genomic DNA. Translation: CAA33749.1.
AF158101 Genomic DNA. Translation: AAD42482.1.
X14845 Genomic DNA. No translation available.
PIRG5BPT4. S25240.
RefSeqNP_049757.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1K28X-ray2.90A1-575[»]
1PDLelectron microscopy12.00A/B/C1-575[»]
1WTHX-ray2.80A1-575[»]
2Z6BX-ray3.11A1-575[»]
DisProtDP00284.
ModBaseSearch...

Protein-protein interaction databases

IntActP16009. 1 interaction.

Protein family/group databases

CAZyGH24. Glycoside Hydrolase Family 24.
TCDB9.B.11.1.1. Gp27/5 T4-baseplate (T4-BP) family.

Genome annotation databases

GeneID1258817.
GenomeReviewsGene locus T4p145 in contig AF158101_GR.

Enzyme and pathway databases

BRENDA3.2.1.17. 1108.

Family and domain databases

InterProIPR002196. Glyco_hydro_24.
IPR001165. Glyco_hydro_30_T4_lys.
IPR010609. Gp5_C.
IPR009590. Gp5_OB_N.
[Graphical view]
PfamPF06715. Gp5_C. 5 hits.
PF06714. Gp5_OB. 1 hit.
PF00959. Phage_lysozyme. 1 hit.
[Graphical view]
PRINTSPR00684. T4LYSOZYME.
ProtoNetSearch...

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Entry information

Entry nameVG05_BPT4
AccessionPrimary (citable) accession number: P16009
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 1, 1990
Last modified: June 16, 2009
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectVirus (Virus annotation project)

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Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents