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Protein

Aromatic amino acid transport protein AroP

Gene

aroP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan).

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • L-phenylalanine transmembrane transporter activity Source: EcoCyc
  • L-tryptophan transmembrane transporter activity Source: EcoCyc
  • L-tyrosine transmembrane transporter activity Source: EcoCyc
  • proton motive force dependent protein transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • phenylalanine transport Source: EcoCyc
  • tryptophan transport Source: EcoCyc
  • tyrosine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:AROP-MONOMER.
ECOL316407:JW0108-MONOMER.
MetaCyc:AROP-MONOMER.

Protein family/group databases

TCDBi2.A.3.1.3. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic amino acid transport protein AroP
Alternative name(s):
General aromatic amino acid permease
Gene namesi
Name:aroP
Ordered Locus Names:b0112, JW0108
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10084. aroP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42PeriplasmicSequence analysis1
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Topological domaini64 – 86CytoplasmicSequence analysisAdd BLAST23
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 117PeriplasmicSequence analysis10
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 155CytoplasmicSequence analysisAdd BLAST17
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 201PeriplasmicSequence analysisAdd BLAST25
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 240CytoplasmicSequence analysisAdd BLAST18
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 271PeriplasmicSequence analysis10
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293 – 333CytoplasmicSequence analysisAdd BLAST41
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Topological domaini355 – 358PeriplasmicSequence analysis4
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Topological domaini380 – 400CytoplasmicSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 425PeriplasmicSequence analysis4
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Topological domaini447 – 457CytoplasmicSequence analysisAdd BLAST11

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541931 – 457Aromatic amino acid transport protein AroPAdd BLAST457

Proteomic databases

PaxDbiP15993.
PRIDEiP15993.

Expressioni

Inductioni

Its activity is regulated by protein TyrR.

Interactioni

Protein-protein interaction databases

BioGridi4259731. 9 interactors.
STRINGi511145.b0112.

Structurei

3D structure databases

ProteinModelPortaliP15993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261849.
InParanoidiP15993.
KOiK11734.
OMAiNYICLLF.
PhylomeDBiP15993.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEGQQHGEQ LKRGLKNRHI QLIALGGAIG TGLFLGSASV IQSAGPGIIL
60 70 80 90 100
GYAIAGFIAF LIMRQLGEMV VEEPVAGSFS HFAYKYWGSF AGFASGWNYW
110 120 130 140 150
VLYVLVAMAE LTAVGKYIQF WYPEIPTWVS AAVFFVVINA INLTNVKVFG
160 170 180 190 200
EMEFWFAIIK VIAVVAMIIF GGWLLFSGNG GPQATVSNLW DQGGFLPHGF
210 220 230 240 250
TGLVMMMAII MFSFGGLELV GITAAEADNP EQSIPKATNQ VIYRILIFYI
260 270 280 290 300
GSLAVLLSLM PWTRVTADTS PFVLIFHELG DTFVANALNI VVLTAALSVY
310 320 330 340 350
NSCVYCNSRM LFGLAQQGNA PKALASVDKR GVPVNTILVS ALVTALCVLI
360 370 380 390 400
NYLAPESAFG LLMALVVSAL VINWAMISLA HMKFRRAKQE QGVVTRFPAL
410 420 430 440 450
LYPLGNWICL LFMAAVLVIM LMTPGMAISV YLIPVWLIVL GIGYLFKEKT

AKAVKAH
Length:457
Mass (Da):49,690
Last modified:June 20, 2003 - v3
Checksum:iB2F66D3F73CD78BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28A → S in CAA35211 (PubMed:2408019).Curated1
Sequence conflicti199G → A in CAA35211 (PubMed:2408019).Curated1
Sequence conflicti199G → A in AAC45299 (PubMed:9150230).Curated1
Sequence conflicti398 – 399PA → L in CAA35211 (PubMed:2408019).Curated2
Sequence conflicti424P → R in CAA35211 (PubMed:2408019).Curated1
Sequence conflicti424P → R in AAC45299 (PubMed:9150230).Curated1
Sequence conflicti427A → G in CAA35211 (PubMed:2408019).Curated1
Sequence conflicti429S → W in CAA35211 (PubMed:2408019).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17333 Genomic DNA. Translation: CAA35211.1.
U87285 Genomic DNA. Translation: AAC45299.1.
U00096 Genomic DNA. Translation: AAC73223.1.
AP009048 Genomic DNA. Translation: BAB96681.2.
PIRiH64733. QRECAA.
RefSeqiNP_414654.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC73223; AAC73223; b0112.
BAB96681; BAB96681; BAB96681.
GeneIDi946018.
KEGGiecj:JW0108.
eco:b0112.
PATRICi32115325. VBIEscCol129921_0114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17333 Genomic DNA. Translation: CAA35211.1.
U87285 Genomic DNA. Translation: AAC45299.1.
U00096 Genomic DNA. Translation: AAC73223.1.
AP009048 Genomic DNA. Translation: BAB96681.2.
PIRiH64733. QRECAA.
RefSeqiNP_414654.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP15993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259731. 9 interactors.
STRINGi511145.b0112.

Protein family/group databases

TCDBi2.A.3.1.3. the amino acid-polyamine-organocation (apc) family.

Proteomic databases

PaxDbiP15993.
PRIDEiP15993.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73223; AAC73223; b0112.
BAB96681; BAB96681; BAB96681.
GeneIDi946018.
KEGGiecj:JW0108.
eco:b0112.
PATRICi32115325. VBIEscCol129921_0114.

Organism-specific databases

EchoBASEiEB0082.
EcoGeneiEG10084. aroP.

Phylogenomic databases

eggNOGiENOG4105C85. Bacteria.
COG1113. LUCA.
HOGENOMiHOG000261849.
InParanoidiP15993.
KOiK11734.
OMAiNYICLLF.
PhylomeDBiP15993.

Enzyme and pathway databases

BioCyciEcoCyc:AROP-MONOMER.
ECOL316407:JW0108-MONOMER.
MetaCyc:AROP-MONOMER.

Miscellaneous databases

PROiP15993.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAROP_ECOLI
AccessioniPrimary (citable) accession number: P15993
Secondary accession number(s): P75650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 20, 2003
Last modified: November 2, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.