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Protein

Heat shock protein 26

Gene

HSP26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Not known. One of the major polypeptides produced on heat shock.

GO - Molecular functioni

  • mRNA binding Source: SGD
  • unfolded protein binding Source: SGD

GO - Biological processi

  • cellular response to heat Source: SGD
  • protein folding Source: SGD
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-29041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 26
Alternative name(s):
26 kDa heat shock protein
Gene namesi
Name:HSP26
Ordered Locus Names:YBR072W
ORF Names:YBR0714
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR072W.
SGDiS000000276. HSP26.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytoplasmic stress granule Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001260042 – 214Heat shock protein 26Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei42PhosphothreonineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei163PhosphothreonineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP15992.
PRIDEiP15992.
TopDownProteomicsiP15992.

PTM databases

iPTMnetiP15992.

Expressioni

Developmental stagei

Expressed during the entry into stationary phase resulting from glucose limitation.

Inductioni

By heat shock, and under other conditions of stress, such as increased salt concentration and starvation.

Interactioni

Subunit structurei

Present in large complexes.

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi32775. 60 interactors.
DIPiDIP-3988N.
IntActiP15992. 36 interactors.
MINTiMINT-536537.

Structurei

3D structure databases

ProteinModelPortaliP15992.
SMRiP15992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000112974.
InParanoidiP15992.
KOiK13993.
OMAiNINIEFH.
OrthoDBiEOG092C5G0L.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNSPFFDF FDNINNEVDA FNRLLGEGGL RGYAPRRQLA NTPAKDSTGK
60 70 80 90 100
EVARPNNYAG ALYDPRDETL DDWFDNDLSL FPSGFGFPRS VAVPVDILDH
110 120 130 140 150
DNNYELKVVV PGVKSKKDID IEYHQNKNQI LVSGEIPSTL NEESKDKVKV
160 170 180 190 200
KESSSGKFKR VITLPDYPGV DADNIKADYA NGVLTLTVPK LKPQKDGKNH
210
VKKIEVSSQE SWGN
Length:214
Mass (Da):23,880
Last modified:January 23, 2007 - v3
Checksum:i0CB8B6BD22C5308F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32G → A in AAA79010 (PubMed:2673926).Curated1
Sequence conflicti207S → C in AAA79010 (PubMed:2673926).Curated1
Sequence conflicti212W → G in AAT92994 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23871 Genomic DNA. Translation: AAA66914.1.
M26942 Genomic DNA. Translation: AAA79010.1.
X76294 Genomic DNA. Translation: CAA53929.1.
Z35941 Genomic DNA. Translation: CAA85016.1.
AY692975 Genomic DNA. Translation: AAT92994.1.
BK006936 Genomic DNA. Translation: DAA07191.1.
PIRiS45465.
RefSeqiNP_009628.1. NM_001178420.1.

Genome annotation databases

EnsemblFungiiYBR072W; YBR072W; YBR072W.
GeneIDi852364.
KEGGisce:YBR072W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23871 Genomic DNA. Translation: AAA66914.1.
M26942 Genomic DNA. Translation: AAA79010.1.
X76294 Genomic DNA. Translation: CAA53929.1.
Z35941 Genomic DNA. Translation: CAA85016.1.
AY692975 Genomic DNA. Translation: AAT92994.1.
BK006936 Genomic DNA. Translation: DAA07191.1.
PIRiS45465.
RefSeqiNP_009628.1. NM_001178420.1.

3D structure databases

ProteinModelPortaliP15992.
SMRiP15992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32775. 60 interactors.
DIPiDIP-3988N.
IntActiP15992. 36 interactors.
MINTiMINT-536537.

PTM databases

iPTMnetiP15992.

Proteomic databases

MaxQBiP15992.
PRIDEiP15992.
TopDownProteomicsiP15992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR072W; YBR072W; YBR072W.
GeneIDi852364.
KEGGisce:YBR072W.

Organism-specific databases

EuPathDBiFungiDB:YBR072W.
SGDiS000000276. HSP26.

Phylogenomic databases

HOGENOMiHOG000112974.
InParanoidiP15992.
KOiK13993.
OMAiNINIEFH.
OrthoDBiEOG092C5G0L.

Enzyme and pathway databases

BioCyciYEAST:G3O-29041-MONOMER.

Miscellaneous databases

PROiP15992.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP26_YEAST
AccessioniPrimary (citable) accession number: P15992
Secondary accession number(s): D6VQ71, Q6B1V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 19300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.