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P15992

- HSP26_YEAST

UniProt

P15992 - HSP26_YEAST

Protein

Heat shock protein 26

Gene

HSP26

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Not known. One of the major polypeptides produced on heat shock.

    GO - Molecular functioni

    1. mRNA binding Source: SGD
    2. unfolded protein binding Source: SGD

    GO - Biological processi

    1. cellular response to heat Source: SGD
    2. protein folding Source: SGD

    Keywords - Biological processi

    Stress response

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29041-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein 26
    Alternative name(s):
    26 kDa heat shock protein
    Gene namesi
    Name:HSP26
    Ordered Locus Names:YBR072W
    ORF Names:YBR0714
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    SGDiS000000276. HSP26.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 214213Heat shock protein 26PRO_0000126004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei42 – 421Phosphothreonine1 Publication
    Modified residuei90 – 901Phosphoserine1 Publication
    Modified residuei163 – 1631Phosphothreonine1 Publication
    Modified residuei208 – 2081Phosphoserine1 Publication
    Modified residuei211 – 2111Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP15992.
    PaxDbiP15992.
    PeptideAtlasiP15992.

    Expressioni

    Developmental stagei

    Expressed during the entry into stationary phase resulting from glucose limitation.

    Inductioni

    By heat shock, and under other conditions of stress, such as increased salt concentration and starvation.

    Gene expression databases

    GenevestigatoriP15992.

    Interactioni

    Subunit structurei

    Present in large complexes.

    Protein-protein interaction databases

    BioGridi32775. 56 interactions.
    DIPiDIP-3988N.
    IntActiP15992. 36 interactions.
    MINTiMINT-536537.
    STRINGi4932.YBR072W.

    Structurei

    3D structure databases

    ProteinModelPortaliP15992.
    SMRiP15992. Positions 95-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0071.
    HOGENOMiHOG000112974.
    KOiK13993.
    OMAiLESRENQ.
    OrthoDBiEOG7B5X7W.

    Family and domain databases

    Gene3Di2.60.40.790. 1 hit.
    InterProiIPR002068. a-crystallin/Hsp20_dom.
    IPR008978. HSP20-like_chaperone.
    [Graphical view]
    PfamiPF00011. HSP20. 1 hit.
    [Graphical view]
    SUPFAMiSSF49764. SSF49764. 1 hit.
    PROSITEiPS01031. HSP20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15992-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFNSPFFDF FDNINNEVDA FNRLLGEGGL RGYAPRRQLA NTPAKDSTGK    50
    EVARPNNYAG ALYDPRDETL DDWFDNDLSL FPSGFGFPRS VAVPVDILDH 100
    DNNYELKVVV PGVKSKKDID IEYHQNKNQI LVSGEIPSTL NEESKDKVKV 150
    KESSSGKFKR VITLPDYPGV DADNIKADYA NGVLTLTVPK LKPQKDGKNH 200
    VKKIEVSSQE SWGN 214
    Length:214
    Mass (Da):23,880
    Last modified:January 23, 2007 - v3
    Checksum:i0CB8B6BD22C5308F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321G → A in AAA79010. (PubMed:2673926)Curated
    Sequence conflicti207 – 2071S → C in AAA79010. (PubMed:2673926)Curated
    Sequence conflicti212 – 2121W → G in AAT92994. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23871 Genomic DNA. Translation: AAA66914.1.
    M26942 Genomic DNA. Translation: AAA79010.1.
    X76294 Genomic DNA. Translation: CAA53929.1.
    Z35941 Genomic DNA. Translation: CAA85016.1.
    AY692975 Genomic DNA. Translation: AAT92994.1.
    BK006936 Genomic DNA. Translation: DAA07191.1.
    PIRiS45465.
    RefSeqiNP_009628.1. NM_001178420.1.

    Genome annotation databases

    EnsemblFungiiYBR072W; YBR072W; YBR072W.
    GeneIDi852364.
    KEGGisce:YBR072W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M23871 Genomic DNA. Translation: AAA66914.1 .
    M26942 Genomic DNA. Translation: AAA79010.1 .
    X76294 Genomic DNA. Translation: CAA53929.1 .
    Z35941 Genomic DNA. Translation: CAA85016.1 .
    AY692975 Genomic DNA. Translation: AAT92994.1 .
    BK006936 Genomic DNA. Translation: DAA07191.1 .
    PIRi S45465.
    RefSeqi NP_009628.1. NM_001178420.1.

    3D structure databases

    ProteinModelPortali P15992.
    SMRi P15992. Positions 95-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32775. 56 interactions.
    DIPi DIP-3988N.
    IntActi P15992. 36 interactions.
    MINTi MINT-536537.
    STRINGi 4932.YBR072W.

    Proteomic databases

    MaxQBi P15992.
    PaxDbi P15992.
    PeptideAtlasi P15992.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR072W ; YBR072W ; YBR072W .
    GeneIDi 852364.
    KEGGi sce:YBR072W.

    Organism-specific databases

    SGDi S000000276. HSP26.

    Phylogenomic databases

    eggNOGi COG0071.
    HOGENOMi HOG000112974.
    KOi K13993.
    OMAi LESRENQ.
    OrthoDBi EOG7B5X7W.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29041-MONOMER.

    Miscellaneous databases

    NextBioi 971137.

    Gene expression databases

    Genevestigatori P15992.

    Family and domain databases

    Gene3Di 2.60.40.790. 1 hit.
    InterProi IPR002068. a-crystallin/Hsp20_dom.
    IPR008978. HSP20-like_chaperone.
    [Graphical view ]
    Pfami PF00011. HSP20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49764. SSF49764. 1 hit.
    PROSITEi PS01031. HSP20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "hsp26 of Saccharomyces cerevisiae is related to the superfamily of small heat shock proteins but is without a demonstrable function."
      Susek R.E., Lindquist S.L.
      Mol. Cell. Biol. 9:5265-5271(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structure and expression of a yeast gene encoding the small heat-shock protein Hsp26."
      Bossier P., Fitch I.T., Boucherie H., Tuite M.F.
      Gene 78:323-330(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CLEAVAGE OF INITIATOR METHIONINE.
    3. "Sequence analysis of a 31 kb DNA fragment from the right arm of Saccharomyces cerevisiae chromosome II."
      van der Aart Q.J.M., Barthe C., Doignon F., Aigle M., Crouzet M., Steensma H.Y.
      Yeast 10:959-964(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-42; SER-90 AND THR-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208 AND SER-211, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHSP26_YEAST
    AccessioniPrimary (citable) accession number: P15992
    Secondary accession number(s): D6VQ71, Q6B1V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 19300 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3