Reviewed, UniProtKB/Swiss-Prot P15991 (HSPB1_CRILO)

Names and origin

Protein names

Recommended name:
    Heat shock protein beta-1
      Short name=HspB1
Alternative name(s):
    Heat shock 27 kDa protein
      Short name=HSP 27

Gene names

Name:	HSPB1
Synonyms:	HSP27

Organism

Cricetulus longicaudatus (Long-tailed hamster) (Chinese hamster)

Taxonomic identifier

10030 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in stress resistance and actin organization.
Subunit structure	Associates with alpha- and beta-tubulin, microtubules and CRYAB. Interacts with HSPB8 and HSPBAP1 By similarity.
Sequence similarities	Belongs to the small heat shock protein (HSP20) family.

Ontologies

Keywords
Biological process	Stress response
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	response to heat Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DAXX	Q9UER7	2	EBI-1559114,EBI-77321	From a different organism.
HSPB1	P04792	1	EBI-1559114,EBI-352682	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Heat shock protein beta-1		PRO_0000125926
Regions
	Region	78 – 213	136	Interaction with TGFB1I1 By similarity
Amino acid modifications
	Modified residue	13	1	Phosphoserine By similarity
	Modified residue	15	1	Phosphoserine By similarity
	Modified residue	27	1	Phosphoserine By similarity
	Modified residue	90	1	Phosphoserine By similarity
	Modified residue	91	1	Phosphoserine By similarity
	Modified residue	131	1	N6-acetyllysine By similarity
	Modified residue	207	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P15991-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 29E633DBBFA3F89F	FASTA	213	23,419
	10 20 30 40 50 60 MTERRVPFSL LRSPSWEPFR DWYPAHSRLF DQAFGVPRLP DEWSQWFSAA GWPGYVRPLP 70 80 90 100 110 120 AATAEGPAAV ALAAPLAAPA FHRALNRQLS SGVSEIRQTA DRWRVSLDVN HFAPEELTVK 130 140 150 160 170 180 TKEGVVEITG KHEERQDEHG YISRCFTRKY TLPPGVDPTL VSSSLSPEGT LTVEAPLPKT 190 200 210 ATQSAEITIP VTFEARAQIG GQEAGKSEQS GAK

References

[1]	"Sequence of the Chinese hamster small heat shock protein HSP27." Lavoie J., Chretien P., Landry J. Nucleic Acids Res. 18:1637-1637(1990) [PubMed: 2326203] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung fibroblast.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X51747 mRNA. Translation: CAA36036.1.
PIR	S15907.
3D structure databases
SMR	P15991. Positions 77-188.
ModBase	Search...
Protein-protein interaction databases
IntAct	P15991. 2 interactions.
Phylogenomic databases
HOVERGEN	P15991.
Family and domain databases
InterPro	IPR001436. Alpha-crystallin/HSP. IPR002068. Hsp20. IPR008978. HSP20-like_chaperone. [Graphical view]
Pfam	PF00011. HSP20. 1 hit. [Graphical view]
PRINTS	PR00299. ACRYSTALLIN.
PROSITE	PS01031. HSP20. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSPB1_CRILO

Accession

Primary (citable) accession number: P15991

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	February 9, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)