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P15977

- MALQ_ECOLI

UniProt

P15977 - MALQ_ECOLI

Protein

4-alpha-glucanotransferase

Gene

malQ

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.

    GO - Molecular functioni

    1. 4-alpha-glucanotransferase activity Source: EcoCyc

    GO - Biological processi

    1. glycogen metabolic process Source: GOC
    2. maltose catabolic process Source: EcoCyc

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    BioCyciEcoCyc:AMYLOMALT-MONOMER.
    ECOL316407:JW3379-MONOMER.
    MetaCyc:AMYLOMALT-MONOMER.

    Protein family/group databases

    CAZyiGH77. Glycoside Hydrolase Family 77.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-alpha-glucanotransferase (EC:2.4.1.25)
    Alternative name(s):
    Amylomaltase
    Disproportionating enzyme
    Short name:
    D-enzyme
    Gene namesi
    Name:malQ
    Synonyms:malA
    Ordered Locus Names:b3416, JW3379
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG10561. malQ.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: EcoCyc

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6946944-alpha-glucanotransferasePRO_0000170125Add
    BLAST

    Proteomic databases

    PaxDbiP15977.
    PRIDEiP15977.

    Expressioni

    Gene expression databases

    GenevestigatoriP15977.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-10147N.
    IntActiP15977. 6 interactions.
    MINTiMINT-1275716.
    STRINGi511145.b3416.

    Structurei

    3D structure databases

    ProteinModelPortaliP15977.
    SMRiP15977. Positions 155-213, 250-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the disproportionating enzyme family.Curated

    Phylogenomic databases

    eggNOGiCOG1640.
    HOGENOMiHOG000245168.
    KOiK00705.
    OMAiWSRQDEL.
    OrthoDBiEOG6SR926.
    PhylomeDBiP15977.

    Family and domain databases

    Gene3Di3.20.20.80. 2 hits.
    InterProiIPR003385. Glyco_hydro_77.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02446. Glyco_hydro_77. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 2 hits.
    TIGRFAMsiTIGR00217. malQ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P15977-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESKRLDNAA LAAGISPNYI NAHGKPQSIS AETKRRLLDA MHQRTATKVA    50
    VTPVPNVMVY TSGKKMPMVV EGSGEYSWLL TTEEGTQYKG HVTGGKAFNL 100
    PTKLPEGYHT LTLTQDDQRA HCRVIVAPKR CYEPQALLNK QKLWGACVQL 150
    YTLRSEKNWG IGDFGDLKAM LVDVAKRGGS FIGLNPIHAL YPANPESASP 200
    YSPSSRRWLN VIYIDVNAVE DFHLSEEAQA WWQLPTTQQT LQQARDADWV 250
    DYSTVTALKM TALRMAWKGF AQRDDEQMAA FRQFVAEQGD SLFWQAAFDA 300
    LHAQQVKEDE MRWGWPAWPE MYQNVDSPEV RQFCEEHRDD VDFYLWLQWL 350
    AYSQFAACWE ISQGYEMPIG LYRDLAVGVA EGGAETWCDR ELYCLKASVG 400
    APPDILGPLG QNWGLPPMDP HIITARAYEP FIELLRANMQ NCGALRIDHV 450
    MSMLRLWWIP YGETADQGAY VHYPVDDLLS ILALESKRHR CMVIGEDLGT 500
    VPVEIVGKLR SSGVYSYKVL YFENDHEKTF RAPKAYPEQS MAVAATHDLP 550
    TLRGYWECGD LTLGKTLGLY PDEVVLRGLY QDRELAKQGL LDALHKYGCL 600
    PKRAGHKASL MSMTPTLNRG LQRYIADSNS ALLGLQPEDW LDMAEPVNIP 650
    GTSYQYKNWR RKLSATLESM FADDGVNKLL KDLDRRRRAA AKKK 694
    Length:694
    Mass (Da):78,503
    Last modified:November 1, 1995 - v2
    Checksum:i73FFB3F8E5619311
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221A → P in AAA24106. (PubMed:2845225)Curated
    Sequence conflicti199 – 2002SP → TA in AAA24106. (PubMed:2845225)Curated
    Sequence conflicti380 – 3812AE → GT in AAA24106. (PubMed:2845225)Curated
    Sequence conflicti462 – 4621G → R in AAA24106. (PubMed:2845225)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32793 Genomic DNA. Translation: AAA24106.1.
    U18997 Genomic DNA. Translation: AAA58214.1.
    U00096 Genomic DNA. Translation: AAC76441.1.
    AP009048 Genomic DNA. Translation: BAE77875.1.
    PIRiC65137.
    RefSeqiNP_417875.1. NC_000913.3.
    YP_492016.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC76441; AAC76441; b3416.
    BAE77875; BAE77875; BAE77875.
    GeneIDi12932222.
    947923.
    KEGGiecj:Y75_p3760.
    eco:b3416.
    PATRICi32122270. VBIEscCol129921_3512.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32793 Genomic DNA. Translation: AAA24106.1 .
    U18997 Genomic DNA. Translation: AAA58214.1 .
    U00096 Genomic DNA. Translation: AAC76441.1 .
    AP009048 Genomic DNA. Translation: BAE77875.1 .
    PIRi C65137.
    RefSeqi NP_417875.1. NC_000913.3.
    YP_492016.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P15977.
    SMRi P15977. Positions 155-213, 250-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-10147N.
    IntActi P15977. 6 interactions.
    MINTi MINT-1275716.
    STRINGi 511145.b3416.

    Protein family/group databases

    CAZyi GH77. Glycoside Hydrolase Family 77.

    Proteomic databases

    PaxDbi P15977.
    PRIDEi P15977.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC76441 ; AAC76441 ; b3416 .
    BAE77875 ; BAE77875 ; BAE77875 .
    GeneIDi 12932222.
    947923.
    KEGGi ecj:Y75_p3760.
    eco:b3416.
    PATRICi 32122270. VBIEscCol129921_3512.

    Organism-specific databases

    EchoBASEi EB0556.
    EcoGenei EG10561. malQ.

    Phylogenomic databases

    eggNOGi COG1640.
    HOGENOMi HOG000245168.
    KOi K00705.
    OMAi WSRQDEL.
    OrthoDBi EOG6SR926.
    PhylomeDBi P15977.

    Enzyme and pathway databases

    BioCyci EcoCyc:AMYLOMALT-MONOMER.
    ECOL316407:JW3379-MONOMER.
    MetaCyc:AMYLOMALT-MONOMER.

    Miscellaneous databases

    PROi P15977.

    Gene expression databases

    Genevestigatori P15977.

    Family and domain databases

    Gene3Di 3.20.20.80. 2 hits.
    InterProi IPR003385. Glyco_hydro_77.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02446. Glyco_hydro_77. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 2 hits.
    TIGRFAMsi TIGR00217. malQ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of malQ, the structural gene for the Escherichia coli enzyme amylomaltase."
      Pugsley A.P., Dubreuil C.
      Mol. Microbiol. 2:473-479(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiMALQ_ECOLI
    AccessioniPrimary (citable) accession number: P15977
    Secondary accession number(s): Q2M781
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3