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Protein

Erythroid transcription factor

Gene

GATA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 228GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri258 – 282GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: BHF-UCL
  • chromatin DNA binding Source: UniProtKB
  • core promoter binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • DNA binding, bending Source: Ensembl
  • enhancer sequence-specific DNA binding Source: Ensembl
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  • RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL
  • sequence-specific DNA binding Source: BHF-UCL
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: GO_Central
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: BHF-UCL
  • transcription factor activity, sequence-specific DNA binding Source: BHF-UCL
  • transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
  • zinc ion binding Source: InterPro

GO - Biological processi

  • animal organ morphogenesis Source: GO_Central
  • basophil differentiation Source: BHF-UCL
  • blood coagulation Source: Reactome
  • cell-cell signaling Source: Ensembl
  • cellular response to thyroid hormone stimulus Source: UniProtKB
  • dendritic cell differentiation Source: Ensembl
  • digestive tract development Source: GO_Central
  • embryonic hemopoiesis Source: Ensembl
  • eosinophil differentiation Source: BHF-UCL
  • eosinophil fate commitment Source: BHF-UCL
  • erythrocyte development Source: BHF-UCL
  • erythrocyte differentiation Source: BHF-UCL
  • heart development Source: GO_Central
  • homeostasis of number of cells within a tissue Source: Ensembl
  • in utero embryonic development Source: Ensembl
  • male gonad development Source: BHF-UCL
  • megakaryocyte differentiation Source: BHF-UCL
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of bone mineralization Source: Ensembl
  • negative regulation of cell proliferation Source: Ensembl
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
  • platelet aggregation Source: BHF-UCL
  • platelet formation Source: BHF-UCL
  • positive regulation of erythrocyte differentiation Source: UniProtKB
  • positive regulation of osteoblast proliferation Source: Ensembl
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of definitive erythrocyte differentiation Source: BHF-UCL
  • regulation of glycoprotein biosynthetic process Source: BHF-UCL
  • regulation of primitive erythrocyte differentiation Source: Ensembl
  • tissue development Source: GO_Central
  • transcriptional activation by promoter-enhancer looping Source: BHF-UCL
  • transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102145-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP15976.
SIGNORiP15976.

Names & Taxonomyi

Protein namesi
Recommended name:
Erythroid transcription factor
Alternative name(s):
Eryf1
GATA-binding factor 1
Short name:
GATA-1
Short name:
GF-1
NF-E1 DNA-binding protein
Gene namesi
Name:GATA1
Synonyms:ERYF1, GF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:4170. GATA1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • transcriptional repressor complex Source: BHF-UCL
  • transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

X-linked dyserythropoietic anemia and thrombocytopenia (XDAT)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDisorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.
See also OMIM:300367
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010115205V → M in XDAT; severe impairment of ZFPM1 binding and erythroid differentiation in vitro. 1 PublicationCorresponds to variant rs104894815dbSNPEnsembl.1
Natural variantiVAR_012706208G → S in XDAT; partially disrupts the interaction with ZFPM1. 1 PublicationCorresponds to variant rs137852312dbSNPEnsembl.1
Natural variantiVAR_012707218D → G in XDAT; partially disrupts the interaction with ZFPM1. 1 PublicationCorresponds to variant rs104894816dbSNPEnsembl.1
Natural variantiVAR_033115218D → Y in XDAT; stronger loss of affinity than of G-218-GATA1 for ZFPM1 and disturbed GATA1 self-association. 1 PublicationCorresponds to variant rs104894808dbSNPEnsembl.1
Thrombocytopenia with beta-thalassemia, X-linked (XLTT)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn unusual form of thrombocytopenia associated with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced (hemo)globin chain synthesis resembling that of beta-thalassemia minor.
See also OMIM:314050
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033114216R → Q in XLTT; does not affect ZFPM1 binding; reduced affinity to palindromic GATA sites; supports erythroid maturation less efficiently than wild-type GATA1. 1 PublicationCorresponds to variant rs104894809dbSNPEnsembl.1
Anemia without thrombocytopenia, X-linked (XLAWT)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of anemia characterized by abnormal morphology of erythrocytes and granulocytes in peripheral blood, bone marrow dysplasia with hypocellularity of erythroid and granulocytic lineages, and normal or increased number of megakaryocytes. Neutropenia of a variable degree is present in affected individuals.
See also OMIM:300835

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi137K → R: Abolishes sumoylation. 1 Publication1
Mutagenesisi142S → A: Loss of sumoylation. 1 Publication1
Mutagenesisi142S → D: Increased sumoylation in vitro. 1 Publication1
Mutagenesisi204C → R: Increase of dissociation rate from bound DNA. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi2623.
MalaCardsiGATA1.
MIMi300367. phenotype.
300835. phenotype.
314050. phenotype.
OpenTargetsiENSG00000102145.
Orphaneti86849. Acute basophilic leukemia.
231393. Beta-thalassemia - X-linked thrombocytopenia.
124. Blackfan-Diamond anemia.
79277. Congenital erythropoietic porphyria.
67044. Thrombocytopenia with congenital dyserythropoietic anemia.
363727. X-linked dyserythropoetic anemia with abnormal platelets and neutropenia.
PharmGKBiPA28584.

Polymorphism and mutation databases

BioMutaiGATA1.
DMDMi120956.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000833971 – 413Erythroid transcription factorAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei116PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Cross-linki137Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei142Phosphoserine1 Publication1
Modified residuei178PhosphoserineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei233N6-acetyllysine; by EP3001 Publication1
Modified residuei245N6-acetyllysine; by EP3001 Publication1
Modified residuei246N6-acetyllysine; by CREBBPBy similarity1
Modified residuei246N6-acetyllysine; by EP3001 Publication1
Modified residuei252N6-acetyllysine; by CREBBPBy similarity1
Modified residuei308N6-acetyllysineBy similarity1
Modified residuei310PhosphoserineBy similarity1
Modified residuei312N6-acetyllysine; by CREBBPBy similarity1
Modified residuei314N6-acetyllysineBy similarity1
Modified residuei315N6-acetyllysineBy similarity1

Post-translational modificationi

Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137 (By similarity).By similarity
Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity (By similarity).By similarity
Acetylated at 2 conserved lysine-rich motifs by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo (By similarity). Acetylated on Lys-233, Lys-245 Lys-246 by EP300.By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP15976.
PaxDbiP15976.
PeptideAtlasiP15976.
PRIDEiP15976.

PTM databases

iPTMnetiP15976.
PhosphoSitePlusiP15976.

Miscellaneous databases

PMAP-CutDBP15976.

Expressioni

Tissue specificityi

Erythrocytes.1 Publication

Gene expression databases

BgeeiENSG00000102145.
CleanExiHS_GATA1.
ExpressionAtlasiP15976. baseline and differential.
GenevisibleiP15976. HS.

Organism-specific databases

HPAiCAB009195.
HPA000232.
HPA000233.

Interactioni

Subunit structurei

May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with BRD3 (By similarity). Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo (By similarity). Interacts with EP300. Interacts with MED1, CCAR1 and CALCOCO1.By similarity9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC24Q8N4L83EBI-3909284,EBI-1104933
FBF1Q8TES7-63EBI-3909284,EBI-10244131
FHL3Q136434EBI-9090198,EBI-741101
FRS3O435593EBI-3909284,EBI-725515
HEXIM2Q96MH23EBI-3909284,EBI-5460660
HOXA1P496393EBI-3909284,EBI-740785
HSPA1BP081075EBI-3909284,EBI-629985
KRTAP10-5P603703EBI-3909284,EBI-10172150
KRTAP9-2Q9BYQ43EBI-3909284,EBI-1044640
PRKAB2O437414EBI-9090198,EBI-1053424
RADILQ96JH83EBI-3909284,EBI-744267

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi108893. 61 interactors.
DIPiDIP-41431N.
IntActiP15976. 34 interactors.
MINTiMINT-247486.
STRINGi9606.ENSP00000365858.

Structurei

3D structure databases

ProteinModelPortaliP15976.
SMRiP15976.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni200 – 330Interaction with MED1 and CCAR11 PublicationAdd BLAST131
Regioni203 – 222Required for interaction with ZFPM1Add BLAST20
Regioni249 – 315Interaction with CALCOCO11 PublicationAdd BLAST67

Domaini

The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding (By similarity).By similarity

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 228GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri258 – 282GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP15976.
KOiK09182.
OMAiPSTAHLY.
OrthoDBiEOG091G0AUR.
PhylomeDBiP15976.
TreeFamiTF315391.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029524. GATA-1.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF190. PTHR10071:SF190. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P15976-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEFPGLGSLG TSEPLPQFVD PALVSSTPES GVFFPSGPEG LDAAASSTAP
60 70 80 90 100
STATAAAAAL AYYRDAEAYR HSPVFQVYPL LNCMEGIPGG SPYAGWAYGK
110 120 130 140 150
TGLYPASTVC PTREDSPPQA VEDLDGKGST SFLETLKTER LSPDLLTLGP
160 170 180 190 200
ALPSSLPVPN SAYGGPDFSS TFFSPTGSPL NSAAYSSPKL RGTLPLPPCE
210 220 230 240 250
ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP LIRPKKRLIV
260 270 280 290 300
SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYYKLHQ VNRPLTMRKD
310 320 330 340 350
GIQTRNRKAS GKGKKKRGSS LGGTGAAEGP AGGFMVVAGG SGSGNCGEVA
360 370 380 390 400
SGLTLGPPGT AHLYQGLGPV VLSGPVSHLM PFPGPLLGSP TGSFPTGPMP
410
PTTSTTVVAP LSS
Length:413
Mass (Da):42,751
Last modified:April 1, 1990 - v1
Checksum:i822BD2DE14B908AD
GO
Isoform 2 (identifier: P15976-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-413: QVNRPLTMRK...STTVVAPLSS → HQHYCGGSAQ...KSLGPRHPLA

Note: No experimental confirmation available.
Show »
Length:335
Mass (Da):35,430
Checksum:i9CE44220E09F69D7
GO
Isoform 3 (identifier: P15976-3) [UniParc]FASTAAdd to basket
Also known as: GATA-1s

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Note: Produced by alternative initiation at Met-84 of isoform 1.
Show »
Length:330
Mass (Da):34,232
Checksum:iE5ACD72BCBDB40B1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010115205V → M in XDAT; severe impairment of ZFPM1 binding and erythroid differentiation in vitro. 1 PublicationCorresponds to variant rs104894815dbSNPEnsembl.1
Natural variantiVAR_012706208G → S in XDAT; partially disrupts the interaction with ZFPM1. 1 PublicationCorresponds to variant rs137852312dbSNPEnsembl.1
Natural variantiVAR_033114216R → Q in XLTT; does not affect ZFPM1 binding; reduced affinity to palindromic GATA sites; supports erythroid maturation less efficiently than wild-type GATA1. 1 PublicationCorresponds to variant rs104894809dbSNPEnsembl.1
Natural variantiVAR_012707218D → G in XDAT; partially disrupts the interaction with ZFPM1. 1 PublicationCorresponds to variant rs104894816dbSNPEnsembl.1
Natural variantiVAR_033115218D → Y in XDAT; stronger loss of affinity than of G-218-GATA1 for ZFPM1 and disturbed GATA1 self-association. 1 PublicationCorresponds to variant rs104894808dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0414511 – 83Missing in isoform 3. CuratedAdd BLAST83
Alternative sequenceiVSP_014782290 – 413QVNRP…APLSS → HQHYCGGSAQLMRAQSMASR GGVVSFSSCSQNSGQPKSLG PRHPLA in isoform 2. 1 PublicationAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17254 mRNA. Translation: CAA35120.1.
M30601 mRNA. Translation: AAA35885.1.
AF196971 Genomic DNA. No translation available.
BC009797 mRNA. Translation: AAH09797.1.
CCDSiCCDS14305.1. [P15976-1]
PIRiA34888.
RefSeqiNP_002040.1. NM_002049.3. [P15976-1]
UniGeneiHs.765.

Genome annotation databases

EnsembliENST00000376670; ENSP00000365858; ENSG00000102145. [P15976-1]
GeneIDi2623.
KEGGihsa:2623.
UCSCiuc004dkq.5. human. [P15976-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17254 mRNA. Translation: CAA35120.1.
M30601 mRNA. Translation: AAA35885.1.
AF196971 Genomic DNA. No translation available.
BC009797 mRNA. Translation: AAH09797.1.
CCDSiCCDS14305.1. [P15976-1]
PIRiA34888.
RefSeqiNP_002040.1. NM_002049.3. [P15976-1]
UniGeneiHs.765.

3D structure databases

ProteinModelPortaliP15976.
SMRiP15976.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108893. 61 interactors.
DIPiDIP-41431N.
IntActiP15976. 34 interactors.
MINTiMINT-247486.
STRINGi9606.ENSP00000365858.

PTM databases

iPTMnetiP15976.
PhosphoSitePlusiP15976.

Polymorphism and mutation databases

BioMutaiGATA1.
DMDMi120956.

Proteomic databases

MaxQBiP15976.
PaxDbiP15976.
PeptideAtlasiP15976.
PRIDEiP15976.

Protocols and materials databases

DNASUi2623.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376670; ENSP00000365858; ENSG00000102145. [P15976-1]
GeneIDi2623.
KEGGihsa:2623.
UCSCiuc004dkq.5. human. [P15976-1]

Organism-specific databases

CTDi2623.
DisGeNETi2623.
GeneCardsiGATA1.
GeneReviewsiGATA1.
HGNCiHGNC:4170. GATA1.
HPAiCAB009195.
HPA000232.
HPA000233.
MalaCardsiGATA1.
MIMi300367. phenotype.
300835. phenotype.
305371. gene.
314050. phenotype.
neXtProtiNX_P15976.
OpenTargetsiENSG00000102145.
Orphaneti86849. Acute basophilic leukemia.
231393. Beta-thalassemia - X-linked thrombocytopenia.
124. Blackfan-Diamond anemia.
79277. Congenital erythropoietic porphyria.
67044. Thrombocytopenia with congenital dyserythropoietic anemia.
363727. X-linked dyserythropoetic anemia with abnormal platelets and neutropenia.
PharmGKBiPA28584.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP15976.
KOiK09182.
OMAiPSTAHLY.
OrthoDBiEOG091G0AUR.
PhylomeDBiP15976.
TreeFamiTF315391.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102145-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP15976.
SIGNORiP15976.

Miscellaneous databases

ChiTaRSiGATA1. human.
GeneWikiiGATA1.
GenomeRNAii2623.
PMAP-CutDBP15976.
PROiP15976.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102145.
CleanExiHS_GATA1.
ExpressionAtlasiP15976. baseline and differential.
GenevisibleiP15976. HS.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029524. GATA-1.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF190. PTHR10071:SF190. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATA1_HUMAN
AccessioniPrimary (citable) accession number: P15976
Secondary accession number(s): Q96GB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 183 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.