P15971 (TOG2A_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Omega-agatoxin-Aa2a Short name=Omega-AGTX-Aa2a Alternative name(s): Omega-agatoxin IIA Short name=Omega-Aga-IIA Omega-agatoxin-2A
Organism	Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier	6908 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Araneae › Araneomorphae › Entelegynae › RTA clade › Agelenidae › Agelenopsis

Protein attributes

Sequence length	28 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N-type calcium channels (Cav2.2/CACNA1B).
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the omega-agatoxin superfamily. Type II/III omega-agatoxin family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Calcium channel inhibitor Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Toxin
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	other organism presynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›28	›28	Omega-agatoxin-Aa2a		PRO_0000087605
Experimental info
	Non-terminal residue	28	1

Sequences

	Sequence		Length	Mass (Da)
	P15971 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 0EDD253248A6C9AE	FASTA	28	3,053
	10 20 GCIEIGGDCD GYQEKSYCQC CRNNGFCS

References

[1]	"Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom." Adams M.E., Bindokas V.P., Hasegawa L., Venema V.J. J. Biol. Chem. 265:861-867(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	C34923.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ArachnoServer	AS000177. omega-agatoxin-Aa2a (N-terminal fragment).
Family and domain databases
InterPro	IPR005853. Omega-agatoxin_II/III_CS. IPR013605. Toxin_34. [Graphical view]
Pfam	PF08396. Toxin_34. 1 hit. [Graphical view]
PROSITE	PS60023. OMEGA_AGA_II_III. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TOG2A_AGEAP

Accession

Primary (citable) accession number: P15971

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program