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P15971 (TOG2A_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Omega-agatoxin-Aa2a

Short name=Omega-AGTX-Aa2a
Alternative name(s):
Omega-agatoxin IIA
Short name=Omega-Aga-IIA
Omega-agatoxin-2A
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length28 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N-type calcium channels (Cav2.2/CACNA1B).

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the omega-agatoxin superfamily. Type II/III omega-agatoxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›28›28Omega-agatoxin-Aa2a
PRO_0000087605

Experimental info

Non-terminal residue281

Sequences

Sequence LengthMass (Da)Tools
P15971 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 0EDD253248A6C9AE

FASTA283,053
        10         20 
GCIEIGGDCD GYQEKSYCQC CRNNGFCS 

« Hide

References

[1]"Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom."
Adams M.E., Bindokas V.P., Hasegawa L., Venema V.J.
J. Biol. Chem. 265:861-867(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

Sequence databases

PIRC34923.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000177. omega-agatoxin-Aa2a (N-terminal fragment).

Family and domain databases

InterProIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTOG2A_AGEAP
AccessionPrimary (citable) accession number: P15971
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families