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P15971

- TOG2A_AGEAP

UniProt

P15971 - TOG2A_AGEAP

Protein

Omega-agatoxin-Aa2a

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N-type calcium channels (Cav2.2/CACNA1B).

    Keywords - Molecular functioni

    Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Omega-agatoxin-Aa2a
    Short name:
    Omega-AGTX-Aa2a
    Alternative name(s):
    Omega-agatoxin IIA
    Short name:
    Omega-Aga-IIA
    Omega-agatoxin-2A
    OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
    Taxonomic identifieri6908 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

    Organism-specific databases

    ArachnoServeriAS000177. omega-agatoxin-Aa2a (N-terminal fragment).

    Subcellular locationi

    GO - Cellular componenti

    1. other organism presynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›28›28Omega-agatoxin-Aa2aPRO_0000087605Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR005853. Omega-agatoxin_II/III_CS.
    IPR013605. Toxin_34.
    [Graphical view]
    PfamiPF08396. Toxin_34. 1 hit.
    [Graphical view]
    PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P15971-1 [UniParc]FASTAAdd to Basket

    « Hide

    GCIEIGGDCD GYQEKSYCQC CRNNGFCS                           28
    Length:28
    Mass (Da):3,053
    Last modified:April 1, 1990 - v1
    Checksum:i0EDD253248A6C9AE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei28 – 281

    Sequence databases

    PIRiC34923.

    Cross-referencesi

    Sequence databases

    PIRi C34923.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ArachnoServeri AS000177. omega-agatoxin-Aa2a (N-terminal fragment).

    Family and domain databases

    InterProi IPR005853. Omega-agatoxin_II/III_CS.
    IPR013605. Toxin_34.
    [Graphical view ]
    Pfami PF08396. Toxin_34. 1 hit.
    [Graphical view ]
    PROSITEi PS60023. OMEGA_AGA_II_III. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom."
      Adams M.E., Bindokas V.P., Hasegawa L., Venema V.J.
      J. Biol. Chem. 265:861-867(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.

    Entry informationi

    Entry nameiTOG2A_AGEAP
    AccessioniPrimary (citable) accession number: P15971
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3