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P15971

- TOG2A_AGEAP

UniProt

P15971 - TOG2A_AGEAP

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Protein

Omega-agatoxin-Aa2a

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N-type calcium channels (Cav2.2/CACNA1B).

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-Aa2a
Short name:
Omega-AGTX-Aa2a
Alternative name(s):
Omega-agatoxin IIA
Short name:
Omega-Aga-IIA
Omega-agatoxin-2A
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000177. omega-agatoxin-Aa2a (N-terminal fragment).

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›28›28Omega-agatoxin-Aa2aPRO_0000087605Add
BLAST

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]
PROSITEiPS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P15971-1 [UniParc]FASTAAdd to Basket

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GCIEIGGDCD GYQEKSYCQC CRNNGFCS                           28
Length:28
Mass (Da):3,053
Last modified:April 1, 1990 - v1
Checksum:i0EDD253248A6C9AE
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei28 – 281

Sequence databases

PIRiC34923.

Cross-referencesi

Sequence databases

PIRi C34923.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000177. omega-agatoxin-Aa2a (N-terminal fragment).

Family and domain databases

InterProi IPR005853. Omega-agatoxin_II/III_CS.
IPR013605. Toxin_34.
[Graphical view ]
Pfami PF08396. Toxin_34. 1 hit.
[Graphical view ]
PROSITEi PS60023. OMEGA_AGA_II_III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom."
    Adams M.E., Bindokas V.P., Hasegawa L., Venema V.J.
    J. Biol. Chem. 265:861-867(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.

Entry informationi

Entry nameiTOG2A_AGEAP
AccessioniPrimary (citable) accession number: P15971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3