Reviewed, UniProtKB/Swiss-Prot P15971 (TOG2A_AGEAP)

Names and origin

Protein names	Recommended name: Omega-agatoxin-Aa2a Short name=Omega-AGTX-Aa2a Alternative name(s): Omega-agatoxin-2A Omega-agatoxin IIA Short name=Omega-Aga-IIA
Organism	Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier	6908 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Araneae › Araneomorphae › Entelegynae › Agelenidae › Agelenopsis

Protein attributes

Sequence length	28 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Omega-agatoxin are antagonist of voltage-sensitive calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N-type calcium channels.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the omega-agatoxin superfamily. Type II/III omega-agatoxin family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Calcium channel inhibitor Ionic channel inhibitor Neurotoxin Presynaptic neurotoxin Toxin
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW synaptic transmission Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell presynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›28	›28	Omega-agatoxin-Aa2a		PRO_0000087605
Experimental info
	Non-terminal residue	28	1

Sequences

	Sequence		Length	Mass (Da)
	P15971-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 0EDD253248A6C9AE	FASTA	28	3,053
	10 20 GCIEIGGDCD GYQEKSYCQC CRNNGFCS

References

[1]	"Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom." Adams M.E., Bindokas V.P., Hasegawa L., Venema V.J. J. Biol. Chem. 265:861-867(1990) [PubMed: 2295621] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	C34923.
3D structure databases
ModBase	Search...
Organism-specific databases
ArachnoServer	AS000177. omega-agatoxin-Aa2a (N-terminal fragment).
Family and domain databases
InterPro	IPR005853. Omega-agatoxin_II/III_CS. [Graphical view]
PROSITE	PS60023. OMEGA_AGA_II_III. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TOG2A_AGEAP

Accession

Primary (citable) accession number: P15971

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)