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P15969

- TOG1A_AGEAP

UniProt

P15969 - TOG1A_AGEAP

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Protein
Omega-agatoxin-1A
Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. This toxin is a blocker of L-type calcium channels (Cav/CACNA1).1 Publication

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-1A
Alternative name(s):
Omega-agatoxin IA
Short name:
Omega-Aga-IA
Cleaved into the following 2 chains:
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000175. omega-agatoxin-Aa1a.

Subcellular locationi

GO - Cellular componenti

  1. other organism presynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 3617
PRO_0000035486Add
BLAST
Chaini37 – 10266Omega-agatoxin-1A major chain
PRO_0000035487Add
BLAST
Propeptidei103 – 1097Glu-rich
PRO_0000035488
Chaini110 – 1123Omega-agatoxin-1A minor chain
PRO_0000035489

Post-translational modificationi

Proteolytically processed to yield the major and the minor chains.

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer of two subunits, a major chain and a minor chain, linked by a disulfide bond.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15969-1 [UniParc]FASTAAdd to Basket

« Hide

MMKFVVFLAC LFVAAHSFAV EGEEEYFEAE VPELERAKAL PPGSVCDGNE    50
SDCKCYGKWH KCRCPWKWHF TGEGPCTCEK GMKHTCITKL HCPNKAEWGL 100
DWRSEESERS PC 112
Length:112
Mass (Da):12,808
Last modified:November 1, 1997 - v2
Checksum:iACC0ED776E49DF23
GO

Mass spectrometryi

Molecular mass is 7791.4 Da from positions 37 - 102 and 110 - 112. Determined by PD. 1 Publication

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011D → N AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95540 mRNA. No translation available.
PIRiA45069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95540 mRNA. No translation available.
PIRi A45069.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

ArachnoServeri AS000175. omega-agatoxin-Aa1a.

Family and domain databases

InterProi IPR013605. Toxin_34.
[Graphical view ]
Pfami PF08396. Toxin_34. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Heterodimeric structure of the spider toxin omega-agatoxin IA revealed by precursor analysis and mass spectrometry."
    Santos A.D., Imperial J.S., Chaudhary T., Beavis R.C., Chait B.T., Hunsperger J.P., Olivera B.M., Adams M.E., Hillyard D.R.
    J. Biol. Chem. 267:20701-20705(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, MASS SPECTROMETRY.
    Tissue: Venom.
  2. "Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom."
    Adams M.E., Bindokas V.P., Hasegawa L., Venema V.J.
    J. Biol. Chem. 265:861-867(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 37-102, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Venom.
  3. "Differential antagonism of transmitter release by subtypes of omega-agatoxins."
    Bindokas V.P., Venema V.J., Adams M.E.
    J. Neurophysiol. 66:590-601(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTOG1A_AGEAP
AccessioniPrimary (citable) accession number: P15969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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