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Protein

Omega-agatoxin-1A

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. This toxin is a blocker of L-type calcium channels (Cav/CACNA1).1 Publication

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-agatoxin-1A
Alternative name(s):
Omega-agatoxin IA
Short name:
Omega-Aga-IA
Cleaved into the following 2 chains:
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000175. omega-agatoxin-Aa1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003548620 – 361 PublicationAdd BLAST17
ChainiPRO_000003548737 – 102Omega-agatoxin-1A major chainAdd BLAST66
PropeptideiPRO_0000035488103 – 109Glu-rich7
ChainiPRO_0000035489110 – 112Omega-agatoxin-1A minor chain3

Post-translational modificationi

Proteolytically processed to yield the major and the minor chains.

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer of two subunits, a major chain and a minor chain, linked by a disulfide bond.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKFVVFLAC LFVAAHSFAV EGEEEYFEAE VPELERAKAL PPGSVCDGNE
60 70 80 90 100
SDCKCYGKWH KCRCPWKWHF TGEGPCTCEK GMKHTCITKL HCPNKAEWGL
110
DWRSEESERS PC
Length:112
Mass (Da):12,808
Last modified:November 1, 1997 - v2
Checksum:iACC0ED776E49DF23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101D → N AA sequence (PubMed:2295621).Curated1

Mass spectrometryi

Molecular mass is 7791.4 Da from positions 37 - 102 and 110 - 112. Determined by PD. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95540 mRNA. No translation available.
PIRiA45069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95540 mRNA. No translation available.
PIRiA45069.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000175. omega-agatoxin-Aa1a.

Family and domain databases

InterProiIPR013605. Toxin_34.
[Graphical view]
PfamiPF08396. Toxin_34. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOG1A_AGEAP
AccessioniPrimary (citable) accession number: P15969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.