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P15969 (TOG1A_AGEAP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Omega-agatoxin-1A
Alternative name(s):
Omega-agatoxin IA
Short name=Omega-Aga-IA
OrganismAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifier6908 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Protein attributes

Sequence length112 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. This toxin is a blocker of L-type calcium channels (Cav/CACNA1). Ref.3

Subunit structure

Heterodimer of two subunits, a major chain and a minor chain, linked by a disulfide bond.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Post-translational modification

Proteolytically processed to yield the major and the minor chains.

Sequence similarities

Belongs to the omega-agatoxin superfamily. Type I omega-agatoxin family.

Mass spectrometry

Molecular mass is 7791.4 Da from positions 37 - 102 and 110 - 112. Determined by PD. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 3617
PRO_0000035486
Chain37 – 10266Omega-agatoxin-1A major chain
PRO_0000035487
Propeptide103 – 1097Glu-rich
PRO_0000035488
Chain110 – 1123Omega-agatoxin-1A minor chain
PRO_0000035489

Experimental info

Sequence conflict1011D → N AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P15969 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: ACC0ED776E49DF23

FASTA11212,808
        10         20         30         40         50         60 
MMKFVVFLAC LFVAAHSFAV EGEEEYFEAE VPELERAKAL PPGSVCDGNE SDCKCYGKWH 

        70         80         90        100        110 
KCRCPWKWHF TGEGPCTCEK GMKHTCITKL HCPNKAEWGL DWRSEESERS PC 

« Hide

References

[1]"Heterodimeric structure of the spider toxin omega-agatoxin IA revealed by precursor analysis and mass spectrometry."
Santos A.D., Imperial J.S., Chaudhary T., Beavis R.C., Chait B.T., Hunsperger J.P., Olivera B.M., Adams M.E., Hillyard D.R.
J. Biol. Chem. 267:20701-20705(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, MASS SPECTROMETRY.
Tissue: Venom.
[2]"Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom."
Adams M.E., Bindokas V.P., Hasegawa L., Venema V.J.
J. Biol. Chem. 265:861-867(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 37-102, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Venom.
[3]"Differential antagonism of transmitter release by subtypes of omega-agatoxins."
Bindokas V.P., Venema V.J., Adams M.E.
J. Neurophysiol. 66:590-601(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95540 mRNA. No translation available.
PIRA45069.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ArachnoServerAS000175. omega-agatoxin-Aa1a.

Family and domain databases

InterProIPR013605. Toxin_34.
[Graphical view]
PfamPF08396. Toxin_34. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTOG1A_AGEAP
AccessionPrimary (citable) accession number: P15969
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families