Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P15962

- RDRP_TBSVC

UniProt

P15962 - RDRP_TBSVC

Protein

RNA-directed RNA polymerase

Gene

ORF1

Organism
Tomato bushy stunt virus (strain Cherry) (TBSV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (05 Oct 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    RNA-dependent RNA polymerase that plays an essential role in the virus replication.Curated

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    GO - Molecular functioni

    1. nucleotide binding Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. viral RNA genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Alternative name(s):
    Protein p92
    Cleaved into the following chain:
    Gene namesi
    ORF Names:ORF1
    OrganismiTomato bushy stunt virus (strain Cherry) (TBSV)
    Taxonomic identifieri12147 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
    Virus hostiCapsicum annuum (Bell pepper) [TaxID: 4072]
    Malus [TaxID: 3749]
    Pyrus (pears) [TaxID: 3766]
    Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
    Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
    Tolmiea menziesii [TaxID: 29777]
    Tulipa [TaxID: 13305]
    ProteomesiUP000001666: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 818818RNA-directed RNA polymerasePRO_0000041336Add
    BLAST
    Chaini1 – 296296Protein p33PRO_0000041337Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP15962.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini524 – 641118RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view]
    PfamiPF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view]
    PROSITEiPS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15962-1 [UniParc]FASTAAdd to Basket

    « Hide

    METIKRMIWP KKEIFVGDFA TGVNRTVPVN IFQLVCRVVL RYMRTGKIEC    50
    DSDSMTKFIV ELLKTDCAAK WEWFMKRRQR GDYIVPLSIA SIPIIPLLSY 100
    ATRVRAVSVK AFGNELSFNV RVPRPSVPKK GLLLRLAAGL ALAPICALAV 150
    YATLPREKLS VFKLRTEARA HMEDEREATD CLVVEPAREL KGKDGEDLLT 200
    GSRLTKVIAS TGRPRRRPYA AKIAQVARAK VGYLKNSPEN RLIYQRVMIE 250
    IMDKDCVRYV DRDVILPLAI GCCFVYPDGV EESAALWGSQ ESLGVKXGGL 300
    VRLPGVVTQI NRDIPSDVLL PQEVLEVRTG PPNAKDRNIF MVAGCPSQAR 350
    FLVHNHCLKN LKRGLVERVF CVERNGKLAR TPQPTKGAFG RLSPFRKAVC 400
    EKVGVAHRLG YDGFLSYYSG AKLRTYTRAV ESLHITPVSE RDSHLTTFVK 450
    AEKISTSKGD PAPRVIQPRN PRYNVELGRY LRHMESKLMK AVDGVFGETT 500
    CIKGYTADEV GAIFRAKWDR FDKPVAIGLD ASRFDQHCSV EALQYEHSFY 550
    RAMYPGNKLL GKLLEWQLHN KGKGYVPDGT ITYRKEGCRM SGDINTSLGN 600
    YLLMCAMVHG YMRHLGINEF SLANCGDDCV LIVERRNLKQ IQRTLPEYFL 650
    NLGYTMKVEQ PVFQLEEVEF CQAHPVQFQG GWKMVRNVRT AMSKDVHCVN 700
    NIRDLATRRA WSNAQHHGGL ALSAGIPVVE TFYSRFKLYD VPRKHQRIDT 750
    VTNVHKWRGS GGSYVVTPES RASFWAAFGL TGDEQLALED RLERWEMDLF 800
    GEEGVDAHEP SILDSAVA 818
    Length:818
    Mass (Da):92,253
    Last modified:October 5, 2010 - v2
    Checksum:iD61AD04D5F94BC42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21958 Genomic RNA. Translation: AAB02534.1.
    M21958 Genomic RNA. Translation: AAB02535.1.
    PIRiA35315. RRVGCT.
    RefSeqiNP_062897.1. NC_001554.1.
    NP_062898.1. NC_001554.1.

    Genome annotation databases

    GeneIDi1493955.
    1493956.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21958 Genomic RNA. Translation: AAB02534.1 .
    M21958 Genomic RNA. Translation: AAB02535.1 .
    PIRi A35315. RRVGCT.
    RefSeqi NP_062897.1. NC_001554.1.
    NP_062898.1. NC_001554.1.

    3D structure databases

    ProteinModelPortali P15962.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1493955.
    1493956.

    Family and domain databases

    InterProi IPR007094. RNA-dir_pol_PSvirus.
    IPR002166. RNA_pol_HCV.
    IPR013707. Tombusvirus_p33.
    [Graphical view ]
    Pfami PF00998. RdRP_3. 1 hit.
    PF08500. Tombus_P33. 1 hit.
    [Graphical view ]
    PROSITEi PS50507. RDRP_SSRNA_POS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome structure and synthesis of infectious RNA from clones of tomato bushy stunt virus."
      Hearne P.Q., Knorr D.A., Hillman B.I., Morris T.J.
      Virology 177:141-151(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_TBSVC
    AccessioniPrimary (citable) accession number: P15962
    Secondary accession number(s): Q88485
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Readthrough of the terminator UAG occurs at position 297.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3