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Protein

RNA silencing suppressor p19

Gene

ORF4

Organism
Artichoke mottled crinkle virus (AMCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Viral suppressor of RNA silencing which binds specifically to silencing RNAs (siRNAs). Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA silencing suppressor p19
Alternative name(s):
19 kDa symptom severity modulator
Gene namesi
ORF Names:ORF4
OrganismiArtichoke mottled crinkle virus (AMCV)
Taxonomic identifieri12142 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTombusviridaeTombusvirus
Virus hostiCynara cardunculus var. scolymus (Globe artichoke) (Cynara scolymus) [TaxID: 59895]

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002228711 – 172RNA silencing suppressor p19Add BLAST172

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP15960
SMRiP15960
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tombusvirus protein p19 family.Curated

Family and domain databases

Gene3Di2.60.40.1810, 1 hit
InterProiView protein in InterPro
IPR004905 Tombusvirus_p19
IPR036131 VP19_sf
PfamiView protein in Pfam
PF03220 Tombus_P19, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005743 Tombus_P19, 1 hit
SUPFAMiSSF103145 SSF103145, 1 hit

Sequencei

Sequence statusi: Complete.

P15960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVIQGNDA REQANGERWD GGSGGTTSGF KLPDESPSWT EWRIHNDETD
60 70 80 90 100
SNKDNPLGFK ESWGFGKVVF KRYLRYDRTE TSLHRVLGSW TGDSVNYAAS
110 120 130 140 150
RFLGVNQIGC TYSIRFRGVS VTISGGSRTL QHICEMAIRS KQELLQLAPV
160 170
EVESNVSRGR PEGAEAFKEE SE
Length:172
Mass (Da):19,280
Last modified:April 1, 1990 - v1
Checksum:i5EE2911E6DA96901
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51456 Genomic RNA Translation: CAA35823.1
PIRiS08430 NKVGBC

Similar proteinsi

Entry informationi

Entry nameiP19_AMCV
AccessioniPrimary (citable) accession number: P15960
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: March 28, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health