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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

COX7C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:COX7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000127184.10.
HGNCiHGNC:2292. COX7C.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 33Mitochondrial matrixBy similarityAdd BLAST17
Transmembranei34 – 60HelicalBy similarityAdd BLAST27
Topological domaini61 – 63Mitochondrial intermembraneBy similarity3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1350.
OpenTargetsiENSG00000127184.
PharmGKBiPA26812.

Chemistry databases

DrugBankiDB02659. Cholic Acid.
DB04464. N-Formylmethionine.

Polymorphism and mutation databases

BioMutaiCOX7C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionCombined sources1 PublicationAdd BLAST16
ChainiPRO_000000616417 – 63Cytochrome c oxidase subunit 7C, mitochondrialAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateBy similarity1
Modified residuei25N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP15954.
MaxQBiP15954.
PaxDbiP15954.
PeptideAtlasiP15954.
PRIDEiP15954.
TopDownProteomicsiP15954.

PTM databases

iPTMnetiP15954.
PhosphoSitePlusiP15954.

Expressioni

Gene expression databases

BgeeiENSG00000127184.
CleanExiHS_COX7C.
ExpressionAtlasiP15954. baseline and differential.
GenevisibleiP15954. HS.

Organism-specific databases

HPAiHPA046647.

Interactioni

Protein-protein interaction databases

BioGridi107743. 13 interactors.
IntActiP15954. 4 interactors.
STRINGi9606.ENSP00000247655.

Structurei

3D structure databases

ProteinModelPortaliP15954.
SMRiP15954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP15954.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG091G16OJ.
PhylomeDBiP15954.
TreeFamiTF105069.

Family and domain databases

CDDicd00929. Cyt_c_Oxidase_VIIc. 1 hit.
Gene3Di4.10.49.10. 1 hit.
InterProiView protein in InterPro
IPR004202. COX7C/Cox8.
IPR036636. COX7C/Cox8_sf.
PANTHERiPTHR13313. PTHR13313. 1 hit.
PfamiView protein in Pfam
PF02935. COX7C. 1 hit.
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWSLLAK MCLYFGSAFA
60
TPFLVVRHQL LKT
Length:63
Mass (Da):7,246
Last modified:April 1, 1990 - v1
Checksum:iA7DF0F4BAF39FB28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16560 mRNA. Translation: CAA34559.1.
AF067639, AF067638 Genomic DNA. Translation: AAC73062.1.
BT007098 mRNA. Translation: AAP35762.1.
BC001005 mRNA. Translation: AAH01005.1.
BC007498 mRNA. Translation: AAH07498.1.
CCDSiCCDS4063.1.
PIRiS15763. OSHU7C.
RefSeqiNP_001858.1. NM_001867.2.
UniGeneiHs.430075.

Genome annotation databases

EnsembliENST00000247655; ENSP00000247655; ENSG00000127184.
ENST00000509578; ENSP00000425759; ENSG00000127184.
GeneIDi1350.
KEGGihsa:1350.
UCSCiuc003kir.4. human.

Similar proteinsi

Entry informationi

Entry nameiCOX7C_HUMAN
AccessioniPrimary (citable) accession number: P15954
Secondary accession number(s): Q6NR81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 25, 2017
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families