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Protein

Cytochrome c oxidase subunit 7C, mitochondrial

Gene

COX7C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7C, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIc
Gene namesi
Name:COX7C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:2292. COX7C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 3317Mitochondrial matrixBy similarityAdd
BLAST
Transmembranei34 – 6027HelicalBy similarityAdd
BLAST
Topological domaini61 – 633Mitochondrial intermembraneBy similarity

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: Reactome
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26812.

Chemistry

DrugBankiDB02659. Cholic Acid.

Polymorphism and mutation databases

BioMutaiCOX7C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1616MitochondrionCombined sources1 PublicationAdd
BLAST
Chaini17 – 6347Cytochrome c oxidase subunit 7C, mitochondrialPRO_0000006164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251N6-acetyllysine; alternateBy similarity
Modified residuei25 – 251N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP15954.
MaxQBiP15954.
PaxDbiP15954.
PeptideAtlasiP15954.
PRIDEiP15954.
TopDownProteomicsiP15954.

PTM databases

iPTMnetiP15954.
PhosphoSiteiP15954.

Expressioni

Gene expression databases

BgeeiP15954.
CleanExiHS_COX7C.
ExpressionAtlasiP15954. baseline and differential.
GenevisibleiP15954. HS.

Organism-specific databases

HPAiHPA046647.

Interactioni

Protein-protein interaction databases

IntActiP15954. 2 interactions.
STRINGi9606.ENSP00000247655.

Structurei

3D structure databases

ProteinModelPortaliP15954.
SMRiP15954. Positions 18-62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIc family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP15954.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG73JKZF.
PhylomeDBiP15954.
TreeFamiTF105069.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGQSIRRFT TSVVRRSHYE EGPGKNLPFS VENKWSLLAK MCLYFGSAFA
60
TPFLVVRHQL LKT
Length:63
Mass (Da):7,246
Last modified:April 1, 1990 - v1
Checksum:iA7DF0F4BAF39FB28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16560 mRNA. Translation: CAA34559.1.
AF067639, AF067638 Genomic DNA. Translation: AAC73062.1.
BT007098 mRNA. Translation: AAP35762.1.
BC001005 mRNA. Translation: AAH01005.1.
BC007498 mRNA. Translation: AAH07498.1.
CCDSiCCDS4063.1.
PIRiS15763. OSHU7C.
RefSeqiNP_001858.1. NM_001867.2.
UniGeneiHs.430075.

Genome annotation databases

EnsembliENST00000247655; ENSP00000247655; ENSG00000127184.
ENST00000509578; ENSP00000425759; ENSG00000127184.
GeneIDi1350.
KEGGihsa:1350.
UCSCiuc003kir.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16560 mRNA. Translation: CAA34559.1.
AF067639, AF067638 Genomic DNA. Translation: AAC73062.1.
BT007098 mRNA. Translation: AAP35762.1.
BC001005 mRNA. Translation: AAH01005.1.
BC007498 mRNA. Translation: AAH07498.1.
CCDSiCCDS4063.1.
PIRiS15763. OSHU7C.
RefSeqiNP_001858.1. NM_001867.2.
UniGeneiHs.430075.

3D structure databases

ProteinModelPortaliP15954.
SMRiP15954. Positions 18-62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP15954. 2 interactions.
STRINGi9606.ENSP00000247655.

Chemistry

DrugBankiDB02659. Cholic Acid.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

iPTMnetiP15954.
PhosphoSiteiP15954.

Polymorphism and mutation databases

BioMutaiCOX7C.

Proteomic databases

EPDiP15954.
MaxQBiP15954.
PaxDbiP15954.
PeptideAtlasiP15954.
PRIDEiP15954.
TopDownProteomicsiP15954.

Protocols and materials databases

DNASUi1350.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247655; ENSP00000247655; ENSG00000127184.
ENST00000509578; ENSP00000425759; ENSG00000127184.
GeneIDi1350.
KEGGihsa:1350.
UCSCiuc003kir.4. human.

Organism-specific databases

CTDi1350.
GeneCardsiCOX7C.
HGNCiHGNC:2292. COX7C.
HPAiHPA046647.
MIMi603774. gene.
neXtProtiNX_P15954.
PharmGKBiPA26812.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4527. Eukaryota.
ENOG4112B97. LUCA.
GeneTreeiENSGT00390000018086.
HOGENOMiHOG000237276.
HOVERGENiHBG051093.
InParanoidiP15954.
KOiK02272.
OMAiVRHQILK.
OrthoDBiEOG73JKZF.
PhylomeDBiP15954.
TreeFamiTF105069.

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Miscellaneous databases

GeneWikiiCOX7C.
GenomeRNAii1350.
PROiP15954.
SOURCEiSearch...

Gene expression databases

BgeeiP15954.
CleanExiHS_COX7C.
ExpressionAtlasiP15954. baseline and differential.
GenevisibleiP15954. HS.

Family and domain databases

Gene3Di4.10.49.10. 1 hit.
InterProiIPR004202. COX7C/Cox8.
[Graphical view]
PfamiPF02935. COX7C. 1 hit.
[Graphical view]
SUPFAMiSSF81427. SSF81427. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase."
    Koga Y., Fabrizi G.M., Mita S., Arnaudo E., Lomax M.I., Agua M.S., Grossman L.I., Schon E.A.
    Nucleic Acids Res. 18:684-684(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping."
    Hofmann S., Lichtner P., Schuffenhauer S., Gerbitz K.D., Meitinger T.
    Cytogenet. Cell Genet. 83:226-227(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Ovary.
  5. "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart."
    van Kuilenburg A.B.P., van Beeumen J.J., van der Meer N.M., Muijsers A.O.
    Eur. J. Biochem. 203:193-199(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-40.
    Tissue: Heart and Skeletal muscle.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: CLEAVAGE OF TRANSIT PEPTIDE [LARGE SCALE ANALYSIS] AFTER ARG-16, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX7C_HUMAN
AccessioniPrimary (citable) accession number: P15954
Secondary accession number(s): Q6NR81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 6, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.