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P15953 (COX3_WHEAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COX3
Encoded onMitochondrion
OrganismTriticum aestivum (Wheat) [Complete proteome]
Taxonomic identifier4565 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeTriticum

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

RNA editing

Edited at positions 82, 86, 97, 104, 105, 138, 141, 171, 176, 189, 252 and 255. Ref.3

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityRNA editing
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Cytochrome c oxidase subunit 3
PRO_0000183871

Regions

Transmembrane41 – 6121Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane137 – 15721Helical; Potential
Transmembrane162 – 18221Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane245 – 26521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P15953 [UniParc].

Last modified August 1, 1992. Version 2.
Checksum: A7918C9FBFC22608

FASTA26529,796
        10         20         30         40         50         60 
MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGATLLSLGL IFILYTMFVW 

        70         80         90        100        110        120 
WRDVLRESTL EGHHTKAVQL GLRYGFILFI VSEVMFFFAF FWAFFHSSLA PTVEIGGIWP 

       130        140        150        160        170        180 
PKGIGVLDPW EIPLLNTLIL LSSGAAVTWA HHAILAGKEK RAVYALVATV LLALVFTGFQ 

       190        200        210        220        230        240 
GMEYYQAPFT ISDSIYGSTF FLATGFHGFH VIIGTLFLIV CGIRQYLGQM TKKHHVGFEA 

       250        260 
AAWYWHFVDV VWLFLFVSIY WWGGI 

« Hide

References

[1]"Structure and transcription of the gene coding for subunit 3 of cytochrome oxidase in wheat mitochondria."
Gualberto J.M., Domon C., Weil J.H., Grienenberger J.-M.
Curr. Genet. 17:41-47(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Capitole.
[2]"Genetic code and phylogenetic origin of oomycetous mitochondria."
Karlovsky P., Fartmann B.
J. Mol. Evol. 34:254-258(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: cv. Capitole.
Tissue: Etiolated plantlet.
[3]"Editing of the wheat coxIII transcript: evidence for twelve C to U and one U to C conversions and for sequence similarities around editing sites."
Gualberto J.M., Weil J.H., Grienenberger J.M.
Nucleic Acids Res. 18:3771-3776(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52539 mRNA. Translation: CAA36775.1.
X15944 Genomic DNA. Translation: CAA34071.1. Sequence problems.
PIROTWT3M. S10331.
RefSeqYP_398397.1. NC_007579.1.

3D structure databases

ProteinModelPortalP15953.
SMRP15953. Positions 5-263.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3800086.

Organism-specific databases

GrameneP15953.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_WHEAT
AccessionPrimary (citable) accession number: P15953
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 1, 1992
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families