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P15952

- COX3_CYPCA

UniProt

P15952 - COX3_CYPCA

Protein

Cytochrome c oxidase subunit 3

Gene

mt-co3

Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:mt-co3
    Synonyms:coiii, coxiii, mtco3
    Encoded oniMitochondrion
    OrganismiCyprinus carpio (Common carp)
    Taxonomic identifieri7962 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 261261Cytochrome c oxidase subunit 3PRO_0000183762Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP15952.
    SMRiP15952. Positions 1-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei81 – 10121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016686.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15952-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHQAHAYHM VDPSPWPLTG AIAALLMTSG LAIWFHFHST TLMTLGLILL    50
    LLTMYQWWRD IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA 100
    FYHSSLAPTP ELGGCWPPTG ITPLDPFEVP LLNTAVLLAS GVTVTWAHHS 150
    IMEGERKQAI QSLALTILLG LYFTALQAME YYEAPFTIAD GVYGSTFFVA 200
    TGFHGLHVII GSTFLAVCLL RQIQYHFTSE HHFGFEAAAW YWHFVDVVWL 250
    FLYVSIYWWG S 261
    Length:261
    Mass (Da):29,640
    Last modified:February 1, 1994 - v2
    Checksum:i285D890751412EF5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti121 – 1211I → M in CAA34866. (PubMed:2156223)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17006 mRNA. Translation: CAA34866.1.
    X61010 Genomic DNA. Translation: CAA43341.1.
    PIRiS36010. OTCA3.
    RefSeqiNP_007088.1. NC_001606.1.

    Genome annotation databases

    GeneIDi807767.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17006 mRNA. Translation: CAA34866.1 .
    X61010 Genomic DNA. Translation: CAA43341.1 .
    PIRi S36010. OTCA3.
    RefSeqi NP_007088.1. NC_001606.1.

    3D structure databases

    ProteinModelPortali P15952.
    SMRi P15952. Positions 1-261.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 807767.

    Organism-specific databases

    CTDi 4514.

    Phylogenomic databases

    HOVERGENi HBG016686.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of carp mitochondrial cytochrome C oxidase III."
      Huang C.J., Huang F.L., Chang Y.S., Tsai Y.J., Lo T.B.
      Nucleic Acids Res. 18:1056-1056(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The complete nucleotide sequence and gene organization of carp (Cyprinus carpio) mitochondrial genome."
      Chang Y.S., Huang F.L., Lo T.B.
      J. Mol. Evol. 38:138-155(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX3_CYPCA
    AccessioniPrimary (citable) accession number: P15952
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3