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P15950

- KLK3_RAT

UniProt

P15950 - KLK3_RAT

Protein

Glandular kallikrein-3, submandibular

Gene

Klk3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei47 – 471Charge relay system
    Active sitei140 – 1401Charge relay system

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.77. 5301.

    Protein family/group databases

    MEROPSiS01.411.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glandular kallikrein-3, submandibular (EC:3.4.21.35)
    Short name:
    rGK-3
    Alternative name(s):
    RSGK-50
    S1 kallikrein
    Tissue kallikrein
    Gene namesi
    Name:Klk3
    Synonyms:Klk-3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 188›188Glandular kallikrein-3, submandibularPRO_0000088702Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi79 ↔ 146PROSITE-ProRule annotation
    Disulfide bondi111 ↔ 125PROSITE-ProRule annotation
    Disulfide bondi136 ↔ 161PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP15950.

    Expressioni

    Gene expression databases

    GenevestigatoriP15950.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025777.

    Structurei

    3D structure databases

    ProteinModelPortaliP15950.
    SMRiP15950. Positions 1-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – 185›185Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP15950.
    OrthoDBiEOG7W9RV6.
    PhylomeDBiP15950.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P15950-1 [UniParc]FASTAAdd to Basket

    « Hide

    NYHVLLGQNN LSEDVQHRLV SQSFRHPDYK PFLMRNHTRK PKDYSNDLML    50
    LHLSEPADIT DGVKVIDLPT KEPKVGSTCL VSGWGSTNPS EWEFPDDLQC 100
    VNIHLLSNEK CIKAYKEKVT DLMLCAGELE GGKDTCRGDS GGPLICDGVL 150
    QGITSWGSVP CGEPNKPGIY TKLIKFTSWI KEVMKENP 188
    Length:188
    Mass (Da):20,986
    Last modified:June 1, 1994 - v2
    Checksum:iB3ECEC65582EB1E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Sequence conflicti34 – 352MR → IW in AAA41465. (PubMed:2998455)Curated
    Sequence conflicti42 – 421K → G in AAA41465. (PubMed:2998455)Curated
    Sequence conflicti186 – 1861E → K in AAA42080. (PubMed:2550051)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26534 Genomic DNA. Translation: AAA42080.1.
    M11564 mRNA. Translation: AAA41465.1.
    PIRiB23863.
    B32340.
    UniGeneiRn.107068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26534 Genomic DNA. Translation: AAA42080.1 .
    M11564 mRNA. Translation: AAA41465.1 .
    PIRi B23863.
    B32340.
    UniGenei Rn.107068.

    3D structure databases

    ProteinModelPortali P15950.
    SMRi P15950. Positions 1-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025777.

    Protein family/group databases

    MEROPSi S01.411.

    Proteomic databases

    PRIDEi P15950.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P15950.
    OrthoDBi EOG7W9RV6.
    PhylomeDBi P15950.
    TreeFami TF331065.

    Enzyme and pathway databases

    BRENDAi 3.4.21.77. 5301.

    Gene expression databases

    Genevestigatori P15950.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of genes encoding rat tonin and a kallikrein-like serine protease."
      Shai S.Y., Woodley-Miller C., Chao J., Chao L.
      Biochemistry 28:5334-5343(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin."
      Ashley P.L., MacDonald R.J.
      Biochemistry 24:4512-4520(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-188.

    Entry informationi

    Entry nameiKLK3_RAT
    AccessioniPrimary (citable) accession number: P15950
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3