Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P15949

- K1KB9_MOUSE

UniProt

P15949 - K1KB9_MOUSE

Protein

Kallikrein 1-related peptidase b9

Gene

Klk1b9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay system
    Active sitei120 – 1201Charge relay system
    Active sitei213 – 2131Charge relay system

    GO - Molecular functioni

    1. peptidase activity Source: MGI
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. zymogen activation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.071.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein 1-related peptidase b9 (EC:3.4.21.35)
    Alternative name(s):
    Epidermal growth factor-binding protein type C
    Short name:
    EGF-BP C
    Glandular kallikrein K9
    Short name:
    mGK-9
    Tissue kallikrein-9
    Gene namesi
    Name:Klk1b9
    Synonyms:Egfbp3, Klk-9, Klk9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:95293. Klk1b9.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818CuratedAdd
    BLAST
    Propeptidei19 – 246Activation peptidePRO_0000027979
    Chaini25 – 261237Kallikrein 1-related peptidase b9PRO_0000027980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
    Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP15949.
    PaxDbiP15949.
    PRIDEiP15949.

    Expressioni

    Gene expression databases

    BgeeiP15949.
    CleanExiMM_KLK1B9.
    GenevestigatoriP15949.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000080133.

    Structurei

    3D structure databases

    ProteinModelPortaliP15949.
    SMRiP15949. Positions 25-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00750000117405.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP15949.
    KOiK01325.
    OMAiIINEYLC.
    OrthoDBiEOG75B84T.
    PhylomeDBiP15949.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15949-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFLILFLAL SLGGIDAAPP VHSRIVGGFK CEKNSQPWHV AVYRYNEYIC    50
    GGVLLDANWV LTAAHCYYEE NKVSLGKNNL YEEEPSAQHR LVSKSFLHPG 100
    YNRSLHRNHI RHPEYDYSND LMLLRLSKPA DITDVVKPIA LPTEEPKLGS 150
    TCLASGWGST TPFKFQNAKD LQCVNLKLLP NEDCGKAHIE KVTDVMLCAG 200
    ETDGGKDTCK GDSGGPLICD GVLQGITSWG FTPCGEPKKP GVYTKLIKFT 250
    SWIKDTMAKN L 261
    Length:261
    Mass (Da):28,900
    Last modified:April 1, 1990 - v1
    Checksum:i796FD4DAE56020D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17962 mRNA. Translation: AAA37541.1.
    M17985, M17983, M17984 Genomic DNA. Translation: AAA37681.1.
    BC024624 mRNA. Translation: AAH24624.1.
    BC048869 mRNA. Translation: AAH48869.1.
    M18588 Genomic DNA. Translation: AAA39350.1. Sequence problems.
    M18608 Genomic DNA. Translation: AAA39351.1.
    CCDSiCCDS21191.1.
    PIRiC29746. A29745.
    I70014.
    RefSeqiNP_034246.1. NM_010116.1.
    UniGeneiMm.440884.

    Genome annotation databases

    EnsembliENSMUST00000081399; ENSMUSP00000080133; ENSMUSG00000059042.
    GeneIDi13648.
    KEGGimmu:13648.
    UCSCiuc009god.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17962 mRNA. Translation: AAA37541.1 .
    M17985 , M17983 , M17984 Genomic DNA. Translation: AAA37681.1 .
    BC024624 mRNA. Translation: AAH24624.1 .
    BC048869 mRNA. Translation: AAH48869.1 .
    M18588 Genomic DNA. Translation: AAA39350.1 . Sequence problems.
    M18608 Genomic DNA. Translation: AAA39351.1 .
    CCDSi CCDS21191.1.
    PIRi C29746. A29745.
    I70014.
    RefSeqi NP_034246.1. NM_010116.1.
    UniGenei Mm.440884.

    3D structure databases

    ProteinModelPortali P15949.
    SMRi P15949. Positions 25-260.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000080133.

    Protein family/group databases

    MEROPSi S01.071.

    Proteomic databases

    MaxQBi P15949.
    PaxDbi P15949.
    PRIDEi P15949.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081399 ; ENSMUSP00000080133 ; ENSMUSG00000059042 .
    GeneIDi 13648.
    KEGGi mmu:13648.
    UCSCi uc009god.1. mouse.

    Organism-specific databases

    CTDi 13648.
    MGIi MGI:95293. Klk1b9.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00750000117405.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P15949.
    KOi K01325.
    OMAi IINEYLC.
    OrthoDBi EOG75B84T.
    PhylomeDBi P15949.
    TreeFami TF331065.

    Enzyme and pathway databases

    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    NextBioi 284370.
    PROi P15949.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15949.
    CleanExi MM_KLK1B9.
    Genevestigatori P15949.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A complete cDNA sequence for the major epidermal growth factor binding protein in the male mouse submandibular gland."
      Blaber M., Isackson P.J., Bradshaw R.A.
      Biochemistry 26:6742-6749(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins."
      Drinkwater C.C., Evans B.A., Richards R.I.
      Biochemistry 26:6750-6756(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Salivary gland.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    4. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
      Evans B.A., Drinkwater C.C., Richards R.I.
      J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 16-54 AND 70-122.
      Strain: BALB/c.
      Tissue: Liver.

    Entry informationi

    Entry nameiK1KB9_MOUSE
    AccessioniPrimary (citable) accession number: P15949
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3