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P15949

- K1KB9_MOUSE

UniProt

P15949 - K1KB9_MOUSE

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Protein

Kallikrein 1-related peptidase b9

Gene

Klk1b9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system
Active sitei120 – 1201Charge relay system
Active sitei213 – 2131Charge relay system

GO - Molecular functioni

  1. peptidase activity Source: MGI
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. zymogen activation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.
REACT_235886. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Protein family/group databases

MEROPSiS01.071.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b9 (EC:3.4.21.35)
Alternative name(s):
Epidermal growth factor-binding protein type C
Short name:
EGF-BP C
Glandular kallikrein K9
Short name:
mGK-9
Tissue kallikrein-9
Gene namesi
Name:Klk1b9
Synonyms:Egfbp3, Klk-9, Klk9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:95293. Klk1b9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818CuratedAdd
BLAST
Propeptidei19 – 246Activation peptidePRO_0000027979
Chaini25 – 261237Kallikrein 1-related peptidase b9PRO_0000027980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP15949.
PaxDbiP15949.
PRIDEiP15949.

Expressioni

Gene expression databases

BgeeiP15949.
CleanExiMM_KLK1B9.
GenevestigatoriP15949.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080133.

Structurei

3D structure databases

ProteinModelPortaliP15949.
SMRiP15949. Positions 25-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP15949.
KOiK01325.
OMAiIINEYLC.
OrthoDBiEOG75B84T.
PhylomeDBiP15949.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15949-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRFLILFLAL SLGGIDAAPP VHSRIVGGFK CEKNSQPWHV AVYRYNEYIC
60 70 80 90 100
GGVLLDANWV LTAAHCYYEE NKVSLGKNNL YEEEPSAQHR LVSKSFLHPG
110 120 130 140 150
YNRSLHRNHI RHPEYDYSND LMLLRLSKPA DITDVVKPIA LPTEEPKLGS
160 170 180 190 200
TCLASGWGST TPFKFQNAKD LQCVNLKLLP NEDCGKAHIE KVTDVMLCAG
210 220 230 240 250
ETDGGKDTCK GDSGGPLICD GVLQGITSWG FTPCGEPKKP GVYTKLIKFT
260
SWIKDTMAKN L
Length:261
Mass (Da):28,900
Last modified:April 1, 1990 - v1
Checksum:i796FD4DAE56020D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17962 mRNA. Translation: AAA37541.1.
M17985, M17983, M17984 Genomic DNA. Translation: AAA37681.1.
BC024624 mRNA. Translation: AAH24624.1.
BC048869 mRNA. Translation: AAH48869.1.
M18588 Genomic DNA. Translation: AAA39350.1. Sequence problems.
M18608 Genomic DNA. Translation: AAA39351.1.
CCDSiCCDS21191.1.
PIRiC29746. A29745.
I70014.
RefSeqiNP_034246.1. NM_010116.1.
UniGeneiMm.440884.

Genome annotation databases

EnsembliENSMUST00000081399; ENSMUSP00000080133; ENSMUSG00000059042.
GeneIDi13648.
KEGGimmu:13648.
UCSCiuc009god.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17962 mRNA. Translation: AAA37541.1 .
M17985 , M17983 , M17984 Genomic DNA. Translation: AAA37681.1 .
BC024624 mRNA. Translation: AAH24624.1 .
BC048869 mRNA. Translation: AAH48869.1 .
M18588 Genomic DNA. Translation: AAA39350.1 . Sequence problems.
M18608 Genomic DNA. Translation: AAA39351.1 .
CCDSi CCDS21191.1.
PIRi C29746. A29745.
I70014.
RefSeqi NP_034246.1. NM_010116.1.
UniGenei Mm.440884.

3D structure databases

ProteinModelPortali P15949.
SMRi P15949. Positions 25-260.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000080133.

Protein family/group databases

MEROPSi S01.071.

Proteomic databases

MaxQBi P15949.
PaxDbi P15949.
PRIDEi P15949.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081399 ; ENSMUSP00000080133 ; ENSMUSG00000059042 .
GeneIDi 13648.
KEGGi mmu:13648.
UCSCi uc009god.1. mouse.

Organism-specific databases

CTDi 13648.
MGIi MGI:95293. Klk1b9.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P15949.
KOi K01325.
OMAi IINEYLC.
OrthoDBi EOG75B84T.
PhylomeDBi P15949.
TreeFami TF331065.

Enzyme and pathway databases

Reactomei REACT_199000. Activation of Matrix Metalloproteinases.
REACT_235886. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Miscellaneous databases

NextBioi 284370.
PROi P15949.
SOURCEi Search...

Gene expression databases

Bgeei P15949.
CleanExi MM_KLK1B9.
Genevestigatori P15949.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A complete cDNA sequence for the major epidermal growth factor binding protein in the male mouse submandibular gland."
    Blaber M., Isackson P.J., Bradshaw R.A.
    Biochemistry 26:6742-6749(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins."
    Drinkwater C.C., Evans B.A., Richards R.I.
    Biochemistry 26:6750-6756(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Salivary gland.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
    Evans B.A., Drinkwater C.C., Richards R.I.
    J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 16-54 AND 70-122.
    Strain: BALB/c.
    Tissue: Liver.

Entry informationi

Entry nameiK1KB9_MOUSE
AccessioniPrimary (citable) accession number: P15949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 26, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3