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Protein

Kallikrein 1-related peptidase b22

Gene

Klk1b22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei118Charge relay system1
Active sitei211Charge relay system1

GO - Molecular functioni

GO - Biological processi

  • zymogen activation Source: MGI

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.039

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b22 (EC:3.4.21.35)
Alternative name(s):
Beta-NGF-endopeptidase
Epidermal growth factor-binding protein type A
Short name:
EGF-BP A
Glandular kallikrein K22
Short name:
mGK-22
Nerve growth factor beta chain endopeptidase
Tissue kallikrein 22
Gene namesi
Name:Klk1b22
Synonyms:Klk-22, Klk22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95291 Klk1b22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Add BLAST17
PropeptideiPRO_000002798918 – 24Activation peptide2 Publications7
ChainiPRO_000002799025 – 259Kallikrein 1-related peptidase b22Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 171PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi150 ↔ 217PROSITE-ProRule annotation
Disulfide bondi182 ↔ 196PROSITE-ProRule annotation
Disulfide bondi207 ↔ 232PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP15948
PRIDEiP15948

Expressioni

Gene expression databases

BgeeiENSMUSG00000060177
CleanExiMM_KLK1B22
ExpressionAtlasiP15948 baseline and differential
GenevisibleiP15948 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076733

Structurei

3D structure databases

ProteinModelPortaliP15948
SMRiP15948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 256Peptidase S1PROSITE-ProRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00910000144067
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP15948
KOiK01325
OMAiCAGEMNG
OrthoDBiEOG091G0DF7
PhylomeDBiP15948
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLILFLTL SLGGIDAAPP VQSRILGGFK CEKNSQPWQV AVYYLDEYLC
60 70 80 90 100
GGVLLDRNWV LTAAHCYEDK YNIWLGKNKL FQDEPSAQHR LVSKSFPHPD
110 120 130 140 150
FNMSLLQSVP TGADLSNDLM LLRLSKPADI TDVVKPIDLP TTEPKLGSTC
160 170 180 190 200
LASGWGSINQ LIYQNPNDLQ CVSIKLHPNE VCVKAHILKV TDVMLCAGEM
210 220 230 240 250
NGGKDTCKGD SGGPLICDGV LQGITSWGST PCGEPNAPAI YTKLIKFTSW

IKDTMAKNP
Length:259
Mass (Da):28,384
Last modified:April 1, 1990 - v1
Checksum:iD7745794D8A87B9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17979, M17977, M17978 Genomic DNA Translation: AAA37682.1 Sequence problems.
M18598 Genomic DNA Translation: AAA39361.1
M18618 Genomic DNA Translation: AAA39362.1
CCDSiCCDS21196.1
PIRiA29746
RefSeqiNP_034244.1, NM_010114.2
UniGeneiMm.5193

Genome annotation databases

EnsembliENSMUST00000077528; ENSMUSP00000076733; ENSMUSG00000060177
GeneIDi13646
KEGGimmu:13646
UCSCiuc009goi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1B22_MOUSE
AccessioniPrimary (citable) accession number: P15948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 25, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health