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Protein

Kallikrein-1

Gene

Klk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B10 3474

Protein family/group databases

MEROPSiS01.167

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-1 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K1
KAL-B
Renal kallikrein
Tissue kallikrein-6
Short name:
mGK-6
Gene namesi
Name:Klk1
Synonyms:Klk-6, Klk6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:102850 Klk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002797519 – 24Activation peptide1 Publication6
ChainiPRO_000002797625 – 261Kallikrein-1Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP15947
PaxDbiP15947
PeptideAtlasiP15947
PRIDEiP15947

Expressioni

Gene expression databases

BgeeiENSMUSG00000063903
CleanExiMM_KLK1
ExpressionAtlasiP15947 baseline and differential
GenevisibleiP15947 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074659

Structurei

3D structure databases

ProteinModelPortaliP15947
SMRiP15947
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00910000144067
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP15947
KOiK01325
OMAiLWLGRHN
OrthoDBiEOG091G0DF7
PhylomeDBiP15947
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFLILFLAL SLGGIDAAPP VQSRIVGGFN CEKNSQPWQV AVYRFTKYQC
60 70 80 90 100
GGILLNANWV LTAAHCHNDK YQVWLGKNNF LEDEPSAQHR LVSKAIPHPD
110 120 130 140 150
FNMSLLNEHT PQPEDDYSND LMLLRLKKPA DITDVVKPID LPTEEPKLGS
160 170 180 190 200
TCLASGWGSI TPVKYEYPDE LQCVNLKLLP NEDCAKAHIE KVTDDMLCAG
210 220 230 240 250
DMDGGKDTCA GDSGGPLICD GVLQGITSWG PSPCGKPNVP GIYTRVLNFN
260
TWIRETMAEN D
Length:261
Mass (Da):28,775
Last modified:December 5, 2001 - v3
Checksum:i7850DDFDBFFB94B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57A → V in AAG11389 (PubMed:3007510).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13500, M13498, M13499 Genomic DNA Translation: AAG11389.1
D10464 mRNA Translation: BAA01257.1
AK002278 mRNA Translation: BAB21982.1
BC010754 mRNA Translation: AAH10754.1
BC027736 mRNA Translation: AAH27736.1
BC053697 mRNA Translation: AAH53697.1
CCDSiCCDS21202.1
PIRiA25606
RefSeqiNP_001307260.1, NM_001320331.1
NP_001307261.1, NM_001320332.1
NP_034769.4, NM_010639.8
UniGeneiMm.142722

Genome annotation databases

EnsembliENSMUST00000075162; ENSMUSP00000074659; ENSMUSG00000063903
GeneIDi16612
KEGGimmu:16612
UCSCiuc009goo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKLK1_MOUSE
AccessioniPrimary (citable) accession number: P15947
Secondary accession number(s): Q61855
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 5, 2001
Last modified: April 25, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health