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P15946 (K1B11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein 1-related peptidase b11

EC=3.4.21.35
Alternative name(s):
Glandular kallikrein K11
Short name=mGK-11
Tissue kallikrein-11
Gene names
Name:Klk1b11
Synonyms:Klk-11, Klk11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Probable
Propeptide19 – 246Activation peptide Probable
PRO_0000027981
Chain25 – 261237Kallikrein 1-related peptidase b11
PRO_0000027982

Regions

Domain25 – 258234Peptidase S1

Sites

Active site651Charge relay system
Active site1201Charge relay system
Active site2131Charge relay system

Amino acid modifications

Glycosylation1021N-linked (GlcNAc...) Probable
Disulfide bond31 ↔ 173 By similarity
Disulfide bond50 ↔ 66 By similarity
Disulfide bond152 ↔ 219 By similarity
Disulfide bond184 ↔ 198 By similarity
Disulfide bond209 ↔ 234 By similarity

Sequences

Sequence LengthMass (Da)Tools
P15946 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 8D32EFE8D835EA7B

FASTA26128,727
        10         20         30         40         50         60 
MWFLILFLAL SLGGIDAAPP VQSRIVGGFN CEKNSQPWHV AVYRYNKYIC GGVLLDRNWV 

        70         80         90        100        110        120 
LTAAHCHVSQ YNVWLGKTKL FQREPSAQHR MVSKSFPHPD YNMSLLIIHN PEPEDDESND 

       130        140        150        160        170        180 
LMLLRLSEPA DITDAVKPIA LPTEEPKLGS TCLVSGWGSI TPTKFQTPDD LQCVSIKLLP 

       190        200        210        220        230        240 
NEVCVKNHNQ KVTDVMLCAG EMGGGKDTCK GDSGGPLICD GVLHGITAWG PIPCGKPNTP 

       250        260 
GVYTKLIKFT NWIKDTMAKN P 

« Hide

References

« Hide 'large scale' references
[1]"Genes for the alpha and gamma subunits of mouse nerve growth factor are contiguous."
Evans B.A., Richards R.I.
EMBO J. 4:133-138(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence of mGK-11, a mouse glandular kallikrein gene."
Drinkwater C.C., Richards R.I.
Nucleic Acids Res. 16:10918-10918(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[4]"Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
Evans B.A., Drinkwater C.C., Richards R.I.
J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-54 AND 69-122.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13215 expand/collapse EMBL AC list , X13216, X13217, X13218 Genomic DNA. Translation: CAA31604.3.
BC013660 mRNA. Translation: AAH13660.1.
M18590 Genomic DNA. Translation: AAA39352.1. Sequence problems.
M18610 Genomic DNA. Translation: AAA39353.1.
CCDSCCDS21192.1.
PIRI70022.
S01971.
RefSeqNP_034770.1. NM_010640.1.
UniGeneMm.443378.

3D structure databases

ProteinModelPortalP15946.
SMRP15946. Positions 25-261.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000007156.

Protein family/group databases

MEROPSS01.041.

Proteomic databases

MaxQBP15946.
PaxDbP15946.
PRIDEP15946.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000007156; ENSMUSP00000007156; ENSMUSG00000044485.
GeneID16613.
KEGGmmu:16613.
UCSCuc009goe.1. mouse.

Organism-specific databases

CTD16613.
MGIMGI:892023. Klk1b11.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00750000117405.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP15946.
KOK01325.
OMAVINEYLC.
OrthoDBEOG75B84T.
PhylomeDBP15946.
TreeFamTF331065.

Gene expression databases

BgeeP15946.
CleanExMM_KLK11.
MM_KLK1B11.
GenevestigatorP15946.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290201.
PROP15946.
SOURCESearch...

Entry information

Entry nameK1B11_MOUSE
AccessionPrimary (citable) accession number: P15946
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot