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P15946

- K1B11_MOUSE

UniProt

P15946 - K1B11_MOUSE

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Protein

Kallikrein 1-related peptidase b11

Gene

Klk1b11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system
Active sitei120 – 1201Charge relay system
Active sitei213 – 2131Charge relay system

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiS01.041.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b11 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K11
Short name:
mGK-11
Tissue kallikrein-11
Gene namesi
Name:Klk1b11
Synonyms:Klk-11, Klk11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:892023. Klk1b11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818CuratedAdd
BLAST
Propeptidei19 – 246Activation peptideCuratedPRO_0000027981
Chaini25 – 261237Kallikrein 1-related peptidase b11PRO_0000027982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP15946.
PaxDbiP15946.
PRIDEiP15946.

Expressioni

Gene expression databases

BgeeiP15946.
CleanExiMM_KLK11.
MM_KLK1B11.
GenevestigatoriP15946.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000007156.

Structurei

3D structure databases

ProteinModelPortaliP15946.
SMRiP15946. Positions 25-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP15946.
KOiK01325.
OMAiVINEYLC.
OrthoDBiEOG75B84T.
PhylomeDBiP15946.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15946-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWFLILFLAL SLGGIDAAPP VQSRIVGGFN CEKNSQPWHV AVYRYNKYIC
60 70 80 90 100
GGVLLDRNWV LTAAHCHVSQ YNVWLGKTKL FQREPSAQHR MVSKSFPHPD
110 120 130 140 150
YNMSLLIIHN PEPEDDESND LMLLRLSEPA DITDAVKPIA LPTEEPKLGS
160 170 180 190 200
TCLVSGWGSI TPTKFQTPDD LQCVSIKLLP NEVCVKNHNQ KVTDVMLCAG
210 220 230 240 250
EMGGGKDTCK GDSGGPLICD GVLHGITAWG PIPCGKPNTP GVYTKLIKFT
260
NWIKDTMAKN P
Length:261
Mass (Da):28,727
Last modified:April 1, 1990 - v1
Checksum:i8D32EFE8D835EA7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13215
, X13216, X13217, X13218 Genomic DNA. Translation: CAA31604.3.
BC013660 mRNA. Translation: AAH13660.1.
M18590 Genomic DNA. Translation: AAA39352.1. Sequence problems.
M18610 Genomic DNA. Translation: AAA39353.1.
CCDSiCCDS21192.1.
PIRiI70022.
S01971.
RefSeqiNP_034770.1. NM_010640.1.
UniGeneiMm.443378.

Genome annotation databases

EnsembliENSMUST00000007156; ENSMUSP00000007156; ENSMUSG00000044485.
GeneIDi16613.
KEGGimmu:16613.
UCSCiuc009goe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13215
, X13216 , X13217 , X13218 Genomic DNA. Translation: CAA31604.3 .
BC013660 mRNA. Translation: AAH13660.1 .
M18590 Genomic DNA. Translation: AAA39352.1 . Sequence problems.
M18610 Genomic DNA. Translation: AAA39353.1 .
CCDSi CCDS21192.1.
PIRi I70022.
S01971.
RefSeqi NP_034770.1. NM_010640.1.
UniGenei Mm.443378.

3D structure databases

ProteinModelPortali P15946.
SMRi P15946. Positions 25-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000007156.

Protein family/group databases

MEROPSi S01.041.

Proteomic databases

MaxQBi P15946.
PaxDbi P15946.
PRIDEi P15946.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007156 ; ENSMUSP00000007156 ; ENSMUSG00000044485 .
GeneIDi 16613.
KEGGi mmu:16613.
UCSCi uc009goe.1. mouse.

Organism-specific databases

CTDi 16613.
MGIi MGI:892023. Klk1b11.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P15946.
KOi K01325.
OMAi VINEYLC.
OrthoDBi EOG75B84T.
PhylomeDBi P15946.
TreeFami TF331065.

Enzyme and pathway databases

Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

Miscellaneous databases

NextBioi 290201.
PROi P15946.
SOURCEi Search...

Gene expression databases

Bgeei P15946.
CleanExi MM_KLK11.
MM_KLK1B11.
Genevestigatori P15946.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes for the alpha and gamma subunits of mouse nerve growth factor are contiguous."
    Evans B.A., Richards R.I.
    EMBO J. 4:133-138(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence of mGK-11, a mouse glandular kallikrein gene."
    Drinkwater C.C., Richards R.I.
    Nucleic Acids Res. 16:10918-10918(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
    Evans B.A., Drinkwater C.C., Richards R.I.
    J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 16-54 AND 69-122.

Entry informationi

Entry nameiK1B11_MOUSE
AccessioniPrimary (citable) accession number: P15946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3