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Protein

Kallikrein 1-related peptidase b5

Gene

Klk1b5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activityi

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay system1
Active sitei120Charge relay system1
Active sitei213Charge relay system1

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: MGI

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B39 3474

Protein family/group databases

MEROPSiS01.037

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein 1-related peptidase b5 (EC:3.4.21.35)
Alternative name(s):
Glandular kallikrein K5
Short name:
mGK-5
Tissue kallikrein-5
Gene namesi
Name:Klk1b5
Synonyms:Klk-5, Klk5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:892020 Klk1b5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18CuratedAdd BLAST18
PropeptideiPRO_000002797319 – 24Activation peptideCurated6
ChainiPRO_000002797425 – 261Kallikrein 1-related peptidase b5Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi102N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

MaxQBiP15945
PaxDbiP15945
PeptideAtlasiP15945
PRIDEiP15945

PTM databases

iPTMnetiP15945
PhosphoSitePlusiP15945

Expressioni

Gene expression databases

BgeeiENSMUSG00000066512
CleanExiMM_KLK1B5
GenevisibleiP15945 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073964

Structurei

3D structure databases

ProteinModelPortaliP15945
SMRiP15945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 258Peptidase S1PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00910000144067
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP15945
KOiK01325
OMAiERTMADN
OrthoDBiEOG091G0DF7
PhylomeDBiP15945
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWFLILFLAL SLGGIDAAPP VQSRIFGGFN CEKNSQPWQV AVYRFTKYQC
60 70 80 90 100
GGVLLNANWV LTAAHCHNDK YQVWLGKNNF FEDEPSAQHR LVSKAIPHPD
110 120 130 140 150
FNMSLLNEHT PQPEDDYSND LMLLRLKKPA DITDVVKPID LPTEEPKLGS
160 170 180 190 200
TCLASGWGSI TPVIYEPADD LQCVNFKLLP NEDCVKAHIE KVTDVMLCAG
210 220 230 240 250
DMDGGKDTCM GDSGGPLICD GVLHGITSWG PSPCGKPNVP GIYTKLIKFN
260
SWIKDTIAKN A
Length:261
Mass (Da):28,748
Last modified:April 1, 1990 - v1
Checksum:i29B4D669335522D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00500 Genomic DNA Translation: CAA68553.1
BC013659 mRNA Translation: AAH13659.1
BC094281 mRNA Translation: AAH94281.1
M18584 Genomic DNA Translation: AAX76511.1
M18604 Genomic DNA Translation: AAD15284.3
CCDSiCCDS21201.1
PIRiS06305 TRMSM5
RefSeqiNP_032482.1, NM_008456.4
UniGeneiMm.443373

Genome annotation databases

EnsembliENSMUST00000074359; ENSMUSP00000073964; ENSMUSG00000066512
GeneIDi16622
KEGGimmu:16622
UCSCiuc009gon.1 mouse

Similar proteinsi

Entry informationi

Entry nameiK1KB5_MOUSE
AccessioniPrimary (citable) accession number: P15945
Secondary accession number(s): Q52KM1, Q565D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health