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P15945 (K1KB5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kallikrein 1-related peptidase b5

EC=3.4.21.35
Alternative name(s):
Glandular kallikrein K5
Short name=mGK-5
Tissue kallikrein-5
Gene names
Name:Klk1b5
Synonyms:Klk-5, Klk5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Catalytic activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Sequence similarities

Belongs to the peptidase S1 family. Kallikrein subfamily.

Contains 1 peptidase S1 domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Probable
Propeptide19 – 246Activation peptide Probable
PRO_0000027973
Chain25 – 261237Kallikrein 1-related peptidase b5
PRO_0000027974

Regions

Domain25 – 258234Peptidase S1

Sites

Active site651Charge relay system
Active site1201Charge relay system
Active site2131Charge relay system

Amino acid modifications

Glycosylation1021N-linked (GlcNAc...) Probable
Disulfide bond31 ↔ 173 By similarity
Disulfide bond50 ↔ 66 By similarity
Disulfide bond152 ↔ 219 By similarity
Disulfide bond184 ↔ 198 By similarity
Disulfide bond209 ↔ 234 By similarity

Sequences

Sequence LengthMass (Da)Tools
P15945 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 29B4D669335522D8

FASTA26128,748
        10         20         30         40         50         60 
MWFLILFLAL SLGGIDAAPP VQSRIFGGFN CEKNSQPWQV AVYRFTKYQC GGVLLNANWV 

        70         80         90        100        110        120 
LTAAHCHNDK YQVWLGKNNF FEDEPSAQHR LVSKAIPHPD FNMSLLNEHT PQPEDDYSND 

       130        140        150        160        170        180 
LMLLRLKKPA DITDVVKPID LPTEEPKLGS TCLASGWGSI TPVIYEPADD LQCVNFKLLP 

       190        200        210        220        230        240 
NEDCVKAHIE KVTDVMLCAG DMDGGKDTCM GDSGGPLICD GVLHGITSWG PSPCGKPNVP 

       250        260 
GIYTKLIKFN SWIKDTIAKN A 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of the mouse glandular kallikrein gene, mGK-5."
Drinkwater C.C., Richards R.I.
Nucleic Acids Res. 15:10052-10052(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[3]"Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
Evans B.A., Drinkwater C.C., Richards R.I.
J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-54 AND 70-122.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00500 Genomic DNA. Translation: CAA68553.1.
BC013659 mRNA. Translation: AAH13659.1.
BC094281 mRNA. Translation: AAH94281.1.
M18584 Genomic DNA. Translation: AAX76511.1.
M18604 Genomic DNA. Translation: AAD15284.3.
CCDSCCDS21201.1.
PIRTRMSM5. S06305.
RefSeqNP_032482.1. NM_008456.3.
UniGeneMm.443373.

3D structure databases

ProteinModelPortalP15945.
SMRP15945. Positions 25-260.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.037.

Proteomic databases

MaxQBP15945.
PaxDbP15945.
PRIDEP15945.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000074359; ENSMUSP00000073964; ENSMUSG00000066512.
GeneID16622.
KEGGmmu:16622.
UCSCuc009gon.1. mouse.

Organism-specific databases

CTD16622.
MGIMGI:892020. Klk1b5.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00750000117405.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidP15945.
KOK01325.
OMAPVIYEPA.
OrthoDBEOG75B84T.
PhylomeDBP15945.
TreeFamTF331065.

Gene expression databases

BgeeP15945.
CleanExMM_KLK1B5.
GenevestigatorP15945.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290231.
PROP15945.
SOURCESearch...

Entry information

Entry nameK1KB5_MOUSE
AccessionPrimary (citable) accession number: P15945
Secondary accession number(s): Q52KM1, Q565D7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot