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P15945

- K1KB5_MOUSE

UniProt

P15945 - K1KB5_MOUSE

Protein

Kallikrein 1-related peptidase b5

Gene

Klk1b5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay system
    Active sitei120 – 1201Charge relay system
    Active sitei213 – 2131Charge relay system

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.037.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein 1-related peptidase b5 (EC:3.4.21.35)
    Alternative name(s):
    Glandular kallikrein K5
    Short name:
    mGK-5
    Tissue kallikrein-5
    Gene namesi
    Name:Klk1b5
    Synonyms:Klk-5, Klk5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:892020. Klk1b5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818CuratedAdd
    BLAST
    Propeptidei19 – 246Activation peptideCuratedPRO_0000027973
    Chaini25 – 261237Kallikrein 1-related peptidase b5PRO_0000027974Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 173PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Curated
    Disulfide bondi152 ↔ 219PROSITE-ProRule annotation
    Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
    Disulfide bondi209 ↔ 234PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    MaxQBiP15945.
    PaxDbiP15945.
    PRIDEiP15945.

    Expressioni

    Gene expression databases

    BgeeiP15945.
    CleanExiMM_KLK1B5.
    GenevestigatoriP15945.

    Structurei

    3D structure databases

    ProteinModelPortaliP15945.
    SMRiP15945. Positions 25-260.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 258234Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00750000117405.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP15945.
    KOiK01325.
    OMAiPVIYEPA.
    OrthoDBiEOG75B84T.
    PhylomeDBiP15945.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15945-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWFLILFLAL SLGGIDAAPP VQSRIFGGFN CEKNSQPWQV AVYRFTKYQC    50
    GGVLLNANWV LTAAHCHNDK YQVWLGKNNF FEDEPSAQHR LVSKAIPHPD 100
    FNMSLLNEHT PQPEDDYSND LMLLRLKKPA DITDVVKPID LPTEEPKLGS 150
    TCLASGWGSI TPVIYEPADD LQCVNFKLLP NEDCVKAHIE KVTDVMLCAG 200
    DMDGGKDTCM GDSGGPLICD GVLHGITSWG PSPCGKPNVP GIYTKLIKFN 250
    SWIKDTIAKN A 261
    Length:261
    Mass (Da):28,748
    Last modified:April 1, 1990 - v1
    Checksum:i29B4D669335522D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00500 Genomic DNA. Translation: CAA68553.1.
    BC013659 mRNA. Translation: AAH13659.1.
    BC094281 mRNA. Translation: AAH94281.1.
    M18584 Genomic DNA. Translation: AAX76511.1.
    M18604 Genomic DNA. Translation: AAD15284.3.
    CCDSiCCDS21201.1.
    PIRiS06305. TRMSM5.
    RefSeqiNP_032482.1. NM_008456.3.
    UniGeneiMm.443373.

    Genome annotation databases

    EnsembliENSMUST00000074359; ENSMUSP00000073964; ENSMUSG00000066512.
    GeneIDi16622.
    KEGGimmu:16622.
    UCSCiuc009gon.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00500 Genomic DNA. Translation: CAA68553.1 .
    BC013659 mRNA. Translation: AAH13659.1 .
    BC094281 mRNA. Translation: AAH94281.1 .
    M18584 Genomic DNA. Translation: AAX76511.1 .
    M18604 Genomic DNA. Translation: AAD15284.3 .
    CCDSi CCDS21201.1.
    PIRi S06305. TRMSM5.
    RefSeqi NP_032482.1. NM_008456.3.
    UniGenei Mm.443373.

    3D structure databases

    ProteinModelPortali P15945.
    SMRi P15945. Positions 25-260.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.037.

    Proteomic databases

    MaxQBi P15945.
    PaxDbi P15945.
    PRIDEi P15945.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074359 ; ENSMUSP00000073964 ; ENSMUSG00000066512 .
    GeneIDi 16622.
    KEGGi mmu:16622.
    UCSCi uc009gon.1. mouse.

    Organism-specific databases

    CTDi 16622.
    MGIi MGI:892020. Klk1b5.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00750000117405.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P15945.
    KOi K01325.
    OMAi PVIYEPA.
    OrthoDBi EOG75B84T.
    PhylomeDBi P15945.
    TreeFami TF331065.

    Enzyme and pathway databases

    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    NextBioi 290231.
    PROi P15945.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15945.
    CleanExi MM_KLK1B5.
    Genevestigatori P15945.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the mouse glandular kallikrein gene, mGK-5."
      Drinkwater C.C., Richards R.I.
      Nucleic Acids Res. 15:10052-10052(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    3. "Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus."
      Evans B.A., Drinkwater C.C., Richards R.I.
      J. Biol. Chem. 262:8027-8034(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-54 AND 70-122.
      Strain: BALB/c.

    Entry informationi

    Entry nameiK1KB5_MOUSE
    AccessioniPrimary (citable) accession number: P15945
    Secondary accession number(s): Q52KM1, Q565D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3