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Protein

Acetyl-CoA hydrolase

Gene

acu-8

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for utilization of acetate.1 Publication

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3055-glutamyl coenzyme A thioester intermediateBy similarity1
Binding sitei395Coenzyme ABy similarity1
Binding sitei399Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetate utilization protein
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:acu-8
ORF Names:NCU09770
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU09770.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155211 – 525Acetyl-CoA hydrolaseAdd BLAST525

Structurei

3D structure databases

ProteinModelPortaliP15937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni280 – 284Coenzyme A bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172597.
InParanoidiP15937.
KOiK01067.
OMAiQAGIGNI.
OrthoDBiEOG092C1EVJ.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PANTHERiPTHR21432. PTHR21432. 1 hit.
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15937-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPIASAAL RARVKRPSML KKLCNPEDML QHFPNGAYIG WSGFTGVGYP
60 70 80 90 100
KKVPTMLADH VEKNGLQGQL KYSLFVGASA GAETENRWAA LDMIARRAPH
110 120 130 140 150
QVGKNIAKGI NEGRINFFDK HLSMFPVDLV YGYYTKDRQN KNLDVVCVEA
160 170 180 190 200
TEIKEDGSIV LGASVGATPE LIQMADKVII EVNTAIPSFD GLHDITFSDL
210 220 230 240 250
PPNRKPYLIQ QCRDRIGTTS VPVDPEKVVG IIECTTPDQT LPNSPADETA
260 270 280 290 300
TAIAGHLIEF FEHEVAHGRL PKNLLPLQSG IGNIANAVIG GLETSNFKNL
310 320 330 340 350
NVWTEVIQDT FLDLFDSGKL DFATATSIRF SPTGFERFYK NWDNYYDKLL
360 370 380 390 400
LRSQSVSNAP EIIRRLGVIG MNTPVEVDIY AHANSTNVMG SRMLNGLGGS
410 420 430 440 450
ADFLRNSKYS IMHTPSTRPS KTDAHGVSCI VPMCTHVDQT EHDLDVIVTE
460 470 480 490 500
NGLADVRGLS PRERARVIID KCAHDVYKPI LKAYFEKAEF ECLRKGMGHE
510 520
PHLLFNSFDM HKALVEEGSM AKVKF
Length:525
Mass (Da):58,006
Last modified:January 4, 2005 - v2
Checksum:iE6134462D4A35423
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14 – 16VKR → QG in AAA33554 (PubMed:2140429).Curated3
Sequence conflicti46 – 56GVGYPKKVPTM → ASATPRRSYY in AAA33554 (PubMed:2140429).CuratedAdd BLAST11
Sequence conflicti65 – 86GLQGQ…AETEN → ASRPAQVQPLRRCLRRRRDR E in AAA33554 (PubMed:2140429).CuratedAdd BLAST22
Sequence conflicti95A → AHDR in AAA33554 (PubMed:2140429).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31521 Genomic DNA. Translation: AAA33554.1.
CM002237 Genomic DNA. Translation: EAA29118.1.
PIRiA36316.
RefSeqiXP_958354.1. XM_953261.3.

Genome annotation databases

EnsemblFungiiEAA29118; EAA29118; NCU09770.
GeneIDi3874501.
KEGGincr:NCU09770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31521 Genomic DNA. Translation: AAA33554.1.
CM002237 Genomic DNA. Translation: EAA29118.1.
PIRiA36316.
RefSeqiXP_958354.1. XM_953261.3.

3D structure databases

ProteinModelPortaliP15937.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA29118; EAA29118; NCU09770.
GeneIDi3874501.
KEGGincr:NCU09770.

Organism-specific databases

EuPathDBiFungiDB:NCU09770.

Phylogenomic databases

HOGENOMiHOG000172597.
InParanoidiP15937.
KOiK01067.
OMAiQAGIGNI.
OrthoDBiEOG092C1EVJ.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PANTHERiPTHR21432. PTHR21432. 1 hit.
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACH1_NEUCR
AccessioniPrimary (citable) accession number: P15937
Secondary accession number(s): Q7RV87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 4, 2005
Last modified: November 2, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.