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P15937

- ACH1_NEUCR

UniProt

P15937 - ACH1_NEUCR

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Protein
Acetyl-CoA hydrolase
Gene
acu-8, NCU09770
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Required for utilization of acetate.1 Publication

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

GO - Molecular functioni

  1. acetate CoA-transferase activity Source: EnsemblFungi
  2. acetyl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetate metabolic process Source: EnsemblFungi
  2. acetyl-CoA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetate utilization protein
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:acu-8
ORF Names:NCU09770
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 6, Linkage Group II

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: EnsemblFungi
  2. mitochondrion Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Acetyl-CoA hydrolase
PRO_0000215521Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU09770.1.

Structurei

3D structure databases

ProteinModelPortaliP15937.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
KOiK01067.
OMAiDYQPILT.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15937-1 [UniParc]FASTAAdd to Basket

« Hide

MASPIASAAL RARVKRPSML KKLCNPEDML QHFPNGAYIG WSGFTGVGYP    50
KKVPTMLADH VEKNGLQGQL KYSLFVGASA GAETENRWAA LDMIARRAPH 100
QVGKNIAKGI NEGRINFFDK HLSMFPVDLV YGYYTKDRQN KNLDVVCVEA 150
TEIKEDGSIV LGASVGATPE LIQMADKVII EVNTAIPSFD GLHDITFSDL 200
PPNRKPYLIQ QCRDRIGTTS VPVDPEKVVG IIECTTPDQT LPNSPADETA 250
TAIAGHLIEF FEHEVAHGRL PKNLLPLQSG IGNIANAVIG GLETSNFKNL 300
NVWTEVIQDT FLDLFDSGKL DFATATSIRF SPTGFERFYK NWDNYYDKLL 350
LRSQSVSNAP EIIRRLGVIG MNTPVEVDIY AHANSTNVMG SRMLNGLGGS 400
ADFLRNSKYS IMHTPSTRPS KTDAHGVSCI VPMCTHVDQT EHDLDVIVTE 450
NGLADVRGLS PRERARVIID KCAHDVYKPI LKAYFEKAEF ECLRKGMGHE 500
PHLLFNSFDM HKALVEEGSM AKVKF 525
Length:525
Mass (Da):58,006
Last modified:January 4, 2005 - v2
Checksum:iE6134462D4A35423
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 163VKR → QG in AAA33554. 1 Publication
Sequence conflicti46 – 5611GVGYPKKVPTM → ASATPRRSYY in AAA33554. 1 Publication
Add
BLAST
Sequence conflicti65 – 8622GLQGQ…AETEN → ASRPAQVQPLRRCLRRRRDR E in AAA33554. 1 Publication
Add
BLAST
Sequence conflicti95 – 951A → AHDR in AAA33554. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31521 Genomic DNA. Translation: AAA33554.1.
CM002237 Genomic DNA. Translation: EAA29118.1.
PIRiA36316.
RefSeqiXP_958354.1. XM_953261.2.
UniGeneiNcr.13786.

Genome annotation databases

EnsemblFungiiEFNCRT00000009606; EFNCRP00000009588; EFNCRG00000009587.
GeneIDi3874501.
KEGGincr:NCU09770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31521 Genomic DNA. Translation: AAA33554.1 .
CM002237 Genomic DNA. Translation: EAA29118.1 .
PIRi A36316.
RefSeqi XP_958354.1. XM_953261.2.
UniGenei Ncr.13786.

3D structure databases

ProteinModelPortali P15937.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU09770.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000009606 ; EFNCRP00000009588 ; EFNCRG00000009587 .
GeneIDi 3874501.
KEGGi ncr:NCU09770.

Phylogenomic databases

eggNOGi COG0427.
HOGENOMi HOG000172597.
KOi K01067.
OMAi DYQPILT.
OrthoDBi EOG7TQV8M.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Duplication-induced mutation of a new Neurospora gene required for acetate utilization: properties of the mutant and predicted amino acid sequence of the protein product."
    Marathe S., Connerton I.F., Fincham J.R.S.
    Mol. Cell. Biol. 10:2638-2644(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "An acetate-sensitive mutant of Neurospora crassa deficient in acetyl-CoA hydrolase."
    Connerton I.F., McCullough W., Fincham J.R.S.
    J. Gen. Microbiol. 138:1797-1800(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiACH1_NEUCR
AccessioniPrimary (citable) accession number: P15937
Secondary accession number(s): Q7RV87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 4, 2005
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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