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P15937 (ACH1_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetyl-CoA hydrolase

EC=3.1.2.1
Alternative name(s):
Acetate utilization protein
Acetyl-CoA deacylase
Short name=Acetyl-CoA acylase
Gene names
Name:acu-8
ORF Names:NCU09770
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for utilization of acetate. Ref.3

Catalytic activity

Acetyl-CoA + H2O = CoA + acetate.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacetate metabolic process

Inferred from electronic annotation. Source: EnsemblFungi

acetyl-CoA metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytosol

Inferred from electronic annotation. Source: EnsemblFungi

mitochondrion

Inferred from electronic annotation. Source: EnsemblFungi

   Molecular_functionacetate CoA-transferase activity

Inferred from electronic annotation. Source: EnsemblFungi

acetyl-CoA hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 525525Acetyl-CoA hydrolase
PRO_0000215521

Experimental info

Sequence conflict14 – 163VKR → QG in AAA33554. Ref.1
Sequence conflict46 – 5611GVGYPKKVPTM → ASATPRRSYY in AAA33554. Ref.1
Sequence conflict65 – 8622GLQGQ…AETEN → ASRPAQVQPLRRCLRRRRDR E in AAA33554. Ref.1
Sequence conflict951A → AHDR in AAA33554. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P15937 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: E6134462D4A35423

FASTA52558,006
        10         20         30         40         50         60 
MASPIASAAL RARVKRPSML KKLCNPEDML QHFPNGAYIG WSGFTGVGYP KKVPTMLADH 

        70         80         90        100        110        120 
VEKNGLQGQL KYSLFVGASA GAETENRWAA LDMIARRAPH QVGKNIAKGI NEGRINFFDK 

       130        140        150        160        170        180 
HLSMFPVDLV YGYYTKDRQN KNLDVVCVEA TEIKEDGSIV LGASVGATPE LIQMADKVII 

       190        200        210        220        230        240 
EVNTAIPSFD GLHDITFSDL PPNRKPYLIQ QCRDRIGTTS VPVDPEKVVG IIECTTPDQT 

       250        260        270        280        290        300 
LPNSPADETA TAIAGHLIEF FEHEVAHGRL PKNLLPLQSG IGNIANAVIG GLETSNFKNL 

       310        320        330        340        350        360 
NVWTEVIQDT FLDLFDSGKL DFATATSIRF SPTGFERFYK NWDNYYDKLL LRSQSVSNAP 

       370        380        390        400        410        420 
EIIRRLGVIG MNTPVEVDIY AHANSTNVMG SRMLNGLGGS ADFLRNSKYS IMHTPSTRPS 

       430        440        450        460        470        480 
KTDAHGVSCI VPMCTHVDQT EHDLDVIVTE NGLADVRGLS PRERARVIID KCAHDVYKPI 

       490        500        510        520 
LKAYFEKAEF ECLRKGMGHE PHLLFNSFDM HKALVEEGSM AKVKF 

« Hide

References

« Hide 'large scale' references
[1]"Duplication-induced mutation of a new Neurospora gene required for acetate utilization: properties of the mutant and predicted amino acid sequence of the protein product."
Marathe S., Connerton I.F., Fincham J.R.S.
Mol. Cell. Biol. 10:2638-2644(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"An acetate-sensitive mutant of Neurospora crassa deficient in acetyl-CoA hydrolase."
Connerton I.F., McCullough W., Fincham J.R.S.
J. Gen. Microbiol. 138:1797-1800(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31521 Genomic DNA. Translation: AAA33554.1.
CM002237 Genomic DNA. Translation: EAA29118.1.
PIRA36316.
RefSeqXP_958354.1. XM_953261.2.
UniGeneNcr.13786.

3D structure databases

ProteinModelPortalP15937.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU09770.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000009606; EFNCRP00000009588; EFNCRG00000009587.
GeneID3874501.
KEGGncr:NCU09770.

Phylogenomic databases

eggNOGCOG0427.
HOGENOMHOG000172597.
KOK01067.
OMADYQPILT.
OrthoDBEOG7TQV8M.

Family and domain databases

InterProIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACH1_NEUCR
AccessionPrimary (citable) accession number: P15937
Secondary accession number(s): Q7RV87
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 4, 2005
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families