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P15937

- ACH1_NEUCR

UniProt

P15937 - ACH1_NEUCR

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Protein

Acetyl-CoA hydrolase

Gene

acu-8

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for utilization of acetate.1 Publication

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei305 – 30515-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei395 – 3951Coenzyme ABy similarity
Binding sitei399 – 3991Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. acetate CoA-transferase activity Source: EnsemblFungi
  2. acetyl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetate metabolic process Source: EnsemblFungi
  2. acetyl-CoA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetate utilization protein
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:acu-8
ORF Names:NCU09770
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 6, Linkage Group II

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: EnsemblFungi
  2. mitochondrion Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Acetyl-CoA hydrolasePRO_0000215521Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU09770.1.

Structurei

3D structure databases

ProteinModelPortaliP15937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni280 – 2845Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
InParanoidiP15937.
KOiK01067.
OMAiDYQPILT.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15937-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPIASAAL RARVKRPSML KKLCNPEDML QHFPNGAYIG WSGFTGVGYP
60 70 80 90 100
KKVPTMLADH VEKNGLQGQL KYSLFVGASA GAETENRWAA LDMIARRAPH
110 120 130 140 150
QVGKNIAKGI NEGRINFFDK HLSMFPVDLV YGYYTKDRQN KNLDVVCVEA
160 170 180 190 200
TEIKEDGSIV LGASVGATPE LIQMADKVII EVNTAIPSFD GLHDITFSDL
210 220 230 240 250
PPNRKPYLIQ QCRDRIGTTS VPVDPEKVVG IIECTTPDQT LPNSPADETA
260 270 280 290 300
TAIAGHLIEF FEHEVAHGRL PKNLLPLQSG IGNIANAVIG GLETSNFKNL
310 320 330 340 350
NVWTEVIQDT FLDLFDSGKL DFATATSIRF SPTGFERFYK NWDNYYDKLL
360 370 380 390 400
LRSQSVSNAP EIIRRLGVIG MNTPVEVDIY AHANSTNVMG SRMLNGLGGS
410 420 430 440 450
ADFLRNSKYS IMHTPSTRPS KTDAHGVSCI VPMCTHVDQT EHDLDVIVTE
460 470 480 490 500
NGLADVRGLS PRERARVIID KCAHDVYKPI LKAYFEKAEF ECLRKGMGHE
510 520
PHLLFNSFDM HKALVEEGSM AKVKF
Length:525
Mass (Da):58,006
Last modified:January 4, 2005 - v2
Checksum:iE6134462D4A35423
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 163VKR → QG in AAA33554. (PubMed:2140429)Curated
Sequence conflicti46 – 5611GVGYPKKVPTM → ASATPRRSYY in AAA33554. (PubMed:2140429)CuratedAdd
BLAST
Sequence conflicti65 – 8622GLQGQ…AETEN → ASRPAQVQPLRRCLRRRRDR E in AAA33554. (PubMed:2140429)CuratedAdd
BLAST
Sequence conflicti95 – 951A → AHDR in AAA33554. (PubMed:2140429)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31521 Genomic DNA. Translation: AAA33554.1.
CM002237 Genomic DNA. Translation: EAA29118.1.
PIRiA36316.
RefSeqiXP_958354.1. XM_953261.2.
UniGeneiNcr.13786.

Genome annotation databases

EnsemblFungiiEFNCRT00000009606; EFNCRP00000009588; EFNCRG00000009587.
GeneIDi3874501.
KEGGincr:NCU09770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31521 Genomic DNA. Translation: AAA33554.1 .
CM002237 Genomic DNA. Translation: EAA29118.1 .
PIRi A36316.
RefSeqi XP_958354.1. XM_953261.2.
UniGenei Ncr.13786.

3D structure databases

ProteinModelPortali P15937.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU09770.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000009606 ; EFNCRP00000009588 ; EFNCRG00000009587 .
GeneIDi 3874501.
KEGGi ncr:NCU09770.

Phylogenomic databases

eggNOGi COG0427.
HOGENOMi HOG000172597.
InParanoidi P15937.
KOi K01067.
OMAi DYQPILT.
OrthoDBi EOG7TQV8M.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Duplication-induced mutation of a new Neurospora gene required for acetate utilization: properties of the mutant and predicted amino acid sequence of the protein product."
    Marathe S., Connerton I.F., Fincham J.R.S.
    Mol. Cell. Biol. 10:2638-2644(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "An acetate-sensitive mutant of Neurospora crassa deficient in acetyl-CoA hydrolase."
    Connerton I.F., McCullough W., Fincham J.R.S.
    J. Gen. Microbiol. 138:1797-1800(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiACH1_NEUCR
AccessioniPrimary (citable) accession number: P15937
Secondary accession number(s): Q7RV87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 4, 2005
Last modified: October 29, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3