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P15937

- ACH1_NEUCR

UniProt

P15937 - ACH1_NEUCR

Protein

Acetyl-CoA hydrolase

Gene

acu-8

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Required for utilization of acetate.1 Publication

    Catalytic activityi

    Acetyl-CoA + H2O = CoA + acetate.

    GO - Molecular functioni

    1. acetate CoA-transferase activity Source: EnsemblFungi
    2. acetyl-CoA hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetate metabolic process Source: EnsemblFungi
    2. acetyl-CoA metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA hydrolase (EC:3.1.2.1)
    Alternative name(s):
    Acetate utilization protein
    Acetyl-CoA deacylase
    Short name:
    Acetyl-CoA acylase
    Gene namesi
    Name:acu-8
    ORF Names:NCU09770
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 6, Linkage Group II

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: EnsemblFungi
    2. mitochondrion Source: EnsemblFungi

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Acetyl-CoA hydrolasePRO_0000215521Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU09770.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP15937.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0427.
    HOGENOMiHOG000172597.
    KOiK01067.
    OMAiDYQPILT.
    OrthoDBiEOG7TQV8M.

    Family and domain databases

    InterProiIPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view]
    PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15937-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPIASAAL RARVKRPSML KKLCNPEDML QHFPNGAYIG WSGFTGVGYP    50
    KKVPTMLADH VEKNGLQGQL KYSLFVGASA GAETENRWAA LDMIARRAPH 100
    QVGKNIAKGI NEGRINFFDK HLSMFPVDLV YGYYTKDRQN KNLDVVCVEA 150
    TEIKEDGSIV LGASVGATPE LIQMADKVII EVNTAIPSFD GLHDITFSDL 200
    PPNRKPYLIQ QCRDRIGTTS VPVDPEKVVG IIECTTPDQT LPNSPADETA 250
    TAIAGHLIEF FEHEVAHGRL PKNLLPLQSG IGNIANAVIG GLETSNFKNL 300
    NVWTEVIQDT FLDLFDSGKL DFATATSIRF SPTGFERFYK NWDNYYDKLL 350
    LRSQSVSNAP EIIRRLGVIG MNTPVEVDIY AHANSTNVMG SRMLNGLGGS 400
    ADFLRNSKYS IMHTPSTRPS KTDAHGVSCI VPMCTHVDQT EHDLDVIVTE 450
    NGLADVRGLS PRERARVIID KCAHDVYKPI LKAYFEKAEF ECLRKGMGHE 500
    PHLLFNSFDM HKALVEEGSM AKVKF 525
    Length:525
    Mass (Da):58,006
    Last modified:January 4, 2005 - v2
    Checksum:iE6134462D4A35423
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 163VKR → QG in AAA33554. (PubMed:2140429)Curated
    Sequence conflicti46 – 5611GVGYPKKVPTM → ASATPRRSYY in AAA33554. (PubMed:2140429)CuratedAdd
    BLAST
    Sequence conflicti65 – 8622GLQGQ…AETEN → ASRPAQVQPLRRCLRRRRDR E in AAA33554. (PubMed:2140429)CuratedAdd
    BLAST
    Sequence conflicti95 – 951A → AHDR in AAA33554. (PubMed:2140429)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31521 Genomic DNA. Translation: AAA33554.1.
    CM002237 Genomic DNA. Translation: EAA29118.1.
    PIRiA36316.
    RefSeqiXP_958354.1. XM_953261.2.
    UniGeneiNcr.13786.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000009606; EFNCRP00000009588; EFNCRG00000009587.
    GeneIDi3874501.
    KEGGincr:NCU09770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31521 Genomic DNA. Translation: AAA33554.1 .
    CM002237 Genomic DNA. Translation: EAA29118.1 .
    PIRi A36316.
    RefSeqi XP_958354.1. XM_953261.2.
    UniGenei Ncr.13786.

    3D structure databases

    ProteinModelPortali P15937.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU09770.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000009606 ; EFNCRP00000009588 ; EFNCRG00000009587 .
    GeneIDi 3874501.
    KEGGi ncr:NCU09770.

    Phylogenomic databases

    eggNOGi COG0427.
    HOGENOMi HOG000172597.
    KOi K01067.
    OMAi DYQPILT.
    OrthoDBi EOG7TQV8M.

    Family and domain databases

    InterProi IPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view ]
    Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Duplication-induced mutation of a new Neurospora gene required for acetate utilization: properties of the mutant and predicted amino acid sequence of the protein product."
      Marathe S., Connerton I.F., Fincham J.R.S.
      Mol. Cell. Biol. 10:2638-2644(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "An acetate-sensitive mutant of Neurospora crassa deficient in acetyl-CoA hydrolase."
      Connerton I.F., McCullough W., Fincham J.R.S.
      J. Gen. Microbiol. 138:1797-1800(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiACH1_NEUCR
    AccessioniPrimary (citable) accession number: P15937
    Secondary accession number(s): Q7RV87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3