Reviewed, UniProtKB/Swiss-Prot P15937 (ACH1_NEUCR)

Names and origin

Protein names

Recommended name:
    Acetyl-CoA hydrolase
    EC=3.1.2.1
Alternative name(s):
    Acetyl-CoA deacylase
      Short name=Acetyl-CoA acylase
    Acetate utilization protein

Gene names

Name:	acu-8
ORF Names:	NCU09770

Organism

Neurospora crassa [Complete proteome]

Taxonomic identifier

5141 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	525 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for utilization of acetate. Ref.3
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 525	525	Acetyl-CoA hydrolase		PRO_0000215521
Experimental info
	Sequence conflict	14 – 16	3	VKR → QG in AAA33554. Ref.1
	Sequence conflict	46 – 56	11	GVGYPKKVPTM → ASATPRRSYY in AAA33554. Ref.1
	Sequence conflict	65 – 86	22	GLQGQ…AETEN → ASRPAQVQPLRRCLRRRRDR E Ref.1
	Sequence conflict	95	1	A → AHDR in AAA33554. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P15937-1 [UniParc]. Last modified January 4, 2005. Version 2. Checksum: E6134462D4A35423	FASTA	525	58,006
	10 20 30 40 50 60 MASPIASAAL RARVKRPSML KKLCNPEDML QHFPNGAYIG WSGFTGVGYP KKVPTMLADH 70 80 90 100 110 120 VEKNGLQGQL KYSLFVGASA GAETENRWAA LDMIARRAPH QVGKNIAKGI NEGRINFFDK 130 140 150 160 170 180 HLSMFPVDLV YGYYTKDRQN KNLDVVCVEA TEIKEDGSIV LGASVGATPE LIQMADKVII 190 200 210 220 230 240 EVNTAIPSFD GLHDITFSDL PPNRKPYLIQ QCRDRIGTTS VPVDPEKVVG IIECTTPDQT 250 260 270 280 290 300 LPNSPADETA TAIAGHLIEF FEHEVAHGRL PKNLLPLQSG IGNIANAVIG GLETSNFKNL 310 320 330 340 350 360 NVWTEVIQDT FLDLFDSGKL DFATATSIRF SPTGFERFYK NWDNYYDKLL LRSQSVSNAP 370 380 390 400 410 420 EIIRRLGVIG MNTPVEVDIY AHANSTNVMG SRMLNGLGGS ADFLRNSKYS IMHTPSTRPS 430 440 450 460 470 480 KTDAHGVSCI VPMCTHVDQT EHDLDVIVTE NGLADVRGLS PRERARVIID KCAHDVYKPI 490 500 510 520 LKAYFEKAEF ECLRKGMGHE PHLLFNSFDM HKALVEEGSM AKVKF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Duplication-induced mutation of a new Neurospora gene required for acetate utilization: properties of the mutant and predicted amino acid sequence of the protein product." Marathe S., Connerton I.F., Fincham J.R.S. Mol. Cell. Biol. 10:2638-2644(1990) [PubMed: 2140429] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]	"An acetate-sensitive mutant of Neurospora crassa deficient in acetyl-CoA hydrolase." Connerton I.F., McCullough W., Fincham J.R.S. J. Gen. Microbiol. 138:1797-1800(1992) [PubMed: 1357077] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M31521 Genomic DNA. Translation: AAA33554.1. AABX02000087 Genomic DNA. Translation: EAA29118.1.
PIR	A36316.
RefSeq	XP_958354.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P15937.
Genome annotation databases
GeneID	3874501.
KEGG	ncr:NCU09770.
NMPDR	fig|5141.1.peg.8353.
Enzyme and pathway databases
BRENDA	3.1.2.1. 266.
Family and domain databases
InterPro	IPR003702. ActCoA_hydro. [Graphical view]
PANTHER	PTHR21432. ActCoA_hydro. 1 hit.
Pfam	PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_NEUCR

Accession

Primary (citable) accession number: P15937
Secondary accession number(s): Q7RV87

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	January 4, 2005
Last modified:	September 1, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)