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Protein

Arsenical resistance operon repressor

Gene

arsR

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processArsenical resistance, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenical resistance operon repressor
Gene namesi
Name:arsR
Encoded oniPlasmid R7730 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606111 – 117Arsenical resistance operon repressorAdd BLAST117

Proteomic databases

PRIDEiP15905.

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Structurei

3D structure databases

ProteinModelPortaliP15905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92HTH arsR-typePROSITE-ProRule annotationAdd BLAST92

Family and domain databases

CDDicd00090. HTH_ARSR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011991. ArsR-like_HTH.
IPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF01022. HTH_5. 1 hit.
PRINTSiPR00778. HTHARSR.
SMARTiView protein in SMART
SM00418. HTH_ARSR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P15905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLTPLQLF KNLSDETRLG IVLLLREMGE LCVCDLCMAL DQSQPKISRH
60 70 80 90 100
LAMLRESGIL LDRKQGKWVH YRLSPHIPSW AAQIIEQAWL SQQDDVQVIA
110
RKLASVNCSG SSKAVCI
Length:117
Mass (Da):13,199
Last modified:April 1, 1990 - v1
Checksum:i1F0D10766E4FD886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16045 Genomic DNA. Translation: CAA34168.1.
PIRiJS0448. BVECAR.
RefSeqiWP_011117595.1. NZ_NTPD01000038.1.

Similar proteinsi

Entry informationi

Entry nameiARSR1_ECOLX
AccessioniPrimary (citable) accession number: P15905
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: January 31, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid