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Protein

S-arrestin

Gene

Sag

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.

Miscellaneous

Arrestin binds calcium.

GO - Molecular functioni

  • opsin binding Source: RGD
  • phosphoprotein binding Source: RGD
  • spectrin binding Source: MGI

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision
LigandCalcium

Enzyme and pathway databases

ReactomeiR-RNO-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
S-arrestin
Alternative name(s):
48 kDa protein
Retinal S-antigen
Short name:
S-AG
Rod photoreceptor arrestin
Gene namesi
Name:Sag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3619. Sag.

Subcellular locationi

Pathology & Biotechi

Involvement in diseasei

S-antigen induces autoimmune uveitis.

Keywords - Diseasei

Autoimmune uveitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002051891 – 403S-arrestinAdd BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi129 ↔ 144Curated
Modified residuei231PhosphothreonineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP15887.
PRIDEiP15887.

PTM databases

iPTMnetiP15887.
PhosphoSitePlusiP15887.

Expressioni

Tissue specificityi

Retina and pineal gland.

Gene expression databases

BgeeiENSRNOG00000018185.
ExpressionAtlasiP15887. baseline.
GenevisibleiP15887. RN.

Interactioni

GO - Molecular functioni

  • opsin binding Source: RGD
  • phosphoprotein binding Source: RGD
  • spectrin binding Source: MGI

Protein-protein interaction databases

MINTiMINT-4564271.
STRINGi10116.ENSRNOP00000024733.

Structurei

3D structure databases

ProteinModelPortaliP15887.
SMRiP15887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiP15887.
KOiK19627.
OMAiAWQFFMS.
PhylomeDBiP15887.
TreeFamiTF314260.

Family and domain databases

Gene3Di2.60.40.840. 1 hit.
InterProiView protein in InterPro
IPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiView protein in Pfam
PF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
PRINTSiPR00309. ARRESTIN.
SMARTiView protein in SMART
SM01017. Arrestin_C. 1 hit.
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiView protein in PROSITE
PS00295. ARRESTINS. 1 hit.

Sequencei

Sequence statusi: Complete.

P15887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAACVKTNKS HVIFKKVSRD KSVTIYLGKR DYIDHVSQVE PVDGVVLVDP
60 70 80 90 100
ELVKGKKVYV TLTCAFRYGQ EDIDVIGLTF RRDLYFSRVQ VYPPVGAMSA
110 120 130 140 150
PTQLQLSLLK KLGDNTYPFL LTFPDYLPCS VMLQPAPQDV GKSCGVDFEV
160 170 180 190 200
KAFATDITDA EEDKIPKKSS VRLLIRKVQH APPEMGPQPC AEASWQFFMS
210 220 230 240 250
DKPLHLSVSL SKEIYFHGEP IPVTVTVTNN TEKVVKKIKV SVEQIANVVL
260 270 280 290 300
YSSDYYVKPV ASEETQEKVQ PNSTLTKTLV LVPLLANNRE RRGIALDGKI
310 320 330 340 350
KHEDTNLASS TIIKEGIDRT VMGILVSYHI KVKLTVSGFL GELTSSEVAT
360 370 380 390 400
EVPFRLMHPQ PEDPAKESVQ DENLVFEEFA RQNLKDTGEN TEGKKDEDAG

QDE
Length:403
Mass (Da):44,950
Last modified:April 1, 1990 - v1
Checksum:i7DD1ED8596C42219
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109L → R in CAA33412 (PubMed:2213004).Curated1
Sequence conflicti109L → R in AAA42107 (PubMed:2213004).Curated1
Sequence conflicti158T → R in AAA42107 (PubMed:2213004).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51781 mRNA. Translation: CAA36076.1.
X15353 mRNA. Translation: CAA33412.1.
M60737 mRNA. Translation: AAA42107.1.
PIRiS03960.
RefSeqiNP_037155.2. NM_013023.2.
XP_008765418.1. XM_008767196.2.
UniGeneiRn.9856.

Genome annotation databases

EnsembliENSRNOT00000085770; ENSRNOP00000071579; ENSRNOG00000018185.
GeneIDi25539.
KEGGirno:25539.
UCSCiRGD:3619. rat.

Similar proteinsi

Entry informationi

Entry nameiARRS_RAT
AccessioniPrimary (citable) accession number: P15887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families