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Protein

S-arrestin

Gene

Sag

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.

GO - Molecular functioni

  • spectrin binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-RNO-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
S-arrestin
Alternative name(s):
48 kDa protein
Retinal S-antigen
Short name:
S-AG
Rod photoreceptor arrestin
Gene namesi
Name:Sag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3619. Sag.

Subcellular locationi

GO - Cellular componenti

  • photoreceptor inner segment Source: RGD
  • photoreceptor outer segment Source: RGD
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

S-antigen induces autoimmune uveitis.

Keywords - Diseasei

Autoimmune uveitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403S-arrestinPRO_0000205189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi129 ↔ 144Curated
Modified residuei231 – 2311PhosphothreonineCombined sources

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP15887.
PRIDEiP15887.

PTM databases

iPTMnetiP15887.
PhosphoSiteiP15887.

Expressioni

Tissue specificityi

Retina and pineal gland.

Gene expression databases

ExpressionAtlasiP15887. baseline.
GenevisibleiP15887. RN.

Interactioni

GO - Molecular functioni

  • spectrin binding Source: MGI

Protein-protein interaction databases

MINTiMINT-4564271.
STRINGi10116.ENSRNOP00000024733.

Structurei

3D structure databases

ProteinModelPortaliP15887.
SMRiP15887. Positions 10-385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiP15887.
KOiK19627.
OMAiKEIYFHG.
PhylomeDBiP15887.
TreeFamiTF314260.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAACVKTNKS HVIFKKVSRD KSVTIYLGKR DYIDHVSQVE PVDGVVLVDP
60 70 80 90 100
ELVKGKKVYV TLTCAFRYGQ EDIDVIGLTF RRDLYFSRVQ VYPPVGAMSA
110 120 130 140 150
PTQLQLSLLK KLGDNTYPFL LTFPDYLPCS VMLQPAPQDV GKSCGVDFEV
160 170 180 190 200
KAFATDITDA EEDKIPKKSS VRLLIRKVQH APPEMGPQPC AEASWQFFMS
210 220 230 240 250
DKPLHLSVSL SKEIYFHGEP IPVTVTVTNN TEKVVKKIKV SVEQIANVVL
260 270 280 290 300
YSSDYYVKPV ASEETQEKVQ PNSTLTKTLV LVPLLANNRE RRGIALDGKI
310 320 330 340 350
KHEDTNLASS TIIKEGIDRT VMGILVSYHI KVKLTVSGFL GELTSSEVAT
360 370 380 390 400
EVPFRLMHPQ PEDPAKESVQ DENLVFEEFA RQNLKDTGEN TEGKKDEDAG

QDE
Length:403
Mass (Da):44,950
Last modified:April 1, 1990 - v1
Checksum:i7DD1ED8596C42219
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091L → R in CAA33412 (PubMed:2213004).Curated
Sequence conflicti109 – 1091L → R in AAA42107 (PubMed:2213004).Curated
Sequence conflicti158 – 1581T → R in AAA42107 (PubMed:2213004).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51781 mRNA. Translation: CAA36076.1.
X15353 mRNA. Translation: CAA33412.1.
M60737 mRNA. Translation: AAA42107.1.
PIRiS03960.
RefSeqiNP_037155.2. NM_013023.2.
XP_008765418.1. XM_008767196.1.
UniGeneiRn.9856.

Genome annotation databases

EnsembliENSRNOT00000085770; ENSRNOP00000071579; ENSRNOG00000018185.
GeneIDi25539.
KEGGirno:25539.
UCSCiRGD:3619. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51781 mRNA. Translation: CAA36076.1.
X15353 mRNA. Translation: CAA33412.1.
M60737 mRNA. Translation: AAA42107.1.
PIRiS03960.
RefSeqiNP_037155.2. NM_013023.2.
XP_008765418.1. XM_008767196.1.
UniGeneiRn.9856.

3D structure databases

ProteinModelPortaliP15887.
SMRiP15887. Positions 10-385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4564271.
STRINGi10116.ENSRNOP00000024733.

PTM databases

iPTMnetiP15887.
PhosphoSiteiP15887.

Proteomic databases

PaxDbiP15887.
PRIDEiP15887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000085770; ENSRNOP00000071579; ENSRNOG00000018185.
GeneIDi25539.
KEGGirno:25539.
UCSCiRGD:3619. rat.

Organism-specific databases

CTDi6295.
RGDi3619. Sag.

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiP15887.
KOiK19627.
OMAiKEIYFHG.
PhylomeDBiP15887.
TreeFamiTF314260.

Enzyme and pathway databases

ReactomeiR-RNO-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

PROiP15887.

Gene expression databases

ExpressionAtlasiP15887. baseline.
GenevisibleiP15887. RN.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARRS_RAT
AccessioniPrimary (citable) accession number: P15887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Arrestin binds calcium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.