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Protein

S-arrestin

Gene

Sag

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.By similarity

GO - Molecular functioni

  • spectrin binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyi

Protein namesi
Recommended name:
S-arrestin
Alternative name(s):
48 kDa protein
Retinal S-antigen
Short name:
S-AG
Rod photoreceptor arrestin
Gene namesi
Name:Sag
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3619 Sag

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002051891 – 403S-arrestinAdd BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP15887
PRIDEiP15887

PTM databases

iPTMnetiP15887
PhosphoSitePlusiP15887

Expressioni

Tissue specificityi

Retina and pineal gland.1 Publication

Gene expression databases

BgeeiENSRNOG00000018185
ExpressionAtlasiP15887 baseline and differential
GenevisibleiP15887 RN

Interactioni

Subunit structurei

Monomer. Homodimer. Homotetramer. Interacts with RHO (via the phosphorylated C-terminus).By similarity

GO - Molecular functioni

  • spectrin binding Source: MGI

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024733

Structurei

3D structure databases

ProteinModelPortaliP15887
SMRiP15887
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The C-terminus interferes with binding to non-phosphorylated RHO. Interaction with phosphorylated RHO triggers displacement of the C-terminus and leads to a conformation change that mediates high-affinity RHO binding.By similarity

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3865 Eukaryota
ENOG410XR0F LUCA
GeneTreeiENSGT00390000013152
HOGENOMiHOG000231319
HOVERGENiHBG002399
InParanoidiP15887
KOiK19627
OMAiAWQFFMS
PhylomeDBiP15887
TreeFamiTF314260

Family and domain databases

Gene3Di2.60.40.640, 1 hit
2.60.40.840, 1 hit
InterProiView protein in InterPro
IPR000698 Arrestin
IPR011021 Arrestin-like_N
IPR014752 Arrestin_C
IPR011022 Arrestin_C-like
IPR017864 Arrestin_CS
IPR014753 Arrestin_N
IPR014756 Ig_E-set
PANTHERiPTHR11792 PTHR11792, 1 hit
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
PRINTSiPR00309 ARRESTIN
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit
SUPFAMiSSF81296 SSF81296, 2 hits
PROSITEiView protein in PROSITE
PS00295 ARRESTINS, 1 hit

Sequencei

Sequence statusi: Complete.

P15887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAACVKTNKS HVIFKKVSRD KSVTIYLGKR DYIDHVSQVE PVDGVVLVDP
60 70 80 90 100
ELVKGKKVYV TLTCAFRYGQ EDIDVIGLTF RRDLYFSRVQ VYPPVGAMSA
110 120 130 140 150
PTQLQLSLLK KLGDNTYPFL LTFPDYLPCS VMLQPAPQDV GKSCGVDFEV
160 170 180 190 200
KAFATDITDA EEDKIPKKSS VRLLIRKVQH APPEMGPQPC AEASWQFFMS
210 220 230 240 250
DKPLHLSVSL SKEIYFHGEP IPVTVTVTNN TEKVVKKIKV SVEQIANVVL
260 270 280 290 300
YSSDYYVKPV ASEETQEKVQ PNSTLTKTLV LVPLLANNRE RRGIALDGKI
310 320 330 340 350
KHEDTNLASS TIIKEGIDRT VMGILVSYHI KVKLTVSGFL GELTSSEVAT
360 370 380 390 400
EVPFRLMHPQ PEDPAKESVQ DENLVFEEFA RQNLKDTGEN TEGKKDEDAG

QDE
Length:403
Mass (Da):44,950
Last modified:April 1, 1990 - v1
Checksum:i7DD1ED8596C42219
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109L → R in CAA33412 (PubMed:2213004).Curated1
Sequence conflicti109L → R in AAA42107 (PubMed:2213004).Curated1
Sequence conflicti158T → R in AAA42107 (PubMed:2213004).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51781 mRNA Translation: CAA36076.1
X15353 mRNA Translation: CAA33412.1
M60737 mRNA Translation: AAA42107.1
PIRiS03960
RefSeqiNP_037155.2, NM_013023.2
XP_008765418.1, XM_008767196.2
UniGeneiRn.9856

Genome annotation databases

EnsembliENSRNOT00000085770; ENSRNOP00000071579; ENSRNOG00000018185
GeneIDi25539
KEGGirno:25539
UCSCiRGD:3619 rat

Similar proteinsi

Entry informationi

Entry nameiARRS_RAT
AccessioniPrimary (citable) accession number: P15887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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