P15882 (CHIN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-chimaerin

Alternative name(s):
A-chimaerin
Alpha-chimerin
N-chimerin
Short name=NC
Rho GTPase-activating protein 2

Gene names

Name:	CHN1
Synonyms:	ARHGAP2, CHN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Subunit structure	Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation By similarity.
Tissue specificity	In neurons in brain regions that are involved in learning and memory processes.
Developmental stage	Increases in amount during brain development coincident with synaptogenesis.
Post-translational modification	Phosphorylated. Phosphorylation is EPHA4 kinase activity-dependent By similarity.
Involvement in disease	Duane retraction syndrome 2 (DURS2) [MIM:604356]: Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10
Sequence similarities	Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Rho-GAP domain. Contains 1 SH2 domain.
Sequence caution	The sequence CAA35769.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Neurogenesis
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	SH2 domain Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ephrin receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB motor neuron axon guidance Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of Rac GTPase activity Inferred from electronic annotation. Source: Compara regulation of axonogenesis Inferred from sequence or structural similarity. Source: UniProtKB regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW SH3/SH2 adaptor activity Traceable author statement Ref.3. Source: ProtInc metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha-2 (identifier: P15882-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Alpha-1 (identifier: P15882-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: MALTLFDTDE...TGQDGVSEKR → MPSKESWSGR...QPLKLFAYSQ

Isoform 3 (identifier: P15882-3)

The sequence of this isoform differs from the canonical sequence as follows:
     184-209: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 459

459

N-chimaerin

PRO_0000056694

Regions

Domain

49 – 135

87

SH2

Domain

268 – 459

192

Rho-GAP

Zinc finger

205 – 255

51

Phorbol-ester/DAG-type

Natural variations

Alternative sequence

1 – 183

183

MALTL…VSEKR → MPSKESWSGRKTNRAAVHKS KQEGRQQDLLIAALGMKLGS PKSSVTIWQPLKLFAYSQ in isoform Alpha-1.

VSP_001636

Alternative sequence

184 – 209

26

Missing in isoform 3.

VSP_043297

Natural variant

20

1

L → F in DURS2; behaves as a dominant gain-of-function allele that increases CHN1 activity in vitro; appears to enhance membrane translocation and CHN1 activity by destabilizing the closed conformation of CHN1 protein in response to phorbol 12-myristate 13-acetate (PMA). Ref.10

VAR_047940

Natural variant

126

1

I → M in DURS2; behaves as a dominant gain-of -function allele that increases CHN1 activity in vitro. Ref.10

VAR_047941

Natural variant

143

1

Y → H in DURS2; behaves as a dominant gain-of-function allele that increases CHN1 activity in vitro; appears to enhance membrane translocation and CHN1 activity by destabilizing the closed conformation of CHN1 protein in response to phorbol 12-myristate 13-acetate (PMA). Ref.10

VAR_047942

Natural variant

223

1

A → V in DURS2; behaves as a dominant gain-of-function allele that increases CHN1 activity in vitro; appears to enhance membrane translocation and CHN1 activity by destabilizing the closed conformation of CHN1 protein in response to phorbol 12-myristate 13-acetate (PMA). Ref.10

VAR_047943

Natural variant

228

1

G → S in DURS2; behaves as a dominant gain-of-function allele that increases CHN1 activity in vitro. Ref.10

VAR_047944

Natural variant

252

1

P → Q in DURS2; behaves as a dominant gain-of-function allele that increases CHN1 activity in vitro; appears to enhance membrane translocation and CHN1 activity by destabilizing the closed conformation of CHN1 protein in response to phorbol 12-myristate 13-acetate (PMA). Ref.10

VAR_047945

Natural variant

313

1

E → K in DURS2; behaves as a dominant gain-of-function allele that increases CHN1 activity in vitro. Ref.10

VAR_047946

Secondary structure

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459

Helix Strand Turn

Details...

Helix

19 – 26

8

Helix

56 – 63

8

Beta strand

69 – 74

6

Beta strand

76 – 78

3

Beta strand

82 – 87

6

Beta strand

89 – 96

8

Beta strand

98 – 107

10

Helix

113 – 129

17

Helix

131 – 136

6

Turn

143 – 145

3

Beta strand

146 – 148

3

Helix

164 – 166

3

Beta strand

208 – 211

4

Turn

220 – 222

3

Beta strand

228 – 230

3

Beta strand

233 – 236

4

Turn

237 – 239

3

Helix

245 – 248

4

Helix

257 – 261

5

Helix

270 – 277

8

Helix

283 – 295

13

Turn

300 – 304

5

Helix

309 – 322

14

Helix

323 – 325

3

Turn

330 – 332

3

Helix

336 – 348

13

Turn

357 – 359

3

Helix

360 – 368

9

Helix

372 – 384

13

Helix

388 – 406

19

Helix

408 – 411

4

Helix

415 – 426

12

Helix

434 – 453

20

Helix

455 – 458

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha-2 [UniParc]. Last modified July 11, 2002. Version 3. Checksum: 04C4CC9BCC611389	FASTA	459	53,172
	10 20 30 40 50 60 MALTLFDTDE YRPPVWKSYL YQLQQEAPHP RRITCTCEVE NRPKYYGREF HGMISREAAD 70 80 90 100 110 120 QLLIVAEGSY LIRESQRQPG TYTLALRFGS QTRNFRLYYD GKHFVGEKRF ESIHDLVTDG 130 140 150 160 170 180 LITLYIETKA AEYIAKMTIN PIYEHVGYTT LNREPAYKKH MPVLKETHDE RDSTGQDGVS 190 200 210 220 230 240 EKRLTSLVRR ATLKENEQIP KYEKIHNFKV HTFRGPHWCE YCANFMWGLI AQGVKCADCG 250 260 270 280 290 300 LNVHKQCSKM VPNDCKPDLK HVKKVYSCDL TTLVKAHTTK RPMVVDMCIR EIESRGLNSE 310 320 330 340 350 360 GLYRVSGFSD LIEDVKMAFD RDGEKADISV NMYEDINIIT GALKLYFRDL PIPLITYDAY 370 380 390 400 410 420 PKFIESAKIM DPDEQLETLH EALKLLPPAH CETLRYLMAH LKRVTLHEKE NLMNAENLGI 430 440 450 VFGPTLMRSP ELDAMAALND IRYQRLVVEL LIKNEDILF
	Isoform Alpha-1 [UniParc]. Checksum: 2E5BF139A231D13C	FASTA	334	38,196
	10 20 30 40 50 60 MPSKESWSGR KTNRAAVHKS KQEGRQQDLL IAALGMKLGS PKSSVTIWQP LKLFAYSQLT 70 80 90 100 110 120 SLVRRATLKE NEQIPKYEKI HNFKVHTFRG PHWCEYCANF MWGLIAQGVK CADCGLNVHK 130 140 150 160 170 180 QCSKMVPNDC KPDLKHVKKV YSCDLTTLVK AHTTKRPMVV DMCIREIESR GLNSEGLYRV 190 200 210 220 230 240 SGFSDLIEDV KMAFDRDGEK ADISVNMYED INIITGALKL YFRDLPIPLI TYDAYPKFIE 250 260 270 280 290 300 SAKIMDPDEQ LETLHEALKL LPPAHCETLR YLMAHLKRVT LHEKENLMNA ENLGIVFGPT 310 320 330 LMRSPELDAM AALNDIRYQR LVVELLIKNE DILF
	Isoform 3 [UniParc]. Checksum: EB3E22E1C704D1BF	FASTA	433	50,034
	10 20 30 40 50 60 MALTLFDTDE YRPPVWKSYL YQLQQEAPHP RRITCTCEVE NRPKYYGREF HGMISREAAD 70 80 90 100 110 120 QLLIVAEGSY LIRESQRQPG TYTLALRFGS QTRNFRLYYD GKHFVGEKRF ESIHDLVTDG 130 140 150 160 170 180 LITLYIETKA AEYIAKMTIN PIYEHVGYTT LNREPAYKKH MPVLKETHDE RDSTGQDGVS 190 200 210 220 230 240 EKRVHTFRGP HWCEYCANFM WGLIAQGVKC ADCGLNVHKQ CSKMVPNDCK PDLKHVKKVY 250 260 270 280 290 300 SCDLTTLVKA HTTKRPMVVD MCIREIESRG LNSEGLYRVS GFSDLIEDVK MAFDRDGEKA 310 320 330 340 350 360 DISVNMYEDI NIITGALKLY FRDLPIPLIT YDAYPKFIES AKIMDPDEQL ETLHEALKLL 370 380 390 400 410 420 PPAHCETLRY LMAHLKRVTL HEKENLMNAE NLGIVFGPTL MRSPELDAMA ALNDIRYQRL 430 VVELLIKNED ILF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene." Hall C., Monfries C., Smith P., Lim H.H., Kozma R., Ahmed S., Vanniasingham V., Leung T., Lim L. J. Mol. Biol. 211:11-16(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-1). Tissue: Retina.
[2]	"Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence." Lim H.H., Michael G.J., Smith P., Lim L., Hall C. Biochem. J. 287:415-422(1992) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes." Hall C., Sin W.C., Teo M., Michael G.J., Smith P., Dong J.M., Lim H.H., Manser E., Spurr N.K., Jones T.A., Lim L. Mol. Cell. Biol. 13:4986-4998(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA-1; ALPHA-2 AND 3). Tissue: Brain, Hippocampus and Small intestine.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA-2). Tissue: Eye.
[8]	"Promoter region of the transcriptional unit for human alpha 1-chimaerin, a neuron-specific GTPase-activating protein for p21rac." Dong J.M., Smith P., Hall C., Lim L. Eur. J. Biochem. 227:636-646(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM ALPHA-1). Tissue: Fibroblast.
[9]	"Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor." Ahmed S., Kozma R., Monfries C., Hall C., Lim H.H., Smith P., Lim L. Biochem. J. 272:767-773(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PHORBOL-ESTER BINDING.
[10]	"Human CHN1 mutations hyperactivate alpha2-chimaerin and cause Duane's retraction syndrome." Miyake N., Chilton J., Psatha M., Cheng L., Andrews C., Chan W.-M., Law K., Crosier M., Lindsay S., Cheung M., Allen J., Gutowski N.J., Ellard S., Young E., Iannaccone A., Appukuttan B., Stout J.T., Christiansen S. , Ciccarelli M.L., Baldi A., Campioni M., Zenteno J.C., Davenport D., Mariani L.E., Sahin M., Guthrie S., Engle E.C. Science 321:839-843(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS DURS2 PHE-20; MET-126; HIS-143; VAL-223; SER-228; GLN-252 AND LYS-313, CHARACTERIZATION OF VARIANTS DURS2 PHE-20; MET-126; HIS-143; VAL-223; SER-228; GLN-252 AND LYS-313.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X51408 mRNA. Translation: CAA35769.1. Different initiation.
Z22641 mRNA. Translation: CAA80354.1.
AK055060 mRNA. Translation: BAG51458.1.
AK289941 mRNA. Translation: BAF82630.1.
AK300890 mRNA. Translation: BAG62531.1.
AC007435 Genomic DNA. No translation available.
AC018890 Genomic DNA. Translation: AAY14688.1.
AC020596 Genomic DNA. Translation: AAY14940.1.
CH471058 Genomic DNA. Translation: EAX11117.1.
CH471058 Genomic DNA. Translation: EAX11118.1.
CH471058 Genomic DNA. Translation: EAX11119.1.
BC011393 mRNA. Translation: AAH11393.1.
S75654 Genomic DNA. Translation: AAB33506.1.

IPI

IPI00013488.
IPI00221041.
IPI00910824.

PIR

A48090.
I53329.

RefSeq

NP_001020372.2. NM_001025201.3.
NP_001193531.1. NM_001206602.1.
NP_001813.1. NM_001822.5.

UniGene

Hs.380138.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2OSA	X-ray	1.80	A	260-459	[»]
3CXL	X-ray	2.60	A	15-459	[»]

ProteinModelPortal

P15882.

ModBase

Search...

Protein-protein interaction databases

IntAct

P15882. 2 interactions.

MINT

MINT-1173390.

STRING

9606.ENSP00000386741.

PTM databases

PhosphoSite

P15882.

Polymorphism databases

DMDM

21903393.

Proteomic databases

PaxDb

P15882.

PRIDE

P15882.

Protocols and materials databases

DNASU

1123.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000295497; ENSP00000295497; ENSG00000128656.
ENST00000409156; ENSP00000386470; ENSG00000128656.
ENST00000409900; ENSP00000386741; ENSG00000128656.

GeneID

1123.

KEGG

hsa:1123.

UCSC

uc002ujg.3. human.
uc002uji.3. human.

Organism-specific databases

CTD

1123.

GeneCards

GC02M175664.

HGNC

HGNC:1943. CHN1.

HPA

HPA036111.

MIM

118423. gene.
604356. phenotype.

neXtProt

NX_P15882.

Orphanet

233. Duane syndrome.

PharmGKB

PA26473.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG295484.

HOGENOM

HOG000231926.

HOVERGEN

HBG080489.

InParanoid

P15882.

OMA

FGNQTRN.

OrthoDB

EOG4W9J3S.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P15882.

Bgee

P15882.

CleanEx

HS_CHN1.

Genevestigator

P15882.

GermOnline

ENSG00000128656. Homo sapiens.

Family and domain databases

Gene3D

1.10.555.10. 1 hit.
3.30.505.10. 1 hit.

InterPro

IPR020454. DAG/PE-bd.
IPR017356. N-chimaerin.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
[Graphical view]

Pfam

PF00130. C1_1. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]

PIRSF

PIRSF038015. N-chimaerin. 1 hit.

PRINTS

PR00008. DAGPEDOMAIN.

SMART

SM00109. C1. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00252. SH2. 1 hit.
[Graphical view]

SUPFAM

SSF48350. Rho_GAP. 1 hit.

PROSITE

PS50238. RHOGAP. 1 hit.
PS50001. SH2. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P15882.

GenomeRNAi

1123.

NextBio

4662.

SOURCE

Search...

Entry information

Entry name

CHIN_HUMAN

Accession

Primary (citable) accession number: P15882
Secondary accession number(s): A8K1M6 , B3KNU6, B4DV19, Q53SD6, Q53SH5, Q96FB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	July 11, 2002
Last modified:	May 1, 2013
This is version 145 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.