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Protein

40S ribosomal protein S2

Gene

RPS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • enzyme binding Source: UniProtKB
  • fibroblast growth factor binding Source: UniProtKB
  • mRNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140988-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S2
Alternative name(s):
40S ribosomal protein S4
Protein LLRep3
Gene namesi
Name:RPS2
Synonyms:RPS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:10404. RPS2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6187.
OpenTargetsiENSG00000140988.
PharmGKBiPA34806.

Polymorphism and mutation databases

BioMutaiRPS2.
DMDMi1710756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001316732 – 29340S ribosomal protein S2Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei252PhosphothreonineCombined sources1
Modified residuei263N6-acetyllysineCombined sources1
Modified residuei264PhosphoserineCombined sources1
Modified residuei270PhosphothreonineCombined sources1
Modified residuei275N6-acetyllysine; alternateCombined sources1
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei281PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4 in the Arg/Gly-rich region.1 Publication
Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP15880.
MaxQBiP15880.
PaxDbiP15880.
PeptideAtlasiP15880.
PRIDEiP15880.

PTM databases

iPTMnetiP15880.
PhosphoSitePlusiP15880.
SwissPalmiP15880.

Expressioni

Gene expression databases

BgeeiENSG00000140988.
CleanExiHS_RPS2.
ExpressionAtlasiP15880. baseline and differential.
GenevisibleiP15880. HS.

Organism-specific databases

HPAiHPA055133.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-443446,EBI-5323863

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • enzyme binding Source: UniProtKB
  • fibroblast growth factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112101. 284 interactors.
IntActiP15880. 48 interactors.
MINTiMINT-3008399.
STRINGi9606.ENSP00000341885.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SC1-293[»]
4V6Xelectron microscopy5.00AC1-293[»]
5A2Qelectron microscopy3.90C1-293[»]
5AJ0electron microscopy3.50BC1-293[»]
5FLXelectron microscopy3.90C1-293[»]
ProteinModelPortaliP15880.
SMRiP15880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 165S5 DRBMPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 53Arg/Gly-richAdd BLAST32

Sequence similaritiesi

Belongs to the ribosomal protein S5P family.Curated
Contains 1 S5 DRBM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001433.
HOGENOMiHOG000072596.
HOVERGENiHBG000437.
InParanoidiP15880.
KOiK02981.
OMAiKRGCGSW.
OrthoDBiEOG091G0LPC.
PhylomeDBiP15880.
TreeFamiTF300806.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDAGAAGG PGGPGGPGMG NRGGFRGGFG SGIRGRGRGR GRGRGRGRGA
60 70 80 90 100
RGGKAEDKEW MPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA
110 120 130 140 150
SLKDEVLKIM PVQKQTRAGQ RTRFKAFVAI GDYNGHVGLG VKCSKEVATA
160 170 180 190 200
IRGAIILAKL SIVPVRRGYW GNKIGKPHTV PCKVTGRCGS VLVRLIPAPR
210 220 230 240 250
GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT FDAISKTYSY
260 270 280 290
LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT
Length:293
Mass (Da):31,324
Last modified:October 1, 1996 - v2
Checksum:i66C0DB7ED393B036
GO

Sequence cautioni

The sequence CAA35078 differs from that shown. Reason: Frameshift at positions 14, 27, 40, 46, 48 and 52.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17206 mRNA. Translation: CAA35078.1. Frameshift.
AK312173 mRNA. Translation: BAG35107.1.
CH471112 Genomic DNA. Translation: EAW85592.1.
CH471112 Genomic DNA. Translation: EAW85595.1.
BC001795 mRNA. Translation: AAH01795.1.
BC006559 mRNA. Translation: AAH06559.1.
BC008862 mRNA. Translation: AAH08862.1.
BC010165 mRNA. Translation: AAH10165.1.
BC012354 mRNA. Translation: AAH12354.1.
BC016178 mRNA. Translation: AAH16178.1.
BC016951 mRNA. Translation: AAH16951.1.
BC018993 mRNA. Translation: AAH18993.1.
BC021545 mRNA. Translation: AAH21545.1.
BC023541 mRNA. Translation: AAH23541.1.
BC025677 mRNA. Translation: AAH25677.1.
BC066321 mRNA. Translation: AAH66321.1.
BC068051 mRNA. Translation: AAH68051.1.
BC071922 mRNA. Translation: AAH71922.1.
BC071923 mRNA. Translation: AAH71923.1.
BC071924 mRNA. Translation: AAH71924.1.
BC073966 mRNA. Translation: AAH73966.1.
BC075830 mRNA. Translation: AAH75830.1.
BC103756 mRNA. Translation: AAI03757.1.
BC105985 mRNA. Translation: AAI05986.1.
CCDSiCCDS10452.1.
PIRiS08228.
RefSeqiNP_002943.2. NM_002952.3.
UniGeneiHs.356366.
Hs.381079.
Hs.498569.
Hs.506997.

Genome annotation databases

EnsembliENST00000343262; ENSP00000341885; ENSG00000140988.
GeneIDi6187.
KEGGihsa:6187.
UCSCiuc002cno.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17206 mRNA. Translation: CAA35078.1. Frameshift.
AK312173 mRNA. Translation: BAG35107.1.
CH471112 Genomic DNA. Translation: EAW85592.1.
CH471112 Genomic DNA. Translation: EAW85595.1.
BC001795 mRNA. Translation: AAH01795.1.
BC006559 mRNA. Translation: AAH06559.1.
BC008862 mRNA. Translation: AAH08862.1.
BC010165 mRNA. Translation: AAH10165.1.
BC012354 mRNA. Translation: AAH12354.1.
BC016178 mRNA. Translation: AAH16178.1.
BC016951 mRNA. Translation: AAH16951.1.
BC018993 mRNA. Translation: AAH18993.1.
BC021545 mRNA. Translation: AAH21545.1.
BC023541 mRNA. Translation: AAH23541.1.
BC025677 mRNA. Translation: AAH25677.1.
BC066321 mRNA. Translation: AAH66321.1.
BC068051 mRNA. Translation: AAH68051.1.
BC071922 mRNA. Translation: AAH71922.1.
BC071923 mRNA. Translation: AAH71923.1.
BC071924 mRNA. Translation: AAH71924.1.
BC073966 mRNA. Translation: AAH73966.1.
BC075830 mRNA. Translation: AAH75830.1.
BC103756 mRNA. Translation: AAI03757.1.
BC105985 mRNA. Translation: AAI05986.1.
CCDSiCCDS10452.1.
PIRiS08228.
RefSeqiNP_002943.2. NM_002952.3.
UniGeneiHs.356366.
Hs.381079.
Hs.498569.
Hs.506997.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SC1-293[»]
4V6Xelectron microscopy5.00AC1-293[»]
5A2Qelectron microscopy3.90C1-293[»]
5AJ0electron microscopy3.50BC1-293[»]
5FLXelectron microscopy3.90C1-293[»]
ProteinModelPortaliP15880.
SMRiP15880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112101. 284 interactors.
IntActiP15880. 48 interactors.
MINTiMINT-3008399.
STRINGi9606.ENSP00000341885.

PTM databases

iPTMnetiP15880.
PhosphoSitePlusiP15880.
SwissPalmiP15880.

Polymorphism and mutation databases

BioMutaiRPS2.
DMDMi1710756.

Proteomic databases

EPDiP15880.
MaxQBiP15880.
PaxDbiP15880.
PeptideAtlasiP15880.
PRIDEiP15880.

Protocols and materials databases

DNASUi6187.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343262; ENSP00000341885; ENSG00000140988.
GeneIDi6187.
KEGGihsa:6187.
UCSCiuc002cno.3. human.

Organism-specific databases

CTDi6187.
DisGeNETi6187.
GeneCardsiRPS2.
H-InvDBHIX0029256.
HIX0039223.
HIX0202579.
HGNCiHGNC:10404. RPS2.
HPAiHPA055133.
MIMi603624. gene.
neXtProtiNX_P15880.
OpenTargetsiENSG00000140988.
PharmGKBiPA34806.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
GeneTreeiENSGT00390000001433.
HOGENOMiHOG000072596.
HOVERGENiHBG000437.
InParanoidiP15880.
KOiK02981.
OMAiKRGCGSW.
OrthoDBiEOG091G0LPC.
PhylomeDBiP15880.
TreeFamiTF300806.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140988-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

GeneWikiiRPS2.
GenomeRNAii6187.
PROiP15880.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140988.
CleanExiHS_RPS2.
ExpressionAtlasiP15880. baseline and differential.
GenevisibleiP15880. HS.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS2_HUMAN
AccessioniPrimary (citable) accession number: P15880
Secondary accession number(s): B2R5G0, D3DU82, Q3MIB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 181 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.