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Protein

Arylsulfatase B

Gene

ARSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).By similarity1 Publication

Catalytic activityi

Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Enzyme regulationi

Inhibited by ethanol (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium1
Metal bindingi54Calcium1
Metal bindingi91Calcium; via 3-oxoalanine1 Publication1
Binding sitei145SubstrateBy similarity1
Active sitei1471
Binding sitei242SubstrateBy similarity1
Metal bindingi300Calcium1
Metal bindingi301Calcium1
Binding sitei318SubstrateBy similarity1

GO - Molecular functioni

  • arylsulfatase activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • N-acetylgalactosamine-4-sulfatase activity Source: UniProtKB

GO - Biological processi

  • autophagy Source: Ensembl
  • central nervous system development Source: Ensembl
  • chondroitin sulfate catabolic process Source: Reactome
  • colon epithelial cell migration Source: UniProtKB
  • glycosphingolipid metabolic process Source: Reactome
  • lysosomal transport Source: ProtInc
  • lysosome organization Source: ProtInc
  • positive regulation of neuron projection development Source: UniProtKB
  • post-translational protein modification Source: Reactome
  • regulation of epithelial cell migration Source: UniProtKB
  • response to estrogen Source: Ensembl
  • response to methylmercury Source: Ensembl
  • response to nutrient Source: Ensembl
  • response to pH Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS03665-MONOMER.
ZFISH:HS03665-MONOMER.
BRENDAi3.1.6.12. 2681.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.
R-HSA-2024101. CS/DS degradation.
R-HSA-6798695. Neutrophil degranulation.
SABIO-RKP15848.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase B (EC:3.1.6.12)
Short name:
ASB
Alternative name(s):
N-acetylgalactosamine-4-sulfatase
Short name:
G4S
Gene namesi
Name:ARSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:714. ARSB.

Subcellular locationi

  • Lysosome By similarity
  • Cell surface By similarity

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • endoplasmic reticulum lumen Source: Reactome
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: Ensembl
  • lysosomal lumen Source: Reactome
  • lysosome Source: ProtInc
  • mitochondrion Source: Ensembl
  • rough endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Involvement in diseasei

Mucopolysaccharidosis 6 (MPS6)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive lysosomal storage disease characterized by intracellular accumulation of dermatan sulfate. Clinical features can include abnormal growth, short stature, stiff joints, skeletal malformations, corneal clouding, hepatosplenomegaly, and cardiac abnormalities. A wide variation in clinical severity is observed.
See also OMIM:253200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01901765S → F in MPS6; intermediate form. 1 Publication1
Natural variantiVAR_01901886Missing in MPS6; severe form; low protein levels and activity. 1 Publication1
Natural variantiVAR_00729492T → M in MPS6; mild form. 1 PublicationCorresponds to variant rs751010538dbSNPEnsembl.1
Natural variantiVAR_00729595R → Q in MPS6; mild/severe form. 1 PublicationCorresponds to variant rs118203942dbSNPEnsembl.1
Natural variantiVAR_019019116P → H in MPS6; severe form. 1 PublicationCorresponds to variant rs775780931dbSNPEnsembl.1
Natural variantiVAR_007296117C → R in MPS6; severe form. 1 PublicationCorresponds to variant rs118203939dbSNPEnsembl.1
Natural variantiVAR_007297137G → V in MPS6; intermediate form. 1 PublicationCorresponds to variant rs118203938dbSNPEnsembl.1
Natural variantiVAR_019020142M → I in MPS6. 1 Publication1
Natural variantiVAR_019021144G → R in MPS6; severe form; severe reduction of activity. 1 PublicationCorresponds to variant rs746206847dbSNPEnsembl.1
Natural variantiVAR_019022146W → L in MPS6. 1 Publication1
Natural variantiVAR_019023146W → R in MPS6. 1 Publication1
Natural variantiVAR_019024146W → S in MPS6. 1 Publication1
Natural variantiVAR_007298152R → W in MPS6; intermediate form. 1 Publication1
Natural variantiVAR_007299160R → Q in MPS6; intermediate form. 1 Publication1
Natural variantiVAR_019025192C → R in MPS6; mild form; severe reduction of activity. 3 Publications1
Natural variantiVAR_007300210Y → C in MPS6; mild/intermediate. 2 PublicationsCorresponds to variant rs118203943dbSNPEnsembl.1
Natural variantiVAR_007301236L → P in MPS6; mild form. 2 PublicationsCorresponds to variant rs118203940dbSNPEnsembl.1
Natural variantiVAR_019026239Q → R in MPS6. 2 Publications1
Natural variantiVAR_007302302G → R in MPS6; severe form. 1 PublicationCorresponds to variant rs779378413dbSNPEnsembl.1
Natural variantiVAR_019027312W → C in MPS6; severe form; low protein levels and activity. 1 Publication1
Natural variantiVAR_019028315R → Q in MPS6; intermediate form. 2 PublicationsCorresponds to variant rs727503809dbSNPEnsembl.1
Natural variantiVAR_019029321L → P in MPS6; intermediate form; severe reduction of activity. 2 Publications1
Natural variantiVAR_019030384S → N in MPS6. 1 PublicationCorresponds to variant rs25414dbSNPEnsembl.1
Natural variantiVAR_007304393H → P in MPS6; mild/severe form. 1 PublicationCorresponds to variant rs118203944dbSNPEnsembl.1
Natural variantiVAR_019031399F → L in MPS6. 1 PublicationCorresponds to variant rs200793396dbSNPEnsembl.1
Natural variantiVAR_007305405C → Y in MPS6; mild form. 1 PublicationCorresponds to variant rs118203941dbSNPEnsembl.1
Natural variantiVAR_019032484R → G in MPS6. 1 PublicationCorresponds to variant rs201101343dbSNPEnsembl.1
Natural variantiVAR_007306498L → P in MPS6; mild/severe form. 1 PublicationCorresponds to variant rs774358117dbSNPEnsembl.1
Natural variantiVAR_019033521C → Y in MPS6; severe form; severe reduction of activity. 1 Publication1
Natural variantiVAR_019034531P → R in MPS6; mild form. 1 Publication1
Multiple sulfatase deficiency (MSD)1 Publication
The protein represented in this entry is involved in disease pathogenesis. Arylsulfatase B activity is impaired in multiple sulfatase deficiency due to mutations in SUMF1. SUMF1 mutations result in defective post-translational modification of ARSB at residue Cys-91 that is not converted to 3-oxoalanine.
Disease descriptionA clinically and biochemically heterogeneous disorder caused by the simultaneous impairment of all sulfatases, due to defective post-translational modification and activation. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.
See also OMIM:272200

Keywords - Diseasei

Disease mutation, Ichthyosis, Leukodystrophy, Metachromatic leukodystrophy, Mucopolysaccharidosis

Organism-specific databases

DisGeNETi411.
MalaCardsiARSB.
MIMi253200. phenotype.
272200. phenotype.
OpenTargetsiENSG00000113273.
Orphaneti276212. Mucopolysaccharidosis type 6, rapidly progressing.
276223. Mucopolysaccharidosis type 6, slowly progressing.
PharmGKBiPA25006.

Chemistry databases

ChEMBLiCHEMBL2399.

Polymorphism and mutation databases

BioMutaiARSB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Or 38Sequence analysisAdd BLAST36
ChainiPRO_000003342137 – 533Arylsulfatase BAdd BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei913-oxoalanine (Cys)1 Publication1
Disulfide bondi117 ↔ 521
Disulfide bondi121 ↔ 155
Disulfide bondi181 ↔ 192
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi279N-linked (GlcNAc...)1
Glycosylationi291N-linked (GlcNAc...)Curated1
Glycosylationi366N-linked (GlcNAc...)1 Publication1
Disulfide bondi405 ↔ 447
Glycosylationi426N-linked (GlcNAc...)1
Glycosylationi458N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP15848.
MaxQBiP15848.
PaxDbiP15848.
PeptideAtlasiP15848.
PRIDEiP15848.

PTM databases

iPTMnetiP15848.
PhosphoSitePlusiP15848.

Expressioni

Gene expression databases

BgeeiENSG00000113273.
CleanExiHS_ARSB.
ExpressionAtlasiP15848. baseline and differential.
GenevisibleiP15848. HS.

Organism-specific databases

HPAiHPA037770.
HPA037771.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi106904. 11 interactors.
IntActiP15848. 2 interactors.
STRINGi9606.ENSP00000264914.

Structurei

Secondary structure

1533
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 54Combined sources9
Helixi61 – 63Combined sources3
Helixi70 – 77Combined sources8
Beta strandi79 – 82Combined sources4
Helixi91 – 100Combined sources10
Helixi104 – 107Combined sources4
Helixi129 – 135Combined sources7
Beta strandi139 – 144Combined sources6
Helixi153 – 155Combined sources3
Helixi157 – 159Combined sources3
Beta strandi163 – 167Combined sources5
Beta strandi169 – 171Combined sources3
Turni175 – 177Combined sources3
Beta strandi179 – 184Combined sources6
Turni185 – 188Combined sources4
Beta strandi189 – 194Combined sources6
Helixi211 – 224Combined sources14
Beta strandi232 – 237Combined sources6
Beta strandi242 – 244Combined sources3
Helixi249 – 251Combined sources3
Helixi253 – 255Combined sources3
Helixi261 – 286Combined sources26
Helixi290 – 292Combined sources3
Beta strandi293 – 301Combined sources9
Helixi305 – 307Combined sources3
Beta strandi320 – 322Combined sources3
Helixi323 – 326Combined sources4
Beta strandi330 – 333Combined sources4
Beta strandi341 – 344Combined sources4
Helixi350 – 352Combined sources3
Helixi353 – 360Combined sources8
Helixi377 – 382Combined sources6
Beta strandi390 – 396Combined sources7
Beta strandi429 – 435Combined sources7
Beta strandi438 – 443Combined sources6
Turni454 – 456Combined sources3
Beta strandi472 – 476Combined sources5
Turni477 – 479Combined sources3
Turni488 – 490Combined sources3
Helixi492 – 507Combined sources16
Helixi519 – 521Combined sources3
Turni524 – 526Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSUX-ray2.50A42-533[»]
ProteinModelPortaliP15848.
SMRiP15848.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15848.

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135354.
HOVERGENiHBG004282.
InParanoidiP15848.
KOiK01135.
OMAiQDPEERH.
OrthoDBiEOG091G06C3.
PhylomeDBiP15848.
TreeFamiTF314186.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15848-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPRGAASLP RGPGPRRLLL PVVLPLLLLL LLAPPGSGAG ASRPPHLVFL
60 70 80 90 100
LADDLGWNDV GFHGSRIRTP HLDALAAGGV LLDNYYTQPL CTPSRSQLLT
110 120 130 140 150
GRYQIRTGLQ HQIIWPCQPS CVPLDEKLLP QLLKEAGYTT HMVGKWHLGM
160 170 180 190 200
YRKECLPTRR GFDTYFGYLL GSEDYYSHER CTLIDALNVT RCALDFRDGE
210 220 230 240 250
EVATGYKNMY STNIFTKRAI ALITNHPPEK PLFLYLALQS VHEPLQVPEE
260 270 280 290 300
YLKPYDFIQD KNRHHYAGMV SLMDEAVGNV TAALKSSGLW NNTVFIFSTD
310 320 330 340 350
NGGQTLAGGN NWPLRGRKWS LWEGGVRGVG FVASPLLKQK GVKNRELIHI
360 370 380 390 400
SDWLPTLVKL ARGHTNGTKP LDGFDVWKTI SEGSPSPRIE LLHNIDPNFV
410 420 430 440 450
DSSPCPRNSM APAKDDSSLP EYSAFNTSVH AAIRHGNWKL LTGYPGCGYW
460 470 480 490 500
FPPPSQYNVS EIPSSDPPTK TLWLFDIDRD PEERHDLSRE YPHIVTKLLS
510 520 530
RLQFYHKHSV PVYFPAQDPR CDPKATGVWG PWM
Length:533
Mass (Da):59,687
Last modified:April 1, 1990 - v1
Checksum:i5983FB6911C4789A
GO
Isoform 2 (identifier: P15848-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     405-533: CPRNSMAPAK...KATGVWGPWM → YWPECSLLL

Note: No experimental confirmation available.
Show »
Length:413
Mass (Da):45,996
Checksum:iA3B6A96052F3E839
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153K → F AA sequence (PubMed:2303452).Curated1
Sequence conflicti408 – 410NSM → SPC AA sequence (PubMed:2303452).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01901765S → F in MPS6; intermediate form. 1 Publication1
Natural variantiVAR_01901886Missing in MPS6; severe form; low protein levels and activity. 1 Publication1
Natural variantiVAR_00729492T → M in MPS6; mild form. 1 PublicationCorresponds to variant rs751010538dbSNPEnsembl.1
Natural variantiVAR_00729595R → Q in MPS6; mild/severe form. 1 PublicationCorresponds to variant rs118203942dbSNPEnsembl.1
Natural variantiVAR_019019116P → H in MPS6; severe form. 1 PublicationCorresponds to variant rs775780931dbSNPEnsembl.1
Natural variantiVAR_007296117C → R in MPS6; severe form. 1 PublicationCorresponds to variant rs118203939dbSNPEnsembl.1
Natural variantiVAR_007297137G → V in MPS6; intermediate form. 1 PublicationCorresponds to variant rs118203938dbSNPEnsembl.1
Natural variantiVAR_019020142M → I in MPS6. 1 Publication1
Natural variantiVAR_019021144G → R in MPS6; severe form; severe reduction of activity. 1 PublicationCorresponds to variant rs746206847dbSNPEnsembl.1
Natural variantiVAR_019022146W → L in MPS6. 1 Publication1
Natural variantiVAR_019023146W → R in MPS6. 1 Publication1
Natural variantiVAR_019024146W → S in MPS6. 1 Publication1
Natural variantiVAR_007298152R → W in MPS6; intermediate form. 1 Publication1
Natural variantiVAR_007299160R → Q in MPS6; intermediate form. 1 Publication1
Natural variantiVAR_019025192C → R in MPS6; mild form; severe reduction of activity. 3 Publications1
Natural variantiVAR_007300210Y → C in MPS6; mild/intermediate. 2 PublicationsCorresponds to variant rs118203943dbSNPEnsembl.1
Natural variantiVAR_007301236L → P in MPS6; mild form. 2 PublicationsCorresponds to variant rs118203940dbSNPEnsembl.1
Natural variantiVAR_019026239Q → R in MPS6. 2 Publications1
Natural variantiVAR_007302302G → R in MPS6; severe form. 1 PublicationCorresponds to variant rs779378413dbSNPEnsembl.1
Natural variantiVAR_019027312W → C in MPS6; severe form; low protein levels and activity. 1 Publication1
Natural variantiVAR_019028315R → Q in MPS6; intermediate form. 2 PublicationsCorresponds to variant rs727503809dbSNPEnsembl.1
Natural variantiVAR_019029321L → P in MPS6; intermediate form; severe reduction of activity. 2 Publications1
Natural variantiVAR_061883358V → L.Corresponds to variant rs1065757dbSNPEnsembl.1
Natural variantiVAR_016061358V → M.6 PublicationsCorresponds to variant rs1065757dbSNPEnsembl.1
Natural variantiVAR_007303376V → M.2 PublicationsCorresponds to variant rs17220759dbSNPEnsembl.1
Natural variantiVAR_019030384S → N in MPS6. 1 PublicationCorresponds to variant rs25414dbSNPEnsembl.1
Natural variantiVAR_007304393H → P in MPS6; mild/severe form. 1 PublicationCorresponds to variant rs118203944dbSNPEnsembl.1
Natural variantiVAR_019031399F → L in MPS6. 1 PublicationCorresponds to variant rs200793396dbSNPEnsembl.1
Natural variantiVAR_007305405C → Y in MPS6; mild form. 1 PublicationCorresponds to variant rs118203941dbSNPEnsembl.1
Natural variantiVAR_019032484R → G in MPS6. 1 PublicationCorresponds to variant rs201101343dbSNPEnsembl.1
Natural variantiVAR_007306498L → P in MPS6; mild/severe form. 1 PublicationCorresponds to variant rs774358117dbSNPEnsembl.1
Natural variantiVAR_019033521C → Y in MPS6; severe form; severe reduction of activity. 1 Publication1
Natural variantiVAR_019034531P → R in MPS6; mild form. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042721405 – 533CPRNS…WGPWM → YWPECSLLL in isoform 2. 1 PublicationAdd BLAST129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05225 mRNA. Translation: AAA51784.1.
M32373 mRNA. Translation: AAA51779.1.
X72735
, X72736, X72737, X72738, X72739, X72740, X72741, X72742 Genomic DNA. Translation: CAA51272.1.
AK314903 mRNA. Translation: BAG37417.1.
AC020937 Genomic DNA. No translation available.
AC025755 Genomic DNA. No translation available.
AC099485 Genomic DNA. No translation available.
AC114963 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95822.1.
BC029051 mRNA. Translation: AAH29051.1.
S57777 Genomic DNA. Translation: AAB19988.1.
CCDSiCCDS4043.1. [P15848-1]
CCDS43334.1. [P15848-2]
PIRiS35990. KJHUAB.
RefSeqiNP_000037.2. NM_000046.3. [P15848-1]
NP_942002.1. NM_198709.2. [P15848-2]
XP_011541692.1. XM_011543390.1. [P15848-1]
UniGeneiHs.149103.
Hs.604199.

Genome annotation databases

EnsembliENST00000264914; ENSP00000264914; ENSG00000113273. [P15848-1]
ENST00000396151; ENSP00000379455; ENSG00000113273. [P15848-2]
ENST00000565165; ENSP00000456339; ENSG00000113273. [P15848-2]
GeneIDi411.
KEGGihsa:411.
UCSCiuc003kfq.5. human. [P15848-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05225 mRNA. Translation: AAA51784.1.
M32373 mRNA. Translation: AAA51779.1.
X72735
, X72736, X72737, X72738, X72739, X72740, X72741, X72742 Genomic DNA. Translation: CAA51272.1.
AK314903 mRNA. Translation: BAG37417.1.
AC020937 Genomic DNA. No translation available.
AC025755 Genomic DNA. No translation available.
AC099485 Genomic DNA. No translation available.
AC114963 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW95822.1.
BC029051 mRNA. Translation: AAH29051.1.
S57777 Genomic DNA. Translation: AAB19988.1.
CCDSiCCDS4043.1. [P15848-1]
CCDS43334.1. [P15848-2]
PIRiS35990. KJHUAB.
RefSeqiNP_000037.2. NM_000046.3. [P15848-1]
NP_942002.1. NM_198709.2. [P15848-2]
XP_011541692.1. XM_011543390.1. [P15848-1]
UniGeneiHs.149103.
Hs.604199.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSUX-ray2.50A42-533[»]
ProteinModelPortaliP15848.
SMRiP15848.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106904. 11 interactors.
IntActiP15848. 2 interactors.
STRINGi9606.ENSP00000264914.

Chemistry databases

ChEMBLiCHEMBL2399.

PTM databases

iPTMnetiP15848.
PhosphoSitePlusiP15848.

Polymorphism and mutation databases

BioMutaiARSB.

Proteomic databases

EPDiP15848.
MaxQBiP15848.
PaxDbiP15848.
PeptideAtlasiP15848.
PRIDEiP15848.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264914; ENSP00000264914; ENSG00000113273. [P15848-1]
ENST00000396151; ENSP00000379455; ENSG00000113273. [P15848-2]
ENST00000565165; ENSP00000456339; ENSG00000113273. [P15848-2]
GeneIDi411.
KEGGihsa:411.
UCSCiuc003kfq.5. human. [P15848-1]

Organism-specific databases

CTDi411.
DisGeNETi411.
GeneCardsiARSB.
HGNCiHGNC:714. ARSB.
HPAiHPA037770.
HPA037771.
MalaCardsiARSB.
MIMi253200. phenotype.
272200. phenotype.
611542. gene.
neXtProtiNX_P15848.
OpenTargetsiENSG00000113273.
Orphaneti276212. Mucopolysaccharidosis type 6, rapidly progressing.
276223. Mucopolysaccharidosis type 6, slowly progressing.
PharmGKBiPA25006.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135354.
HOVERGENiHBG004282.
InParanoidiP15848.
KOiK01135.
OMAiQDPEERH.
OrthoDBiEOG091G06C3.
PhylomeDBiP15848.
TreeFamiTF314186.

Enzyme and pathway databases

BioCyciMetaCyc:HS03665-MONOMER.
ZFISH:HS03665-MONOMER.
BRENDAi3.1.6.12. 2681.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.
R-HSA-2024101. CS/DS degradation.
R-HSA-6798695. Neutrophil degranulation.
SABIO-RKP15848.

Miscellaneous databases

ChiTaRSiARSB. human.
EvolutionaryTraceiP15848.
GenomeRNAii411.
PROiP15848.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000113273.
CleanExiHS_ARSB.
ExpressionAtlasiP15848. baseline and differential.
GenevisibleiP15848. HS.

Family and domain databases

Gene3Di3.40.720.10. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARSB_HUMAN
AccessioniPrimary (citable) accession number: P15848
Secondary accession number(s): B2RC20, Q8N322, Q9UDI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 175 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.