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P15846 (TPMM_TRICO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin, muscle
OrganismTrichostrongylus colubriformis (Black scour worm)
Taxonomic identifier6319 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaTrichostrongylidaeTrichostrongylinaeTrichostrongylus

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Subunit structure

Homodimer.

Developmental stage

Present in L3 (third stage), L4 and adult worms.

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similarities

Belongs to the tropomyosin family.

Ontologies

Keywords
   DomainCoiled coil
Repeat
   Technical termDirect protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Tropomyosin, muscle
PRO_0000205648

Regions

Coiled coil1 – 284284

Experimental info

Sequence conflict2771T → R AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P15846 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 230573B1EE2449C1

FASTA28433,051
        10         20         30         40         50         60 
MDAIKKKMQA MKIEKDNALD RADAAEEKVR QITEKLERVE EELRDTQKKM MQTENDLDKA 

        70         80         90        100        110        120 
QEDLAAATSQ LEEKEKKVQE AEAEVAALNR RMTLLEEELE RAEERLKIAT EKLEEATHNV 

       130        140        150        160        170        180 
DESERVRKVM ENGSFQDEER ANTIEAQLKE AQMLAEEADR KYDEVARKLA MVEADLERAE 

       190        200        210        220        230        240 
ERAEAGENKI VELEEELRVV GNNLKSLEVS EEKALQREDS YEEQIRTISS RLKEAETRAE 

       250        260        270        280 
FAERSVQKLQ KEVDRLEDEL VHEKERYKAI SEELDSTFQE LSGY 

« Hide

References

[1]"Characterization of cDNA clones coding for muscle tropomyosin of the nematode Trichostrongylus colubriformis."
Frenkel M.J., Savin K.W., Bakker R.E., Ward C.W.
Mol. Biochem. Parasitol. 37:191-200(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A novel host-protective antigen from Trichostrongylus colubriformis."
O'Donnell I.J., Dineen J.K., Wagland B., Letho S., Werkmeister J.A., Ward C.W.
Int. J. Parasitol. 19:327-335(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J04669 mRNA. Translation: AAA30103.1.
PIRA44980.

3D structure databases

ProteinModelPortalP15846.
SMRP15846. Positions 1-283.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPMM_TRICO
AccessionPrimary (citable) accession number: P15846
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families