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Protein

Tropomyosin, muscle

Gene
N/A
Organism
Trichostrongylus colubriformis (Black scour worm)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin, muscle
OrganismiTrichostrongylus colubriformis (Black scour worm)
Taxonomic identifieri6319 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaTrichostrongylidaeTrichostrongylinaeTrichostrongylus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Tropomyosin, musclePRO_0000205648Add
BLAST

Expressioni

Developmental stagei

Present in L3 (third stage), L4 and adult worms.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP15846.
SMRiP15846. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284Add
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15846-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAIKKKMQA MKIEKDNALD RADAAEEKVR QITEKLERVE EELRDTQKKM
60 70 80 90 100
MQTENDLDKA QEDLAAATSQ LEEKEKKVQE AEAEVAALNR RMTLLEEELE
110 120 130 140 150
RAEERLKIAT EKLEEATHNV DESERVRKVM ENGSFQDEER ANTIEAQLKE
160 170 180 190 200
AQMLAEEADR KYDEVARKLA MVEADLERAE ERAEAGENKI VELEEELRVV
210 220 230 240 250
GNNLKSLEVS EEKALQREDS YEEQIRTISS RLKEAETRAE FAERSVQKLQ
260 270 280
KEVDRLEDEL VHEKERYKAI SEELDSTFQE LSGY
Length:284
Mass (Da):33,051
Last modified:April 1, 1990 - v1
Checksum:i230573B1EE2449C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti277 – 2771T → R AA sequence (PubMed:2759773)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04669 mRNA. Translation: AAA30103.1.
PIRiA44980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04669 mRNA. Translation: AAA30103.1.
PIRiA44980.

3D structure databases

ProteinModelPortaliP15846.
SMRiP15846. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of cDNA clones coding for muscle tropomyosin of the nematode Trichostrongylus colubriformis."
    Frenkel M.J., Savin K.W., Bakker R.E., Ward C.W.
    Mol. Biochem. Parasitol. 37:191-200(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel host-protective antigen from Trichostrongylus colubriformis."
    O'Donnell I.J., Dineen J.K., Wagland B., Letho S., Werkmeister J.A., Ward C.W.
    Int. J. Parasitol. 19:327-335(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiTPMM_TRICO
AccessioniPrimary (citable) accession number: P15846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.