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P15846

- TPMM_TRICO

UniProt

P15846 - TPMM_TRICO

Protein

Tropomyosin, muscle

Gene
N/A
Organism
Trichostrongylus colubriformis (Black scour worm)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tropomyosin, muscle
    OrganismiTrichostrongylus colubriformis (Black scour worm)
    Taxonomic identifieri6319 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaTrichostrongylidaeTrichostrongylinaeTrichostrongylus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Tropomyosin, musclePRO_0000205648Add
    BLAST

    Expressioni

    Developmental stagei

    Present in L3 (third stage), L4 and adult worms.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP15846.
    SMRiP15846. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 284284Add
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

    Sequence similaritiesi

    Belongs to the tropomyosin family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.
    PROSITEiPS00326. TROPOMYOSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15846-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAIKKKMQA MKIEKDNALD RADAAEEKVR QITEKLERVE EELRDTQKKM    50
    MQTENDLDKA QEDLAAATSQ LEEKEKKVQE AEAEVAALNR RMTLLEEELE 100
    RAEERLKIAT EKLEEATHNV DESERVRKVM ENGSFQDEER ANTIEAQLKE 150
    AQMLAEEADR KYDEVARKLA MVEADLERAE ERAEAGENKI VELEEELRVV 200
    GNNLKSLEVS EEKALQREDS YEEQIRTISS RLKEAETRAE FAERSVQKLQ 250
    KEVDRLEDEL VHEKERYKAI SEELDSTFQE LSGY 284
    Length:284
    Mass (Da):33,051
    Last modified:April 1, 1990 - v1
    Checksum:i230573B1EE2449C1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti277 – 2771T → R AA sequence (PubMed:2759773)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04669 mRNA. Translation: AAA30103.1.
    PIRiA44980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04669 mRNA. Translation: AAA30103.1 .
    PIRi A44980.

    3D structure databases

    ProteinModelPortali P15846.
    SMRi P15846. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    PROSITEi PS00326. TROPOMYOSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of cDNA clones coding for muscle tropomyosin of the nematode Trichostrongylus colubriformis."
      Frenkel M.J., Savin K.W., Bakker R.E., Ward C.W.
      Mol. Biochem. Parasitol. 37:191-200(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A novel host-protective antigen from Trichostrongylus colubriformis."
      O'Donnell I.J., Dineen J.K., Wagland B., Letho S., Werkmeister J.A., Ward C.W.
      Int. J. Parasitol. 19:327-335(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiTPMM_TRICO
    AccessioniPrimary (citable) accession number: P15846
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3