P15846 (TPMM_TRICO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Tropomyosin, muscle
Organism	Trichostrongylus colubriformis (Black scour worm)
Taxonomic identifier	6319 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Strongylida › Trichostrongyloidea › Trichostrongylidae › Trichostrongylinae › Trichostrongylus

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subunit structure	Homodimer.
Developmental stage	Present in L3 (third stage), L4 and adult worms.
Domain	The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Sequence similarities	Belongs to the tropomyosin family.

Ontologies

Keywords
Domain	Coiled coil Repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Tropomyosin, muscle		PRO_0000205648
Regions
	Coiled coil	1 – 284	284
Experimental info
	Sequence conflict	277	1	T → R AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P15846 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 230573B1EE2449C1	FASTA	284	33,051
	10 20 30 40 50 60 MDAIKKKMQA MKIEKDNALD RADAAEEKVR QITEKLERVE EELRDTQKKM MQTENDLDKA 70 80 90 100 110 120 QEDLAAATSQ LEEKEKKVQE AEAEVAALNR RMTLLEEELE RAEERLKIAT EKLEEATHNV 130 140 150 160 170 180 DESERVRKVM ENGSFQDEER ANTIEAQLKE AQMLAEEADR KYDEVARKLA MVEADLERAE 190 200 210 220 230 240 ERAEAGENKI VELEEELRVV GNNLKSLEVS EEKALQREDS YEEQIRTISS RLKEAETRAE 250 260 270 280 FAERSVQKLQ KEVDRLEDEL VHEKERYKAI SEELDSTFQE LSGY

References

[1]	"Characterization of cDNA clones coding for muscle tropomyosin of the nematode Trichostrongylus colubriformis." Frenkel M.J., Savin K.W., Bakker R.E., Ward C.W. Mol. Biochem. Parasitol. 37:191-200(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"A novel host-protective antigen from Trichostrongylus colubriformis." O'Donnell I.J., Dineen J.K., Wagland B., Letho S., Werkmeister J.A., Ward C.W. Int. J. Parasitol. 19:327-335(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04669 mRNA. Translation: AAA30103.1.
PIR	A44980.
3D structure databases
ProteinModelPortal	P15846.
SMR	P15846. Positions 1-283.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000533. Tropomyosin. [Graphical view]
Pfam	PF00261. Tropomyosin. 1 hit. [Graphical view]
PRINTS	PR00194. TROPOMYOSIN.
PROSITE	PS00326. TROPOMYOSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPMM_TRICO

Accession

Primary (citable) accession number: P15846

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)