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P15825

- RL10_HALMA

UniProt

P15825 - RL10_HALMA

Protein

50S ribosomal protein L10

Gene

rpl10

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.Curated

    GO - Molecular functioni

    1. large ribosomal subunit rRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ribosome biogenesis Source: InterPro
    2. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-1279-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L10UniRule annotation
    Alternative name(s):
    Acidic ribosomal protein P0 homologUniRule annotation
    HMal10
    L10E
    Gene namesi
    Name:rpl10UniRule annotation
    Synonyms:rpl10e, rplP0UniRule annotation
    Ordered Locus Names:rrnAC1417
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 34834850S ribosomal protein L10PRO_0000154789Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion Probable.2 Publications

    Protein-protein interaction databases

    STRINGi272569.rrnAC1417.

    Structurei

    Secondary structure

    1
    348
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi14 – 2815
    Beta strandi29 – 357
    Helixi43 – 508
    Beta strandi55 – 606
    Helixi64 – 718
    Turni76 – 783
    Helixi79 – 824
    Beta strandi91 – 966
    Helixi98 – 1014
    Beta strandi102 – 1065
    Beta strandi111 – 1133
    Beta strandi123 – 1253
    Helixi138 – 1414
    Turni142 – 1454
    Beta strandi149 – 1513
    Beta strandi153 – 1586
    Beta strandi167 – 1693
    Helixi173 – 1819
    Beta strandi195 – 1973
    Beta strandi199 – 2035

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JJ2X-ray2.40G1-348[»]
    1K73X-ray3.01I1-348[»]
    1K8AX-ray3.00I1-348[»]
    1K9MX-ray3.00I1-348[»]
    1KC8X-ray3.01I1-348[»]
    1KD1X-ray3.00I1-348[»]
    1KQSX-ray3.10G1-348[»]
    1M1KX-ray3.20I1-348[»]
    1M90X-ray2.80I1-348[»]
    1N8RX-ray3.00I1-348[»]
    1NJIX-ray3.00I1-348[»]
    1Q7YX-ray3.20I1-348[»]
    1Q81X-ray2.95I1-348[»]
    1Q82X-ray2.98I1-348[»]
    1Q86X-ray3.00I1-348[»]
    1QVFX-ray3.10G1-348[»]
    1QVGX-ray2.90G1-348[»]
    1S72X-ray2.40G1-348[»]
    1VQ4X-ray2.70G1-348[»]
    1VQ5X-ray2.60G1-348[»]
    1VQ6X-ray2.70G1-348[»]
    1VQ7X-ray2.50G1-348[»]
    1VQ8X-ray2.20G1-348[»]
    1VQ9X-ray2.40G1-348[»]
    1VQKX-ray2.30G1-348[»]
    1VQLX-ray2.30G1-348[»]
    1VQMX-ray2.30G1-348[»]
    1VQNX-ray2.40G1-348[»]
    1VQOX-ray2.20G1-348[»]
    1VQPX-ray2.25G1-348[»]
    1W2BX-ray3.50G1-348[»]
    1YHQX-ray2.40G1-348[»]
    1YI2X-ray2.65G1-348[»]
    1YIJX-ray2.60G1-348[»]
    1YITX-ray2.80G1-348[»]
    1YJ9X-ray2.90G1-348[»]
    1YJNX-ray3.00G1-348[»]
    1YJWX-ray2.90G1-348[»]
    1ZB4model-A1-130[»]
    2OTJX-ray2.90G1-348[»]
    2OTLX-ray2.70G1-348[»]
    2QA4X-ray3.00G1-348[»]
    2QEXX-ray2.90G1-348[»]
    3CC2X-ray2.40G1-348[»]
    3CC4X-ray2.70G1-348[»]
    3CC7X-ray2.70G1-348[»]
    3CCEX-ray2.75G1-348[»]
    3CCJX-ray2.70G1-348[»]
    3CCLX-ray2.90G1-348[»]
    3CCMX-ray2.55G1-348[»]
    3CCQX-ray2.90G1-348[»]
    3CCRX-ray3.00G1-348[»]
    3CCSX-ray2.95G1-348[»]
    3CCUX-ray2.80G1-348[»]
    3CCVX-ray2.90G1-348[»]
    3CD6X-ray2.75G1-348[»]
    3CMAX-ray2.80G1-348[»]
    3CMEX-ray2.95G1-348[»]
    3CPWX-ray2.70G1-348[»]
    3CXCX-ray3.00G1-348[»]
    3G4SX-ray3.20G1-348[»]
    3G6EX-ray2.70G1-348[»]
    3G71X-ray2.85G1-348[»]
    3I55X-ray3.11G1-348[»]
    3I56X-ray2.90G1-348[»]
    3OW2X-ray2.70G12-73[»]
    4HUBX-ray2.40G6-211[»]
    ProteinModelPortaliP15825.
    SMRiP15825. Positions 7-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP15825.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L10P family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0244.
    HOGENOMiHOG000229909.
    KOiK02864.
    OMAiIRMSRNT.

    Family and domain databases

    Gene3Di1.10.10.380. 2 hits.
    HAMAPiMF_00280. Ribosomal_L10_arch.
    InterProiIPR022909. 50S_L10_arch.
    IPR001790. Ribosomal_L10/acidic_P0.
    IPR013522. Ribosomal_L10_N_arc.
    [Graphical view]
    PfamiPF00466. Ribosomal_L10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15825-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAESERKTE TIPEWKQEEV DAIVEMIESY ESVGVVNIAG IPSRQLQDMR    50
    RDLHGTAELR VSRNTLLERA LDDVDDGLED LNGYITGQVG LIGTDDNPFS 100
    LFQELEASKT PAPIGAGEVA PNDIVIPEGD TGVDPGPFVG ELQSVGADAR 150
    IQEGSIQVLS DSTVLDTGEE VSQELSNVLN ELGIEPKEVG LDLRAVFADG 200
    VLFEPEELEL DIDEYRSDIQ AAAGRAFNLS VNADYPTATT APTMLQSARG 250
    NAKSLALQAA IEDPEVVPDL VSKADAQVRA LASQIDDEEA LPEELQGVEA 300
    DVATEEPTDD QDDDTASEDD ADADDAAEEA DDDDDDDEDA GDALGAMF 348
    Length:348
    Mass (Da):37,150
    Last modified:January 4, 2005 - v2
    Checksum:i4063B1C9D2FCB164
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti248 – 2481A → D in CAA35795. (PubMed:2320419)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51430 Genomic DNA. Translation: CAA35795.1.
    AY596297 Genomic DNA. Translation: AAV46344.1.
    PIRiS08422. R5HS10.
    RefSeqiYP_136050.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV46344; AAV46344; rrnAC1417.
    GeneIDi3128417.
    KEGGihma:rrnAC1417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51430 Genomic DNA. Translation: CAA35795.1 .
    AY596297 Genomic DNA. Translation: AAV46344.1 .
    PIRi S08422. R5HS10.
    RefSeqi YP_136050.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JJ2 X-ray 2.40 G 1-348 [» ]
    1K73 X-ray 3.01 I 1-348 [» ]
    1K8A X-ray 3.00 I 1-348 [» ]
    1K9M X-ray 3.00 I 1-348 [» ]
    1KC8 X-ray 3.01 I 1-348 [» ]
    1KD1 X-ray 3.00 I 1-348 [» ]
    1KQS X-ray 3.10 G 1-348 [» ]
    1M1K X-ray 3.20 I 1-348 [» ]
    1M90 X-ray 2.80 I 1-348 [» ]
    1N8R X-ray 3.00 I 1-348 [» ]
    1NJI X-ray 3.00 I 1-348 [» ]
    1Q7Y X-ray 3.20 I 1-348 [» ]
    1Q81 X-ray 2.95 I 1-348 [» ]
    1Q82 X-ray 2.98 I 1-348 [» ]
    1Q86 X-ray 3.00 I 1-348 [» ]
    1QVF X-ray 3.10 G 1-348 [» ]
    1QVG X-ray 2.90 G 1-348 [» ]
    1S72 X-ray 2.40 G 1-348 [» ]
    1VQ4 X-ray 2.70 G 1-348 [» ]
    1VQ5 X-ray 2.60 G 1-348 [» ]
    1VQ6 X-ray 2.70 G 1-348 [» ]
    1VQ7 X-ray 2.50 G 1-348 [» ]
    1VQ8 X-ray 2.20 G 1-348 [» ]
    1VQ9 X-ray 2.40 G 1-348 [» ]
    1VQK X-ray 2.30 G 1-348 [» ]
    1VQL X-ray 2.30 G 1-348 [» ]
    1VQM X-ray 2.30 G 1-348 [» ]
    1VQN X-ray 2.40 G 1-348 [» ]
    1VQO X-ray 2.20 G 1-348 [» ]
    1VQP X-ray 2.25 G 1-348 [» ]
    1W2B X-ray 3.50 G 1-348 [» ]
    1YHQ X-ray 2.40 G 1-348 [» ]
    1YI2 X-ray 2.65 G 1-348 [» ]
    1YIJ X-ray 2.60 G 1-348 [» ]
    1YIT X-ray 2.80 G 1-348 [» ]
    1YJ9 X-ray 2.90 G 1-348 [» ]
    1YJN X-ray 3.00 G 1-348 [» ]
    1YJW X-ray 2.90 G 1-348 [» ]
    1ZB4 model - A 1-130 [» ]
    2OTJ X-ray 2.90 G 1-348 [» ]
    2OTL X-ray 2.70 G 1-348 [» ]
    2QA4 X-ray 3.00 G 1-348 [» ]
    2QEX X-ray 2.90 G 1-348 [» ]
    3CC2 X-ray 2.40 G 1-348 [» ]
    3CC4 X-ray 2.70 G 1-348 [» ]
    3CC7 X-ray 2.70 G 1-348 [» ]
    3CCE X-ray 2.75 G 1-348 [» ]
    3CCJ X-ray 2.70 G 1-348 [» ]
    3CCL X-ray 2.90 G 1-348 [» ]
    3CCM X-ray 2.55 G 1-348 [» ]
    3CCQ X-ray 2.90 G 1-348 [» ]
    3CCR X-ray 3.00 G 1-348 [» ]
    3CCS X-ray 2.95 G 1-348 [» ]
    3CCU X-ray 2.80 G 1-348 [» ]
    3CCV X-ray 2.90 G 1-348 [» ]
    3CD6 X-ray 2.75 G 1-348 [» ]
    3CMA X-ray 2.80 G 1-348 [» ]
    3CME X-ray 2.95 G 1-348 [» ]
    3CPW X-ray 2.70 G 1-348 [» ]
    3CXC X-ray 3.00 G 1-348 [» ]
    3G4S X-ray 3.20 G 1-348 [» ]
    3G6E X-ray 2.70 G 1-348 [» ]
    3G71 X-ray 2.85 G 1-348 [» ]
    3I55 X-ray 3.11 G 1-348 [» ]
    3I56 X-ray 2.90 G 1-348 [» ]
    3OW2 X-ray 2.70 G 12-73 [» ]
    4HUB X-ray 2.40 G 6-211 [» ]
    ProteinModelPortali P15825.
    SMRi P15825. Positions 7-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC1417.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV46344 ; AAV46344 ; rrnAC1417 .
    GeneIDi 3128417.
    KEGGi hma:rrnAC1417.

    Phylogenomic databases

    eggNOGi COG0244.
    HOGENOMi HOG000229909.
    KOi K02864.
    OMAi IRMSRNT.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-1279-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P15825.

    Family and domain databases

    Gene3Di 1.10.10.380. 2 hits.
    HAMAPi MF_00280. Ribosomal_L10_arch.
    InterProi IPR022909. 50S_L10_arch.
    IPR001790. Ribosomal_L10/acidic_P0.
    IPR013522. Ribosomal_L10_N_arc.
    [Graphical view ]
    Pfami PF00466. Ribosomal_L10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the genes encoding the L11, L1, L10 and L12 equivalent ribosomal proteins from the archaebacterium Halobacterium marismortui."
      Arndt E., Weigel C.
      Nucleic Acids Res. 18:1285-1285(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    3. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    4. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    8. "Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation."
      Diaconu M., Kothe U., Schlunzen F., Fischer N., Harms J.M., Tonevitsky A.G., Stark H., Rodnina M.V., Wahl M.C.
      Cell 121:991-1004(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: MODEL, PROBABLE INTERACTION WITH L11 (RPL11) AND L12 (RPL12).
    9. "Structure of the base of the L7/L12 stalk of the Haloarcula marismortui large ribosomal subunit: analysis of L11 movements."
      Kavran J.M., Steitz T.A.
      J. Mol. Biol. 371:1047-1059(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), RRNA-BINDING, INTERACTION WITH L11.
    10. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 6-211 OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL10_HALMA
    AccessioniPrimary (citable) accession number: P15825
    Secondary accession number(s): Q5V2A8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Has been called L10e and L10E in this organism; in this case "e/E" is for E.coli-like, not eukaryotic-type protein.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3