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P15825

- RL10_HALMA

UniProt

P15825 - RL10_HALMA

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Protein
50S ribosomal protein L10
Gene
rpl10, rpl10e, rplP0, rrnAC1417
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors Inferred.UniRule annotation

GO - Molecular functioni

  1. large ribosomal subunit rRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. ribosome biogenesis Source: InterPro
  2. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-1279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L10
Alternative name(s):
Acidic ribosomal protein P0 homolog
HMal10
L10E
Gene namesi
Name:rpl10
Synonyms:rpl10e, rplP0
Ordered Locus Names:rrnAC1417
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34834850S ribosomal protein L10UniRule annotation
PRO_0000154789Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion Inferred.6 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1417.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 2815
Beta strandi29 – 357
Helixi43 – 508
Beta strandi55 – 606
Helixi64 – 718
Turni76 – 783
Helixi79 – 824
Beta strandi91 – 966
Helixi98 – 1014
Beta strandi102 – 1065
Beta strandi111 – 1133
Beta strandi123 – 1253
Helixi138 – 1414
Turni142 – 1454
Beta strandi149 – 1513
Beta strandi153 – 1586
Beta strandi167 – 1693
Helixi173 – 1819
Beta strandi195 – 1973
Beta strandi199 – 2035

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JJ2X-ray2.40G1-348[»]
1K73X-ray3.01I1-348[»]
1K8AX-ray3.00I1-348[»]
1K9MX-ray3.00I1-348[»]
1KC8X-ray3.01I1-348[»]
1KD1X-ray3.00I1-348[»]
1KQSX-ray3.10G1-348[»]
1M1KX-ray3.20I1-348[»]
1M90X-ray2.80I1-348[»]
1N8RX-ray3.00I1-348[»]
1NJIX-ray3.00I1-348[»]
1Q7YX-ray3.20I1-348[»]
1Q81X-ray2.95I1-348[»]
1Q82X-ray2.98I1-348[»]
1Q86X-ray3.00I1-348[»]
1QVFX-ray3.10G1-348[»]
1QVGX-ray2.90G1-348[»]
1S72X-ray2.40G1-348[»]
1VQ4X-ray2.70G1-348[»]
1VQ5X-ray2.60G1-348[»]
1VQ6X-ray2.70G1-348[»]
1VQ7X-ray2.50G1-348[»]
1VQ8X-ray2.20G1-348[»]
1VQ9X-ray2.40G1-348[»]
1VQKX-ray2.30G1-348[»]
1VQLX-ray2.30G1-348[»]
1VQMX-ray2.30G1-348[»]
1VQNX-ray2.40G1-348[»]
1VQOX-ray2.20G1-348[»]
1VQPX-ray2.25G1-348[»]
1W2BX-ray3.50G1-348[»]
1YHQX-ray2.40G1-348[»]
1YI2X-ray2.65G1-348[»]
1YIJX-ray2.60G1-348[»]
1YITX-ray2.80G1-348[»]
1YJ9X-ray2.90G1-348[»]
1YJNX-ray3.00G1-348[»]
1YJWX-ray2.90G1-348[»]
1ZB4model-A1-130[»]
2OTJX-ray2.90G1-348[»]
2OTLX-ray2.70G1-348[»]
2QA4X-ray3.00G1-348[»]
2QEXX-ray2.90G1-348[»]
3CC2X-ray2.40G1-348[»]
3CC4X-ray2.70G1-348[»]
3CC7X-ray2.70G1-348[»]
3CCEX-ray2.75G1-348[»]
3CCJX-ray2.70G1-348[»]
3CCLX-ray2.90G1-348[»]
3CCMX-ray2.55G1-348[»]
3CCQX-ray2.90G1-348[»]
3CCRX-ray3.00G1-348[»]
3CCSX-ray2.95G1-348[»]
3CCUX-ray2.80G1-348[»]
3CCVX-ray2.90G1-348[»]
3CD6X-ray2.75G1-348[»]
3CMAX-ray2.80G1-348[»]
3CMEX-ray2.95G1-348[»]
3CPWX-ray2.70G1-348[»]
3CXCX-ray3.00G1-348[»]
3G4SX-ray3.20G1-348[»]
3G6EX-ray2.70G1-348[»]
3G71X-ray2.85G1-348[»]
3I55X-ray3.11G1-348[»]
3I56X-ray2.90G1-348[»]
3OW2X-ray2.70G12-73[»]
4HUBX-ray2.40G6-211[»]
ProteinModelPortaliP15825.
SMRiP15825. Positions 7-132.

Miscellaneous databases

EvolutionaryTraceiP15825.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0244.
HOGENOMiHOG000229909.
KOiK02864.
OMAiIRMSRNT.

Family and domain databases

Gene3Di1.10.10.380. 2 hits.
HAMAPiMF_00280. Ribosomal_L10_arch.
InterProiIPR022909. 50S_L10_arch.
IPR001790. Ribosomal_L10/acidic_P0.
IPR013522. Ribosomal_L10_N_arc.
[Graphical view]
PfamiPF00466. Ribosomal_L10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15825-1 [UniParc]FASTAAdd to Basket

« Hide

MSAESERKTE TIPEWKQEEV DAIVEMIESY ESVGVVNIAG IPSRQLQDMR    50
RDLHGTAELR VSRNTLLERA LDDVDDGLED LNGYITGQVG LIGTDDNPFS 100
LFQELEASKT PAPIGAGEVA PNDIVIPEGD TGVDPGPFVG ELQSVGADAR 150
IQEGSIQVLS DSTVLDTGEE VSQELSNVLN ELGIEPKEVG LDLRAVFADG 200
VLFEPEELEL DIDEYRSDIQ AAAGRAFNLS VNADYPTATT APTMLQSARG 250
NAKSLALQAA IEDPEVVPDL VSKADAQVRA LASQIDDEEA LPEELQGVEA 300
DVATEEPTDD QDDDTASEDD ADADDAAEEA DDDDDDDEDA GDALGAMF 348
Length:348
Mass (Da):37,150
Last modified:January 4, 2005 - v2
Checksum:i4063B1C9D2FCB164
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481A → D in CAA35795. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51430 Genomic DNA. Translation: CAA35795.1.
AY596297 Genomic DNA. Translation: AAV46344.1.
PIRiS08422. R5HS10.
RefSeqiYP_136050.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV46344; AAV46344; rrnAC1417.
GeneIDi3128417.
KEGGihma:rrnAC1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51430 Genomic DNA. Translation: CAA35795.1 .
AY596297 Genomic DNA. Translation: AAV46344.1 .
PIRi S08422. R5HS10.
RefSeqi YP_136050.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JJ2 X-ray 2.40 G 1-348 [» ]
1K73 X-ray 3.01 I 1-348 [» ]
1K8A X-ray 3.00 I 1-348 [» ]
1K9M X-ray 3.00 I 1-348 [» ]
1KC8 X-ray 3.01 I 1-348 [» ]
1KD1 X-ray 3.00 I 1-348 [» ]
1KQS X-ray 3.10 G 1-348 [» ]
1M1K X-ray 3.20 I 1-348 [» ]
1M90 X-ray 2.80 I 1-348 [» ]
1N8R X-ray 3.00 I 1-348 [» ]
1NJI X-ray 3.00 I 1-348 [» ]
1Q7Y X-ray 3.20 I 1-348 [» ]
1Q81 X-ray 2.95 I 1-348 [» ]
1Q82 X-ray 2.98 I 1-348 [» ]
1Q86 X-ray 3.00 I 1-348 [» ]
1QVF X-ray 3.10 G 1-348 [» ]
1QVG X-ray 2.90 G 1-348 [» ]
1S72 X-ray 2.40 G 1-348 [» ]
1VQ4 X-ray 2.70 G 1-348 [» ]
1VQ5 X-ray 2.60 G 1-348 [» ]
1VQ6 X-ray 2.70 G 1-348 [» ]
1VQ7 X-ray 2.50 G 1-348 [» ]
1VQ8 X-ray 2.20 G 1-348 [» ]
1VQ9 X-ray 2.40 G 1-348 [» ]
1VQK X-ray 2.30 G 1-348 [» ]
1VQL X-ray 2.30 G 1-348 [» ]
1VQM X-ray 2.30 G 1-348 [» ]
1VQN X-ray 2.40 G 1-348 [» ]
1VQO X-ray 2.20 G 1-348 [» ]
1VQP X-ray 2.25 G 1-348 [» ]
1W2B X-ray 3.50 G 1-348 [» ]
1YHQ X-ray 2.40 G 1-348 [» ]
1YI2 X-ray 2.65 G 1-348 [» ]
1YIJ X-ray 2.60 G 1-348 [» ]
1YIT X-ray 2.80 G 1-348 [» ]
1YJ9 X-ray 2.90 G 1-348 [» ]
1YJN X-ray 3.00 G 1-348 [» ]
1YJW X-ray 2.90 G 1-348 [» ]
1ZB4 model - A 1-130 [» ]
2OTJ X-ray 2.90 G 1-348 [» ]
2OTL X-ray 2.70 G 1-348 [» ]
2QA4 X-ray 3.00 G 1-348 [» ]
2QEX X-ray 2.90 G 1-348 [» ]
3CC2 X-ray 2.40 G 1-348 [» ]
3CC4 X-ray 2.70 G 1-348 [» ]
3CC7 X-ray 2.70 G 1-348 [» ]
3CCE X-ray 2.75 G 1-348 [» ]
3CCJ X-ray 2.70 G 1-348 [» ]
3CCL X-ray 2.90 G 1-348 [» ]
3CCM X-ray 2.55 G 1-348 [» ]
3CCQ X-ray 2.90 G 1-348 [» ]
3CCR X-ray 3.00 G 1-348 [» ]
3CCS X-ray 2.95 G 1-348 [» ]
3CCU X-ray 2.80 G 1-348 [» ]
3CCV X-ray 2.90 G 1-348 [» ]
3CD6 X-ray 2.75 G 1-348 [» ]
3CMA X-ray 2.80 G 1-348 [» ]
3CME X-ray 2.95 G 1-348 [» ]
3CPW X-ray 2.70 G 1-348 [» ]
3CXC X-ray 3.00 G 1-348 [» ]
3G4S X-ray 3.20 G 1-348 [» ]
3G6E X-ray 2.70 G 1-348 [» ]
3G71 X-ray 2.85 G 1-348 [» ]
3I55 X-ray 3.11 G 1-348 [» ]
3I56 X-ray 2.90 G 1-348 [» ]
3OW2 X-ray 2.70 G 12-73 [» ]
4HUB X-ray 2.40 G 6-211 [» ]
ProteinModelPortali P15825.
SMRi P15825. Positions 7-132.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC1417.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV46344 ; AAV46344 ; rrnAC1417 .
GeneIDi 3128417.
KEGGi hma:rrnAC1417.

Phylogenomic databases

eggNOGi COG0244.
HOGENOMi HOG000229909.
KOi K02864.
OMAi IRMSRNT.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-1279-MONOMER.

Miscellaneous databases

EvolutionaryTracei P15825.

Family and domain databases

Gene3Di 1.10.10.380. 2 hits.
HAMAPi MF_00280. Ribosomal_L10_arch.
InterProi IPR022909. 50S_L10_arch.
IPR001790. Ribosomal_L10/acidic_P0.
IPR013522. Ribosomal_L10_N_arc.
[Graphical view ]
Pfami PF00466. Ribosomal_L10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the genes encoding the L11, L1, L10 and L12 equivalent ribosomal proteins from the archaebacterium Halobacterium marismortui."
    Arndt E., Weigel C.
    Nucleic Acids Res. 18:1285-1285(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  3. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  4. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  8. "Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation."
    Diaconu M., Kothe U., Schlunzen F., Fischer N., Harms J.M., Tonevitsky A.G., Stark H., Rodnina M.V., Wahl M.C.
    Cell 121:991-1004(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: MODEL, PROBABLE INTERACTION WITH L11 (RPL11) AND L12 (RPL12).
  9. "Structure of the base of the L7/L12 stalk of the Haloarcula marismortui large ribosomal subunit: analysis of L11 movements."
    Kavran J.M., Steitz T.A.
    J. Mol. Biol. 371:1047-1059(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), RRNA-BINDING, INTERACTION WITH L11.
  10. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 6-211 OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL10_HALMA
AccessioniPrimary (citable) accession number: P15825
Secondary accession number(s): Q5V2A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 4, 2005
Last modified: May 14, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Has been called L10e and L10E in this organism; in this case "e/E" is for E.coli-like, not eukaryotic-type protein.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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