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P15823 (ADA1B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name=Alpha-1B adrenoceptor
Gene names
Name:Adra1b
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Alpha-1B adrenergic receptor
PRO_0000069072

Regions

Topological domain1 – 4545Extracellular By similarity
Transmembrane46 – 7025Helical; Name=1; By similarity
Topological domain71 – 8313Cytoplasmic By similarity
Transmembrane84 – 10522Helical; Name=2; By similarity
Topological domain106 – 11510Extracellular By similarity
Transmembrane116 – 14126Helical; Name=3; By similarity
Topological domain142 – 16120Cytoplasmic By similarity
Transmembrane162 – 18221Helical; Name=4; By similarity
Topological domain183 – 20119Extracellular By similarity
Transmembrane202 – 22423Helical; Name=5; By similarity
Topological domain225 – 29571Cytoplasmic By similarity
Transmembrane296 – 31924Helical; Name=6; By similarity
Topological domain320 – 3267Extracellular By similarity
Transmembrane327 – 35125Helical; Name=7; By similarity
Topological domain352 – 515164Cytoplasmic By similarity
Compositional bias371 – 3788Poly-Arg

Amino acid modifications

Modified residue2641Phosphothreonine By similarity
Modified residue2671Phosphoserine By similarity
Lipidation3651S-palmitoyl cysteine Potential
Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation341N-linked (GlcNAc...) Potential
Disulfide bond118 ↔ 195 By similarity

Experimental info

Sequence conflict114 – 1163GRI → LSF in AAA63478. Ref.2
Sequence conflict2031Y → C Ref.1
Sequence conflict2031Y → C Ref.4
Sequence conflict2071S → C Ref.1
Sequence conflict2071S → C Ref.4
Sequence conflict3061C → S in AAA40647. Ref.3
Sequence conflict415 – 4162TQ → QK in CAA35934. Ref.1
Sequence conflict4401C → Y in AAA40647. Ref.3
Sequence conflict484 – 4863GDT → ATA in CAA35934. Ref.1
Sequence conflict4931T → S in AAA40647. Ref.3
Sequence conflict5111A → G in CAA35934. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P15823 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: AF0C3759F80C3135

FASTA51556,586
        10         20         30         40         50         60 
MNPDLDTGHN TSAPAHWGEL KDDNFTGPNQ TSSNSTLPQL DVTRAISVGL VLGAFILFAI 

        70         80         90        100        110        120 
VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP FSATLEVLGY WVLGRIFCDI 

       130        140        150        160        170        180 
WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP 

       190        200        210        220        230        240 
LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG 

       250        260        270        280        290        300 
VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 

       310        320        330        340        350        360 
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFM 

       370        380        390        400        410        420 
RILGCQCRGG RRRRRRRRLG ACAYTYRPWT RGGSLERSQS RKDSLDDSGS CMSGTQRTLP 

       430        440        450        460        470        480 
SASPSPGYLG RGTQPPVELC AFPEWKPGAL LSLPEPPGRR GRLDSGPLFT FKLLGDPESP 

       490        500        510 
GTEGDTSNGG CDTTTDLANG QPGFKSNMPL APGHF

« Hide

References

[1]"Sequence of a rat brain cDNA encoding an alpha-1B adrenergic receptor."
Voigt M.M., Kispert J., Chin H.
Nucleic Acids Res. 18:1053-1053(1990) [PubMed: 2156222] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5."
Lomasney J.W., Cotecchia S., Lorenz W., Leung W.-Y., Schwinn D.A., Yang-Feng T.L., Brownstein M., Lefkowitz R.J., Caron M.G.
J. Biol. Chem. 266:6365-6369(1991) [PubMed: 1706716] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Isolation and characterization of the gene encoding the rat alpha 1B adrenergic receptor."
Gao B., Kunos G.
Gene 131:243-247(1993) [PubMed: 8406017] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"cAMP responsive element-mediated regulation of the gene transcription of the alpha 1B adrenergic receptor by thyrotropin."
Kanasaki M., Matsubara H., Murasawa S., Masaki H., Nio Y., Inada M.
J. Clin. Invest. 94:2245-2254(1994) [PubMed: 7989580] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-253.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X51585 mRNA. Translation: CAA35934.1.
M60655 mRNA. Translation: AAA63478.1.
L08610, L08609 Genomic DNA. Translation: AAA40647.1.
D32045 Genomic DNA. Translation: BAA06806.1.
IPIIPI00327747.
PIRJC1525.
UniGeneRn.10032.

3D structure databases

ProteinModelPortalP15823.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP15823.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD2054. Adra1b.

Phylogenomic databases

eggNOGroNOG13643.
HOVERGENHBG106962.

Gene expression databases

GenevestigatorP15823.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR001115. Adrene_rcpt_A1B.
IPR002233. Adrnrgc_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADA1B_RAT
AccessionPrimary (citable) accession number: P15823
Secondary accession number(s): Q63215
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: June 1, 1994
Last modified: September 21, 2011
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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