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P15822

- ZEP1_HUMAN

UniProt

P15822 - ZEP1_HUMAN

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Protein

Zinc finger protein 40

Gene

HIVEP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri406 – 42823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri959 – 98628C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2088 – 211023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2116 – 214025C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: ProtInc
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 40
Alternative name(s):
Cirhin interaction protein
Short name:
CIRIP
Gate keeper of apoptosis-activating protein
Short name:
GAAP
Human immunodeficiency virus type I enhancer-binding protein 1
Short name:
HIV-EP1
Major histocompatibility complex-binding protein 1
Short name:
MBP-1
Positive regulatory domain II-binding factor 1
Short name:
PRDII-BF1
Gene namesi
Name:HIVEP1
Synonyms:ZNF40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4920. HIVEP1.

Subcellular locationi

Isoform 3 : Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: HPA
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27182718Zinc finger protein 40PRO_0000047369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei429 – 4291Phosphothreonine1 Publication
Modified residuei492 – 4921Phosphoserine1 Publication
Modified residuei495 – 4951Phosphoserine1 Publication
Modified residuei1036 – 10361Phosphoserine1 Publication
Modified residuei1735 – 17351Phosphoserine1 Publication
Modified residuei1749 – 17491Phosphoserine2 Publications
Modified residuei1753 – 17531Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15822.
PaxDbiP15822.
PRIDEiP15822.

PTM databases

PhosphoSiteiP15822.

Expressioni

Inductioni

By mitogens and phorbol ester.

Gene expression databases

BgeeiP15822.
CleanExiHS_HIVEP1.
ExpressionAtlasiP15822. baseline and differential.
GenevestigatoriP15822.

Organism-specific databases

HPAiHPA050724.

Interactioni

Subunit structurei

Interacts with CIRH1A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542536EBI-722264,EBI-930964
CACNA1AO005552EBI-722264,EBI-766279
CIRH1AQ969X63EBI-722264,EBI-2602591

Protein-protein interaction databases

BioGridi109343. 37 interactions.
IntActiP15822. 55 interactions.
MINTiMINT-1188428.
STRINGi9606.ENSP00000368698.

Structurei

Secondary structure

1
2718
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni2091 – 20933
Helixi2100 – 210910
Beta strandi2119 – 21224
Beta strandi2124 – 21274
Helixi2128 – 21369
Beta strandi2137 – 21404

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BBONMR-A2087-2143[»]
3ZNFNMR-A2114-2143[»]
4ZNFNMR-A2114-2143[»]
ProteinModelPortaliP15822.
SMRiP15822. Positions 405-461, 2087-2143.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15822.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi803 – 8064Poly-Ser

Domaini

Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between.

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri406 – 42823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri434 – 45623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri959 – 98628C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2088 – 211023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri2116 – 214025C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG296349.
HOGENOMiHOG000169307.
HOVERGENiHBG018160.
InParanoidiP15822.
OMAiPPLATKT.
OrthoDBiEOG7GJ6C1.
PhylomeDBiP15822.
TreeFamiTF331837.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P15822-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRTKQIHPR NLRDKIEEAQ KELNGAEVSK KEILQAGVKG TSESLKGVKR
60 70 80 90 100
KKIVAENHLK KIPKSPLRNP LQAKHKQNTE ESSFAVLHSA SESHKKQNYI
110 120 130 140 150
PVKNGKQFTK QNGETPGIIA EASKSEESVS PKKPLFLQQP SELRRWRSEG
160 170 180 190 200
ADPAKFSDLD EQCDSSSLSS KTRTDNSECI SSHCGTTSPS YTNTAFDVLL
210 220 230 240 250
KAMEPELSTL SQKGSPCAIK TEKLRPNKTA RSPPKLKNSS MDAPNQTSQE
260 270 280 290 300
LVAESQSSCT SYTVHMSAAQ KNEQGAMQSA SHLYHQHEHF VPKSNQHNQQ
310 320 330 340 350
LPGCSGFTGS LTNLQNQENA KLEQVYNIAV TSSVGLTSPS SRSQVTPQNQ
360 370 380 390 400
QMDSASPLSI SPANSTQSPP MPIYNSTHVA SVVNQSVEQM CNLLLKDQKP
410 420 430 440 450
KKQGKYICEY CNRACAKPSV LLKHIRSHTG ERPYPCVTCG FSFKTKSNLY
460 470 480 490 500
KHKKSHAHTI KLGLVLQPDA GGLFLSHESP KALSIHSDVE DSGESEEEGA
510 520 530 540 550
TDERQHDLGA MELQPVHIIK RMSNAETLLK SSFTPSSPEN VIGDFLLQDR
560 570 580 590 600
SAESQAVTEL PKVVVHHVTV SPLRTDSPKA MDPKPELSSA QKQKDLQVTN
610 620 630 640 650
VQPLSANMSQ GGVSRLETNE NSHQKGDMNP LEGKQDSHVG TVHAQLQRQQ
660 670 680 690 700
ATDYSQEQQG KLLSPRSLGS TDSGYFSRSE SADQTVSPPT PFARRLPSTE
710 720 730 740 750
QDSGRSNGPS AALVTTSTPS ALPTGEKALL LPGQMRPPLA TKTLEERISK
760 770 780 790 800
LISDNEALVD DKQLDSVKPR RTSLSRRGSI DSPKSYIFKD SFQFDLKPVG
810 820 830 840 850
RRTSSSSDIP KSPFTPTEKS KQVFLLSVPS LDCLPITRSN SMPTTGYSAV
860 870 880 890 900
PANIIPPPHP LRGSQSFDDK IGTFYDDVFV SGPNAPVPQS GHPRTLVRQA
910 920 930 940 950
AIEDSSANES HVLGTGQSLD ESHQGCHAAG EAMSVRSKAL AQGPHIEKKK
960 970 980 990 1000
SHQGRGTMFE CETCRNRYRK LENFENHKKF YCSELHGPKT KVAMREPEHS
1010 1020 1030 1040 1050
PVPGGLQPQI LHYRVAGSSG IWEQTPQIRK RRKMKSVGDD EELQQNESGT
1060 1070 1080 1090 1100
SPKSSEGLQF QNALGCNPSL PKHNVTIRSD QQHKNIQLQN SHIHLVARGP
1110 1120 1130 1140 1150
EQTMDPKLST IMEQQISSAA QDKIELQRHG TGISVIQHTN SLSRPNSFDK
1160 1170 1180 1190 1200
PEPFERASPV SFQELNRTGK SGSLKVIGIS QEESHPSRDG SHPHQLALSD
1210 1220 1230 1240 1250
ALRGELQESS RKSPSERHVL GQPSRLVRQH NIQVPEILVT EEPDRDLEAQ
1260 1270 1280 1290 1300
CHDQEKSEKF SWPQRSETLS KLPTEKLPPK KKRLRLAEIE HSSTESSFDS
1310 1320 1330 1340 1350
TLSRSLSRES SLSHTSSFSA SLDIEDVSKT EASPKIDFLN KAEFLMIPAG
1360 1370 1380 1390 1400
LNTLNVPGCH REMRRTASEQ INCTQTSMEV SDLRSKSFDC GSITPPQTTP
1410 1420 1430 1440 1450
LTELQPPSSP SRVGVTGHVP LLERRRGPLV RQISLNIAPD SHLSPVHPTS
1460 1470 1480 1490 1500
FQNTALPSVN AVPYQGPQLT STSLAEFSAN TLHSQTQVKD LQAETSNSSS
1510 1520 1530 1540 1550
TNVFPVQQLC DINLLNQIHA PPSHQSTQLS LQVSTQGSKP DKNSVLSGSS
1560 1570 1580 1590 1600
KSEDCFAPKY QLHCQVFTSG PSCSSNPVHS LPNQVISDPV GTDHCVTSAT
1610 1620 1630 1640 1650
LPTKLIDSMS NSHPLLPPEL RPLGSQVQKV PSSFMLPIRL QSSVPAYCFA
1660 1670 1680 1690 1700
TLTSLPQILV TQDLPNQPIC QTNHSVVPIS EEQNSVPTLQ KGHQNALPNP
1710 1720 1730 1740 1750
EKEFLCENVF SEMSQNSSLS ESLPITQKIS VGRLSPQQES SASSKRMLSP
1760 1770 1780 1790 1800
ANSLDIAMEK HQKRAKDENG AVCATDVRPL EALSSRVNEA SKQKKPILVR
1810 1820 1830 1840 1850
QVCTTEPLDG VMLEKDVFSQ PEISNEAVNL TNVLPADNSS TGCSKFVVIE
1860 1870 1880 1890 1900
PISELQEFEN IKSSTSLTLT VRSSPAPSEN THISPLKCTD NNQERKSPGV
1910 1920 1930 1940 1950
KNQGDKVNIQ EQSQQPVTSL SLFNIKDTQQ LAFPSLKTTT NFTWCYLLRQ
1960 1970 1980 1990 2000
KSLHLPQKDQ KTSAYTDWTV SASNPNPLGL PTKVALALLN SKQNTGKSLY
2010 2020 2030 2040 2050
CQAITTHSKS DLLVYSSKWK SSLSKRALGN QKSTVVEFSN KDASEINSEQ
2060 2070 2080 2090 2100
DKENSLIKSE PRRIKIFDGG YKSNEEYVYV RGRGRGKYIC EECGIRCKKP
2110 2120 2130 2140 2150
SMLKKHIRTH TDVRPYHCTY CNFSFKTKGN LTKHMKSKAH SKKCVDLGVS
2160 2170 2180 2190 2200
VGLIDEQDTE ESDEKQRFSY ERSGYDLEES DGPDEDDNEN EDDDEDSQAE
2210 2220 2230 2240 2250
SVLSATPSVT ASPQHLPSRS SLQDPVSTDE DVRITDCFSG VHTDPMDVLP
2260 2270 2280 2290 2300
RALLTRMTVL STAQSDYNRK TLSPGKARQR AARDENDTIP SVDTSRSPCH
2310 2320 2330 2340 2350
QMSVDYPESE EILRSSMAGK AVAITQSPSS VRLPPAAAEH SPQTAAGMPS
2360 2370 2380 2390 2400
VASPHPDPQE QKQQITLQPT PGLPSPHTHL FSHLPLHSQQ QSRTPYNMVP
2410 2420 2430 2440 2450
VGGIHVVPAG LTYSTFVPLQ AGPVQLTIPA VSVVHRTLGT HRNTVTEVSG
2460 2470 2480 2490 2500
TTNPAGVAEL SSVVPCIPIG QIRVPGLQNL STPGLQSLPS LSMETVNIVG
2510 2520 2530 2540 2550
LANTNMAPQV HPPGLALNAV GLQVLTANPS SQSSPAPQAH IPGLQILNIA
2560 2570 2580 2590 2600
LPTLIPSVSQ VAVDAQGAPE MPASQSKACE TQPKQTSVAS ANQVSRTESP
2610 2620 2630 2640 2650
QGLPTVQREN AKKVLNPPAP AGDHARLDGL SKMDTEKAAS ANHVKPKPEL
2660 2670 2680 2690 2700
TSIQGQPAST SQPLLKAHSE VFTKPSGQQT LSPDRQVPRP TALPRRQPTV
2710
HFSDVSSDDD EDRLVIAT
Length:2,718
Mass (Da):296,865
Last modified:July 28, 2009 - v3
Checksum:i64C1C1CF06AC25ED
GO
Isoform 2 (identifier: P15822-2) [UniParc]FASTAAdd to Basket

Also known as: Delta 2, GAAP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-2017: Missing.
     2018-2024: KWKSSLS → MGQKFQK

Show »
Length:701
Mass (Da):75,714
Checksum:i001EB17FE50AC810
GO
Isoform 3 (identifier: P15822-3) [UniParc]FASTAAdd to Basket

Also known as: GAAP-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-2002: Missing.
     2003-2024: AITTHSKSDLLVYSSKWKSSLS → MGQKFQKKSYRLVLKELRNPLL

Show »
Length:716
Mass (Da):77,538
Checksum:i1F340537E16FCFF1
GO

Sequence cautioni

The sequence CAA35798.1 differs from that shown. Reason: Frameshift at several positions.
The sequence CAH73909.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAH73982.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI14768.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI21070.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti515 – 5151P → N in CAA35798. (PubMed:2106471)Curated
Sequence conflicti1227 – 12271V → I in CAA35798. (PubMed:2106471)Curated
Sequence conflicti1436 – 14361N → G in CAA35798. (PubMed:2106471)Curated
Sequence conflicti1660 – 16601V → E in AAA17534. (PubMed:2108316)Curated
Sequence conflicti1883 – 18831I → L in CAA35798. (PubMed:2106471)Curated
Sequence conflicti2067 – 20671F → C in AAV85766. 1 PublicationCurated
Sequence conflicti2080 – 20801V → I in CAA35798. (PubMed:2106471)Curated
Sequence conflicti2149 – 21491V → I in CAA35798. (PubMed:2106471)Curated
Sequence conflicti2388 – 23881S → P in AAV85766. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871T → M.
Corresponds to variant rs2228209 [ dbSNP | Ensembl ].
VAR_057383
Natural varianti362 – 3621P → L.
Corresponds to variant rs34221818 [ dbSNP | Ensembl ].
VAR_057384
Natural varianti716 – 7161T → A.
Corresponds to variant rs2228210 [ dbSNP | Ensembl ].
VAR_057385
Natural varianti828 – 8281V → I.
Corresponds to variant rs2228218 [ dbSNP | Ensembl ].
VAR_057386
Natural varianti873 – 8731T → A.2 Publications
Corresponds to variant rs6900196 [ dbSNP | Ensembl ].
VAR_057387
Natural varianti1074 – 10741N → S.1 Publication
Corresponds to variant rs2228220 [ dbSNP | Ensembl ].
VAR_057388
Natural varianti1170 – 11701K → N.1 Publication
Corresponds to variant rs34258344 [ dbSNP | Ensembl ].
VAR_057389
Natural varianti1520 – 15201A → G.1 Publication
Corresponds to variant rs2228212 [ dbSNP | Ensembl ].
VAR_057390
Natural varianti1609 – 16091M → I.1 Publication
Corresponds to variant rs2228213 [ dbSNP | Ensembl ].
VAR_057391
Natural varianti1915 – 19151Q → R.1 Publication
Corresponds to variant rs1126472 [ dbSNP | Ensembl ].
VAR_057392
Natural varianti2444 – 24441T → M.
Corresponds to variant rs2228214 [ dbSNP | Ensembl ].
VAR_059892
Natural varianti2692 – 26921A → G.2 Publications
Corresponds to variant rs1042054 [ dbSNP | Ensembl ].
VAR_059893

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 20172017Missing in isoform 2. 1 PublicationVSP_037714Add
BLAST
Alternative sequencei1 – 20022002Missing in isoform 3. 1 PublicationVSP_037715Add
BLAST
Alternative sequencei2003 – 202422AITTH…KSSLS → MGQKFQKKSYRLVLKELRNP LL in isoform 3. 1 PublicationVSP_037716Add
BLAST
Alternative sequencei2018 – 20247KWKSSLS → MGQKFQK in isoform 2. 1 PublicationVSP_037717

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51435 mRNA. Translation: CAA35798.1. Frameshift.
AL391828
, AL137221, AL157373, Z98050 Genomic DNA. Translation: CAH73909.1. Sequence problems.
AL157373
, AL137221, AL391828, Z98050 Genomic DNA. Translation: CAH73982.1. Sequence problems.
AL137221
, AL157373, AL391828, Z98050 Genomic DNA. Translation: CAI14768.1. Sequence problems.
Z98050
, AL137221, AL157373, AL391828 Genomic DNA. Translation: CAI21070.1. Sequence problems.
BC140816 mRNA. Translation: AAI40817.1.
M32019 mRNA. Translation: AAA17534.1.
AY673640 mRNA. Translation: AAV85766.1.
CCDSiCCDS43426.1. [P15822-1]
PIRiA34203.
RefSeqiNP_002105.3. NM_002114.3.
UniGeneiHs.567284.

Genome annotation databases

EnsembliENST00000379388; ENSP00000368698; ENSG00000095951.
GeneIDi3096.
UCSCiuc003nac.3. human. [P15822-1]

Polymorphism databases

DMDMi254763385.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X51435 mRNA. Translation: CAA35798.1 . Frameshift.
AL391828
, AL137221 , AL157373 , Z98050 Genomic DNA. Translation: CAH73909.1 . Sequence problems.
AL157373
, AL137221 , AL391828 , Z98050 Genomic DNA. Translation: CAH73982.1 . Sequence problems.
AL137221
, AL157373 , AL391828 , Z98050 Genomic DNA. Translation: CAI14768.1 . Sequence problems.
Z98050
, AL137221 , AL157373 , AL391828 Genomic DNA. Translation: CAI21070.1 . Sequence problems.
BC140816 mRNA. Translation: AAI40817.1 .
M32019 mRNA. Translation: AAA17534.1 .
AY673640 mRNA. Translation: AAV85766.1 .
CCDSi CCDS43426.1. [P15822-1 ]
PIRi A34203.
RefSeqi NP_002105.3. NM_002114.3.
UniGenei Hs.567284.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BBO NMR - A 2087-2143 [» ]
3ZNF NMR - A 2114-2143 [» ]
4ZNF NMR - A 2114-2143 [» ]
ProteinModelPortali P15822.
SMRi P15822. Positions 405-461, 2087-2143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109343. 37 interactions.
IntActi P15822. 55 interactions.
MINTi MINT-1188428.
STRINGi 9606.ENSP00000368698.

Chemistry

ChEMBLi CHEMBL2909.

PTM databases

PhosphoSitei P15822.

Polymorphism databases

DMDMi 254763385.

Proteomic databases

MaxQBi P15822.
PaxDbi P15822.
PRIDEi P15822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379388 ; ENSP00000368698 ; ENSG00000095951 .
GeneIDi 3096.
UCSCi uc003nac.3. human. [P15822-1 ]

Organism-specific databases

CTDi 3096.
GeneCardsi GC06P012009.
HGNCi HGNC:4920. HIVEP1.
HPAi HPA050724.
MIMi 194540. gene.
neXtProti NX_P15822.
PharmGKBi PA29297.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296349.
HOGENOMi HOG000169307.
HOVERGENi HBG018160.
InParanoidi P15822.
OMAi PPLATKT.
OrthoDBi EOG7GJ6C1.
PhylomeDBi P15822.
TreeFami TF331837.

Miscellaneous databases

ChiTaRSi HIVEP1. human.
EvolutionaryTracei P15822.
GeneWikii HIVEP1.
GenomeRNAii 3096.
NextBioi 12285.
PROi P15822.
SOURCEi Search...

Gene expression databases

Bgeei P15822.
CleanExi HS_HIVEP1.
ExpressionAtlasi P15822. baseline and differential.
Genevestigatori P15822.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence."
    Fan C.M., Maniatis T.
    Genes Dev. 4:29-42(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-1074; ASN-1170; ARG-1915 AND GLY-2692.
  2. "Transcriptional regulator of genes involved in the control of cell growth or cell proliferation. Use of said regulator as a therapeutic or diagnostic agent."
    Tovey M.
    Patent number CA2448384, 12-DEC-2002
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), FUNCTION (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION (ISOFORMS 2 AND 3).
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ALA-873 AND GLY-1520.
  5. "A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes."
    Baldwin A.S. Jr., LeClair K.P., Singh H., Sharp P.A.
    Mol. Cell. Biol. 10:1406-1414(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 817-2718 (ISOFORM 1), VARIANTS ALA-873; ILE-1609 AND GLY-2692.
  6. Yu B., Mitchell G.A., Richter A.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2035-2718 (ISOFORM 1).
    Tissue: Liver.
  7. "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products."
    Muchardt C., Seeler J.S., Nirula A., Shurland D.L., Gaynor R.B.
    J. Virol. 66:244-250(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 2), ALTERNATIVE SPLICING.
  8. "Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression."
    Seeler J.S., Muchardt C., Suessle A., Gaynor R.B.
    J. Virol. 68:1002-1009(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 1).
  9. "GAAP-1: a transcriptional activator of p53 and IRF-1 possesses pro-apoptotic activity."
    Lallemand C., Palmieri M., Blanchard B., Meritet J.F., Tovey M.G.
    EMBO Rep. 3:153-158(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2), ALTERNATIVE SPLICING.
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-429; SER-1036 AND SER-1735, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Cirhin up-regulates a canonical NF-kappaB element through strong interaction with Cirip/HIVEP1."
    Yu B., Mitchell G.A., Richter A.
    Exp. Cell Res. 315:3086-3098(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CIRH1A.
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492; SER-495; SER-1749 AND SER-1753, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1749 AND SER-1753, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution."
    Omichinski J.G., Clore G.M., Appella E., Sakaguchi K., Gronenborn A.M.
    Biochemistry 29:9324-9334(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2114-2143.
  17. "High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1."
    Omichinski J.G., Clore G.M., Robien M., Sakaguchi K., Appella E., Gronenborn A.M.
    Biochemistry 31:3907-3917(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2088-2143.

Entry informationi

Entry nameiZEP1_HUMAN
AccessioniPrimary (citable) accession number: P15822
Secondary accession number(s): B2RTU3
, Q14122, Q5MPB1, Q5VW60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3