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Protein

Zinc finger protein 40

Gene

HIVEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri406 – 428C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri956 – 986CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri2088 – 2110C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2116 – 2140C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000095951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 40
Alternative name(s):
Cirhin interaction protein
Short name:
CIRIP
Gate keeper of apoptosis-activating protein
Short name:
GAAP
Human immunodeficiency virus type I enhancer-binding protein 1
Short name:
HIV-EP1
Major histocompatibility complex-binding protein 1
Short name:
MBP-1
Positive regulatory domain II-binding factor 1
Short name:
PRDII-BF1
Gene namesi
Name:HIVEP1
Synonyms:ZNF40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4920. HIVEP1.

Subcellular locationi

Isoform 3 :
  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • mitochondrion Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3096.
PharmGKBiPA29297.

Chemistry databases

ChEMBLiCHEMBL2909.

Polymorphism and mutation databases

BioMutaiHIVEP1.
DMDMi254763385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473691 – 2718Zinc finger protein 40Add BLAST2718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1
Modified residuei429PhosphothreonineCombined sources1
Modified residuei476PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei1036PhosphoserineCombined sources1
Modified residuei1051PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1180PhosphoserineCombined sources1
Modified residuei1268PhosphothreonineCombined sources1
Modified residuei1735PhosphoserineCombined sources1
Modified residuei1740PhosphoserineCombined sources1
Modified residuei1749PhosphoserineCombined sources1
Modified residuei1753PhosphoserineCombined sources1
Modified residuei1884PhosphoserineCombined sources1
Modified residuei2033PhosphoserineCombined sources1
Modified residuei2327PhosphoserineCombined sources1
Modified residuei2599PhosphoserineCombined sources1
Modified residuei2669PhosphoserineCombined sources1
Modified residuei2682PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15822.
PaxDbiP15822.
PeptideAtlasiP15822.
PRIDEiP15822.

PTM databases

iPTMnetiP15822.
PhosphoSitePlusiP15822.

Expressioni

Inductioni

By mitogens and phorbol ester.

Gene expression databases

BgeeiENSG00000095951.
CleanExiHS_HIVEP1.
ExpressionAtlasiP15822. baseline and differential.
GenevisibleiP15822. HS.

Organism-specific databases

HPAiHPA050724.

Interactioni

Subunit structurei

Interacts with UTP4.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542536EBI-722264,EBI-930964
CACNA1AO005552EBI-722264,EBI-766279
UTP4Q969X63EBI-722264,EBI-2602591

Protein-protein interaction databases

BioGridi109343. 49 interactors.
IntActiP15822. 78 interactors.
MINTiMINT-1188428.
STRINGi9606.ENSP00000368698.

Structurei

Secondary structure

12718
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni2091 – 2093Combined sources3
Helixi2100 – 2109Combined sources10
Beta strandi2119 – 2122Combined sources4
Beta strandi2124 – 2127Combined sources4
Helixi2128 – 2136Combined sources9
Beta strandi2137 – 2140Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BBONMR-A2087-2143[»]
3ZNFNMR-A2114-2143[»]
4ZNFNMR-A2114-2143[»]
ProteinModelPortaliP15822.
SMRiP15822.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP15822.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi803 – 806Poly-Ser4

Domaini

Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in-between.

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 CCHC HIVEP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri406 – 428C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri956 – 986CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri2088 – 2110C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2116 – 2140C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000169307.
HOVERGENiHBG018160.
InParanoidiP15822.
KOiK09239.
OrthoDBiEOG091G003C.
PhylomeDBiP15822.
TreeFamiTF331837.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS51811. ZF_CCHC_HIVEP. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15822-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRTKQIHPR NLRDKIEEAQ KELNGAEVSK KEILQAGVKG TSESLKGVKR
60 70 80 90 100
KKIVAENHLK KIPKSPLRNP LQAKHKQNTE ESSFAVLHSA SESHKKQNYI
110 120 130 140 150
PVKNGKQFTK QNGETPGIIA EASKSEESVS PKKPLFLQQP SELRRWRSEG
160 170 180 190 200
ADPAKFSDLD EQCDSSSLSS KTRTDNSECI SSHCGTTSPS YTNTAFDVLL
210 220 230 240 250
KAMEPELSTL SQKGSPCAIK TEKLRPNKTA RSPPKLKNSS MDAPNQTSQE
260 270 280 290 300
LVAESQSSCT SYTVHMSAAQ KNEQGAMQSA SHLYHQHEHF VPKSNQHNQQ
310 320 330 340 350
LPGCSGFTGS LTNLQNQENA KLEQVYNIAV TSSVGLTSPS SRSQVTPQNQ
360 370 380 390 400
QMDSASPLSI SPANSTQSPP MPIYNSTHVA SVVNQSVEQM CNLLLKDQKP
410 420 430 440 450
KKQGKYICEY CNRACAKPSV LLKHIRSHTG ERPYPCVTCG FSFKTKSNLY
460 470 480 490 500
KHKKSHAHTI KLGLVLQPDA GGLFLSHESP KALSIHSDVE DSGESEEEGA
510 520 530 540 550
TDERQHDLGA MELQPVHIIK RMSNAETLLK SSFTPSSPEN VIGDFLLQDR
560 570 580 590 600
SAESQAVTEL PKVVVHHVTV SPLRTDSPKA MDPKPELSSA QKQKDLQVTN
610 620 630 640 650
VQPLSANMSQ GGVSRLETNE NSHQKGDMNP LEGKQDSHVG TVHAQLQRQQ
660 670 680 690 700
ATDYSQEQQG KLLSPRSLGS TDSGYFSRSE SADQTVSPPT PFARRLPSTE
710 720 730 740 750
QDSGRSNGPS AALVTTSTPS ALPTGEKALL LPGQMRPPLA TKTLEERISK
760 770 780 790 800
LISDNEALVD DKQLDSVKPR RTSLSRRGSI DSPKSYIFKD SFQFDLKPVG
810 820 830 840 850
RRTSSSSDIP KSPFTPTEKS KQVFLLSVPS LDCLPITRSN SMPTTGYSAV
860 870 880 890 900
PANIIPPPHP LRGSQSFDDK IGTFYDDVFV SGPNAPVPQS GHPRTLVRQA
910 920 930 940 950
AIEDSSANES HVLGTGQSLD ESHQGCHAAG EAMSVRSKAL AQGPHIEKKK
960 970 980 990 1000
SHQGRGTMFE CETCRNRYRK LENFENHKKF YCSELHGPKT KVAMREPEHS
1010 1020 1030 1040 1050
PVPGGLQPQI LHYRVAGSSG IWEQTPQIRK RRKMKSVGDD EELQQNESGT
1060 1070 1080 1090 1100
SPKSSEGLQF QNALGCNPSL PKHNVTIRSD QQHKNIQLQN SHIHLVARGP
1110 1120 1130 1140 1150
EQTMDPKLST IMEQQISSAA QDKIELQRHG TGISVIQHTN SLSRPNSFDK
1160 1170 1180 1190 1200
PEPFERASPV SFQELNRTGK SGSLKVIGIS QEESHPSRDG SHPHQLALSD
1210 1220 1230 1240 1250
ALRGELQESS RKSPSERHVL GQPSRLVRQH NIQVPEILVT EEPDRDLEAQ
1260 1270 1280 1290 1300
CHDQEKSEKF SWPQRSETLS KLPTEKLPPK KKRLRLAEIE HSSTESSFDS
1310 1320 1330 1340 1350
TLSRSLSRES SLSHTSSFSA SLDIEDVSKT EASPKIDFLN KAEFLMIPAG
1360 1370 1380 1390 1400
LNTLNVPGCH REMRRTASEQ INCTQTSMEV SDLRSKSFDC GSITPPQTTP
1410 1420 1430 1440 1450
LTELQPPSSP SRVGVTGHVP LLERRRGPLV RQISLNIAPD SHLSPVHPTS
1460 1470 1480 1490 1500
FQNTALPSVN AVPYQGPQLT STSLAEFSAN TLHSQTQVKD LQAETSNSSS
1510 1520 1530 1540 1550
TNVFPVQQLC DINLLNQIHA PPSHQSTQLS LQVSTQGSKP DKNSVLSGSS
1560 1570 1580 1590 1600
KSEDCFAPKY QLHCQVFTSG PSCSSNPVHS LPNQVISDPV GTDHCVTSAT
1610 1620 1630 1640 1650
LPTKLIDSMS NSHPLLPPEL RPLGSQVQKV PSSFMLPIRL QSSVPAYCFA
1660 1670 1680 1690 1700
TLTSLPQILV TQDLPNQPIC QTNHSVVPIS EEQNSVPTLQ KGHQNALPNP
1710 1720 1730 1740 1750
EKEFLCENVF SEMSQNSSLS ESLPITQKIS VGRLSPQQES SASSKRMLSP
1760 1770 1780 1790 1800
ANSLDIAMEK HQKRAKDENG AVCATDVRPL EALSSRVNEA SKQKKPILVR
1810 1820 1830 1840 1850
QVCTTEPLDG VMLEKDVFSQ PEISNEAVNL TNVLPADNSS TGCSKFVVIE
1860 1870 1880 1890 1900
PISELQEFEN IKSSTSLTLT VRSSPAPSEN THISPLKCTD NNQERKSPGV
1910 1920 1930 1940 1950
KNQGDKVNIQ EQSQQPVTSL SLFNIKDTQQ LAFPSLKTTT NFTWCYLLRQ
1960 1970 1980 1990 2000
KSLHLPQKDQ KTSAYTDWTV SASNPNPLGL PTKVALALLN SKQNTGKSLY
2010 2020 2030 2040 2050
CQAITTHSKS DLLVYSSKWK SSLSKRALGN QKSTVVEFSN KDASEINSEQ
2060 2070 2080 2090 2100
DKENSLIKSE PRRIKIFDGG YKSNEEYVYV RGRGRGKYIC EECGIRCKKP
2110 2120 2130 2140 2150
SMLKKHIRTH TDVRPYHCTY CNFSFKTKGN LTKHMKSKAH SKKCVDLGVS
2160 2170 2180 2190 2200
VGLIDEQDTE ESDEKQRFSY ERSGYDLEES DGPDEDDNEN EDDDEDSQAE
2210 2220 2230 2240 2250
SVLSATPSVT ASPQHLPSRS SLQDPVSTDE DVRITDCFSG VHTDPMDVLP
2260 2270 2280 2290 2300
RALLTRMTVL STAQSDYNRK TLSPGKARQR AARDENDTIP SVDTSRSPCH
2310 2320 2330 2340 2350
QMSVDYPESE EILRSSMAGK AVAITQSPSS VRLPPAAAEH SPQTAAGMPS
2360 2370 2380 2390 2400
VASPHPDPQE QKQQITLQPT PGLPSPHTHL FSHLPLHSQQ QSRTPYNMVP
2410 2420 2430 2440 2450
VGGIHVVPAG LTYSTFVPLQ AGPVQLTIPA VSVVHRTLGT HRNTVTEVSG
2460 2470 2480 2490 2500
TTNPAGVAEL SSVVPCIPIG QIRVPGLQNL STPGLQSLPS LSMETVNIVG
2510 2520 2530 2540 2550
LANTNMAPQV HPPGLALNAV GLQVLTANPS SQSSPAPQAH IPGLQILNIA
2560 2570 2580 2590 2600
LPTLIPSVSQ VAVDAQGAPE MPASQSKACE TQPKQTSVAS ANQVSRTESP
2610 2620 2630 2640 2650
QGLPTVQREN AKKVLNPPAP AGDHARLDGL SKMDTEKAAS ANHVKPKPEL
2660 2670 2680 2690 2700
TSIQGQPAST SQPLLKAHSE VFTKPSGQQT LSPDRQVPRP TALPRRQPTV
2710
HFSDVSSDDD EDRLVIAT
Length:2,718
Mass (Da):296,865
Last modified:July 28, 2009 - v3
Checksum:i64C1C1CF06AC25ED
GO
Isoform 2 (identifier: P15822-2) [UniParc]FASTAAdd to basket
Also known as: Delta 2, GAAP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-2017: Missing.
     2018-2024: KWKSSLS → MGQKFQK

Show »
Length:701
Mass (Da):75,714
Checksum:i001EB17FE50AC810
GO
Isoform 3 (identifier: P15822-3) [UniParc]FASTAAdd to basket
Also known as: GAAP-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-2002: Missing.
     2003-2024: AITTHSKSDLLVYSSKWKSSLS → MGQKFQKKSYRLVLKELRNPLL

Show »
Length:716
Mass (Da):77,538
Checksum:i1F340537E16FCFF1
GO

Sequence cautioni

The sequence CAA35798 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence CAH73909 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH73982 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI14768 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21070 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti515P → N in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1227V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1436N → G in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti1660V → E in AAA17534 (PubMed:2108316).Curated1
Sequence conflicti1883I → L in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2067F → C in AAV85766 (Ref. 6) Curated1
Sequence conflicti2080V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2149V → I in CAA35798 (PubMed:2106471).Curated1
Sequence conflicti2388S → P in AAV85766 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057383187T → M.Corresponds to variant rs2228209dbSNPEnsembl.1
Natural variantiVAR_057384362P → L.Corresponds to variant rs34221818dbSNPEnsembl.1
Natural variantiVAR_057385716T → A.Corresponds to variant rs2228210dbSNPEnsembl.1
Natural variantiVAR_057386828V → I.Corresponds to variant rs2228218dbSNPEnsembl.1
Natural variantiVAR_057387873T → A.2 PublicationsCorresponds to variant rs6900196dbSNPEnsembl.1
Natural variantiVAR_0573881074N → S.1 PublicationCorresponds to variant rs2228220dbSNPEnsembl.1
Natural variantiVAR_0573891170K → N.1 PublicationCorresponds to variant rs34258344dbSNPEnsembl.1
Natural variantiVAR_0573901520A → G.1 PublicationCorresponds to variant rs2228212dbSNPEnsembl.1
Natural variantiVAR_0573911609M → I.1 PublicationCorresponds to variant rs2228213dbSNPEnsembl.1
Natural variantiVAR_0573921915Q → R.1 PublicationCorresponds to variant rs1126472dbSNPEnsembl.1
Natural variantiVAR_0598922444T → M.Corresponds to variant rs2228214dbSNPEnsembl.1
Natural variantiVAR_0598932692A → G.2 PublicationsCorresponds to variant rs1042054dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377141 – 2017Missing in isoform 2. 1 PublicationAdd BLAST2017
Alternative sequenceiVSP_0377151 – 2002Missing in isoform 3. 1 PublicationAdd BLAST2002
Alternative sequenceiVSP_0377162003 – 2024AITTH…KSSLS → MGQKFQKKSYRLVLKELRNP LL in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0377172018 – 2024KWKSSLS → MGQKFQK in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51435 mRNA. Translation: CAA35798.1. Frameshift.
AL391828
, AL137221, AL157373, Z98050 Genomic DNA. Translation: CAH73909.1. Sequence problems.
AL157373
, AL137221, AL391828, Z98050 Genomic DNA. Translation: CAH73982.1. Sequence problems.
AL137221
, AL157373, AL391828, Z98050 Genomic DNA. Translation: CAI14768.1. Sequence problems.
Z98050
, AL137221, AL157373, AL391828 Genomic DNA. Translation: CAI21070.1. Sequence problems.
BC140816 mRNA. Translation: AAI40817.1.
M32019 mRNA. Translation: AAA17534.1.
AY673640 mRNA. Translation: AAV85766.1.
CCDSiCCDS43426.1. [P15822-1]
PIRiA34203.
RefSeqiNP_002105.3. NM_002114.3.
UniGeneiHs.567284.

Genome annotation databases

EnsembliENST00000379388; ENSP00000368698; ENSG00000095951.
GeneIDi3096.
KEGGihsa:3096.
UCSCiuc003nac.4. human. [P15822-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51435 mRNA. Translation: CAA35798.1. Frameshift.
AL391828
, AL137221, AL157373, Z98050 Genomic DNA. Translation: CAH73909.1. Sequence problems.
AL157373
, AL137221, AL391828, Z98050 Genomic DNA. Translation: CAH73982.1. Sequence problems.
AL137221
, AL157373, AL391828, Z98050 Genomic DNA. Translation: CAI14768.1. Sequence problems.
Z98050
, AL137221, AL157373, AL391828 Genomic DNA. Translation: CAI21070.1. Sequence problems.
BC140816 mRNA. Translation: AAI40817.1.
M32019 mRNA. Translation: AAA17534.1.
AY673640 mRNA. Translation: AAV85766.1.
CCDSiCCDS43426.1. [P15822-1]
PIRiA34203.
RefSeqiNP_002105.3. NM_002114.3.
UniGeneiHs.567284.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BBONMR-A2087-2143[»]
3ZNFNMR-A2114-2143[»]
4ZNFNMR-A2114-2143[»]
ProteinModelPortaliP15822.
SMRiP15822.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109343. 49 interactors.
IntActiP15822. 78 interactors.
MINTiMINT-1188428.
STRINGi9606.ENSP00000368698.

Chemistry databases

ChEMBLiCHEMBL2909.

PTM databases

iPTMnetiP15822.
PhosphoSitePlusiP15822.

Polymorphism and mutation databases

BioMutaiHIVEP1.
DMDMi254763385.

Proteomic databases

MaxQBiP15822.
PaxDbiP15822.
PeptideAtlasiP15822.
PRIDEiP15822.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379388; ENSP00000368698; ENSG00000095951.
GeneIDi3096.
KEGGihsa:3096.
UCSCiuc003nac.4. human. [P15822-1]

Organism-specific databases

CTDi3096.
DisGeNETi3096.
GeneCardsiHIVEP1.
HGNCiHGNC:4920. HIVEP1.
HPAiHPA050724.
MIMi194540. gene.
neXtProtiNX_P15822.
PharmGKBiPA29297.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000169307.
HOVERGENiHBG018160.
InParanoidiP15822.
KOiK09239.
OrthoDBiEOG091G003C.
PhylomeDBiP15822.
TreeFamiTF331837.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000095951-MONOMER.

Miscellaneous databases

ChiTaRSiHIVEP1. human.
EvolutionaryTraceiP15822.
GeneWikiiHIVEP1.
GenomeRNAii3096.
PROiP15822.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095951.
CleanExiHS_HIVEP1.
ExpressionAtlasiP15822. baseline and differential.
GenevisibleiP15822. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS51811. ZF_CCHC_HIVEP. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZEP1_HUMAN
AccessioniPrimary (citable) accession number: P15822
Secondary accession number(s): B2RTU3
, Q14122, Q5MPB1, Q5VW60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 28, 2009
Last modified: November 30, 2016
This is version 177 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.