SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P15814

- IGLL1_HUMAN

UniProt

P15814 - IGLL1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Immunoglobulin lambda-like polypeptide 1
Gene
IGLL1, IGL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Critical for B-cell development.1 Publication

GO - Biological processi

  1. immune response Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda-like polypeptide 1
Alternative name(s):
CD179 antigen-like family member B
Ig lambda-5
Immunoglobulin omega polypeptide
Immunoglobulin-related protein 14.1
CD_antigen: CD179b
Gene namesi
Name:IGLL1
Synonyms:IGL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:5870. IGLL1.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Agammaglobulinemia 2, autosomal recessive (AGM2) [MIM:613500]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421P → L in AGM2. 1 Publication
Corresponds to variant rs1064422 [ dbSNP | Ensembl ].
VAR_034869

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi613500. phenotype.
Orphaneti33110. Autosomal agammaglobulinemia.
PharmGKBiPA29756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737 Reviewed prediction
Add
BLAST
Chaini38 – 213176Immunoglobulin lambda-like polypeptide 1
PRO_0000014777Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi135 ↔ 1941 Publication
Disulfide bondi212 – 212Interchain (with a heavy chain) By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP15814.
PaxDbiP15814.
PeptideAtlasiP15814.
PRIDEiP15814.

PTM databases

PhosphoSiteiP15814.

Expressioni

Tissue specificityi

Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).1 Publication

Gene expression databases

ArrayExpressiP15814.
BgeeiP15814.
CleanExiHS_IGLL1.
GenevestigatoriP15814.

Interactioni

Subunit structurei

Associates non-covalently with VPREB1.1 Publication

Protein-protein interaction databases

BioGridi109759. 1 interaction.
IntActiP15814. 5 interactions.
MINTiMINT-4657105.
STRINGi9606.ENSP00000329312.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni61 – 655
Helixi66 – 705
Helixi72 – 754
Beta strandi102 – 1087
Beta strandi115 – 1195
Helixi123 – 1264
Turni127 – 1293
Beta strandi131 – 14313
Beta strandi146 – 1516
Beta strandi158 – 1625
Beta strandi173 – 1819
Helixi183 – 1886
Beta strandi192 – 1987
Beta strandi201 – 2077

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2H32X-ray2.70B93-213[»]
2H3NX-ray2.30B/D94-209[»]
2LKQNMR-A59-82[»]
ProteinModelPortaliP15814.
SMRiP15814. Positions 13-212.

Miscellaneous databases

EvolutionaryTraceiP15814.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 20895Ig-like C1-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 10812J region (By similarity to lambda light-chain)
Add
BLAST
Regioni109 – 213105C region (By similarity to lambda light-chain)
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG46716.
HOGENOMiHOG000113013.
HOVERGENiHBG039526.
InParanoidiP15814.
KOiK06554.
OMAiKHNSVTH.
OrthoDBiEOG7X0VQW.
PhylomeDBiP15814.
TreeFamiTF335549.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P15814-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRPGTGQGGL EAPGEPGPNL RQRWPLLLLG LAVVTHGLLR PTAASQSRAL    50
GPGAPGGSSR SSLRSRWGRF LLQRGSWTGP RCWPRGFQSK HNSVTHVFGS 100
GTQLTVLSQP KATPSVTLFP PSSEELQANK ATLVCLMNDF YPGILTVTWK 150
ADGTPITQGV EMTTPSKQSN NKYAASSYLS LTPEQWRSRR SYSCQVMHEG 200
STVEKTVAPA ECS 213
Length:213
Mass (Da):22,963
Last modified:April 1, 1990 - v1
Checksum:i9133A7742B943C79
GO
Isoform 2 (identifier: P15814-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-213: FLLQRGSWTG...EKTVAPAECS → SAQGHPLGHSVPAVL

Note: No experimental confirmation available.

Show »
Length:84
Mass (Da):8,574
Checksum:i60CEE4A92442032A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201P → L.
Corresponds to variant rs1064425 [ dbSNP | Ensembl ].
VAR_049878
Natural varianti142 – 1421P → L in AGM2. 1 Publication
Corresponds to variant rs1064422 [ dbSNP | Ensembl ].
VAR_034869
Natural varianti189 – 1891R → H.
Corresponds to variant rs8138122 [ dbSNP | Ensembl ].
VAR_059392

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 213144FLLQR…PAECS → SAQGHPLGHSVPAVL in isoform 2.
VSP_042748Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27749 mRNA. Translation: AAA36100.1.
M34513, M34511, M34512 Genomic DNA. Translation: AAA36096.1.
AP000345 Genomic DNA. No translation available.
BC030239 mRNA. Translation: AAH30239.2.
BC012293 mRNA. Translation: AAH12293.1.
X03528 Genomic DNA. Translation: CAA27229.1.
X03530 Genomic DNA. Translation: CAA27231.1.
CCDSiCCDS13809.1. [P15814-1]
CCDS13810.1. [P15814-2]
PIRiA33911.
RefSeqiNP_064455.1. NM_020070.3. [P15814-1]
NP_690594.1. NM_152855.2. [P15814-2]
UniGeneiHs.348935.

Genome annotation databases

EnsembliENST00000249053; ENSP00000249053; ENSG00000128322. [P15814-2]
ENST00000330377; ENSP00000329312; ENSG00000128322. [P15814-1]
GeneIDi3543.
KEGGihsa:3543.
UCSCiuc002zxd.3. human. [P15814-1]
uc002zxe.3. human. [P15814-2]

Polymorphism databases

DMDMi123944.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

IGLL1base

IGLL1 mutation db

Wikipedia

IGLL1

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27749 mRNA. Translation: AAA36100.1 .
M34513 , M34511 , M34512 Genomic DNA. Translation: AAA36096.1 .
AP000345 Genomic DNA. No translation available.
BC030239 mRNA. Translation: AAH30239.2 .
BC012293 mRNA. Translation: AAH12293.1 .
X03528 Genomic DNA. Translation: CAA27229.1 .
X03530 Genomic DNA. Translation: CAA27231.1 .
CCDSi CCDS13809.1. [P15814-1 ]
CCDS13810.1. [P15814-2 ]
PIRi A33911.
RefSeqi NP_064455.1. NM_020070.3. [P15814-1 ]
NP_690594.1. NM_152855.2. [P15814-2 ]
UniGenei Hs.348935.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2H32 X-ray 2.70 B 93-213 [» ]
2H3N X-ray 2.30 B/D 94-209 [» ]
2LKQ NMR - A 59-82 [» ]
ProteinModelPortali P15814.
SMRi P15814. Positions 13-212.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109759. 1 interaction.
IntActi P15814. 5 interactions.
MINTi MINT-4657105.
STRINGi 9606.ENSP00000329312.

PTM databases

PhosphoSitei P15814.

Polymorphism databases

DMDMi 123944.

Proteomic databases

MaxQBi P15814.
PaxDbi P15814.
PeptideAtlasi P15814.
PRIDEi P15814.

Protocols and materials databases

DNASUi 3543.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249053 ; ENSP00000249053 ; ENSG00000128322 . [P15814-2 ]
ENST00000330377 ; ENSP00000329312 ; ENSG00000128322 . [P15814-1 ]
GeneIDi 3543.
KEGGi hsa:3543.
UCSCi uc002zxd.3. human. [P15814-1 ]
uc002zxe.3. human. [P15814-2 ]

Organism-specific databases

CTDi 3543.
GeneCardsi GC22M023915.
HGNCi HGNC:5870. IGLL1.
MIMi 146770. gene.
613500. phenotype.
neXtProti NX_P15814.
Orphaneti 33110. Autosomal agammaglobulinemia.
PharmGKBi PA29756.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46716.
HOGENOMi HOG000113013.
HOVERGENi HBG039526.
InParanoidi P15814.
KOi K06554.
OMAi KHNSVTH.
OrthoDBi EOG7X0VQW.
PhylomeDBi P15814.
TreeFami TF335549.

Miscellaneous databases

EvolutionaryTracei P15814.
GeneWikii IGLL1.
GenomeRNAii 3543.
NextBioi 13836.
PROi P15814.
SOURCEi Search...

Gene expression databases

ArrayExpressi P15814.
Bgeei P15814.
CleanExi HS_IGLL1.
Genevestigatori P15814.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein."
    Hollis G.F., Evans R.J., Stafford-Hollis J.M., Korsmeyer S.J., McKearn J.P.
    Proc. Natl. Acad. Sci. U.S.A. 86:5552-5556(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution."
    Evans R.J., Hollis G.F.
    J. Exp. Med. 173:305-311(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lymphoid tissue.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  5. "The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene."
    Schiff C., Bensmana M., Guglielmi P., Milili M., Lefranc M.-P., Fougereau M.
    Int. Immunol. 2:201-207(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-193, TISSUE SPECIFICITY.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-213.
  7. "Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia."
    Minegishi Y., Coustan-Smith E., Wang Y.H., Cooper M.D., Campana D., Conley M.E.
    J. Exp. Med. 187:71-77(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, VARIANT AGM2 LEU-142.
  8. "Structural insight into pre-B cell receptor function."
    Bankovich A.J., Raunser S., Juo Z.S., Walz T., Davis M.M., Garcia K.C.
    Science 316:291-294(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 93-209 IN COMPLEX WITH VPREB1, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiIGLL1_HUMAN
AccessioniPrimary (citable) accession number: P15814
Secondary accession number(s): Q0P681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi