Reviewed, UniProtKB/Swiss-Prot P15812 (CD1E_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell surface glycoprotein CD1e, membrane-associated
      Short name=mCD1e
Alternative name(s):
    R2G1
    CD_antigen=CD1e
Cleaved into the following chain:
    1- Recommended name:
            T-cell surface glycoprotein CD1e, soluble
                Short name=sCD1e

Gene names

Name:

CD1E

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	T-cell surface glycoprotein CD1e, soluble is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. Ref.2 Ref.10
Subunit structure	Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.
Subcellular location	T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note: Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells. Ref.2 Ref.11 Ref.12 T-cell surface glycoprotein CD1e, soluble: Lysosome lumen.
Tissue specificity	Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues. Ref.2
Post-translational modification	Mono-ubiquitinated. Proteolytically cleaved in late endosomes to yield a soluble form. Ref.2 Ref.11 Ref.12
Polymorphism	Six alleles of CD1E are known. CD1E*01 has His-102/Glu-106/Ser-149/Arg-164/Leu-194, CD1E*02 has His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Glu-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has His-102/Glu-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has His-102/Arg-106/Asn-149/Arg-164/Leu-194. The sequence shown is that of allele CD1E*01.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.
Sequence caution	The sequence CAA33100.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Immune response
Cellular component	Endosome Golgi apparatus Lysosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation Inferred from electronic annotation. Source: InterPro immune response Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW early endosome Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Ref.1 Non-traceable author statement. Source: UniProtKB late endosome Inferred from electronic annotation. Source: UniProtKB-SubCell lysosome Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 12 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P15812-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P15812-2)

The sequence of this isoform differs from the canonical sequence as follows:
     334-345: Missing.

Isoform 3 (identifier: P15812-3)

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Isoform 4 (identifier: P15812-4)

The sequence of this isoform differs from the canonical sequence as follows:
     248-302: Missing.
     334-345: Missing.

Isoform 5 (identifier: P15812-5)

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L

Isoform 6 (identifier: P15812-6)

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     334-345: Missing.

Isoform 7 (identifier: P15812-7)

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     248-302: Missing.
     334-345: Missing.

Isoform 8 (identifier: P15812-8)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.

Isoform 9 (identifier: P15812-9)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     334-345: Missing.

Isoform 10 (identifier: P15812-10)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Isoform 11 (identifier: P15812-11)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.

Isoform 12 (identifier: P15812-12)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.
     334-345: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 388	369	T-cell surface glycoprotein CD1e, membrane-associated		PRO_0000014582
	Propeptide	20 – 31	12	Removed in sCD1e		PRO_0000379780
	Chain	32 – 388	357	T-cell surface glycoprotein CD1e, soluble		PRO_0000379781
Regions
	Transmembrane	305 – 325	21	Potential
	Domain	191 – 301	111	Ig-like
Amino acid modifications
	Glycosylation	47	1	N-linked (GlcNAc...) Potential
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Disulfide bond	230 ↔ 285		By similarity
Natural variations
	Alternative sequence	20 – 208	189	Missing in isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12.		VSP_037708
	Alternative sequence	119 – 209	91	YPFEI…LKRKV → L in isoform 5, isoform 6 and isoform 7.		VSP_037709
	Alternative sequence	248 – 302	55	Missing in isoform 4, isoform 7, isoform 11 and isoform 12.		VSP_037710
	Alternative sequence	268 – 290	23	YLRAT…RVKHS → WIFHLSHPDLFDCDSYPGHI GCS in isoform 3 and isoform 10.		VSP_037711
	Alternative sequence	291 – 388	98	Missing in isoform 3 and isoform 10.		VSP_037712
	Alternative sequence	334 – 345	12	Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 9 and isoform 12.		VSP_037713
	Natural variant	15	1	G → E: dbSNP rs3180089.		VAR_056035
	Natural variant	102	1	H → R in allele CD1E*05. dbSNP rs2873587. Ref.7		VAR_058324
	Natural variant	106	1	Q → R in allele CD1E*02, allele CD1E*05 and CD1E*06. dbSNP rs1065457. Ref.2 Ref.7 Ref.6		VAR_010191
	Natural variant	149	1	S → N in allele CD1E*05. dbSNP rs35116276.		VAR_058325
	Natural variant	164	1	R → W in allele CD1E*03. Ref.7 Ref.8		VAR_010192
	Natural variant	194	1	L → P in allele CD1E*04; impairs localization to late endosomal compartments and lipid antigen presentation. Ref.8 Ref.13		VAR_010193
Experimental info
	Sequence conflict	209	1	V → A in BAG64215. Ref.3
	Sequence conflict	248	1	E → G in BAG64215. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 28, 2009. Version 2. Checksum: F6503AE9608C6568	FASTA	388	43,626
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 130 140 150 160 170 180 FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 190 200 210 220 230 240 ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 250 260 270 280 290 300 WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 310 320 330 340 350 360 WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM GANTQDTKNS 370 380 RHQFCLAQVS WIKNRVLKKW KTRLNQLW
	Isoform 2. Checksum: 52F553915C2B64C6	FASTA	376	42,350
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 130 140 150 160 170 180 FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 190 200 210 220 230 240 ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 250 260 270 280 290 300 WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 310 320 330 340 350 360 WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSPVFLMGA NTQDTKNSRH QFCLAQVSWI 370 KNRVLKKWKT RLNQLW
	Isoform 3. Checksum: 424FE9E60BE8A14C	FASTA	290	32,724
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 130 140 150 160 170 180 FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 190 200 210 220 230 240 ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 250 260 270 280 290 WVMWMRGEQE QRGTQRGDVL PNADETWWIF HLSHPDLFDC DSYPGHIGCS
	Isoform 4. Checksum: 89D16362E367AF3F	FASTA	321	36,381
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 130 140 150 160 170 180 FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 190 200 210 220 230 240 ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 250 260 270 280 290 300 WVMWMRGGYS IFLILICLTV IVTLVILVVV DSRLKKQSPV FLMGANTQDT KNSRHQFCLA 310 320 QVSWIKNRVL KKWKTRLNQL W
	Isoform 5. Checksum: 1F49C172E6EDCDE0	FASTA	298	33,553
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLELK 130 140 150 160 170 180 PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE QRGTQRGDVL PNADETWYLR 190 200 210 220 230 240 ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK 250 260 270 280 290 KQSSNKNILS PHTPSPVFLM GANTQDTKNS RHQFCLAQVS WIKNRVLKKW KTRLNQLW
	Isoform 6. Checksum: 87E830F20FD041B0	FASTA	286	32,276
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLELK 130 140 150 160 170 180 PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE QRGTQRGDVL PNADETWYLR 190 200 210 220 230 240 ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK 250 260 270 280 KQSPVFLMGA NTQDTKNSRH QFCLAQVSWI KNRVLKKWKT RLNQLW
	Isoform 7. Checksum: 453FEB8FE4A34853	FASTA	231	26,308
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLELK 130 140 150 160 170 180 PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGGYS IFLILICLTV IVTLVILVVV 190 200 210 220 230 DSRLKKQSPV FLMGANTQDT KNSRHQFCLA QVSWIKNRVL KKWKTRLNQL W
	Isoform 8. Checksum: 51D51CBAF23FA31E	FASTA	199	22,263
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGEQ 70 80 90 100 110 120 EQRGTQRGDV LPNADETWYL RATLDVAAGE AAGLSCRVKH SSLGGHDLII HWGGYSIFLI 130 140 150 160 170 180 LICLTVIVTL VILVVVDSRL KKQSSNKNIL SPHTPSPVFL MGANTQDTKN SRHQFCLAQV 190 SWIKNRVLKK WKTRLNQLW
	Isoform 9. Checksum: DB1402070352AEF8	FASTA	187	20,987
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGEQ 70 80 90 100 110 120 EQRGTQRGDV LPNADETWYL RATLDVAAGE AAGLSCRVKH SSLGGHDLII HWGGYSIFLI 130 140 150 160 170 180 LICLTVIVTL VILVVVDSRL KKQSPVFLMG ANTQDTKNSR HQFCLAQVSW IKNRVLKKWK TRLNQLW
	Isoform 10. Checksum: 41978EA9D317C67E	FASTA	101	11,361
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGEQ 70 80 90 100 EQRGTQRGDV LPNADETWWI FHLSHPDLFD CDSYPGHIGC S
	Isoform 11. Checksum: D433B9593AE045AB	FASTA	144	16,294
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGGY 70 80 90 100 110 120 SIFLILICLT VIVTLVILVV VDSRLKKQSS NKNILSPHTP SPVFLMGANT QDTKNSRHQF 130 140 CLAQVSWIKN RVLKKWKTRL NQLW
	Isoform 12. Checksum: 146E065421A1E709	FASTA	132	15,018
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGGY 70 80 90 100 110 120 SIFLILICLT VIVTLVILVV VDSRLKKQSP VFLMGANTQD TKNSRHQFCL AQVSWIKNRV 130 LKKWKTRLNQ LW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two classes of CD1 genes." Calabi F., Jarvis J.M., Martin L., Milstein C. Eur. J. Immunol. 19:285-292(1989) [PubMed: 2467814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells." Angenieux C., Salamero J., Fricker D., Cazenave J.-P., Goud B., Hanau D., de La Salle H. J. Biol. Chem. 275:37757-37764(2000) [PubMed: 10948205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11 AND 12), VARIANT ARG-106, FUNCTION, INTERACTION WITH B2M, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thymus.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE CD1E*01).
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES CD1E*01).
[6]	"Polymorphism of human CD1 genes." Han M., Hannick L.I., DiBrino M., Robinson M.A. Tissue Antigens 54:122-127(1999) [PubMed: 10488738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-118, VARIANT ARG-106.
[7]	"Two novel CD1 E alleles identified in black African individuals." Tamouza R., Sghiri R., Ramasawmy R., Neonato M.G., Mombo L.E., Poirier J.C., Schaeffer V., Fortier C., Labie D., Girot R., Toubert A., Krishnamoorthy R., Charron D. Tissue Antigens 59:417-420(2002) [PubMed: 12144626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-208 (ALLELES CD1E*05 AND CD1E*06), VARIANTS ARG-102; ARG-106; ASN-149 AND TRP-164.
[8]	"Identification of two novel human CD1E alleles." Mirones I., Oteo M., Parra-Cuadrado J.F., Martinez-Naves E. Tissue Antigens 56:159-161(2000) [PubMed: 11019917] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-208 (ALLELES CD1E*03 AND CD1E*04), VARIANTS TRP-164 AND PRO-194.
[9]	"Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens." Martin L.H., Calabi F., Milstein C. Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed: 3097645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-301.
[10]	"Assistance of microbial glycolipid antigen processing by CD1e." de la Salle H., Mariotti S., Angenieux C., Gilleron M., Garcia-Alles L.-F., Malm D., Berg T., Paoletti S., Maitre B., Mourey L., Salamero J., Cazenave J.-P., Hanau D., Mori L., Puzo G., De Libero G. Science 310:1321-1324(2005) [PubMed: 16311334] [Abstract] Cited for: FUNCTION.
[11]	"Control of the intracellular pathway of CD1e." Maitre B., Angenieux C., Salamero J., Hanau D., Fricker D., Signorino F., Proamer F., Cazenave J.-P., Goud B., Tourne S., de la Salle H. Traffic 9:431-445(2008) [PubMed: 18208508] [Abstract] Cited for: SUBCELLULAR LOCATION, UBIQUITINATION, PROTEOLYTIC PROCESSING.
[12]	"The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments." Maitre B., Angenieux C., Wurtz V., Layre E., Gilleron M., Collmann A., Mariotti S., Mori L., Fricker D., Cazenave J.P., van Dorsselaer A., Gachet C., de Libero G., Puzo G., Hanau D., de la Salle H. Biochem. J. 419:661-668(2009) [PubMed: 19196239] [Abstract] Cited for: PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION.
[13]	"A naturally occurring mutation in CD1e impairs lipid antigen presentation." Tourne S., Maitre B., Collmann A., Layre E., Mariotti S., Signorino-Gelo F., Loch C., Salamero J., Gilleron M., Angenieux C., Cazenave J.P., Mori L., Hanau D., Puzo G., De Libero G., de la Salle H. J. Immunol. 180:3642-3646(2008) [PubMed: 18325888] [Abstract] Cited for: POLYMORPHISM, VARIANT PRO-194.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X14975 Genomic DNA. Translation: CAA33100.1. Sequence problems. AJ289111 mRNA. Translation: CAB93150.1. AJ289112 mRNA. Translation: CAB93151.1. AJ289113 mRNA. Translation: CAB93152.1. AJ289114 mRNA. Translation: CAB93153.1. AJ289115 mRNA. Translation: CAB93154.1. AJ289116 mRNA. Translation: CAB93155.1. AJ289117 mRNA. Translation: CAB93156.1. AJ289118 mRNA. Translation: CAB93157.1. AJ289119 mRNA. Translation: CAB93158.1. AJ289120 mRNA. Translation: CAB93159.1. AJ289121 mRNA. Translation: CAB93160.1. AJ289122 mRNA. Translation: CAB93161.1. AK303108 mRNA. Translation: BAG64215.1. AL121986 Genomic DNA. Translation: CAI10854.1. AL121986 Genomic DNA. Translation: CAI10855.1. AL121986 Genomic DNA. Translation: CAI10856.1. AL121986 Genomic DNA. Translation: CAI10857.1. AL121986 Genomic DNA. Translation: CAI10858.1. AL121986 Genomic DNA. Translation: CAI10859.1. AL121986 Genomic DNA. Translation: CAI10860.1. AL121986 Genomic DNA. Translation: CAI10861.1. AL121986 Genomic DNA. Translation: CAI10862.1. AL121986 Genomic DNA. Translation: CAI10863.1. AL121986 Genomic DNA. Translation: CAI10864.1. AL121986 Genomic DNA. Translation: CAI10865.1. CH471121 Genomic DNA. Translation: EAW52828.1. CH471121 Genomic DNA. Translation: EAW52830.1. CH471121 Genomic DNA. Translation: EAW52831.1. CH471121 Genomic DNA. Translation: EAW52832.1. CH471121 Genomic DNA. Translation: EAW52833.1. CH471121 Genomic DNA. Translation: EAW52834.1. CH471121 Genomic DNA. Translation: EAW52835.1. CH471121 Genomic DNA. Translation: EAW52837.1. CH471121 Genomic DNA. Translation: EAW52838.1. CH471121 Genomic DNA. Translation: EAW52839.1. CH471121 Genomic DNA. Translation: EAW52840.1. AF142669 Genomic DNA. Translation: AAD37582.1. AF364032, AF364031 Genomic DNA. Translation: AAK52913.1. AF364034, AF364033 Genomic DNA. Translation: AAK52914.1. AJ251334 Genomic DNA. Translation: CAB82829.1. AJ251335 Genomic DNA. Translation: CAC07175.1. M14666 Genomic DNA. Translation: AAA51937.1.
IPI	IPI00418592. IPI00427974. IPI00427982. IPI00427983. IPI00477640. IPI00478106. IPI00552171. IPI00642364. IPI00644470. IPI00645910. IPI00646173. IPI00647002.
PIR	HLHUR2. S07716.
RefSeq	NP_001036048.1. NP_001036049.1. NP_001036050.1. NP_001036051.1. NP_001036052.1. NP_112155.2.
UniGene	Hs.249217
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P15812.
Proteomic databases
PRIDE	P15812.
Genome annotation databases
Ensembl	ENST00000368167; ENSP00000357149; ENSG00000158488; Homo sapiens. [Genome view]
GeneID	913.
KEGG	hsa:913.
Organism-specific databases
CTD	913.
GeneCards	GC01P156590.
HGNC	HGNC:1638. CD1E.
MIM	188411. gene.
PharmGKB	PA26197.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P15812.
Gene expression databases
ArrayExpress	P15812.
Bgee	P15812.
CleanEx	HS_CD1E.
Genevestigator	P15812.
GermOnline	ENSG00000158488. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. [Graphical view]
SMART	SM00407. IGc1. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CD1E_HUMAN

Accession

Primary (citable) accession number: P15812
Secondary accession number(s): B4DZV3 , Q5TDJ9, Q5TDK3, Q5TDK4, Q5TDK5, Q5TDK6, Q5TDK8, Q5TDL1, Q712E4, Q712E5, Q712E6, Q712E7, Q712E8, Q712E9, Q712F0, Q712F1, Q712F2, Q712F3, Q712F4, Q712F5, Q96TD0, Q96TD1, Q9UMM1, Q9Y5M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	July 28, 2009
Last modified:	November 24, 2009
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.