P15812 (CD1E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell surface glycoprotein CD1e, membrane-associated
Short name=hCD1e

Alternative name(s):
R2G1
CD_antigen=CD1e

Cleaved into the following chain:

1. T-cell surface glycoprotein CD1e, soluble
   Short name=sCD1e

Gene names

Name:

CD1E

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	T-cell surface glycoprotein CD1e, soluble is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. Ref.2 Ref.10
Subunit structure	Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.
Subcellular location	T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note: Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells. Ref.2 Ref.11 Ref.12 T-cell surface glycoprotein CD1e, soluble: Lysosome lumen Ref.2 Ref.11 Ref.12.
Tissue specificity	Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues. Ref.2
Post-translational modification	Mono-ubiquitinated. Proteolytically cleaved in late endosomes to yield a soluble form. Ref.2 Ref.11 Ref.12
Polymorphism	Six alleles of CD1E are known. CD1E*01 has His-102/Gln-106/Ser-149/Arg-164/Leu-194, CD1E*02 has His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Gln-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has His-102/Gln-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has His-102/Arg-106/Asn-149/Arg-164/Leu-194. The sequence shown is that of allele CD1E*01.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.
Sequence caution	The sequence CAA33100.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Endosome Golgi apparatus Lysosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation Inferred from electronic annotation. Source: InterPro immune response Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell early endosome Inferred from electronic annotation. Source: UniProtKB-SubCell integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB late endosome Inferred from electronic annotation. Source: UniProtKB-SubCell lysosomal lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 12 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P15812-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P15812-2)

The sequence of this isoform differs from the canonical sequence as follows:
     334-345: Missing.

Isoform 3 (identifier: P15812-3)

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Isoform 4 (identifier: P15812-4)

The sequence of this isoform differs from the canonical sequence as follows:
     248-302: Missing.
     334-345: Missing.

Isoform 5 (identifier: P15812-5)

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L

Isoform 6 (identifier: P15812-6)

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     334-345: Missing.

Isoform 7 (identifier: P15812-7)

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     248-302: Missing.
     334-345: Missing.

Isoform 8 (identifier: P15812-8)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.

Isoform 9 (identifier: P15812-9)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     334-345: Missing.

Isoform 10 (identifier: P15812-10)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Isoform 11 (identifier: P15812-11)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.

Isoform 12 (identifier: P15812-12)

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.
     334-345: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Potential

Chain

20 – 388

369

T-cell surface glycoprotein CD1e, membrane-associated

PRO_0000014582

Propeptide

20 – 31

12

Removed in sCD1e

PRO_0000379780

Chain

32 – 388

357

T-cell surface glycoprotein CD1e, soluble

PRO_0000379781

Regions

Transmembrane

305 – 325

21

Helical; Potential

Domain

191 – 301

111

Ig-like

Amino acid modifications

Glycosylation

47

1

N-linked (GlcNAc...) Potential

Glycosylation

84

1

N-linked (GlcNAc...) Potential

Disulfide bond

230 ↔ 285

By similarity

Natural variations

Alternative sequence

20 – 208

189

Missing in isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12.

VSP_037708

Alternative sequence

119 – 209

91

YPFEI…LKRKV → L in isoform 5, isoform 6 and isoform 7.

VSP_037709

Alternative sequence

248 – 302

55

Missing in isoform 4, isoform 7, isoform 11 and isoform 12.

VSP_037710

Alternative sequence

268 – 290

23

YLRAT…RVKHS → WIFHLSHPDLFDCDSYPGHI GCS in isoform 3 and isoform 10.

VSP_037711

Alternative sequence

291 – 388

98

Missing in isoform 3 and isoform 10.

VSP_037712

Alternative sequence

334 – 345

12

Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 9 and isoform 12.

VSP_037713

Natural variant

15

1

G → E.
Corresponds to variant rs3180089 [ dbSNP | Ensembl ].

VAR_056035

Natural variant

102

1

H → R in allele CD1E*05. Ref.7
Corresponds to variant rs2873587 [ dbSNP | Ensembl ].

VAR_058324

Natural variant

106

1

Q → R in allele CD1E*02, allele CD1E*05 and CD1E*06. Ref.2 Ref.6 Ref.7
Corresponds to variant rs1065457 [ dbSNP | Ensembl ].

VAR_010191

Natural variant

149

1

S → N in allele CD1E*05. Ref.7
Corresponds to variant rs35116276 [ dbSNP | Ensembl ].

VAR_058325

Natural variant

164

1

R → W in allele CD1E*03. Ref.7 Ref.8

VAR_010192

Natural variant

194

1

L → P in allele CD1E*04; impairs localization to late endosomal compartments and lipid antigen presentation. Ref.8 Ref.13

VAR_010193

Experimental info

Sequence conflict

209

1

V → A in BAG64215. Ref.3

Sequence conflict

248

1

E → G in BAG64215. Ref.3

Secondary structure

1

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388

Helix Strand Turn

Details...

Beta strand

37 – 46

10

Beta strand

52 – 59

8

Beta strand

62 – 68

7

Turn

69 – 72

4

Beta strand

73 – 75

3

Helix

79 – 82

4

Helix

87 – 111

25

Turn

112 – 116

5

Beta strand

119 – 129

11

Beta strand

132 – 134

3

Beta strand

136 – 139

4

Beta strand

142 – 145

4

Turn

159 – 161

3

Helix

163 – 174

12

Helix

176 – 201

26

Turn

202 – 205

4

Beta strand

222 – 224

3

Beta strand

228 – 230

3

Beta strand

232 – 234

3

Beta strand

236 – 238

3

Beta strand

241 – 244

4

Beta strand

260 – 262

3

Turn

263 – 265

3

Beta strand

266 – 269

4

Beta strand

271 – 273

3

Helix

277 – 280

4

Beta strand

285 – 288

4

Turn

290 – 292

3

Beta strand

300 – 302

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 28, 2009. Version 2. Checksum: F6503AE9608C6568	FASTA	388	43,626
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 130 140 150 160 170 180 FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 190 200 210 220 230 240 ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 250 260 270 280 290 300 WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 310 320 330 340 350 360 WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM GANTQDTKNS 370 380 RHQFCLAQVS WIKNRVLKKW KTRLNQLW
	Isoform 2 [UniParc]. Checksum: 52F553915C2B64C6	FASTA	376	42,350
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 130 140 150 160 170 180 FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 190 200 210 220 230 240 ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 250 260 270 280 290 300 WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 310 320 330 340 350 360 WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSPVFLMGA NTQDTKNSRH QFCLAQVSWI 370 KNRVLKKWKT RLNQLW
	Isoform 3 [UniParc]. Checksum: 424FE9E60BE8A14C	FASTA	290	32,724
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 130 140 150 160 170 180 FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 190 200 210 220 230 240 ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 250 260 270 280 290 WVMWMRGEQE QRGTQRGDVL PNADETWWIF HLSHPDLFDC DSYPGHIGCS
	Isoform 4 [UniParc]. Checksum: 89D16362E367AF3F	FASTA	321	36,381
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP 130 140 150 160 170 180 FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE 190 200 210 220 230 240 ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV 250 260 270 280 290 300 WVMWMRGGYS IFLILICLTV IVTLVILVVV DSRLKKQSPV FLMGANTQDT KNSRHQFCLA 310 320 QVSWIKNRVL KKWKTRLNQL W
	Isoform 5 [UniParc]. Checksum: 1F49C172E6EDCDE0	FASTA	298	33,553
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLELK 130 140 150 160 170 180 PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE QRGTQRGDVL PNADETWYLR 190 200 210 220 230 240 ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK 250 260 270 280 290 KQSSNKNILS PHTPSPVFLM GANTQDTKNS RHQFCLAQVS WIKNRVLKKW KTRLNQLW
	Isoform 6 [UniParc]. Checksum: 87E830F20FD041B0	FASTA	286	32,276
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLELK 130 140 150 160 170 180 PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE QRGTQRGDVL PNADETWYLR 190 200 210 220 230 240 ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK 250 260 270 280 KQSPVFLMGA NTQDTKNSRH QFCLAQVSWI KNRVLKKWKT RLNQLW
	Isoform 7 [UniParc]. Checksum: 453FEB8FE4A34853	FASTA	231	26,308
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG 70 80 90 100 110 120 DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLELK 130 140 150 160 170 180 PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGGYS IFLILICLTV IVTLVILVVV 190 200 210 220 230 DSRLKKQSPV FLMGANTQDT KNSRHQFCLA QVSWIKNRVL KKWKTRLNQL W
	Isoform 8 [UniParc]. Checksum: 51D51CBAF23FA31E	FASTA	199	22,263
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGEQ 70 80 90 100 110 120 EQRGTQRGDV LPNADETWYL RATLDVAAGE AAGLSCRVKH SSLGGHDLII HWGGYSIFLI 130 140 150 160 170 180 LICLTVIVTL VILVVVDSRL KKQSSNKNIL SPHTPSPVFL MGANTQDTKN SRHQFCLAQV 190 SWIKNRVLKK WKTRLNQLW
	Isoform 9 [UniParc]. Checksum: DB1402070352AEF8	FASTA	187	20,987
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGEQ 70 80 90 100 110 120 EQRGTQRGDV LPNADETWYL RATLDVAAGE AAGLSCRVKH SSLGGHDLII HWGGYSIFLI 130 140 150 160 170 180 LICLTVIVTL VILVVVDSRL KKQSPVFLMG ANTQDTKNSR HQFCLAQVSW IKNRVLKKWK TRLNQLW
	Isoform 10 [UniParc]. Checksum: 41978EA9D317C67E	FASTA	101	11,361
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGEQ 70 80 90 100 EQRGTQRGDV LPNADETWWI FHLSHPDLFD CDSYPGHIGC S
	Isoform 11 [UniParc]. Checksum: D433B9593AE045AB	FASTA	144	16,294
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGGY 70 80 90 100 110 120 SIFLILICLT VIVTLVILVV VDSRLKKQSS NKNILSPHTP SPVFLMGANT QDTKNSRHQF 130 140 CLAQVSWIKN RVLKKWKTRL NQLW
	Isoform 12 [UniParc]. Checksum: 146E065421A1E709	FASTA	132	15,018
	10 20 30 40 50 60 MLLLFLLFEG LCCPGENTAV KPEAWLSCGP SPGPGRLQLV CHVSGFYPKP VWVMWMRGGY 70 80 90 100 110 120 SIFLILICLT VIVTLVILVV VDSRLKKQSP VFLMGANTQD TKNSRHQFCL AQVSWIKNRV 130 LKKWKTRLNQ LW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two classes of CD1 genes." Calabi F., Jarvis J.M., Martin L., Milstein C. Eur. J. Immunol. 19:285-292(1989) [PubMed: 2467814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells." Angenieux C., Salamero J., Fricker D., Cazenave J.-P., Goud B., Hanau D., de La Salle H. J. Biol. Chem. 275:37757-37764(2000) [PubMed: 10948205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11 AND 12), VARIANT ARG-106, FUNCTION, INTERACTION WITH B2M, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thymus.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE CD1E*01).
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES CD1E*01).
[6]	"Polymorphism of human CD1 genes." Han M., Hannick L.I., DiBrino M., Robinson M.A. Tissue Antigens 54:122-127(1999) [PubMed: 10488738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-118, VARIANT ARG-106.
[7]	"Two novel CD1 E alleles identified in black African individuals." Tamouza R., Sghiri R., Ramasawmy R., Neonato M.G., Mombo L.E., Poirier J.C., Schaeffer V., Fortier C., Labie D., Girot R., Toubert A., Krishnamoorthy R., Charron D. Tissue Antigens 59:417-420(2002) [PubMed: 12144626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-208 (ALLELES CD1E*05 AND CD1E*06), VARIANTS ARG-102; ARG-106; ASN-149 AND TRP-164.
[8]	"Identification of two novel human CD1E alleles." Mirones I., Oteo M., Parra-Cuadrado J.F., Martinez-Naves E. Tissue Antigens 56:159-161(2000) [PubMed: 11019917] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-208 (ALLELES CD1E*03 AND CD1E*04), VARIANTS TRP-164 AND PRO-194.
[9]	"Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens." Martin L.H., Calabi F., Milstein C. Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed: 3097645] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-301.
[10]	"Assistance of microbial glycolipid antigen processing by CD1e." de la Salle H., Mariotti S., Angenieux C., Gilleron M., Garcia-Alles L.-F., Malm D., Berg T., Paoletti S., Maitre B., Mourey L., Salamero J., Cazenave J.-P., Hanau D., Mori L., Puzo G., De Libero G. Science 310:1321-1324(2005) [PubMed: 16311334] [Abstract] Cited for: FUNCTION.
[11]	"Control of the intracellular pathway of CD1e." Maitre B., Angenieux C., Salamero J., Hanau D., Fricker D., Signorino F., Proamer F., Cazenave J.-P., Goud B., Tourne S., de la Salle H. Traffic 9:431-445(2008) [PubMed: 18208508] [Abstract] Cited for: SUBCELLULAR LOCATION, UBIQUITINATION, PROTEOLYTIC PROCESSING.
[12]	"The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments." Maitre B., Angenieux C., Wurtz V., Layre E., Gilleron M., Collmann A., Mariotti S., Mori L., Fricker D., Cazenave J.P., van Dorsselaer A., Gachet C., de Libero G., Puzo G., Hanau D., de la Salle H. Biochem. J. 419:661-668(2009) [PubMed: 19196239] [Abstract] Cited for: PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION.
[13]	"A naturally occurring mutation in CD1e impairs lipid antigen presentation." Tourne S., Maitre B., Collmann A., Layre E., Mariotti S., Signorino-Gelo F., Loch C., Salamero J., Gilleron M., Angenieux C., Cazenave J.P., Mori L., Hanau D., Puzo G., De Libero G., de la Salle H. J. Immunol. 180:3642-3646(2008) [PubMed: 18325888] [Abstract] Cited for: POLYMORPHISM, VARIANT PRO-194.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X14975 Genomic DNA. Translation: CAA33100.1. Sequence problems.
AJ289111 mRNA. Translation: CAB93150.1.
AJ289112 mRNA. Translation: CAB93151.1.
AJ289113 mRNA. Translation: CAB93152.1.
AJ289114 mRNA. Translation: CAB93153.1.
AJ289115 mRNA. Translation: CAB93154.1.
AJ289116 mRNA. Translation: CAB93155.1.
AJ289117 mRNA. Translation: CAB93156.1.
AJ289118 mRNA. Translation: CAB93157.1.
AJ289119 mRNA. Translation: CAB93158.1.
AJ289120 mRNA. Translation: CAB93159.1.
AJ289121 mRNA. Translation: CAB93160.1.
AJ289122 mRNA. Translation: CAB93161.1.
AK303108 mRNA. Translation: BAG64215.1.
AL121986 Genomic DNA. Translation: CAI10854.1.
AL121986 Genomic DNA. Translation: CAI10855.1.
AL121986 Genomic DNA. Translation: CAI10856.1.
AL121986 Genomic DNA. Translation: CAI10857.1.
AL121986 Genomic DNA. Translation: CAI10858.1.
AL121986 Genomic DNA. Translation: CAI10859.1.
AL121986 Genomic DNA. Translation: CAI10860.1.
AL121986 Genomic DNA. Translation: CAI10861.1.
AL121986 Genomic DNA. Translation: CAI10862.1.
AL121986 Genomic DNA. Translation: CAI10863.1.
AL121986 Genomic DNA. Translation: CAI10864.1.
AL121986 Genomic DNA. Translation: CAI10865.1.
CH471121 Genomic DNA. Translation: EAW52828.1.
CH471121 Genomic DNA. Translation: EAW52830.1.
CH471121 Genomic DNA. Translation: EAW52831.1.
CH471121 Genomic DNA. Translation: EAW52832.1.
CH471121 Genomic DNA. Translation: EAW52833.1.
CH471121 Genomic DNA. Translation: EAW52834.1.
CH471121 Genomic DNA. Translation: EAW52835.1.
CH471121 Genomic DNA. Translation: EAW52837.1.
CH471121 Genomic DNA. Translation: EAW52838.1.
CH471121 Genomic DNA. Translation: EAW52839.1.
CH471121 Genomic DNA. Translation: EAW52840.1.
AF142669 Genomic DNA. Translation: AAD37582.1.
AF364032, AF364031 Genomic DNA. Translation: AAK52913.1.
AF364034, AF364033 Genomic DNA. Translation: AAK52914.1.
AJ251334 Genomic DNA. Translation: CAB82829.1.
AJ251335 Genomic DNA. Translation: CAC07175.1.
M14666 Genomic DNA. Translation: AAA51937.1.

IPI

IPI00418592.
IPI00427974.
IPI00427982.
IPI00427983.
IPI00477640.
IPI00478106.
IPI00552171.
IPI00642364.
IPI00644470.
IPI00645910.
IPI00646173.
IPI00647002.

PIR

HLHUR2. S07716.

RefSeq

NP_001036048.1. NM_001042583.2.
NP_001036049.1. NM_001042584.2.
NP_001036050.1. NM_001042585.2.
NP_001036051.1. NM_001042586.2.
NP_001036052.1. NM_001042587.2.
NP_001172036.1. NM_001185107.1.
NP_001172037.1. NM_001185108.1.
NP_001172039.1. NM_001185110.1.
NP_001172041.1. NM_001185112.1.
NP_001172042.1. NM_001185113.1.
NP_001172044.1. NM_001185115.1.
NP_112155.2. NM_030893.3.

UniGene

Hs.249217.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3S6C	X-ray	2.90	A	32-303	[»]

ProteinModelPortal

P15812.

SMR

P15812. Positions 33-336.

ModBase

Search...

Protein-protein interaction databases

STRING

P15812.

Polymorphism databases

DMDM

254763260.

Proteomic databases

PRIDE

P15812.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000368167; ENSP00000357149; ENSG00000158488.

GeneID

913.

KEGG

hsa:913.

Organism-specific databases

CTD

913.

GeneCards

GC01P158323.

HGNC

HGNC:1638. CD1E.

MIM

188411. gene.

neXtProt

NX_P15812.

PharmGKB

PA26197.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG004453.

InParanoid

P15812.

OrthoDB

EOG44XJH1.

Gene expression databases

ArrayExpress

P15812.

Bgee

P15812.

CleanEx

HS_CD1E.

Genevestigator

P15812.

GermOnline

ENSG00000158488. Homo sapiens.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]

Gene3D

G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 2 hits.

KO

K06448.

Pfam

PF07654. C1-set. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

SOURCE

Search...

Entry information

Entry name

CD1E_HUMAN

Accession

Primary (citable) accession number: P15812
Secondary accession number(s): B4DZV3 , Q5TDJ9, Q5TDK3, Q5TDK4, Q5TDK5, Q5TDK6, Q5TDK8, Q5TDL1, Q712E4, Q712E5, Q712E6, Q712E7, Q712E8, Q712E9, Q712F0, Q712F1, Q712F2, Q712F3, Q712F4, Q712F5, Q96TD0, Q96TD1, Q9UMM1, Q9Y5M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	July 28, 2009
Last modified:	January 25, 2012
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.