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Protein

T-cell surface glycoprotein CD1e, membrane-associated

Gene

CD1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1e, membrane-associated
Short name:
hCD1e
Alternative name(s):
R2G1
CD_antigen: CD1e
Cleaved into the following chain:
Gene namesi
Name:CD1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:1638. CD1E.

Subcellular locationi

T-cell surface glycoprotein CD1e, membrane-associated :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • early endosome Source: UniProtKB-SubCell
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: UniProtKB
  • late endosome Source: UniProtKB-SubCell
  • lysosomal lumen Source: UniProtKB-SubCell
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi913.
OpenTargetsiENSG00000158488.
PharmGKBiPA26197.

Polymorphism and mutation databases

BioMutaiCD1E.
DMDMi254763260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001458220 – 388T-cell surface glycoprotein CD1e, membrane-associatedAdd BLAST369
PropeptideiPRO_000037978020 – 31Removed in sCD1eAdd BLAST12
ChainiPRO_000037978132 – 388T-cell surface glycoprotein CD1e, solubleAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi230 ↔ 285PROSITE-ProRule annotation

Post-translational modificationi

Mono-ubiquitinated.1 Publication
Proteolytically cleaved in late endosomes to yield a soluble form.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP15812.
PaxDbiP15812.
PeptideAtlasiP15812.
PRIDEiP15812.

PTM databases

iPTMnetiP15812.
PhosphoSitePlusiP15812.

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.1 Publication

Gene expression databases

BgeeiENSG00000158488.
CleanExiHS_CD1E.
ExpressionAtlasiP15812. baseline and differential.
GenevisibleiP15812. HS.

Organism-specific databases

HPAiHPA057769.

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107351. 28 interactors.
MINTiMINT-4656055.
STRINGi9606.ENSP00000357149.

Structurei

Secondary structure

1388
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 46Combined sources10
Beta strandi52 – 59Combined sources8
Beta strandi62 – 68Combined sources7
Turni69 – 72Combined sources4
Beta strandi73 – 75Combined sources3
Helixi79 – 82Combined sources4
Helixi87 – 111Combined sources25
Turni112 – 116Combined sources5
Beta strandi119 – 129Combined sources11
Beta strandi132 – 134Combined sources3
Beta strandi136 – 139Combined sources4
Beta strandi142 – 145Combined sources4
Turni159 – 161Combined sources3
Helixi163 – 174Combined sources12
Helixi176 – 201Combined sources26
Turni202 – 205Combined sources4
Beta strandi222 – 224Combined sources3
Beta strandi228 – 230Combined sources3
Beta strandi232 – 234Combined sources3
Beta strandi236 – 238Combined sources3
Beta strandi241 – 244Combined sources4
Beta strandi260 – 262Combined sources3
Turni263 – 265Combined sources3
Beta strandi266 – 269Combined sources4
Beta strandi271 – 273Combined sources3
Helixi277 – 280Combined sources4
Beta strandi285 – 288Combined sources4
Turni290 – 292Combined sources3
Beta strandi300 – 302Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S6CX-ray2.90A32-303[»]
ProteinModelPortaliP15812.
SMRiP15812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 301Ig-likeAdd BLAST111

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITU1. Eukaryota.
ENOG4111EG6. LUCA.
GeneTreeiENSGT00480000042665.
HOVERGENiHBG004453.
InParanoidiP15812.
KOiK06448.
OMAiMGANTQD.
OrthoDBiEOG091G0H36.
PhylomeDBiP15812.
TreeFamiTF336723.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P15812-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW
60 70 80 90 100
AHSEGSGWLG DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY
110 120 130 140 150
FHSFIQIVQA SAGQFQLEYP FEIQILAGCR MNAPQIFLNM AYQGSDFLSF
160 170 180 190 200
QGISWEPSPG AGIRAQNICK VLNRYLDIKE ILQSLLGHTC PRFLAGLMEA
210 220 230 240 250
GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE
260 270 280 290 300
QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH
310 320 330 340 350
WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM
360 370 380
GANTQDTKNS RHQFCLAQVS WIKNRVLKKW KTRLNQLW
Length:388
Mass (Da):43,626
Last modified:July 28, 2009 - v2
Checksum:iF6503AE9608C6568
GO
Isoform 2 (identifier: P15812-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-345: Missing.

Show »
Length:376
Mass (Da):42,350
Checksum:i52F553915C2B64C6
GO
Isoform 3 (identifier: P15812-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Show »
Length:290
Mass (Da):32,724
Checksum:i424FE9E60BE8A14C
GO
Isoform 4 (identifier: P15812-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-302: Missing.
     334-345: Missing.

Show »
Length:321
Mass (Da):36,381
Checksum:i89D16362E367AF3F
GO
Isoform 5 (identifier: P15812-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L

Show »
Length:298
Mass (Da):33,553
Checksum:i1F49C172E6EDCDE0
GO
Isoform 6 (identifier: P15812-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     334-345: Missing.

Show »
Length:286
Mass (Da):32,276
Checksum:i87E830F20FD041B0
GO
Isoform 7 (identifier: P15812-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     248-302: Missing.
     334-345: Missing.

Show »
Length:231
Mass (Da):26,308
Checksum:i453FEB8FE4A34853
GO
Isoform 8 (identifier: P15812-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.

Show »
Length:199
Mass (Da):22,263
Checksum:i51D51CBAF23FA31E
GO
Isoform 9 (identifier: P15812-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     334-345: Missing.

Show »
Length:187
Mass (Da):20,987
Checksum:iDB1402070352AEF8
GO
Isoform 10 (identifier: P15812-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Show »
Length:101
Mass (Da):11,361
Checksum:i41978EA9D317C67E
GO
Isoform 11 (identifier: P15812-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.

Show »
Length:144
Mass (Da):16,294
Checksum:iD433B9593AE045AB
GO
Isoform 12 (identifier: P15812-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.
     334-345: Missing.

Show »
Length:132
Mass (Da):15,018
Checksum:i146E065421A1E709
GO
Isoform 13 (identifier: P15812-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-119: APQALQSYHL...ASAGQFQLEY → D

Show »
Length:289
Mass (Da):32,303
Checksum:i4377F02F388916F9
GO

Sequence cautioni

The sequence CAA33100 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209V → A in BAG64215 (PubMed:14702039).Curated1
Sequence conflicti248E → G in BAG64215 (PubMed:14702039).Curated1

Polymorphismi

Six alleles of CD1E are known. CD1E*01 has His-102/Gln-106/Ser-149/Arg-164/Leu-194, CD1E*02 has His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Gln-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has His-102/Gln-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has His-102/Arg-106/Asn-149/Arg-164/Leu-194 (PubMed:12144626, PubMed:11019917, PubMed:18325888). The sequence shown is that of allele CD1E*01.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05603515G → E.Corresponds to variant rs3180089dbSNPEnsembl.1
Natural variantiVAR_058324102H → R in allele CD1E*05. 1 PublicationCorresponds to variant rs2873587dbSNPEnsembl.1
Natural variantiVAR_010191106Q → R in allele CD1E*02, allele CD1E*05 and CD1E*06. 3 PublicationsCorresponds to variant rs1065457dbSNPEnsembl.1
Natural variantiVAR_058325149S → N in allele CD1E*05. 1 PublicationCorresponds to variant rs35116276dbSNPEnsembl.1
Natural variantiVAR_010192164R → W in allele CD1E*03. 2 PublicationsCorresponds to variant rs199655202dbSNPEnsembl.1
Natural variantiVAR_010193194L → P in allele CD1E*04; impairs localization to late endosomal compartments and lipid antigen presentation. 2 PublicationsCorresponds to variant rs200741122dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03770820 – 208Missing in isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_04696120 – 119APQAL…FQLEY → D in isoform 13. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_037709119 – 209YPFEI…LKRKV → L in isoform 5, isoform 6 and isoform 7. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_037710248 – 302Missing in isoform 4, isoform 7, isoform 11 and isoform 12. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_037711268 – 290YLRAT…RVKHS → WIFHLSHPDLFDCDSYPGHI GCS in isoform 3 and isoform 10. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_037712291 – 388Missing in isoform 3 and isoform 10. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_037713334 – 345Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 9 and isoform 12. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14975 Genomic DNA. Translation: CAA33100.1. Sequence problems.
AJ289111 mRNA. Translation: CAB93150.1.
AJ289112 mRNA. Translation: CAB93151.1.
AJ289113 mRNA. Translation: CAB93152.1.
AJ289114 mRNA. Translation: CAB93153.1.
AJ289115 mRNA. Translation: CAB93154.1.
AJ289116 mRNA. Translation: CAB93155.1.
AJ289117 mRNA. Translation: CAB93156.1.
AJ289118 mRNA. Translation: CAB93157.1.
AJ289119 mRNA. Translation: CAB93158.1.
AJ289120 mRNA. Translation: CAB93159.1.
AJ289121 mRNA. Translation: CAB93160.1.
AJ289122 mRNA. Translation: CAB93161.1.
AK303108 mRNA. Translation: BAG64215.1.
AK311643 mRNA. No translation available.
AL121986 Genomic DNA. Translation: CAI10854.1.
AL121986 Genomic DNA. Translation: CAI10855.1.
AL121986 Genomic DNA. Translation: CAI10856.1.
AL121986 Genomic DNA. Translation: CAI10857.1.
AL121986 Genomic DNA. Translation: CAI10858.1.
AL121986 Genomic DNA. Translation: CAI10859.1.
AL121986 Genomic DNA. Translation: CAI10860.1.
AL121986 Genomic DNA. Translation: CAI10861.1.
AL121986 Genomic DNA. Translation: CAI10862.1.
AL121986 Genomic DNA. Translation: CAI10863.1.
AL121986 Genomic DNA. Translation: CAI10864.1.
AL121986 Genomic DNA. Translation: CAI10865.1.
CH471121 Genomic DNA. Translation: EAW52828.1.
CH471121 Genomic DNA. Translation: EAW52830.1.
CH471121 Genomic DNA. Translation: EAW52831.1.
CH471121 Genomic DNA. Translation: EAW52832.1.
CH471121 Genomic DNA. Translation: EAW52833.1.
CH471121 Genomic DNA. Translation: EAW52834.1.
CH471121 Genomic DNA. Translation: EAW52835.1.
CH471121 Genomic DNA. Translation: EAW52837.1.
CH471121 Genomic DNA. Translation: EAW52838.1.
CH471121 Genomic DNA. Translation: EAW52839.1.
CH471121 Genomic DNA. Translation: EAW52840.1.
AF142669 Genomic DNA. Translation: AAD37582.1.
AH010757 Genomic DNA. Translation: AAK52913.1.
AH010758 Genomic DNA. Translation: AAK52914.1.
AJ251334 Genomic DNA. Translation: CAB82829.1.
AJ251335 Genomic DNA. Translation: CAC07175.1.
M14666 Genomic DNA. Translation: AAA51937.1.
CCDSiCCDS41417.1. [P15812-1]
CCDS41418.1. [P15812-2]
CCDS41419.1. [P15812-4]
CCDS41420.1. [P15812-9]
CCDS41421.1. [P15812-3]
CCDS41422.1. [P15812-10]
CCDS53384.1. [P15812-7]
CCDS53385.1. [P15812-5]
CCDS53386.1. [P15812-6]
CCDS53387.1. [P15812-13]
CCDS53388.1. [P15812-11]
CCDS53389.1. [P15812-12]
CCDS53390.1. [P15812-8]
PIRiS07716. HLHUR2.
RefSeqiNP_001036048.1. NM_001042583.2. [P15812-2]
NP_001036049.1. NM_001042584.2. [P15812-3]
NP_001036050.1. NM_001042585.2. [P15812-4]
NP_001036051.1. NM_001042586.2. [P15812-9]
NP_001036052.1. NM_001042587.2. [P15812-10]
NP_001172036.1. NM_001185107.1. [P15812-5]
NP_001172037.1. NM_001185108.1. [P15812-7]
NP_001172039.1. NM_001185110.1. [P15812-12]
NP_001172041.1. NM_001185112.1. [P15812-8]
NP_001172042.1. NM_001185113.1. [P15812-11]
NP_001172043.1. NM_001185114.1. [P15812-13]
NP_001172044.1. NM_001185115.1. [P15812-6]
NP_112155.2. NM_030893.3. [P15812-1]
XP_011508436.1. XM_011510134.2. [P15812-3]
UniGeneiHs.249217.

Genome annotation databases

EnsembliENST00000368154; ENSP00000357136; ENSG00000158488. [P15812-11]
ENST00000368155; ENSP00000357137; ENSG00000158488. [P15812-7]
ENST00000368156; ENSP00000357138; ENSG00000158488. [P15812-6]
ENST00000368157; ENSP00000357139; ENSG00000158488. [P15812-12]
ENST00000368160; ENSP00000357142; ENSG00000158488. [P15812-2]
ENST00000368161; ENSP00000357143; ENSG00000158488. [P15812-3]
ENST00000368163; ENSP00000357145; ENSG00000158488. [P15812-4]
ENST00000368164; ENSP00000357146; ENSG00000158488. [P15812-10]
ENST00000368165; ENSP00000357147; ENSG00000158488. [P15812-5]
ENST00000368166; ENSP00000357148; ENSG00000158488. [P15812-9]
ENST00000368167; ENSP00000357149; ENSG00000158488. [P15812-1]
ENST00000444681; ENSP00000402906; ENSG00000158488. [P15812-13]
ENST00000452291; ENSP00000416228; ENSG00000158488. [P15812-8]
GeneIDi913.
KEGGihsa:913.
UCSCiuc001fry.4. human. [P15812-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14975 Genomic DNA. Translation: CAA33100.1. Sequence problems.
AJ289111 mRNA. Translation: CAB93150.1.
AJ289112 mRNA. Translation: CAB93151.1.
AJ289113 mRNA. Translation: CAB93152.1.
AJ289114 mRNA. Translation: CAB93153.1.
AJ289115 mRNA. Translation: CAB93154.1.
AJ289116 mRNA. Translation: CAB93155.1.
AJ289117 mRNA. Translation: CAB93156.1.
AJ289118 mRNA. Translation: CAB93157.1.
AJ289119 mRNA. Translation: CAB93158.1.
AJ289120 mRNA. Translation: CAB93159.1.
AJ289121 mRNA. Translation: CAB93160.1.
AJ289122 mRNA. Translation: CAB93161.1.
AK303108 mRNA. Translation: BAG64215.1.
AK311643 mRNA. No translation available.
AL121986 Genomic DNA. Translation: CAI10854.1.
AL121986 Genomic DNA. Translation: CAI10855.1.
AL121986 Genomic DNA. Translation: CAI10856.1.
AL121986 Genomic DNA. Translation: CAI10857.1.
AL121986 Genomic DNA. Translation: CAI10858.1.
AL121986 Genomic DNA. Translation: CAI10859.1.
AL121986 Genomic DNA. Translation: CAI10860.1.
AL121986 Genomic DNA. Translation: CAI10861.1.
AL121986 Genomic DNA. Translation: CAI10862.1.
AL121986 Genomic DNA. Translation: CAI10863.1.
AL121986 Genomic DNA. Translation: CAI10864.1.
AL121986 Genomic DNA. Translation: CAI10865.1.
CH471121 Genomic DNA. Translation: EAW52828.1.
CH471121 Genomic DNA. Translation: EAW52830.1.
CH471121 Genomic DNA. Translation: EAW52831.1.
CH471121 Genomic DNA. Translation: EAW52832.1.
CH471121 Genomic DNA. Translation: EAW52833.1.
CH471121 Genomic DNA. Translation: EAW52834.1.
CH471121 Genomic DNA. Translation: EAW52835.1.
CH471121 Genomic DNA. Translation: EAW52837.1.
CH471121 Genomic DNA. Translation: EAW52838.1.
CH471121 Genomic DNA. Translation: EAW52839.1.
CH471121 Genomic DNA. Translation: EAW52840.1.
AF142669 Genomic DNA. Translation: AAD37582.1.
AH010757 Genomic DNA. Translation: AAK52913.1.
AH010758 Genomic DNA. Translation: AAK52914.1.
AJ251334 Genomic DNA. Translation: CAB82829.1.
AJ251335 Genomic DNA. Translation: CAC07175.1.
M14666 Genomic DNA. Translation: AAA51937.1.
CCDSiCCDS41417.1. [P15812-1]
CCDS41418.1. [P15812-2]
CCDS41419.1. [P15812-4]
CCDS41420.1. [P15812-9]
CCDS41421.1. [P15812-3]
CCDS41422.1. [P15812-10]
CCDS53384.1. [P15812-7]
CCDS53385.1. [P15812-5]
CCDS53386.1. [P15812-6]
CCDS53387.1. [P15812-13]
CCDS53388.1. [P15812-11]
CCDS53389.1. [P15812-12]
CCDS53390.1. [P15812-8]
PIRiS07716. HLHUR2.
RefSeqiNP_001036048.1. NM_001042583.2. [P15812-2]
NP_001036049.1. NM_001042584.2. [P15812-3]
NP_001036050.1. NM_001042585.2. [P15812-4]
NP_001036051.1. NM_001042586.2. [P15812-9]
NP_001036052.1. NM_001042587.2. [P15812-10]
NP_001172036.1. NM_001185107.1. [P15812-5]
NP_001172037.1. NM_001185108.1. [P15812-7]
NP_001172039.1. NM_001185110.1. [P15812-12]
NP_001172041.1. NM_001185112.1. [P15812-8]
NP_001172042.1. NM_001185113.1. [P15812-11]
NP_001172043.1. NM_001185114.1. [P15812-13]
NP_001172044.1. NM_001185115.1. [P15812-6]
NP_112155.2. NM_030893.3. [P15812-1]
XP_011508436.1. XM_011510134.2. [P15812-3]
UniGeneiHs.249217.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S6CX-ray2.90A32-303[»]
ProteinModelPortaliP15812.
SMRiP15812.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107351. 28 interactors.
MINTiMINT-4656055.
STRINGi9606.ENSP00000357149.

PTM databases

iPTMnetiP15812.
PhosphoSitePlusiP15812.

Polymorphism and mutation databases

BioMutaiCD1E.
DMDMi254763260.

Proteomic databases

MaxQBiP15812.
PaxDbiP15812.
PeptideAtlasiP15812.
PRIDEiP15812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368154; ENSP00000357136; ENSG00000158488. [P15812-11]
ENST00000368155; ENSP00000357137; ENSG00000158488. [P15812-7]
ENST00000368156; ENSP00000357138; ENSG00000158488. [P15812-6]
ENST00000368157; ENSP00000357139; ENSG00000158488. [P15812-12]
ENST00000368160; ENSP00000357142; ENSG00000158488. [P15812-2]
ENST00000368161; ENSP00000357143; ENSG00000158488. [P15812-3]
ENST00000368163; ENSP00000357145; ENSG00000158488. [P15812-4]
ENST00000368164; ENSP00000357146; ENSG00000158488. [P15812-10]
ENST00000368165; ENSP00000357147; ENSG00000158488. [P15812-5]
ENST00000368166; ENSP00000357148; ENSG00000158488. [P15812-9]
ENST00000368167; ENSP00000357149; ENSG00000158488. [P15812-1]
ENST00000444681; ENSP00000402906; ENSG00000158488. [P15812-13]
ENST00000452291; ENSP00000416228; ENSG00000158488. [P15812-8]
GeneIDi913.
KEGGihsa:913.
UCSCiuc001fry.4. human. [P15812-1]

Organism-specific databases

CTDi913.
DisGeNETi913.
GeneCardsiCD1E.
HGNCiHGNC:1638. CD1E.
HPAiHPA057769.
MIMi188411. gene.
neXtProtiNX_P15812.
OpenTargetsiENSG00000158488.
PharmGKBiPA26197.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITU1. Eukaryota.
ENOG4111EG6. LUCA.
GeneTreeiENSGT00480000042665.
HOVERGENiHBG004453.
InParanoidiP15812.
KOiK06448.
OMAiMGANTQD.
OrthoDBiEOG091G0H36.
PhylomeDBiP15812.
TreeFamiTF336723.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158488-MONOMER.

Miscellaneous databases

GeneWikiiCD1E.
GenomeRNAii913.
PROiP15812.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158488.
CleanExiHS_CD1E.
ExpressionAtlasiP15812. baseline and differential.
GenevisibleiP15812. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16497. MHC_I_3. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD1E_HUMAN
AccessioniPrimary (citable) accession number: P15812
Secondary accession number(s): B4DZV3
, E7EP01, Q5TDJ9, Q5TDK3, Q5TDK4, Q5TDK5, Q5TDK6, Q5TDK8, Q5TDL1, Q712E4, Q712E5, Q712E6, Q712E7, Q712E8, Q712E9, Q712F0, Q712F1, Q712F2, Q712F3, Q712F4, Q712F5, Q96TD0, Q96TD1, Q9UMM1, Q9Y5M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.