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P15812

- CD1E_HUMAN

UniProt

P15812 - CD1E_HUMAN

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Protein
T-cell surface glycoprotein CD1e, membrane-associated
Gene
CD1E
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.3 Publications

GO - Molecular functioni

  1. beta-2-microglobulin binding Source: RefGenome
  2. endogenous lipid antigen binding Source: RefGenome
  3. exogenous lipid antigen binding Source: RefGenome
  4. lipopeptide binding Source: RefGenome

GO - Biological processi

  1. antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: RefGenome
  2. immune response Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1e, membrane-associated
Short name:
hCD1e
Alternative name(s):
R2G1
CD_antigen: CD1e
Cleaved into the following chain:
Gene namesi
Name:CD1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:1638. CD1E.

Subcellular locationi

Chain T-cell surface glycoprotein CD1e, membrane-associated : Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome
Note: Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.3 Publications
Chain T-cell surface glycoprotein CD1e, soluble : Lysosome lumen 3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei305 – 32521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. early endosome Source: UniProtKB-SubCell
  3. integral component of plasma membrane Source: UniProtKB
  4. late endosome Source: UniProtKB-SubCell
  5. lysosomal lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 388369T-cell surface glycoprotein CD1e, membrane-associated
PRO_0000014582Add
BLAST
Propeptidei20 – 3112Removed in sCD1e
PRO_0000379780Add
BLAST
Chaini32 – 388357T-cell surface glycoprotein CD1e, soluble
PRO_0000379781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi230 ↔ 285 By similarity

Post-translational modificationi

Mono-ubiquitinated.
Proteolytically cleaved in late endosomes to yield a soluble form.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP15812.
PaxDbiP15812.
PRIDEiP15812.

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.1 Publication

Gene expression databases

ArrayExpressiP15812.
BgeeiP15812.
CleanExiHS_CD1E.
GenevestigatoriP15812.

Organism-specific databases

HPAiHPA057769.

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.1 Publication

Protein-protein interaction databases

BioGridi107351. 1 interaction.
MINTiMINT-4656055.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 4610
Beta strandi52 – 598
Beta strandi62 – 687
Turni69 – 724
Beta strandi73 – 753
Helixi79 – 824
Helixi87 – 11125
Turni112 – 1165
Beta strandi119 – 12911
Beta strandi132 – 1343
Beta strandi136 – 1394
Beta strandi142 – 1454
Turni159 – 1613
Helixi163 – 17412
Helixi176 – 20126
Turni202 – 2054
Beta strandi222 – 2243
Beta strandi228 – 2303
Beta strandi232 – 2343
Beta strandi236 – 2383
Beta strandi241 – 2444
Beta strandi260 – 2623
Turni263 – 2653
Beta strandi266 – 2694
Beta strandi271 – 2733
Helixi277 – 2804
Beta strandi285 – 2884
Turni290 – 2923
Beta strandi300 – 3023

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S6CX-ray2.90A32-303[»]
ProteinModelPortaliP15812.
SMRiP15812. Positions 33-308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini191 – 301111Ig-like
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26626.
HOVERGENiHBG004453.
InParanoidiP15812.
KOiK06448.
OrthoDBiEOG7DZ8K9.
PhylomeDBiP15812.
TreeFamiTF336723.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (13)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 13 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P15812-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW    50
AHSEGSGWLG DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY 100
FHSFIQIVQA SAGQFQLEYP FEIQILAGCR MNAPQIFLNM AYQGSDFLSF 150
QGISWEPSPG AGIRAQNICK VLNRYLDIKE ILQSLLGHTC PRFLAGLMEA 200
GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE 250
QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 300
WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM 350
GANTQDTKNS RHQFCLAQVS WIKNRVLKKW KTRLNQLW 388
Length:388
Mass (Da):43,626
Last modified:July 28, 2009 - v2
Checksum:iF6503AE9608C6568
GO
Isoform 2 (identifier: P15812-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     334-345: Missing.

Show »
Length:376
Mass (Da):42,350
Checksum:i52F553915C2B64C6
GO
Isoform 3 (identifier: P15812-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Show »
Length:290
Mass (Da):32,724
Checksum:i424FE9E60BE8A14C
GO
Isoform 4 (identifier: P15812-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-302: Missing.
     334-345: Missing.

Show »
Length:321
Mass (Da):36,381
Checksum:i89D16362E367AF3F
GO
Isoform 5 (identifier: P15812-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L

Show »
Length:298
Mass (Da):33,553
Checksum:i1F49C172E6EDCDE0
GO
Isoform 6 (identifier: P15812-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     334-345: Missing.

Show »
Length:286
Mass (Da):32,276
Checksum:i87E830F20FD041B0
GO
Isoform 7 (identifier: P15812-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-209: YPFEIQILAG...AGESELKRKV → L
     248-302: Missing.
     334-345: Missing.

Show »
Length:231
Mass (Da):26,308
Checksum:i453FEB8FE4A34853
GO
Isoform 8 (identifier: P15812-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.

Show »
Length:199
Mass (Da):22,263
Checksum:i51D51CBAF23FA31E
GO
Isoform 9 (identifier: P15812-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     334-345: Missing.

Show »
Length:187
Mass (Da):20,987
Checksum:iDB1402070352AEF8
GO
Isoform 10 (identifier: P15812-10) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
     291-388: Missing.

Show »
Length:101
Mass (Da):11,361
Checksum:i41978EA9D317C67E
GO
Isoform 11 (identifier: P15812-11) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.

Show »
Length:144
Mass (Da):16,294
Checksum:iD433B9593AE045AB
GO
Isoform 12 (identifier: P15812-12) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-208: Missing.
     248-302: Missing.
     334-345: Missing.

Show »
Length:132
Mass (Da):15,018
Checksum:i146E065421A1E709
GO
Isoform 13 (identifier: P15812-13) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-119: APQALQSYHL...ASAGQFQLEY → D

Show »
Length:289
Mass (Da):32,303
Checksum:i4377F02F388916F9
GO

Sequence cautioni

The sequence CAA33100.1 differs from that shown. Reason: Erroneous gene model prediction.

Polymorphismi

Six alleles of CD1E are known. CD1E*01 has His-102/Gln-106/Ser-149/Arg-164/Leu-194, CD1E*02 has His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Gln-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has His-102/Gln-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has His-102/Arg-106/Asn-149/Arg-164/Leu-194. The sequence shown is that of allele CD1E*01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151G → E.
Corresponds to variant rs3180089 [ dbSNP | Ensembl ].
VAR_056035
Natural varianti102 – 1021H → R in allele CD1E*05. 1 Publication
Corresponds to variant rs2873587 [ dbSNP | Ensembl ].
VAR_058324
Natural varianti106 – 1061Q → R in allele CD1E*02, allele CD1E*05 and CD1E*06. 3 Publications
Corresponds to variant rs1065457 [ dbSNP | Ensembl ].
VAR_010191
Natural varianti149 – 1491S → N in allele CD1E*05. 1 Publication
Corresponds to variant rs35116276 [ dbSNP | Ensembl ].
VAR_058325
Natural varianti164 – 1641R → W in allele CD1E*03. 2 Publications
VAR_010192
Natural varianti194 – 1941L → P in allele CD1E*04; impairs localization to late endosomal compartments and lipid antigen presentation. 2 Publications
Corresponds to variant rs200741122 [ dbSNP | Ensembl ].
VAR_010193

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 208189Missing in isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12.
VSP_037708Add
BLAST
Alternative sequencei20 – 119100APQAL…FQLEY → D in isoform 13.
VSP_046961Add
BLAST
Alternative sequencei119 – 20991YPFEI…LKRKV → L in isoform 5, isoform 6 and isoform 7.
VSP_037709Add
BLAST
Alternative sequencei248 – 30255Missing in isoform 4, isoform 7, isoform 11 and isoform 12.
VSP_037710Add
BLAST
Alternative sequencei268 – 29023YLRAT…RVKHS → WIFHLSHPDLFDCDSYPGHI GCS in isoform 3 and isoform 10.
VSP_037711Add
BLAST
Alternative sequencei291 – 38898Missing in isoform 3 and isoform 10.
VSP_037712Add
BLAST
Alternative sequencei334 – 34512Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 9 and isoform 12.
VSP_037713Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091V → A in BAG64215. 1 Publication
Sequence conflicti248 – 2481E → G in BAG64215. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14975 Genomic DNA. Translation: CAA33100.1. Sequence problems.
AJ289111 mRNA. Translation: CAB93150.1.
AJ289112 mRNA. Translation: CAB93151.1.
AJ289113 mRNA. Translation: CAB93152.1.
AJ289114 mRNA. Translation: CAB93153.1.
AJ289115 mRNA. Translation: CAB93154.1.
AJ289116 mRNA. Translation: CAB93155.1.
AJ289117 mRNA. Translation: CAB93156.1.
AJ289118 mRNA. Translation: CAB93157.1.
AJ289119 mRNA. Translation: CAB93158.1.
AJ289120 mRNA. Translation: CAB93159.1.
AJ289121 mRNA. Translation: CAB93160.1.
AJ289122 mRNA. Translation: CAB93161.1.
AK303108 mRNA. Translation: BAG64215.1.
AK311643 mRNA. No translation available.
AL121986 Genomic DNA. Translation: CAI10854.1.
AL121986 Genomic DNA. Translation: CAI10855.1.
AL121986 Genomic DNA. Translation: CAI10856.1.
AL121986 Genomic DNA. Translation: CAI10857.1.
AL121986 Genomic DNA. Translation: CAI10858.1.
AL121986 Genomic DNA. Translation: CAI10859.1.
AL121986 Genomic DNA. Translation: CAI10860.1.
AL121986 Genomic DNA. Translation: CAI10861.1.
AL121986 Genomic DNA. Translation: CAI10862.1.
AL121986 Genomic DNA. Translation: CAI10863.1.
AL121986 Genomic DNA. Translation: CAI10864.1.
AL121986 Genomic DNA. Translation: CAI10865.1.
CH471121 Genomic DNA. Translation: EAW52828.1.
CH471121 Genomic DNA. Translation: EAW52830.1.
CH471121 Genomic DNA. Translation: EAW52831.1.
CH471121 Genomic DNA. Translation: EAW52832.1.
CH471121 Genomic DNA. Translation: EAW52833.1.
CH471121 Genomic DNA. Translation: EAW52834.1.
CH471121 Genomic DNA. Translation: EAW52835.1.
CH471121 Genomic DNA. Translation: EAW52837.1.
CH471121 Genomic DNA. Translation: EAW52838.1.
CH471121 Genomic DNA. Translation: EAW52839.1.
CH471121 Genomic DNA. Translation: EAW52840.1.
AF142669 Genomic DNA. Translation: AAD37582.1.
AH010757 Genomic DNA. Translation: AAK52913.1.
AH010758 Genomic DNA. Translation: AAK52914.1.
AJ251334 Genomic DNA. Translation: CAB82829.1.
AJ251335 Genomic DNA. Translation: CAC07175.1.
M14666 Genomic DNA. Translation: AAA51937.1.
CCDSiCCDS41417.1. [P15812-1]
CCDS41418.1. [P15812-2]
CCDS41419.1. [P15812-4]
CCDS41420.1. [P15812-9]
CCDS41421.1. [P15812-3]
CCDS41422.1. [P15812-10]
CCDS53384.1. [P15812-7]
CCDS53385.1. [P15812-5]
CCDS53386.1. [P15812-6]
CCDS53387.1. [P15812-13]
CCDS53388.1. [P15812-11]
CCDS53389.1. [P15812-12]
CCDS53390.1. [P15812-8]
PIRiS07716. HLHUR2.
RefSeqiNP_001036048.1. NM_001042583.2. [P15812-2]
NP_001036049.1. NM_001042584.2. [P15812-3]
NP_001036050.1. NM_001042585.2. [P15812-4]
NP_001036051.1. NM_001042586.2. [P15812-9]
NP_001036052.1. NM_001042587.2. [P15812-10]
NP_001172036.1. NM_001185107.1. [P15812-5]
NP_001172037.1. NM_001185108.1. [P15812-7]
NP_001172039.1. NM_001185110.1. [P15812-12]
NP_001172041.1. NM_001185112.1. [P15812-8]
NP_001172042.1. NM_001185113.1. [P15812-11]
NP_001172043.1. NM_001185114.1. [P15812-13]
NP_001172044.1. NM_001185115.1. [P15812-6]
NP_112155.2. NM_030893.3. [P15812-1]
UniGeneiHs.249217.

Genome annotation databases

EnsembliENST00000368154; ENSP00000357136; ENSG00000158488. [P15812-11]
ENST00000368155; ENSP00000357137; ENSG00000158488. [P15812-7]
ENST00000368156; ENSP00000357138; ENSG00000158488. [P15812-6]
ENST00000368157; ENSP00000357139; ENSG00000158488. [P15812-12]
ENST00000368160; ENSP00000357142; ENSG00000158488. [P15812-2]
ENST00000368161; ENSP00000357143; ENSG00000158488. [P15812-3]
ENST00000368163; ENSP00000357145; ENSG00000158488. [P15812-4]
ENST00000368164; ENSP00000357146; ENSG00000158488. [P15812-10]
ENST00000368165; ENSP00000357147; ENSG00000158488. [P15812-5]
ENST00000368166; ENSP00000357148; ENSG00000158488. [P15812-9]
ENST00000368167; ENSP00000357149; ENSG00000158488. [P15812-1]
ENST00000444681; ENSP00000402906; ENSG00000158488. [P15812-13]
ENST00000452291; ENSP00000416228; ENSG00000158488. [P15812-8]
GeneIDi913.
KEGGihsa:913.
UCSCiuc001fry.3. human. [P15812-4]
uc001frz.3. human. [P15812-6]
uc001fsa.3. human. [P15812-11]
uc001fsc.3. human. [P15812-8]
uc001fsd.3. human. [P15812-3]
uc001fse.3. human. [P15812-1]
uc001fsf.3. human. [P15812-2]
uc001fsg.3. human. [P15812-10]
uc001fsh.3. human. [P15812-9]
uc001fsj.3. human. [P15812-7]
uc001fsk.3. human. [P15812-5]
uc010pig.2. human. [P15812-12]

Polymorphism databases

DMDMi254763260.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14975 Genomic DNA. Translation: CAA33100.1 . Sequence problems.
AJ289111 mRNA. Translation: CAB93150.1 .
AJ289112 mRNA. Translation: CAB93151.1 .
AJ289113 mRNA. Translation: CAB93152.1 .
AJ289114 mRNA. Translation: CAB93153.1 .
AJ289115 mRNA. Translation: CAB93154.1 .
AJ289116 mRNA. Translation: CAB93155.1 .
AJ289117 mRNA. Translation: CAB93156.1 .
AJ289118 mRNA. Translation: CAB93157.1 .
AJ289119 mRNA. Translation: CAB93158.1 .
AJ289120 mRNA. Translation: CAB93159.1 .
AJ289121 mRNA. Translation: CAB93160.1 .
AJ289122 mRNA. Translation: CAB93161.1 .
AK303108 mRNA. Translation: BAG64215.1 .
AK311643 mRNA. No translation available.
AL121986 Genomic DNA. Translation: CAI10854.1 .
AL121986 Genomic DNA. Translation: CAI10855.1 .
AL121986 Genomic DNA. Translation: CAI10856.1 .
AL121986 Genomic DNA. Translation: CAI10857.1 .
AL121986 Genomic DNA. Translation: CAI10858.1 .
AL121986 Genomic DNA. Translation: CAI10859.1 .
AL121986 Genomic DNA. Translation: CAI10860.1 .
AL121986 Genomic DNA. Translation: CAI10861.1 .
AL121986 Genomic DNA. Translation: CAI10862.1 .
AL121986 Genomic DNA. Translation: CAI10863.1 .
AL121986 Genomic DNA. Translation: CAI10864.1 .
AL121986 Genomic DNA. Translation: CAI10865.1 .
CH471121 Genomic DNA. Translation: EAW52828.1 .
CH471121 Genomic DNA. Translation: EAW52830.1 .
CH471121 Genomic DNA. Translation: EAW52831.1 .
CH471121 Genomic DNA. Translation: EAW52832.1 .
CH471121 Genomic DNA. Translation: EAW52833.1 .
CH471121 Genomic DNA. Translation: EAW52834.1 .
CH471121 Genomic DNA. Translation: EAW52835.1 .
CH471121 Genomic DNA. Translation: EAW52837.1 .
CH471121 Genomic DNA. Translation: EAW52838.1 .
CH471121 Genomic DNA. Translation: EAW52839.1 .
CH471121 Genomic DNA. Translation: EAW52840.1 .
AF142669 Genomic DNA. Translation: AAD37582.1 .
AH010757 Genomic DNA. Translation: AAK52913.1 .
AH010758 Genomic DNA. Translation: AAK52914.1 .
AJ251334 Genomic DNA. Translation: CAB82829.1 .
AJ251335 Genomic DNA. Translation: CAC07175.1 .
M14666 Genomic DNA. Translation: AAA51937.1 .
CCDSi CCDS41417.1. [P15812-1 ]
CCDS41418.1. [P15812-2 ]
CCDS41419.1. [P15812-4 ]
CCDS41420.1. [P15812-9 ]
CCDS41421.1. [P15812-3 ]
CCDS41422.1. [P15812-10 ]
CCDS53384.1. [P15812-7 ]
CCDS53385.1. [P15812-5 ]
CCDS53386.1. [P15812-6 ]
CCDS53387.1. [P15812-13 ]
CCDS53388.1. [P15812-11 ]
CCDS53389.1. [P15812-12 ]
CCDS53390.1. [P15812-8 ]
PIRi S07716. HLHUR2.
RefSeqi NP_001036048.1. NM_001042583.2. [P15812-2 ]
NP_001036049.1. NM_001042584.2. [P15812-3 ]
NP_001036050.1. NM_001042585.2. [P15812-4 ]
NP_001036051.1. NM_001042586.2. [P15812-9 ]
NP_001036052.1. NM_001042587.2. [P15812-10 ]
NP_001172036.1. NM_001185107.1. [P15812-5 ]
NP_001172037.1. NM_001185108.1. [P15812-7 ]
NP_001172039.1. NM_001185110.1. [P15812-12 ]
NP_001172041.1. NM_001185112.1. [P15812-8 ]
NP_001172042.1. NM_001185113.1. [P15812-11 ]
NP_001172043.1. NM_001185114.1. [P15812-13 ]
NP_001172044.1. NM_001185115.1. [P15812-6 ]
NP_112155.2. NM_030893.3. [P15812-1 ]
UniGenei Hs.249217.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3S6C X-ray 2.90 A 32-303 [» ]
ProteinModelPortali P15812.
SMRi P15812. Positions 33-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107351. 1 interaction.
MINTi MINT-4656055.

Polymorphism databases

DMDMi 254763260.

Proteomic databases

MaxQBi P15812.
PaxDbi P15812.
PRIDEi P15812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368154 ; ENSP00000357136 ; ENSG00000158488 . [P15812-11 ]
ENST00000368155 ; ENSP00000357137 ; ENSG00000158488 . [P15812-7 ]
ENST00000368156 ; ENSP00000357138 ; ENSG00000158488 . [P15812-6 ]
ENST00000368157 ; ENSP00000357139 ; ENSG00000158488 . [P15812-12 ]
ENST00000368160 ; ENSP00000357142 ; ENSG00000158488 . [P15812-2 ]
ENST00000368161 ; ENSP00000357143 ; ENSG00000158488 . [P15812-3 ]
ENST00000368163 ; ENSP00000357145 ; ENSG00000158488 . [P15812-4 ]
ENST00000368164 ; ENSP00000357146 ; ENSG00000158488 . [P15812-10 ]
ENST00000368165 ; ENSP00000357147 ; ENSG00000158488 . [P15812-5 ]
ENST00000368166 ; ENSP00000357148 ; ENSG00000158488 . [P15812-9 ]
ENST00000368167 ; ENSP00000357149 ; ENSG00000158488 . [P15812-1 ]
ENST00000444681 ; ENSP00000402906 ; ENSG00000158488 . [P15812-13 ]
ENST00000452291 ; ENSP00000416228 ; ENSG00000158488 . [P15812-8 ]
GeneIDi 913.
KEGGi hsa:913.
UCSCi uc001fry.3. human. [P15812-4 ]
uc001frz.3. human. [P15812-6 ]
uc001fsa.3. human. [P15812-11 ]
uc001fsc.3. human. [P15812-8 ]
uc001fsd.3. human. [P15812-3 ]
uc001fse.3. human. [P15812-1 ]
uc001fsf.3. human. [P15812-2 ]
uc001fsg.3. human. [P15812-10 ]
uc001fsh.3. human. [P15812-9 ]
uc001fsj.3. human. [P15812-7 ]
uc001fsk.3. human. [P15812-5 ]
uc010pig.2. human. [P15812-12 ]

Organism-specific databases

CTDi 913.
GeneCardsi GC01P158323.
HGNCi HGNC:1638. CD1E.
HPAi HPA057769.
MIMi 188411. gene.
neXtProti NX_P15812.
PharmGKBi PA26197.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26626.
HOVERGENi HBG004453.
InParanoidi P15812.
KOi K06448.
OrthoDBi EOG7DZ8K9.
PhylomeDBi P15812.
TreeFami TF336723.

Miscellaneous databases

GeneWikii CD1E.
GenomeRNAii 913.
NextBioi 3766.
PROi P15812.
SOURCEi Search...

Gene expression databases

ArrayExpressi P15812.
Bgeei P15812.
CleanExi HS_CD1E.
Genevestigatori P15812.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells."
    Angenieux C., Salamero J., Fricker D., Cazenave J.-P., Goud B., Hanau D., de La Salle H.
    J. Biol. Chem. 275:37757-37764(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11 AND 12), VARIANT ARG-106, FUNCTION, INTERACTION WITH B2M, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-386 (ISOFORM 13).
    Tissue: Thymus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE CD1E*01).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES CD1E*01).
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-118, VARIANT ARG-106.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-208 (ALLELES CD1E*05 AND CD1E*06), VARIANTS ARG-102; ARG-106; ASN-149 AND TRP-164.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-208 (ALLELES CD1E*03 AND CD1E*04), VARIANTS TRP-164 AND PRO-194.
  9. "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."
    Martin L.H., Calabi F., Milstein C.
    Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-301.
  10. Cited for: FUNCTION.
  11. Cited for: SUBCELLULAR LOCATION, UBIQUITINATION, PROTEOLYTIC PROCESSING.
  12. "The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments."
    Maitre B., Angenieux C., Wurtz V., Layre E., Gilleron M., Collmann A., Mariotti S., Mori L., Fricker D., Cazenave J.P., van Dorsselaer A., Gachet C., de Libero G., Puzo G., Hanau D., de la Salle H.
    Biochem. J. 419:661-668(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION.
  13. Cited for: POLYMORPHISM, VARIANT PRO-194.
  14. Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 32-303 IN COMPLEX WITH B2M, FUNCTION, LIPID-BINDING, SUBUNIT.

Entry informationi

Entry nameiCD1E_HUMAN
AccessioniPrimary (citable) accession number: P15812
Secondary accession number(s): B4DZV3
, E7EP01, Q5TDJ9, Q5TDK3, Q5TDK4, Q5TDK5, Q5TDK6, Q5TDK8, Q5TDL1, Q712E4, Q712E5, Q712E6, Q712E7, Q712E8, Q712E9, Q712F0, Q712F1, Q712F2, Q712F3, Q712F4, Q712F5, Q96TD0, Q96TD1, Q9UMM1, Q9Y5M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 28, 2009
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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