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P15812

- CD1E_HUMAN

UniProt

P15812 - CD1E_HUMAN

Protein

T-cell surface glycoprotein CD1e, membrane-associated

Gene

CD1E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.3 Publications

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW

    GO - Biological processi

    1. antigen processing and presentation Source: InterPro
    2. immune response Source: UniProtKB

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell surface glycoprotein CD1e, membrane-associated
    Short name:
    hCD1e
    Alternative name(s):
    R2G1
    CD_antigen: CD1e
    Cleaved into the following chain:
    Gene namesi
    Name:CD1E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:1638. CD1E.

    Subcellular locationi

    Chain T-cell surface glycoprotein CD1e, membrane-associated : Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome
    Note: Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of plasma membrane Source: UniProtKB
    4. late endosome Source: UniProtKB-SubCell
    5. lysosomal lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26197.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 388369T-cell surface glycoprotein CD1e, membrane-associatedPRO_0000014582Add
    BLAST
    Propeptidei20 – 3112Removed in sCD1ePRO_0000379780Add
    BLAST
    Chaini32 – 388357T-cell surface glycoprotein CD1e, solublePRO_0000379781Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi230 ↔ 285PROSITE-ProRule annotation

    Post-translational modificationi

    Mono-ubiquitinated.1 Publication
    Proteolytically cleaved in late endosomes to yield a soluble form.3 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP15812.
    PaxDbiP15812.
    PRIDEiP15812.

    Expressioni

    Tissue specificityi

    Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.1 Publication

    Gene expression databases

    ArrayExpressiP15812.
    BgeeiP15812.
    CleanExiHS_CD1E.
    GenevestigatoriP15812.

    Organism-specific databases

    HPAiHPA057769.

    Interactioni

    Subunit structurei

    Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.1 Publication

    Protein-protein interaction databases

    BioGridi107351. 1 interaction.
    MINTiMINT-4656055.

    Structurei

    Secondary structure

    1
    388
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi37 – 4610
    Beta strandi52 – 598
    Beta strandi62 – 687
    Turni69 – 724
    Beta strandi73 – 753
    Helixi79 – 824
    Helixi87 – 11125
    Turni112 – 1165
    Beta strandi119 – 12911
    Beta strandi132 – 1343
    Beta strandi136 – 1394
    Beta strandi142 – 1454
    Turni159 – 1613
    Helixi163 – 17412
    Helixi176 – 20126
    Turni202 – 2054
    Beta strandi222 – 2243
    Beta strandi228 – 2303
    Beta strandi232 – 2343
    Beta strandi236 – 2383
    Beta strandi241 – 2444
    Beta strandi260 – 2623
    Turni263 – 2653
    Beta strandi266 – 2694
    Beta strandi271 – 2733
    Helixi277 – 2804
    Beta strandi285 – 2884
    Turni290 – 2923
    Beta strandi300 – 3023

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3S6CX-ray2.90A32-303[»]
    ProteinModelPortaliP15812.
    SMRiP15812. Positions 33-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini191 – 301111Ig-likeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26626.
    HOVERGENiHBG004453.
    InParanoidiP15812.
    KOiK06448.
    OrthoDBiEOG7DZ8K9.
    PhylomeDBiP15812.
    TreeFamiTF336723.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (13)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 13 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P15812-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW    50
    AHSEGSGWLG DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY 100
    FHSFIQIVQA SAGQFQLEYP FEIQILAGCR MNAPQIFLNM AYQGSDFLSF 150
    QGISWEPSPG AGIRAQNICK VLNRYLDIKE ILQSLLGHTC PRFLAGLMEA 200
    GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE 250
    QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH 300
    WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM 350
    GANTQDTKNS RHQFCLAQVS WIKNRVLKKW KTRLNQLW 388
    Length:388
    Mass (Da):43,626
    Last modified:July 28, 2009 - v2
    Checksum:iF6503AE9608C6568
    GO
    Isoform 2 (identifier: P15812-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         334-345: Missing.

    Show »
    Length:376
    Mass (Da):42,350
    Checksum:i52F553915C2B64C6
    GO
    Isoform 3 (identifier: P15812-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
         291-388: Missing.

    Show »
    Length:290
    Mass (Da):32,724
    Checksum:i424FE9E60BE8A14C
    GO
    Isoform 4 (identifier: P15812-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         248-302: Missing.
         334-345: Missing.

    Show »
    Length:321
    Mass (Da):36,381
    Checksum:i89D16362E367AF3F
    GO
    Isoform 5 (identifier: P15812-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         119-209: YPFEIQILAG...AGESELKRKV → L

    Show »
    Length:298
    Mass (Da):33,553
    Checksum:i1F49C172E6EDCDE0
    GO
    Isoform 6 (identifier: P15812-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         119-209: YPFEIQILAG...AGESELKRKV → L
         334-345: Missing.

    Show »
    Length:286
    Mass (Da):32,276
    Checksum:i87E830F20FD041B0
    GO
    Isoform 7 (identifier: P15812-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         119-209: YPFEIQILAG...AGESELKRKV → L
         248-302: Missing.
         334-345: Missing.

    Show »
    Length:231
    Mass (Da):26,308
    Checksum:i453FEB8FE4A34853
    GO
    Isoform 8 (identifier: P15812-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-208: Missing.

    Show »
    Length:199
    Mass (Da):22,263
    Checksum:i51D51CBAF23FA31E
    GO
    Isoform 9 (identifier: P15812-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-208: Missing.
         334-345: Missing.

    Show »
    Length:187
    Mass (Da):20,987
    Checksum:iDB1402070352AEF8
    GO
    Isoform 10 (identifier: P15812-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-208: Missing.
         268-290: YLRATLDVAAGEAAGLSCRVKHS → WIFHLSHPDLFDCDSYPGHIGCS
         291-388: Missing.

    Show »
    Length:101
    Mass (Da):11,361
    Checksum:i41978EA9D317C67E
    GO
    Isoform 11 (identifier: P15812-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-208: Missing.
         248-302: Missing.

    Show »
    Length:144
    Mass (Da):16,294
    Checksum:iD433B9593AE045AB
    GO
    Isoform 12 (identifier: P15812-12) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-208: Missing.
         248-302: Missing.
         334-345: Missing.

    Show »
    Length:132
    Mass (Da):15,018
    Checksum:i146E065421A1E709
    GO
    Isoform 13 (identifier: P15812-13) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-119: APQALQSYHL...ASAGQFQLEY → D

    Show »
    Length:289
    Mass (Da):32,303
    Checksum:i4377F02F388916F9
    GO

    Sequence cautioni

    The sequence CAA33100.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti209 – 2091V → A in BAG64215. (PubMed:14702039)Curated
    Sequence conflicti248 – 2481E → G in BAG64215. (PubMed:14702039)Curated

    Polymorphismi

    Six alleles of CD1E are known. CD1E*01 has His-102/Gln-106/Ser-149/Arg-164/Leu-194, CD1E*02 has His-102/Arg-106/Ser-149/Arg-164/Leu-194, CD1E*03 (9L) has His-102/Gln-106/Ser-149/Trp-164/Leu-194, CD1E*04 (15L) has His-102/Gln-106/Ser-149/Arg-164/Pro-194, CD1E*05 has Arg-102/Arg-106/Ser-149/Arg-164/Leu-194 and CD1E*06 has His-102/Arg-106/Asn-149/Arg-164/Leu-194. The sequence shown is that of allele CD1E*01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151G → E.
    Corresponds to variant rs3180089 [ dbSNP | Ensembl ].
    VAR_056035
    Natural varianti102 – 1021H → R in allele CD1E*05. 1 Publication
    Corresponds to variant rs2873587 [ dbSNP | Ensembl ].
    VAR_058324
    Natural varianti106 – 1061Q → R in allele CD1E*02, allele CD1E*05 and CD1E*06. 3 Publications
    Corresponds to variant rs1065457 [ dbSNP | Ensembl ].
    VAR_010191
    Natural varianti149 – 1491S → N in allele CD1E*05. 1 Publication
    Corresponds to variant rs35116276 [ dbSNP | Ensembl ].
    VAR_058325
    Natural varianti164 – 1641R → W in allele CD1E*03. 2 Publications
    VAR_010192
    Natural varianti194 – 1941L → P in allele CD1E*04; impairs localization to late endosomal compartments and lipid antigen presentation. 2 Publications
    Corresponds to variant rs200741122 [ dbSNP | Ensembl ].
    VAR_010193

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei20 – 208189Missing in isoform 8, isoform 9, isoform 10, isoform 11 and isoform 12. 1 PublicationVSP_037708Add
    BLAST
    Alternative sequencei20 – 119100APQAL…FQLEY → D in isoform 13. 1 PublicationVSP_046961Add
    BLAST
    Alternative sequencei119 – 20991YPFEI…LKRKV → L in isoform 5, isoform 6 and isoform 7. 1 PublicationVSP_037709Add
    BLAST
    Alternative sequencei248 – 30255Missing in isoform 4, isoform 7, isoform 11 and isoform 12. 1 PublicationVSP_037710Add
    BLAST
    Alternative sequencei268 – 29023YLRAT…RVKHS → WIFHLSHPDLFDCDSYPGHI GCS in isoform 3 and isoform 10. 1 PublicationVSP_037711Add
    BLAST
    Alternative sequencei291 – 38898Missing in isoform 3 and isoform 10. 1 PublicationVSP_037712Add
    BLAST
    Alternative sequencei334 – 34512Missing in isoform 2, isoform 4, isoform 6, isoform 7, isoform 9 and isoform 12. 1 PublicationVSP_037713Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14975 Genomic DNA. Translation: CAA33100.1. Sequence problems.
    AJ289111 mRNA. Translation: CAB93150.1.
    AJ289112 mRNA. Translation: CAB93151.1.
    AJ289113 mRNA. Translation: CAB93152.1.
    AJ289114 mRNA. Translation: CAB93153.1.
    AJ289115 mRNA. Translation: CAB93154.1.
    AJ289116 mRNA. Translation: CAB93155.1.
    AJ289117 mRNA. Translation: CAB93156.1.
    AJ289118 mRNA. Translation: CAB93157.1.
    AJ289119 mRNA. Translation: CAB93158.1.
    AJ289120 mRNA. Translation: CAB93159.1.
    AJ289121 mRNA. Translation: CAB93160.1.
    AJ289122 mRNA. Translation: CAB93161.1.
    AK303108 mRNA. Translation: BAG64215.1.
    AK311643 mRNA. No translation available.
    AL121986 Genomic DNA. Translation: CAI10854.1.
    AL121986 Genomic DNA. Translation: CAI10855.1.
    AL121986 Genomic DNA. Translation: CAI10856.1.
    AL121986 Genomic DNA. Translation: CAI10857.1.
    AL121986 Genomic DNA. Translation: CAI10858.1.
    AL121986 Genomic DNA. Translation: CAI10859.1.
    AL121986 Genomic DNA. Translation: CAI10860.1.
    AL121986 Genomic DNA. Translation: CAI10861.1.
    AL121986 Genomic DNA. Translation: CAI10862.1.
    AL121986 Genomic DNA. Translation: CAI10863.1.
    AL121986 Genomic DNA. Translation: CAI10864.1.
    AL121986 Genomic DNA. Translation: CAI10865.1.
    CH471121 Genomic DNA. Translation: EAW52828.1.
    CH471121 Genomic DNA. Translation: EAW52830.1.
    CH471121 Genomic DNA. Translation: EAW52831.1.
    CH471121 Genomic DNA. Translation: EAW52832.1.
    CH471121 Genomic DNA. Translation: EAW52833.1.
    CH471121 Genomic DNA. Translation: EAW52834.1.
    CH471121 Genomic DNA. Translation: EAW52835.1.
    CH471121 Genomic DNA. Translation: EAW52837.1.
    CH471121 Genomic DNA. Translation: EAW52838.1.
    CH471121 Genomic DNA. Translation: EAW52839.1.
    CH471121 Genomic DNA. Translation: EAW52840.1.
    AF142669 Genomic DNA. Translation: AAD37582.1.
    AH010757 Genomic DNA. Translation: AAK52913.1.
    AH010758 Genomic DNA. Translation: AAK52914.1.
    AJ251334 Genomic DNA. Translation: CAB82829.1.
    AJ251335 Genomic DNA. Translation: CAC07175.1.
    M14666 Genomic DNA. Translation: AAA51937.1.
    CCDSiCCDS41417.1. [P15812-1]
    CCDS41418.1. [P15812-2]
    CCDS41419.1. [P15812-4]
    CCDS41420.1. [P15812-9]
    CCDS41421.1. [P15812-3]
    CCDS41422.1. [P15812-10]
    CCDS53384.1. [P15812-7]
    CCDS53385.1. [P15812-5]
    CCDS53386.1. [P15812-6]
    CCDS53387.1. [P15812-13]
    CCDS53388.1. [P15812-11]
    CCDS53389.1. [P15812-12]
    CCDS53390.1. [P15812-8]
    PIRiS07716. HLHUR2.
    RefSeqiNP_001036048.1. NM_001042583.2. [P15812-2]
    NP_001036049.1. NM_001042584.2. [P15812-3]
    NP_001036050.1. NM_001042585.2. [P15812-4]
    NP_001036051.1. NM_001042586.2. [P15812-9]
    NP_001036052.1. NM_001042587.2. [P15812-10]
    NP_001172036.1. NM_001185107.1. [P15812-5]
    NP_001172037.1. NM_001185108.1. [P15812-7]
    NP_001172039.1. NM_001185110.1. [P15812-12]
    NP_001172041.1. NM_001185112.1. [P15812-8]
    NP_001172042.1. NM_001185113.1. [P15812-11]
    NP_001172043.1. NM_001185114.1. [P15812-13]
    NP_001172044.1. NM_001185115.1. [P15812-6]
    NP_112155.2. NM_030893.3. [P15812-1]
    UniGeneiHs.249217.

    Genome annotation databases

    EnsembliENST00000368154; ENSP00000357136; ENSG00000158488. [P15812-11]
    ENST00000368155; ENSP00000357137; ENSG00000158488. [P15812-7]
    ENST00000368156; ENSP00000357138; ENSG00000158488. [P15812-6]
    ENST00000368157; ENSP00000357139; ENSG00000158488. [P15812-12]
    ENST00000368160; ENSP00000357142; ENSG00000158488. [P15812-2]
    ENST00000368161; ENSP00000357143; ENSG00000158488. [P15812-3]
    ENST00000368163; ENSP00000357145; ENSG00000158488. [P15812-4]
    ENST00000368164; ENSP00000357146; ENSG00000158488. [P15812-10]
    ENST00000368165; ENSP00000357147; ENSG00000158488. [P15812-5]
    ENST00000368166; ENSP00000357148; ENSG00000158488. [P15812-9]
    ENST00000368167; ENSP00000357149; ENSG00000158488. [P15812-1]
    ENST00000444681; ENSP00000402906; ENSG00000158488. [P15812-13]
    ENST00000452291; ENSP00000416228; ENSG00000158488. [P15812-8]
    GeneIDi913.
    KEGGihsa:913.
    UCSCiuc001fry.3. human. [P15812-4]
    uc001frz.3. human. [P15812-6]
    uc001fsa.3. human. [P15812-11]
    uc001fsc.3. human. [P15812-8]
    uc001fsd.3. human. [P15812-3]
    uc001fse.3. human. [P15812-1]
    uc001fsf.3. human. [P15812-2]
    uc001fsg.3. human. [P15812-10]
    uc001fsh.3. human. [P15812-9]
    uc001fsj.3. human. [P15812-7]
    uc001fsk.3. human. [P15812-5]
    uc010pig.2. human. [P15812-12]

    Polymorphism databases

    DMDMi254763260.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14975 Genomic DNA. Translation: CAA33100.1 . Sequence problems.
    AJ289111 mRNA. Translation: CAB93150.1 .
    AJ289112 mRNA. Translation: CAB93151.1 .
    AJ289113 mRNA. Translation: CAB93152.1 .
    AJ289114 mRNA. Translation: CAB93153.1 .
    AJ289115 mRNA. Translation: CAB93154.1 .
    AJ289116 mRNA. Translation: CAB93155.1 .
    AJ289117 mRNA. Translation: CAB93156.1 .
    AJ289118 mRNA. Translation: CAB93157.1 .
    AJ289119 mRNA. Translation: CAB93158.1 .
    AJ289120 mRNA. Translation: CAB93159.1 .
    AJ289121 mRNA. Translation: CAB93160.1 .
    AJ289122 mRNA. Translation: CAB93161.1 .
    AK303108 mRNA. Translation: BAG64215.1 .
    AK311643 mRNA. No translation available.
    AL121986 Genomic DNA. Translation: CAI10854.1 .
    AL121986 Genomic DNA. Translation: CAI10855.1 .
    AL121986 Genomic DNA. Translation: CAI10856.1 .
    AL121986 Genomic DNA. Translation: CAI10857.1 .
    AL121986 Genomic DNA. Translation: CAI10858.1 .
    AL121986 Genomic DNA. Translation: CAI10859.1 .
    AL121986 Genomic DNA. Translation: CAI10860.1 .
    AL121986 Genomic DNA. Translation: CAI10861.1 .
    AL121986 Genomic DNA. Translation: CAI10862.1 .
    AL121986 Genomic DNA. Translation: CAI10863.1 .
    AL121986 Genomic DNA. Translation: CAI10864.1 .
    AL121986 Genomic DNA. Translation: CAI10865.1 .
    CH471121 Genomic DNA. Translation: EAW52828.1 .
    CH471121 Genomic DNA. Translation: EAW52830.1 .
    CH471121 Genomic DNA. Translation: EAW52831.1 .
    CH471121 Genomic DNA. Translation: EAW52832.1 .
    CH471121 Genomic DNA. Translation: EAW52833.1 .
    CH471121 Genomic DNA. Translation: EAW52834.1 .
    CH471121 Genomic DNA. Translation: EAW52835.1 .
    CH471121 Genomic DNA. Translation: EAW52837.1 .
    CH471121 Genomic DNA. Translation: EAW52838.1 .
    CH471121 Genomic DNA. Translation: EAW52839.1 .
    CH471121 Genomic DNA. Translation: EAW52840.1 .
    AF142669 Genomic DNA. Translation: AAD37582.1 .
    AH010757 Genomic DNA. Translation: AAK52913.1 .
    AH010758 Genomic DNA. Translation: AAK52914.1 .
    AJ251334 Genomic DNA. Translation: CAB82829.1 .
    AJ251335 Genomic DNA. Translation: CAC07175.1 .
    M14666 Genomic DNA. Translation: AAA51937.1 .
    CCDSi CCDS41417.1. [P15812-1 ]
    CCDS41418.1. [P15812-2 ]
    CCDS41419.1. [P15812-4 ]
    CCDS41420.1. [P15812-9 ]
    CCDS41421.1. [P15812-3 ]
    CCDS41422.1. [P15812-10 ]
    CCDS53384.1. [P15812-7 ]
    CCDS53385.1. [P15812-5 ]
    CCDS53386.1. [P15812-6 ]
    CCDS53387.1. [P15812-13 ]
    CCDS53388.1. [P15812-11 ]
    CCDS53389.1. [P15812-12 ]
    CCDS53390.1. [P15812-8 ]
    PIRi S07716. HLHUR2.
    RefSeqi NP_001036048.1. NM_001042583.2. [P15812-2 ]
    NP_001036049.1. NM_001042584.2. [P15812-3 ]
    NP_001036050.1. NM_001042585.2. [P15812-4 ]
    NP_001036051.1. NM_001042586.2. [P15812-9 ]
    NP_001036052.1. NM_001042587.2. [P15812-10 ]
    NP_001172036.1. NM_001185107.1. [P15812-5 ]
    NP_001172037.1. NM_001185108.1. [P15812-7 ]
    NP_001172039.1. NM_001185110.1. [P15812-12 ]
    NP_001172041.1. NM_001185112.1. [P15812-8 ]
    NP_001172042.1. NM_001185113.1. [P15812-11 ]
    NP_001172043.1. NM_001185114.1. [P15812-13 ]
    NP_001172044.1. NM_001185115.1. [P15812-6 ]
    NP_112155.2. NM_030893.3. [P15812-1 ]
    UniGenei Hs.249217.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3S6C X-ray 2.90 A 32-303 [» ]
    ProteinModelPortali P15812.
    SMRi P15812. Positions 33-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107351. 1 interaction.
    MINTi MINT-4656055.

    Polymorphism databases

    DMDMi 254763260.

    Proteomic databases

    MaxQBi P15812.
    PaxDbi P15812.
    PRIDEi P15812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368154 ; ENSP00000357136 ; ENSG00000158488 . [P15812-11 ]
    ENST00000368155 ; ENSP00000357137 ; ENSG00000158488 . [P15812-7 ]
    ENST00000368156 ; ENSP00000357138 ; ENSG00000158488 . [P15812-6 ]
    ENST00000368157 ; ENSP00000357139 ; ENSG00000158488 . [P15812-12 ]
    ENST00000368160 ; ENSP00000357142 ; ENSG00000158488 . [P15812-2 ]
    ENST00000368161 ; ENSP00000357143 ; ENSG00000158488 . [P15812-3 ]
    ENST00000368163 ; ENSP00000357145 ; ENSG00000158488 . [P15812-4 ]
    ENST00000368164 ; ENSP00000357146 ; ENSG00000158488 . [P15812-10 ]
    ENST00000368165 ; ENSP00000357147 ; ENSG00000158488 . [P15812-5 ]
    ENST00000368166 ; ENSP00000357148 ; ENSG00000158488 . [P15812-9 ]
    ENST00000368167 ; ENSP00000357149 ; ENSG00000158488 . [P15812-1 ]
    ENST00000444681 ; ENSP00000402906 ; ENSG00000158488 . [P15812-13 ]
    ENST00000452291 ; ENSP00000416228 ; ENSG00000158488 . [P15812-8 ]
    GeneIDi 913.
    KEGGi hsa:913.
    UCSCi uc001fry.3. human. [P15812-4 ]
    uc001frz.3. human. [P15812-6 ]
    uc001fsa.3. human. [P15812-11 ]
    uc001fsc.3. human. [P15812-8 ]
    uc001fsd.3. human. [P15812-3 ]
    uc001fse.3. human. [P15812-1 ]
    uc001fsf.3. human. [P15812-2 ]
    uc001fsg.3. human. [P15812-10 ]
    uc001fsh.3. human. [P15812-9 ]
    uc001fsj.3. human. [P15812-7 ]
    uc001fsk.3. human. [P15812-5 ]
    uc010pig.2. human. [P15812-12 ]

    Organism-specific databases

    CTDi 913.
    GeneCardsi GC01P158323.
    HGNCi HGNC:1638. CD1E.
    HPAi HPA057769.
    MIMi 188411. gene.
    neXtProti NX_P15812.
    PharmGKBi PA26197.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26626.
    HOVERGENi HBG004453.
    InParanoidi P15812.
    KOi K06448.
    OrthoDBi EOG7DZ8K9.
    PhylomeDBi P15812.
    TreeFami TF336723.

    Miscellaneous databases

    GeneWikii CD1E.
    GenomeRNAii 913.
    NextBioi 3766.
    PROi P15812.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15812.
    Bgeei P15812.
    CleanExi HS_CD1E.
    Genevestigatori P15812.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells."
      Angenieux C., Salamero J., Fricker D., Cazenave J.-P., Goud B., Hanau D., de La Salle H.
      J. Biol. Chem. 275:37757-37764(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11 AND 12), VARIANT ARG-106, FUNCTION, INTERACTION WITH B2M, PROTEOLYTIC PROCESSING, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-386 (ISOFORM 13).
      Tissue: Thymus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE CD1E*01).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES CD1E*01).
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-118, VARIANT ARG-106.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-208 (ALLELES CD1E*05 AND CD1E*06), VARIANTS ARG-102; ARG-106; ASN-149 AND TRP-164.
    8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-208 (ALLELES CD1E*03 AND CD1E*04), VARIANTS TRP-164 AND PRO-194.
    9. "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."
      Martin L.H., Calabi F., Milstein C.
      Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 209-301.
    10. Cited for: FUNCTION.
    11. Cited for: SUBCELLULAR LOCATION, UBIQUITINATION, PROTEOLYTIC PROCESSING.
    12. "The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments."
      Maitre B., Angenieux C., Wurtz V., Layre E., Gilleron M., Collmann A., Mariotti S., Mori L., Fricker D., Cazenave J.P., van Dorsselaer A., Gachet C., de Libero G., Puzo G., Hanau D., de la Salle H.
      Biochem. J. 419:661-668(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING, SUBCELLULAR LOCATION.
    13. Cited for: POLYMORPHISM, VARIANT PRO-194.
    14. Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 32-303 IN COMPLEX WITH B2M, FUNCTION, LIPID-BINDING, SUBUNIT.

    Entry informationi

    Entry nameiCD1E_HUMAN
    AccessioniPrimary (citable) accession number: P15812
    Secondary accession number(s): B4DZV3
    , E7EP01, Q5TDJ9, Q5TDK3, Q5TDK4, Q5TDK5, Q5TDK6, Q5TDK8, Q5TDL1, Q712E4, Q712E5, Q712E6, Q712E7, Q712E8, Q712E9, Q712F0, Q712F1, Q712F2, Q712F3, Q712F4, Q712F5, Q96TD0, Q96TD1, Q9UMM1, Q9Y5M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3