Reviewed,
UniProtKB/Swiss-Prot P15791 (KCC2D_RAT)
Last modified
October 13, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Calcium/calmodulin-dependent protein kinase type II delta chain Short name=CaM-kinase II delta chain Short name=CaM kinase II subunit delta Short name=CaMK-II subunit delta EC=2.7.11.17 | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 533 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Enzyme regulation | Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity. |
| Subunit structure | CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. |
| Tissue specificity | Isoform Delta 1 is the predominant form in the brain, isoform Delta 2 and isoform Delta 3 predominate in the aorta and isoform Delta 4 in skeletal muscle. |
| Sequence similarities | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. |
Ontologies
Alternative products
| This entry describes 7 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Delta 1 (identifier: P15791-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Delta 2 (identifier: P15791-2) The sequence of this isoform differs from the canonical sequence as follows: 329-362: Missing. | ||||||
| Isoform Delta 3 (identifier: P15791-3) The sequence of this isoform differs from the canonical sequence as follows: 329-335: INNKANV → KRKSSSV 337-359: Missing. 360-362: GNK → QMM | ||||||
| Isoform Delta 4 (identifier: P15791-4) The sequence of this isoform differs from the canonical sequence as follows: 349-362: Missing. | ||||||
| Isoform Delta 5 (identifier: P15791-5) The sequence of this isoform differs from the canonical sequence as follows: 329-362: Missing. 512-533: KPPCIPNGKENFSGGTSLWQNI → N | ||||||
| Isoform Delta 6 (identifier: P15791-6) The sequence of this isoform differs from the canonical sequence as follows: 512-533: KPPCIPNGKENFSGGTSLWQNI → N | ||||||
| Isoform Delta 7 (identifier: P15791-7) The sequence of this isoform differs from the canonical sequence as follows: 349-362: Missing. 512-533: KPPCIPNGKENFSGGTSLWQNI → N |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 533 | 533 | Calcium/calmodulin-dependent protein kinase type II delta chain | PRO_0000086100 | |||||
Regions | |||||||||
| Domain | 14 – 272 | 259 | Protein kinase | ||||||
| Nucleotide binding | 20 – 28 | 9 | ATP By similarity | ||||||
| Region | 291 – 301 | 11 | Calmodulin-binding By similarity | ||||||
Sites | |||||||||
| Active site | 136 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 43 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 3 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 231 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 287 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 315 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 319 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 364 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 365 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 367 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 371 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 506 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 329 – 362 | 34 | Missing in isoform Delta 2 and isoform Delta 5. | VSP_004784 | |||||
| Alternative sequence | 329 – 335 | 7 | INNKANV → KRKSSSV in isoform Delta 3. | VSP_004785 | |||||
| Alternative sequence | 337 – 359 | 23 | Missing in isoform Delta 3. | VSP_004786 | |||||
| Alternative sequence | 349 – 362 | 14 | Missing in isoform Delta 4 and isoform Delta 7. | VSP_004788 | |||||
| Alternative sequence | 360 – 362 | 3 | GNK → QMM in isoform Delta 3. | VSP_004787 | |||||
| Alternative sequence | 512 – 533 | 22 | KPPCI…LWQNI → N in isoform Delta 5, isoform Delta 6 and isoform Delta 7. | VSP_012043 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs." Tobimatsu T., Fujisawa H. J. Biol. Chem. 264:17907-17912(1989) [PubMed: 2553697] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA 1). |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM DELTA 2). Tissue: Prostate. |
| [3] | "Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta." Schworer C.M., Rothblum L.I., Thekkumkara T.J., Singer H.A. J. Biol. Chem. 268:14443-14449(1993) [PubMed: 8390994] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 314-533 (ISOFORMS DELTA 2; DELTA 3 AND DELTA 4). Strain: Sprague-Dawley. Tissue: Aorta and Skeletal muscle. |
| [4] | "New isoforms of multifunctional calcium/calmodulin-dependent protein kinase II." Mayer P., Moehlig M., Schatz H., Pfeiffer A. FEBS Lett. 333:315-318(1993) [PubMed: 8224201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 307-533 (ISOFORMS DELTA 1; DELTA 2; DELTA 4; DELTA 5; DELTA 6 AND DELTA 7). |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| J05072 mRNA. Translation: AAA40866.1. BC107562 mRNA. Translation: AAI07563.1. L13406 mRNA. Translation: AAA41479.1. L13407 mRNA. Translation: AAA41480.1. L13408 mRNA. Translation: AAA41481.1. X77192 Genomic DNA. Translation: CAA54412.1. X77193 Genomic DNA. Translation: CAA54413.1. X77194 Genomic DNA. Translation: CAA54414.1. X77195 Genomic DNA. Translation: CAA54415.1. X75774 Genomic DNA. Translation: CAA53395.1. | |
| IPI | IPI00212226. IPI00213583. IPI00231612. IPI00231613. IPI00231614. IPI00480684. IPI00480796. |
| PIR | A34366. |
| RefSeq | NP_036651.1. |
| UniGene | Rn.87208 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HKX based on UniProtKB P11798. |
| SMR | P15791. Positions 8-315, 370-508. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P15791. |
Proteomic databases | |
| PRIDE | P15791. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000015457; ENSRNOP00000015457; ENSRNOG00000011589; Rattus norvegicus. [Genome view] ENSRNOT00000016035; ENSRNOP00000016035; ENSRNOG00000011589; Rattus norvegicus. [Genome view] |
| GeneID | 24246. |
| KEGG | rno:24246. |
Organism-specific databases | |
| CTD | 24246. |
| RGD | 2263. Camk2d. |
Phylogenomic databases | |
| HOVERGEN | P15791. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.17. 248. |
Gene expression databases | |
| Genevestigator | P15791. |
Family and domain databases | |
| InterPro | IPR015742. Ca/calmodulin-dep_kinase. IPR013543. Ca/calmodulin-dep_kinase-assoc. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| PANTHER | PTHR22982:SF64. CaMKII. 1 hit. |
| Pfam | PF08332. CaMKII_AD. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 602745. |
Entry information
| Entry name | KCC2D_RAT | ||||||||
| Accession | Primary (citable) accession number: P15791 Secondary accession number(s): P97915 Q63908 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


