Reviewed, UniProtKB/Swiss-Prot P15787 (MT2_COLLI)

Names and origin

Protein names	Recommended name:     Metallothionein-2       Short name=MT-2 Alternative name(s):     Metallothionein-II       Short name=MT-II
Organism	Columba livia (Domestic pigeon)
Taxonomic identifier	8932 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Columbiformes › Columbidae › Columba

Protein attributes

Sequence length	63 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Metal-thiolate cluster
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 63	63	Metallothionein-2		PRO_0000197262
Regions
	Region	1 – 30	30	Beta
	Region	31 – 63	33	Alpha
Sites
	Metal binding	6	1	Cluster B
	Metal binding	8	1	Cluster B
	Metal binding	14	1	Cluster B
	Metal binding	16	1	Cluster B
	Metal binding	20	1	Cluster B
	Metal binding	22	1	Cluster B
	Metal binding	25	1	Cluster B
	Metal binding	27	1	Cluster B
	Metal binding	30	1	Cluster B
	Metal binding	34	1	Cluster A
	Metal binding	35	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	38	1	Cluster A
	Metal binding	42	1	Cluster A
	Metal binding	45	1	Cluster A
	Metal binding	49	1	Cluster A
	Metal binding	51	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	61	1	Cluster A
	Metal binding	62	1	Cluster A

Sequences

	Sequence		Length	Mass (Da)
	P15787-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: A2B84227E94C365E	FASTA	63	6,452
	10 20 30 40 50 60 MDPQDCTCAA GDSCSCAGSC KCKNCRCQSC RKSCCSCCPA SCSNCAKGCV CKEPSSSKCS CCH

References

[1]	"Pigeon metallothionein consists of two species." Lin L.-Y., Lin W.C., Huang P.C. Biochim. Biophys. Acta 1037:248-255(1990) [PubMed: 2407296] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
PIR	S08191.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P15787.
Family and domain databases
InterPro	IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MT2_COLLI

Accession

Primary (citable) accession number: P15787

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	November 1, 1997
Last modified:	November 24, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)