Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pulmonary surfactant-associated protein B

Gene

SFTPB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGaseous exchange

Enzyme and pathway databases

ReactomeiR-BTA-5683826 Surfactant metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein B
Short name:
SP-B
Alternative name(s):
6 kDa protein
Pulmonary surfactant-associated proteolipid SPL(Phe)
Gene namesi
Name:SFTPB
Synonyms:SFTP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:34528 SFTPB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000028512423 – 187Add BLAST165
ChainiPRO_0000175240188 – 266Pulmonary surfactant-associated protein BAdd BLAST79
PropeptideiPRO_0000285125267 – 373Add BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 142PROSITE-ProRule annotation
Disulfide bondi71 ↔ 136PROSITE-ProRule annotation
Glycosylationi73N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi99 ↔ 111PROSITE-ProRule annotation
Disulfide bondi195 ↔ 264PROSITE-ProRule annotation
Disulfide bondi198 ↔ 258PROSITE-ProRule annotation
Disulfide bondi222 ↔ 233PROSITE-ProRule annotation
Disulfide bondi235InterchainPROSITE-ProRule annotation
Disulfide bondi291 ↔ 358PROSITE-ProRule annotation
Disulfide bondi294 ↔ 352PROSITE-ProRule annotation
Glycosylationi303N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi317 ↔ 327PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15781
PRIDEiP15781

Expressioni

Gene expression databases

BgeeiENSBTAG00000021230

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042549

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IL7model-A188-266[»]
2IP3model-A188-266[»]
ProteinModelPortaliP15781
SMRiP15781
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 64Saposin A-typePROSITE-ProRule annotationAdd BLAST41
Domaini64 – 146Saposin B-type 1PROSITE-ProRule annotationAdd BLAST83
Domaini191 – 268Saposin B-type 2PROSITE-ProRule annotationAdd BLAST78
Domaini287 – 362Saposin B-type 3PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1340 Eukaryota
ENOG410XSI5 LUCA
GeneTreeiENSGT00530000063434
HOGENOMiHOG000115745
HOVERGENiHBG006905
InParanoidiP15781
OMAiCWLCRTL
OrthoDBiEOG091G0K86
TreeFamiTF316942

Family and domain databases

InterProiView protein in InterPro
IPR003119 SAP_A
IPR007856 SapB_1
IPR008138 SapB_2
IPR008373 Saposin
IPR011001 Saposin-like
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF02199 SapA, 1 hit
PF05184 SapB_1, 1 hit
PF03489 SapB_2, 2 hits
PRINTSiPR01797 SAPOSIN
SMARTiView protein in SMART
SM00162 SAPA, 1 hit
SM00741 SapB, 3 hits
SUPFAMiSSF47862 SSF47862, 2 hits
PROSITEiView protein in PROSITE
PS51110 SAP_A, 1 hit
PS50015 SAP_B, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSHLLPWL LLLPILCGPG TAAAITYSLA CAQGPEFWCQ SLEQALQCRA
60 70 80 90 100
LGHCLQEVWG HVEADDLCQE CENISRLLTK MAKEAIFQDS VRKFLEQECD
110 120 130 140 150
VLPLKLLAPL CRHLLDTYFP LIIEHFQSHM NPKFICQHVG LCKPRHPEPG
160 170 180 190 200
KGPEPWGPLL DKLALPLLPG VPQAKPGPQT QDLSEQLFPI PIPYCWLCRT
210 220 230 240 250
LIKRIQAVIP KGVLAMTVAQ VCHVVPLLVG GICQCLVERY SVILLDTLLG
260 270 280 290 300
RMLPQLVCGL VLRCSSEDSA GPALPALGSV PGEWLPQDSD CQLCMFVTTQ
310 320 330 340 350
AGNSSEQATP QAMRQACLGT WLDRQKCERF VEENAPRLQT LVSSGWDAHM
360 370
ACQALGTCAA PFSPLQCVHS PHF
Length:373
Mass (Da):41,060
Last modified:May 1, 2007 - v3
Checksum:iA41A31AE5A5C0F82
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198C → L AA sequence (PubMed:3689402).Curated1
Sequence conflicti204R → K AA sequence (PubMed:3689402).Curated1
Sequence conflicti233 – 239CQCLVER → IQQLVIE AA sequence (PubMed:3689402).Curated7
Sequence conflicti245L → LT AA sequence (PubMed:3689402).Curated1
Sequence conflicti252Missing AA sequence (PubMed:3689402).Curated1
Sequence conflicti255Q → N AA sequence (PubMed:3689402).Curated1
Sequence conflicti261V → R AA sequence (PubMed:3689402).Curated1
Sequence conflicti266S → G AA sequence (PubMed:3689402).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118395 mRNA Translation: AAI18396.1
PIRiA29667
RefSeqiNP_001068779.1, NM_001075311.2
XP_005212817.1, XM_005212760.2
UniGeneiBt.42696

Genome annotation databases

EnsembliENSBTAT00000045134; ENSBTAP00000042549; ENSBTAG00000021230
GeneIDi507398
KEGGibta:507398

Similar proteinsi

Entry informationi

Entry nameiPSPB_BOVIN
AccessioniPrimary (citable) accession number: P15781
Secondary accession number(s): Q148E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health