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Protein

Envelope small membrane protein

Gene

E

Organism
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the viral envelope that plays a central role in virus morphogenesis and assembly. It is sufficient to form virus-like particles. Seems to be important for creating the membrane curvature needed to acquire the rounded, stable and infectious particle phenotype. Acts as a viroporin, inducing the formation of hydrophilic pores in cellular membranes. Also induces apoptosis (By similarity).By similarity

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope small membrane protein
Short name:
E protein
Short name:
sM protein
Gene namesi
Name:E
Synonyms:sM
ORF Names:5b
OrganismiBovine coronavirus (strain Mebus) (BCoV) (BCV)
Taxonomic identifieri11132 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeBetacoronavirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000007554 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17Virion surfaceSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 84IntravirionSequence analysisAdd BLAST46

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001060861 – 84Envelope small membrane proteinAdd BLAST84

Interactioni

Subunit structurei

Homooligomer. Interacts with the M membrane protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the coronaviruses E protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090001NY.

Family and domain databases

InterProiView protein in InterPro
IPR003873. NS3/E.
PfamiView protein in Pfam
PF02723. NS3_envE. 1 hit.

Sequencei

Sequence statusi: Complete.

P15779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMADAYFAD TVWYVGQIIF IVAICLLVII VVVAFLATFK LCIQLCGMCN
60 70 80
TLGLSPSIYV FNRGRQFYEF YNDVKPPVLD VDDV
Length:84
Mass (Da):9,542
Last modified:April 1, 1990 - v1
Checksum:i49D0797F6D44DC10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00735 Genomic RNA. Translation: AAA42914.1.
PIRiD46346.

Similar proteinsi

Entry informationi

Entry nameiVEMP_CVBM
AccessioniPrimary (citable) accession number: P15779
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 5, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome