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Protein

Parathyroid hormone

Gene

PTH

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-GGA-373080 Class B/2 (Secretin family receptors)
R-GGA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone
Short name:
PTH
Gene namesi
Name:PTH
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
PropeptideiPRO_000002325726 – 316
ChainiPRO_000002325832 – 119Parathyroid hormoneAdd BLAST88

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP15743

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008579

Structurei

3D structure databases

ProteinModelPortaliP15743
SMRiP15743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J02X Eukaryota
ENOG410ZH2H LUCA
GeneTreeiENSGT00390000018603
HOGENOMiHOG000033707
HOVERGENiHBG008319
InParanoidiP15743
KOiK05261
OMAiEIQFMHN
OrthoDBiEOG091G13ZF
PhylomeDBiP15743
TreeFamiTF336197

Family and domain databases

InterProiView protein in InterPro
IPR003625 PTH
IPR001415 PTH/PTH-rel
PANTHERiPTHR10541:SF2 PTHR10541:SF2, 1 hit
PfamiView protein in Pfam
PF01279 Parathyroid, 1 hit
PIRSFiPIRSF001832 PTH, 1 hit
SMARTiView protein in SMART
SM00087 PTH, 1 hit
PROSITEiView protein in PROSITE
PS00335 PARATHYROID, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTKNLAKA IVILYAICFF TNSDGRPMMK RSVSEMQLMH NLGEHRHTVE
60 70 80 90 100
RQDWLQMKLQ DVHSALEDAR TQRPRNKEDI VLGEIRNRRL LPEHLRAAVQ
110
KKSIDLDKAY MNVLFKTKP
Length:119
Mass (Da):13,943
Last modified:April 1, 1990 - v1
Checksum:iB309D8E772997F6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31604 mRNA Translation: AAA49093.1
M36522 mRNA Translation: AAB02866.1
PIRiA34937
RefSeqiNP_990783.1, NM_205452.2
UniGeneiGga.78

Genome annotation databases

EnsembliENSGALT00000061928; ENSGALP00000044567; ENSGALG00000042878
GeneIDi396436
KEGGigga:396436

Similar proteinsi

Entry informationi

Entry nameiPTHY_CHICK
AccessioniPrimary (citable) accession number: P15743
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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