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Protein

Tumor necrosis factor receptor superfamily member 4

Gene

Tnfrsf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).By similarity

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-RNO-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
MRC OX40
OX40 antigen
OX40L receptor
CD_antigen: CD134
Gene namesi
Name:Tnfrsf4
Synonyms:Ox40, Txgp1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi3920 Tnfrsf4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 210ExtracellularSequence analysisAdd BLAST191
Transmembranei211 – 235HelicalSequence analysisAdd BLAST25
Topological domaini236 – 271CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003455620 – 271Tumor necrosis factor receptor superfamily member 4Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 37PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 76PROSITE-ProRule annotation
Disulfide bondi79 ↔ 94PROSITE-ProRule annotation
Disulfide bondi82 ↔ 102PROSITE-ProRule annotation
Disulfide bondi104 ↔ 122PROSITE-ProRule annotation
Disulfide bondi125 ↔ 138PROSITE-ProRule annotation
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 163PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15725
PRIDEiP15725

Expressioni

Tissue specificityi

Activated T-cells.

Gene expression databases

BgeeiENSRNOG00000020106
GenevisibleiP15725 RN

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5.By similarity

Protein-protein interaction databases

IntActiP15725, 1 interactor
STRINGi10116.ENSRNOP00000027251

Structurei

3D structure databases

ProteinModelPortaliP15725
SMRiP15725
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 60TNFR-Cys 1Add BLAST36
Repeati61 – 102TNFR-Cys 2Add BLAST42
Repeati103 – 123TNFR-Cys 3; truncatedAdd BLAST21
Repeati124 – 164TNFR-Cys 4Add BLAST41

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0US Eukaryota
ENOG4111DUJ LUCA
GeneTreeiENSGT00730000111452
HOGENOMiHOG000049154
HOVERGENiHBG005031
InParanoidiP15725
KOiK05142
OMAiPIQEEHA
OrthoDBiEOG091G03XW
PhylomeDBiP15725
TreeFamiTF330135

Family and domain databases

CDDicd13406 TNFRSF4, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020445 TNFR_4
IPR034022 TNFRSF4_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 3 hits
PRINTSiPR01921 TNFACTORR4
SMARTiView protein in SMART
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVWVQQPTA FLLLGLSLGV TVKLNCVKDT YPSGHKCCRE CQPGHGMVSR
60 70 80 90 100
CDHTRDTVCH PCEPGFYNEA VNYDTCKQCT QCNHRSGSEL KQNCTPTEDT
110 120 130 140 150
VCQCRPGTQP RQDSSHKLGV DCVPCPPGHF SPGSNQACKP WTNCTLSGKQ
160 170 180 190 200
IRHPASNSLD TVCEDRSLLA TLLWETQRTT FRPTTVPSTT VWPRTSQLPS
210 220 230 240 250
TPTLVAPEGP AFAVILGLGL GLLAPLTVLL ALYLLRKAWR SPNTPKPCWG
260 270
NSFRTPIQEE QTDTHFTLAK I
Length:271
Mass (Da):29,895
Last modified:April 1, 1990 - v1
Checksum:iC06465136B16E821
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17037 mRNA Translation: CAA34897.1
PIRiS12783
RefSeqiNP_037181.1, NM_013049.1
UniGeneiRn.48883

Genome annotation databases

EnsembliENSRNOT00000027251; ENSRNOP00000027251; ENSRNOG00000020106
GeneIDi25572
KEGGirno:25572

Similar proteinsi

Entry informationi

Entry nameiTNR4_RAT
AccessioniPrimary (citable) accession number: P15725
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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