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Protein

Tumor necrosis factor receptor superfamily member 4

Gene

Tnfrsf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).By similarity

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 4
Alternative name(s):
MRC OX40
OX40 antigen
OX40L receptor
CD_antigen: CD134
Gene namesi
Name:Tnfrsf4
Synonyms:Ox40, Txgp1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi3920. Tnfrsf4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 210191ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23525HelicalSequence analysisAdd
BLAST
Topological domaini236 – 27136CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 271252Tumor necrosis factor receptor superfamily member 4PRO_0000034556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 37PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 76PROSITE-ProRule annotation
Disulfide bondi79 ↔ 94PROSITE-ProRule annotation
Disulfide bondi82 ↔ 102PROSITE-ProRule annotation
Disulfide bondi104 ↔ 122PROSITE-ProRule annotation
Disulfide bondi125 ↔ 138PROSITE-ProRule annotation
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 163PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP15725.
PRIDEiP15725.

Expressioni

Tissue specificityi

Activated T-cells.

Gene expression databases

GenevisibleiP15725. RN.

Interactioni

Subunit structurei

Interacts with TRAF2, TRAF3 and TRAF5.By similarity

Protein-protein interaction databases

IntActiP15725. 1 interaction.
STRINGi10116.ENSRNOP00000027251.

Structurei

3D structure databases

ProteinModelPortaliP15725.
SMRiP15725. Positions 24-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 6036TNFR-Cys 1Add
BLAST
Repeati61 – 10242TNFR-Cys 2Add
BLAST
Repeati103 – 12321TNFR-Cys 3; truncatedAdd
BLAST
Repeati124 – 16441TNFR-Cys 4Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0US. Eukaryota.
ENOG4111DUJ. LUCA.
GeneTreeiENSGT00730000111452.
HOGENOMiHOG000049154.
HOVERGENiHBG005031.
InParanoidiP15725.
KOiK05142.
OMAiHHRAWRL.
OrthoDBiEOG7KH9KN.
PhylomeDBiP15725.
TreeFamiTF330135.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020445. TNFR_4.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01921. TNFACTORR4.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVWVQQPTA FLLLGLSLGV TVKLNCVKDT YPSGHKCCRE CQPGHGMVSR
60 70 80 90 100
CDHTRDTVCH PCEPGFYNEA VNYDTCKQCT QCNHRSGSEL KQNCTPTEDT
110 120 130 140 150
VCQCRPGTQP RQDSSHKLGV DCVPCPPGHF SPGSNQACKP WTNCTLSGKQ
160 170 180 190 200
IRHPASNSLD TVCEDRSLLA TLLWETQRTT FRPTTVPSTT VWPRTSQLPS
210 220 230 240 250
TPTLVAPEGP AFAVILGLGL GLLAPLTVLL ALYLLRKAWR SPNTPKPCWG
260 270
NSFRTPIQEE QTDTHFTLAK I
Length:271
Mass (Da):29,895
Last modified:April 1, 1990 - v1
Checksum:iC06465136B16E821
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17037 mRNA. Translation: CAA34897.1.
PIRiS12783.
RefSeqiNP_037181.1. NM_013049.1.
UniGeneiRn.48883.

Genome annotation databases

EnsembliENSRNOT00000027251; ENSRNOP00000027251; ENSRNOG00000020106.
GeneIDi25572.
KEGGirno:25572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17037 mRNA. Translation: CAA34897.1.
PIRiS12783.
RefSeqiNP_037181.1. NM_013049.1.
UniGeneiRn.48883.

3D structure databases

ProteinModelPortaliP15725.
SMRiP15725. Positions 24-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP15725. 1 interaction.
STRINGi10116.ENSRNOP00000027251.

Proteomic databases

PaxDbiP15725.
PRIDEiP15725.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027251; ENSRNOP00000027251; ENSRNOG00000020106.
GeneIDi25572.
KEGGirno:25572.

Organism-specific databases

CTDi7293.
RGDi3920. Tnfrsf4.

Phylogenomic databases

eggNOGiENOG410J0US. Eukaryota.
ENOG4111DUJ. LUCA.
GeneTreeiENSGT00730000111452.
HOGENOMiHOG000049154.
HOVERGENiHBG005031.
InParanoidiP15725.
KOiK05142.
OMAiHHRAWRL.
OrthoDBiEOG7KH9KN.
PhylomeDBiP15725.
TreeFamiTF330135.

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

PROiP15725.

Gene expression databases

GenevisibleiP15725. RN.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020445. TNFR_4.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01921. TNFACTORR4.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes -- a molecule related to nerve growth factor receptor."
    Mallett S., Fossum S., Barclay A.N.
    EMBO J. 9:1063-1068(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: T-cell.

Entry informationi

Entry nameiTNR4_RAT
AccessioniPrimary (citable) accession number: P15725
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.