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Protein

Myelin basic protein

Gene

MBP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin basic protein
Short name:
MBP
Gene namesi
Name:MBP
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001589962 – 174Myelin basic proteinAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine; in forms C1, C2 and C31 Publication1
Modified residuei4Deamidated glutamine; in forms C1 and C2; partial1 Publication1
Modified residuei8Phosphoserine; in forms C2 and C31 Publication1
Modified residuei19Phosphoserine; in form C21 Publication1
Modified residuei25Citrulline; in forms C1, C2 and C31 Publication1
Modified residuei34Phosphoserine; in forms C2 and C31 Publication1
Modified residuei42Citrulline; in form C31 Publication1
Modified residuei65Phosphoserine; in forms C2 and C31 Publication1
Modified residuei72Deamidated glutamine; in forms C1, C2 and C3; partial1 Publication1
Modified residuei74Phosphoserine; in form C21 Publication1
Modified residuei91Deamidated asparagine; in forms C1, C2 and C3; partial1 Publication1
Modified residuei97Phosphothreonine; in forms C2 and C31 Publication1
Modified residuei102Deamidated glutamine; in form C11 Publication1
Modified residuei102Deamidated glutamine; in forms C1, C2 and C3; partial1 Publication1
Modified residuei106Omega-N-methylarginine; in forms C1, C2 and C3; alternate1 Publication1
Modified residuei106Symmetric dimethylarginine; in forms C1, C2 and C3; alternate1 Publication1
Modified residuei114Phosphoserine; in forms C2 and C31 Publication1
Modified residuei142Phosphoserine; in forms C2 and C31 Publication1
Modified residuei147Deamidated glutamine; in forms C1, C2 and C3; partial1 Publication1
Modified residuei165Phosphoserine; in forms C2 and C31 Publication1
Modified residuei166Citrulline; in forms C2 and C31 Publication1
Modified residuei169Phosphoserine; in forms C2 and C31 Publication1

Post-translational modificationi

Several charge isomers are produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues. Chicken MBP contains 4 charge components denoted as C1, C2, C3 and C8. C1 lacks any phosphorylation sites, whereas C2 and C3 contain respectively 10 and 8 phosphorylation sites and arginine residues modified to citrulline. All three charge components contain deamidated glutamines and asparagine, and a methylated arginine.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP15720.

PTM databases

iPTMnetiP15720.

Expressioni

Developmental stagei

In the optic lobe, first detected at embryonic day 14. Expression strongly increases between embryonic days 16 and 18, reaches a maximum at postnatal day 1, and then declines again to the adult level.

Gene expression databases

BgeeiENSGALG00000013640.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP15720.
SMRiP15720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin basic protein family.Curated

Phylogenomic databases

eggNOGiENOG410J981. Eukaryota.
ENOG41115M7. LUCA.
GeneTreeiENSGT00390000014772.
HOGENOMiHOG000293395.
HOVERGENiHBG008347.
InParanoidiP15720.
KOiK17269.
OMAiKKRTTHY.
OrthoDBiEOG091G11QQ.
PhylomeDBiP15720.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
PROSITEiPS00569. MYELIN_MBP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P15720-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASQKRSSFR HGSKMASAST TDHARHGSPR HRDSGLLDSL GRFFGGDRHV
60 70 80 90 100
PRRGFGKDIH AARASHVGSI PQRSQHGRPG DDNPVVHFFK NIVSPRTPPP
110 120 130 140 150
MQAKGRGLSL TRFSWGGEGH KPGYGSGKFY EHKSAHKGHK GSYHEGQGTL
160 170
SKIFKLGGSG SRPGSRSGSP VARR
Note: Major isoform.
Length:174
Mass (Da):18,808
Last modified:January 23, 2007 - v2
Checksum:i1935D29D945A317D
GO
Isoform 2 (identifier: P15720-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-115: Missing.

Show »
Length:163
Mass (Da):17,547
Checksum:i65DE3893E1530FD6
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003323105 – 115Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17103 mRNA. Translation: CAA34959.1.
PIRiS08535.
RefSeqiNP_990611.1. NM_205280.1. [P15720-1]
UniGeneiGga.15971.
Gga.2913.

Genome annotation databases

EnsembliENSGALT00000022187; ENSGALP00000022148; ENSGALG00000013640. [P15720-1]
GeneIDi396217.
KEGGigga:396217.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17103 mRNA. Translation: CAA34959.1.
PIRiS08535.
RefSeqiNP_990611.1. NM_205280.1. [P15720-1]
UniGeneiGga.15971.
Gga.2913.

3D structure databases

ProteinModelPortaliP15720.
SMRiP15720.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP15720.

Proteomic databases

PaxDbiP15720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000022187; ENSGALP00000022148; ENSGALG00000013640. [P15720-1]
GeneIDi396217.
KEGGigga:396217.

Organism-specific databases

CTDi4155.

Phylogenomic databases

eggNOGiENOG410J981. Eukaryota.
ENOG41115M7. LUCA.
GeneTreeiENSGT00390000014772.
HOGENOMiHOG000293395.
HOVERGENiHBG008347.
InParanoidiP15720.
KOiK17269.
OMAiKKRTTHY.
OrthoDBiEOG091G11QQ.
PhylomeDBiP15720.

Miscellaneous databases

PROiP15720.

Gene expression databases

BgeeiENSGALG00000013640.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
PROSITEiPS00569. MYELIN_MBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMBP_CHICK
AccessioniPrimary (citable) accession number: P15720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.