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P15704

- GUN_CLOSA

UniProt

P15704 - GUN_CLOSA

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Protein

Endoglucanase

Gene
eglA
Organism
Clostridium saccharobutylicum
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751Proton donor By similarity
Active sitei263 – 2631Nucleophile By similarity

GO - Molecular functioni

  1. cellulase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase (EC:3.2.1.4)
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:eglA
OrganismiClostridium saccharobutylicum
Taxonomic identifieri169679 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Add
BLAST
Chaini35 – 448414EndoglucanasePRO_0000007844Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP15704.
SMRiP15704. Positions 45-335.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR004867. CHB_HEX_C_dom.
IPR026876. Fn3_assoc_repeat.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
PF03174. CHB_HEX_C. 1 hit.
PF13287. Fn3_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15704-1 [UniParc]FASTAAdd to Basket

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MFSKIKKINF FKKTFSFLIA VVMMLFTVLG TNTYKAEAAT TSFGGQLKVV    50
GSQLCDSNGK PIQLKGMSSH GLQWYVNFVN YDSMKFLRDK WGVNVIRAAM 100
YTNEGGYISN PSSQKEKIKK IVQDAIDLNM YVIIDWHILS DNNPNTYKEQ 150
AKSFFQEMAE EYGKYSNVIY EICNEPNGGT NWANDIKPYA NYIIPAIRAI 200
DPNNIIIVGT STWSQDVDIA ADNPLRYSNI MYTCHFYAGT HTQSLRDKIN 250
YAMSKGIAIF VTEWGTSDAS GNGGPYLDES QKWVDFMASK NISWTNWALC 300
DKSEASAALK SGSSTTGGWT DSDLTTSGLF VKKSIGGSNT TSQTSAPTFS 350
LQSGTYDSAQ TVTLTSSDND SVIHYTTDGT TPTSSSPVYT SPITISKTTT 400
VKAFTTKTGM TDSNITSAVY TISNTDPVKQ VSAPTFSYNQ EHTIQLKL 448
Length:448
Mass (Da):49,366
Last modified:April 1, 1990 - v1
Checksum:i6FE6AC97C836A598
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31311 Genomic DNA. Translation: AAA23230.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31311 Genomic DNA. Translation: AAA23230.1 .

3D structure databases

ProteinModelPortali P15704.
SMRi P15704. Positions 45-335.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR004867. CHB_HEX_C_dom.
IPR026876. Fn3_assoc_repeat.
IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
PF03174. CHB_HEX_C. 1 hit.
PF13287. Fn3_assoc. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of an endo-beta-1,4-glucanase gene from Clostridium acetobutylicum P262 showing homology with endoglucanase genes from Bacillus spp."
    Zappe H., Jones W.A., Jones D.T., Woods D.R.
    Appl. Environ. Microbiol. 54:1289-1292(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-117 / DSM 13864 / NCP 262.

Entry informationi

Entry nameiGUN_CLOSA
AccessioniPrimary (citable) accession number: P15704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 16, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The C-terminal region of C.acetobutylicum is not required for activity.

Caution

Was originally (1 Publication) thought to originate from C.acetobutylicum.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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