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Protein

Endoglucanase

Gene

eglA

Organism
Clostridium saccharobutylicum
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Proton donorBy similarity1
Active sitei263NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase (EC:3.2.1.4)
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:eglA
OrganismiClostridium saccharobutylicum
Taxonomic identifieri169679 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000000784435 – 448EndoglucanaseAdd BLAST414

Structurei

3D structure databases

ProteinModelPortaliP15704.
SMRiP15704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSKIKKINF FKKTFSFLIA VVMMLFTVLG TNTYKAEAAT TSFGGQLKVV
60 70 80 90 100
GSQLCDSNGK PIQLKGMSSH GLQWYVNFVN YDSMKFLRDK WGVNVIRAAM
110 120 130 140 150
YTNEGGYISN PSSQKEKIKK IVQDAIDLNM YVIIDWHILS DNNPNTYKEQ
160 170 180 190 200
AKSFFQEMAE EYGKYSNVIY EICNEPNGGT NWANDIKPYA NYIIPAIRAI
210 220 230 240 250
DPNNIIIVGT STWSQDVDIA ADNPLRYSNI MYTCHFYAGT HTQSLRDKIN
260 270 280 290 300
YAMSKGIAIF VTEWGTSDAS GNGGPYLDES QKWVDFMASK NISWTNWALC
310 320 330 340 350
DKSEASAALK SGSSTTGGWT DSDLTTSGLF VKKSIGGSNT TSQTSAPTFS
360 370 380 390 400
LQSGTYDSAQ TVTLTSSDND SVIHYTTDGT TPTSSSPVYT SPITISKTTT
410 420 430 440
VKAFTTKTGM TDSNITSAVY TISNTDPVKQ VSAPTFSYNQ EHTIQLKL
Length:448
Mass (Da):49,366
Last modified:April 1, 1990 - v1
Checksum:i6FE6AC97C836A598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31311 Genomic DNA. Translation: AAA23230.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31311 Genomic DNA. Translation: AAA23230.1.

3D structure databases

ProteinModelPortaliP15704.
SMRiP15704.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUN_CLOSA
AccessioniPrimary (citable) accession number: P15704
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The C-terminal region of C.acetobutylicum is not required for activity.

Caution

Was originally thought to originate from C.acetobutylicum.1 Publication

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.