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P15704

- GUN_CLOSA

UniProt

P15704 - GUN_CLOSA

Protein

Endoglucanase

Gene

eglA

Organism
Clostridium saccharobutylicum
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei175 – 1751Proton donorBy similarity
    Active sitei263 – 2631NucleophileBy similarity

    GO - Molecular functioni

    1. cellulase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH5. Glycoside Hydrolase Family 5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoglucanase (EC:3.2.1.4)
    Alternative name(s):
    Cellulase
    Endo-1,4-beta-glucanase
    Gene namesi
    Name:eglA
    OrganismiClostridium saccharobutylicum
    Taxonomic identifieri169679 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Add
    BLAST
    Chaini35 – 448414EndoglucanasePRO_0000007844Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP15704.
    SMRiP15704. Positions 45-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR004867. CHB_HEX_C_dom.
    IPR026876. Fn3_assoc_repeat.
    IPR001547. Glyco_hydro_5.
    IPR018087. Glyco_hydro_5_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    PF03174. CHB_HEX_C. 1 hit.
    PF13287. Fn3_assoc. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15704-1 [UniParc]FASTAAdd to Basket

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    MFSKIKKINF FKKTFSFLIA VVMMLFTVLG TNTYKAEAAT TSFGGQLKVV    50
    GSQLCDSNGK PIQLKGMSSH GLQWYVNFVN YDSMKFLRDK WGVNVIRAAM 100
    YTNEGGYISN PSSQKEKIKK IVQDAIDLNM YVIIDWHILS DNNPNTYKEQ 150
    AKSFFQEMAE EYGKYSNVIY EICNEPNGGT NWANDIKPYA NYIIPAIRAI 200
    DPNNIIIVGT STWSQDVDIA ADNPLRYSNI MYTCHFYAGT HTQSLRDKIN 250
    YAMSKGIAIF VTEWGTSDAS GNGGPYLDES QKWVDFMASK NISWTNWALC 300
    DKSEASAALK SGSSTTGGWT DSDLTTSGLF VKKSIGGSNT TSQTSAPTFS 350
    LQSGTYDSAQ TVTLTSSDND SVIHYTTDGT TPTSSSPVYT SPITISKTTT 400
    VKAFTTKTGM TDSNITSAVY TISNTDPVKQ VSAPTFSYNQ EHTIQLKL 448
    Length:448
    Mass (Da):49,366
    Last modified:April 1, 1990 - v1
    Checksum:i6FE6AC97C836A598
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31311 Genomic DNA. Translation: AAA23230.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31311 Genomic DNA. Translation: AAA23230.1 .

    3D structure databases

    ProteinModelPortali P15704.
    SMRi P15704. Positions 45-335.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH5. Glycoside Hydrolase Family 5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR004867. CHB_HEX_C_dom.
    IPR026876. Fn3_assoc_repeat.
    IPR001547. Glyco_hydro_5.
    IPR018087. Glyco_hydro_5_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    PF03174. CHB_HEX_C. 1 hit.
    PF13287. Fn3_assoc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of an endo-beta-1,4-glucanase gene from Clostridium acetobutylicum P262 showing homology with endoglucanase genes from Bacillus spp."
      Zappe H., Jones W.A., Jones D.T., Woods D.R.
      Appl. Environ. Microbiol. 54:1289-1292(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC BAA-117 / DSM 13864 / NCP 262.

    Entry informationi

    Entry nameiGUN_CLOSA
    AccessioniPrimary (citable) accession number: P15704
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The C-terminal region of C.acetobutylicum is not required for activity.

    Caution

    Was originally thought to originate from C.acetobutylicum.1 Publication

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3