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Protein

Vascular endothelial growth factor A

Gene

VEGFA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).By similarity

GO - Molecular functioni

  1. cytokine activity Source: BHF-UCL
  2. growth factor activity Source: BHF-UCL
  3. heparin binding Source: UniProtKB-KW
  4. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. cellular response to hypoxia Source: MGI
  4. positive regulation of angiogenesis Source: UniProtKB
  5. positive regulation of cell division Source: UniProtKB-KW
  6. positive regulation of endothelial cell migration Source: UniProtKB
  7. positive regulation of endothelial cell proliferation Source: BHF-UCL
  8. positive regulation of focal adhesion assembly Source: UniProtKB
  9. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  10. positive regulation of protein complex assembly Source: UniProtKB
  11. positive regulation of protein phosphorylation Source: UniProtKB
  12. tube formation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor A
Short name:
VEGF-A
Alternative name(s):
Vascular permeability factor
Short name:
VPF
Gene namesi
Name:VEGFA
Synonyms:VEGF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Secreted By similarity
Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.By similarity

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26262 PublicationsAdd
BLAST
Chaini27 – 190164Vascular endothelial growth factor APRO_0000023383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 93By similarity
Disulfide bondi76 – 76InterchainBy similarity
Disulfide bondi82 ↔ 127By similarity
Disulfide bondi85 – 85InterchainBy similarity
Disulfide bondi86 ↔ 129By similarity
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP15691.
SMRiP15691. Positions 37-134, 136-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000105.
InParanoidiP15691.
KOiK05448.

Family and domain databases

Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: P15691-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF
60 70 80 90 100
CRPIETLVDI FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN
110 120 130 140 150
ITMQIMRIKP HQSQHIGEMS FLQHNKCECR PKKDKARQEN PCGPCSERRK
160 170 180 190
HLFVQDPQTC KCSCKNTDSR CKARQLELNE RTCRCDKPRR
Length:190
Mass (Da):22,310
Last modified:April 1, 1990 - v1
Checksum:iEDBF903E46E24789
GO
Isoform Beta (identifier: P15691-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-183: Missing.
     184-184: R → K

Show »
Length:145
Mass (Da):17,086
Checksum:i9923B0D500BC3378
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei139 – 18345Missing in isoform Beta. 1 PublicationVSP_004613Add
BLAST
Alternative sequencei184 – 1841R → K in isoform Beta. 1 PublicationVSP_004614

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32976 mRNA. Translation: AAA30502.1.
M31836 mRNA. Translation: AAA30804.1.
M33750 mRNA. Translation: AAA30805.1.
PIRiA33787.
B40080.
RefSeqiNP_776641.1. NM_174216.1. [P15691-1]
UniGeneiBt.4138.

Genome annotation databases

GeneIDi281572.
KEGGibta:281572.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32976 mRNA. Translation: AAA30502.1.
M31836 mRNA. Translation: AAA30804.1.
M33750 mRNA. Translation: AAA30805.1.
PIRiA33787.
B40080.
RefSeqiNP_776641.1. NM_174216.1. [P15691-1]
UniGeneiBt.4138.

3D structure databases

ProteinModelPortaliP15691.
SMRiP15691. Positions 37-134, 136-190.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281572.
KEGGibta:281572.

Organism-specific databases

CTDi7422.

Phylogenomic databases

HOVERGENiHBG000105.
InParanoidiP15691.
KOiK05448.

Miscellaneous databases

NextBioi20805521.

Family and domain databases

Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Vascular endothelial growth factor is a secreted angiogenic mitogen."
    Leung D.W., Cachianes G., Kuang W.-J., Goeddel D.V., Ferrara N.
    Science 246:1306-1309(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-47.
  2. "Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family."
    Tischer E., Gospodarowicz D., Mitchell R., Silva M., Schilling J., Lau K., Crisp T., Fiddes J.C., Abraham J.A.
    Biochem. Biophys. Res. Commun. 165:1198-1206(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-190 (ISOFORMS ALPHA AND BETA).
  3. "Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells."
    Ferrara N., Henzel W.J.
    Biochem. Biophys. Res. Commun. 161:851-858(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-31.

Entry informationi

Entry nameiVEGFA_BOVIN
AccessioniPrimary (citable) accession number: P15691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: January 7, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.