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P15691 (VEGFA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vascular endothelial growth factor A

Short name=VEGF-A
Alternative name(s):
Vascular permeability factor
Short name=VPF
Gene names
Name:VEGFA
Synonyms:VEGF
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin By similarity.

Subunit structure

Homodimer; disulfide-linked. Also found as heterodimer with PGF By similarity.

Subcellular location

Secreted By similarity. Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin By similarity.

Sequence similarities

Belongs to the PDGF/VEGF growth factor family.

Ontologies

Keywords
   Biological processAngiogenesis
Differentiation
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   LigandHeparin-binding
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to hypoxia

Inferred from direct assay PubMed 10575000. Source: MGI

positive regulation of angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of endothelial cell migration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of endothelial cell proliferation

Inferred from direct assay PubMed 2798412. Source: BHF-UCL

positive regulation of focal adhesion assembly

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein complex assembly

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

tube formation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentextracellular space

Inferred from direct assay PubMed 2798412. Source: BHF-UCL

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 2798412. Source: BHF-UCL

growth factor activity

Inferred from direct assay PubMed 2798412. Source: BHF-UCL

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein homodimerization activity

Inferred from direct assay PubMed 2798412. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: P15691-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: P15691-2)

The sequence of this isoform differs from the canonical sequence as follows:
     139-183: Missing.
     184-184: R → K

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Ref.1 Ref.3
Chain27 – 190164Vascular endothelial growth factor A
PRO_0000023383

Amino acid modifications

Glycosylation1001N-linked (GlcNAc...) Potential
Disulfide bond51 ↔ 93 By similarity
Disulfide bond76Interchain By similarity
Disulfide bond82 ↔ 127 By similarity
Disulfide bond85Interchain By similarity
Disulfide bond86 ↔ 129 By similarity

Natural variations

Alternative sequence139 – 18345Missing in isoform Beta.
VSP_004613
Alternative sequence1841R → K in isoform Beta.
VSP_004614

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: EDBF903E46E24789

FASTA19022,310
        10         20         30         40         50         60 
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF CRPIETLVDI 

        70         80         90        100        110        120 
FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN ITMQIMRIKP HQSQHIGEMS 

       130        140        150        160        170        180 
FLQHNKCECR PKKDKARQEN PCGPCSERRK HLFVQDPQTC KCSCKNTDSR CKARQLELNE 

       190 
RTCRCDKPRR 

« Hide

Isoform Beta [UniParc].

Checksum: 9923B0D500BC3378
Show »

FASTA14517,086

References

[1]"Vascular endothelial growth factor is a secreted angiogenic mitogen."
Leung D.W., Cachianes G., Kuang W.-J., Goeddel D.V., Ferrara N.
Science 246:1306-1309(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-47.
[2]"Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family."
Tischer E., Gospodarowicz D., Mitchell R., Silva M., Schilling J., Lau K., Crisp T., Fiddes J.C., Abraham J.A.
Biochem. Biophys. Res. Commun. 165:1198-1206(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-190 (ISOFORMS ALPHA AND BETA).
[3]"Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells."
Ferrara N., Henzel W.J.
Biochem. Biophys. Res. Commun. 161:851-858(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 27-31.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32976 mRNA. Translation: AAA30502.1.
M31836 mRNA. Translation: AAA30804.1.
M33750 mRNA. Translation: AAA30805.1.
PIRA33787.
B40080.
RefSeqNP_776641.1. NM_174216.1.
UniGeneBt.4138.

3D structure databases

ProteinModelPortalP15691.
SMRP15691. Positions 37-134, 136-190.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281572.
KEGGbta:281572.

Organism-specific databases

CTD7422.

Phylogenomic databases

HOVERGENHBG000105.
KOK05448.

Family and domain databases

Gene3D2.10.160.10. 1 hit.
InterProIPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMSSF57593. SSF57593. 1 hit.
PROSITEPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805521.

Entry information

Entry nameVEGFA_BOVIN
AccessionPrimary (citable) accession number: P15691
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families