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P15691

- VEGFA_BOVIN

UniProt

P15691 - VEGFA_BOVIN

Protein

Vascular endothelial growth factor A

Gene

VEGFA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin By similarity.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: BHF-UCL
    2. growth factor activity Source: BHF-UCL
    3. heparin binding Source: UniProtKB-KW
    4. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. cellular response to hypoxia Source: MGI
    4. positive regulation of angiogenesis Source: UniProtKB
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of endothelial cell migration Source: UniProtKB
    7. positive regulation of endothelial cell proliferation Source: BHF-UCL
    8. positive regulation of focal adhesion assembly Source: UniProtKB
    9. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    10. positive regulation of protein complex assembly Source: UniProtKB
    11. positive regulation of protein phosphorylation Source: UniProtKB
    12. tube formation Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vascular endothelial growth factor A
    Short name:
    VEGF-A
    Alternative name(s):
    Vascular permeability factor
    Short name:
    VPF
    Gene namesi
    Name:VEGFA
    Synonyms:VEGF
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Secreted By similarity
    Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.By similarity

    GO - Cellular componenti

    1. extracellular space Source: BHF-UCL
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26262 PublicationsAdd
    BLAST
    Chaini27 – 190164Vascular endothelial growth factor APRO_0000023383Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 93By similarity
    Disulfide bondi76 – 76InterchainBy similarity
    Disulfide bondi82 ↔ 127By similarity
    Disulfide bondi85 – 85InterchainBy similarity
    Disulfide bondi86 ↔ 129By similarity
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Also found as heterodimer with PGF By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP15691.
    SMRiP15691. Positions 37-134, 136-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PDGF/VEGF growth factor family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG000105.
    KOiK05448.

    Family and domain databases

    Gene3Di2.10.160.10. 1 hit.
    2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    IPR027928. VEGF_C.
    [Graphical view]
    PfamiPF00341. PDGF. 1 hit.
    PF14554. VEGF_C. 1 hit.
    [Graphical view]
    SMARTiSM00141. PDGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    SSF57593. SSF57593. 1 hit.
    PROSITEiPS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: P15691-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGGQKPHEVV KFMDVYQRSF    50
    CRPIETLVDI FQEYPDEIEF IFKPSCVPLM RCGGCCNDES LECVPTEEFN 100
    ITMQIMRIKP HQSQHIGEMS FLQHNKCECR PKKDKARQEN PCGPCSERRK 150
    HLFVQDPQTC KCSCKNTDSR CKARQLELNE RTCRCDKPRR 190
    Length:190
    Mass (Da):22,310
    Last modified:April 1, 1990 - v1
    Checksum:iEDBF903E46E24789
    GO
    Isoform Beta (identifier: P15691-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         139-183: Missing.
         184-184: R → K

    Show »
    Length:145
    Mass (Da):17,086
    Checksum:i9923B0D500BC3378
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei139 – 18345Missing in isoform Beta. 1 PublicationVSP_004613Add
    BLAST
    Alternative sequencei184 – 1841R → K in isoform Beta. 1 PublicationVSP_004614

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32976 mRNA. Translation: AAA30502.1.
    M31836 mRNA. Translation: AAA30804.1.
    M33750 mRNA. Translation: AAA30805.1.
    PIRiA33787.
    B40080.
    RefSeqiNP_776641.1. NM_174216.1. [P15691-1]
    UniGeneiBt.4138.

    Genome annotation databases

    GeneIDi281572.
    KEGGibta:281572.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32976 mRNA. Translation: AAA30502.1 .
    M31836 mRNA. Translation: AAA30804.1 .
    M33750 mRNA. Translation: AAA30805.1 .
    PIRi A33787.
    B40080.
    RefSeqi NP_776641.1. NM_174216.1. [P15691-1 ]
    UniGenei Bt.4138.

    3D structure databases

    ProteinModelPortali P15691.
    SMRi P15691. Positions 37-134, 136-190.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 281572.
    KEGGi bta:281572.

    Organism-specific databases

    CTDi 7422.

    Phylogenomic databases

    HOVERGENi HBG000105.
    KOi K05448.

    Miscellaneous databases

    NextBioi 20805521.

    Family and domain databases

    Gene3Di 2.10.160.10. 1 hit.
    2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR023581. PD_growth_factor_CS.
    IPR000072. PDGF/VEGF_dom.
    IPR027928. VEGF_C.
    [Graphical view ]
    Pfami PF00341. PDGF. 1 hit.
    PF14554. VEGF_C. 1 hit.
    [Graphical view ]
    SMARTi SM00141. PDGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    SSF57593. SSF57593. 1 hit.
    PROSITEi PS00249. PDGF_1. 1 hit.
    PS50278. PDGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vascular endothelial growth factor is a secreted angiogenic mitogen."
      Leung D.W., Cachianes G., Kuang W.-J., Goeddel D.V., Ferrara N.
      Science 246:1306-1309(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-47.
    2. "Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family."
      Tischer E., Gospodarowicz D., Mitchell R., Silva M., Schilling J., Lau K., Crisp T., Fiddes J.C., Abraham J.A.
      Biochem. Biophys. Res. Commun. 165:1198-1206(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-190 (ISOFORMS ALPHA AND BETA).
    3. "Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells."
      Ferrara N., Henzel W.J.
      Biochem. Biophys. Res. Commun. 161:851-858(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-31.

    Entry informationi

    Entry nameiVEGFA_BOVIN
    AccessioniPrimary (citable) accession number: P15691
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3