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Reviewed, UniProtKB/Swiss-Prot P15689 (NDUS2_PARTE)

Last modified June 16, 2009. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit
    EC=1.6.5.3
    EC=1.6.99.3
Alternative name(s):
    NADH dehydrogenase subunit 7
Gene names
Name: NAD7
Encoded onMitochondrion
OrganismParamecium tetraurelia
Taxonomic identifier5888 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.

Catalytic activity

NADH + ubiquinone = NAD+ + ubiquinol.

NADH + acceptor = NAD+ + reduced acceptor.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the complex I 49 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 400400NADH-ubiquinone oxidoreductase 49 kDa subunit
PRO_0000118590

Sequences

Sequence LengthMass (Da)Tools
P15689-1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 1E66944DF516D4F7

FASTA40046,077
        10         20         30         40         50         60 
MKAICVNFGP QHPAAHGVLR LILQLNGEVV EKMDIHIGLL HRGSEKLMET KPYLQSMPYF 

        70         80         90        100        110        120 
DRLDYVSMMV QEHAYCLAIE ALLNTTNYTA NFVLVRTMFD ELTRILNHML AIACHALDIG 

       130        140        150        160        170        180 
SMSSIFWAFE EREKIMEFYE RVCGRRMHAA FYRPNEVNLN FLSVKLLTDI LEFNNNCLTT 

       190        200        210        220        230        240 
LSEMHNILTY NKIWKQRLVN IGSISYKDCL DFGLTGVMAR STGIKRDLRM DAFDTYANYY 

       250        260        270        280        290        300 
YLNFRSYTGQ AGDSYDRFLI RMNEMSESIN IISQAIFKLT TSKNTCSPAS ILKALNKKKF 

       310        320        330        340        350        360 
ISQTYKNEYS SMEKLITHFK YWSEGFKIQS NWTYQAVESP KGEFGVTLVS DGSNKPYRCK 

       370        380        390        400 
VRSPAYHHLQ VLPKMSKGHL LADLSALIGT IDIVFGEIDR 

« Hide

References

[1]"Nucleotide sequence of the mitochondrial genome of Paramecium."
Pritchard A.E., Seilhamer J.J., Mahalingam R., Sable C.L., Venuti S.E., Cummings D.J.
Nucleic Acids Res. 18:173-180(1990) [PubMed: 2308823] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Stock 51.
[2]"An unusual region of Paramecium mitochondrial DNA containing chloroplast-like genes."
Pritchard A.E., Venuti S.E., Ghalambor M.A., Sable C.L., Cummings D.J.
Gene 78:121-134(1989) [PubMed: 2670676] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

X15917 Genomic DNA. Translation: CAA34042.1.
M26930 Genomic DNA. Translation: AAA79254.1.
PIRS07733.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA1.6.5.3. 21526.
1.6.99.3. 21526.

Family and domain databases

InterProIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_su-49kDa_CS.
[Graphical view]
PfamPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
PROSITEPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNDUS2_PARTE
AccessionPrimary (citable) accession number: P15689
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents