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P15689

- NDUS2_PARTE

UniProt

P15689 - NDUS2_PARTE

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Protein
NADH-ubiquinone oxidoreductase 49 kDa subunit
Gene
NAD7
Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  3. quinone binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400NADH-ubiquinone oxidoreductase 49 kDa subunit
PRO_0000118590Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP15689.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.645.10. 3 hits.
InterProiIPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00346. Complex1_49kDa. 1 hit.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
PROSITEiPS00535. COMPLEX1_49K. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15689-1 [UniParc]FASTAAdd to Basket

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MKAICVNFGP QHPAAHGVLR LILQLNGEVV EKMDIHIGLL HRGSEKLMET    50
KPYLQSMPYF DRLDYVSMMV QEHAYCLAIE ALLNTTNYTA NFVLVRTMFD 100
ELTRILNHML AIACHALDIG SMSSIFWAFE EREKIMEFYE RVCGRRMHAA 150
FYRPNEVNLN FLSVKLLTDI LEFNNNCLTT LSEMHNILTY NKIWKQRLVN 200
IGSISYKDCL DFGLTGVMAR STGIKRDLRM DAFDTYANYY YLNFRSYTGQ 250
AGDSYDRFLI RMNEMSESIN IISQAIFKLT TSKNTCSPAS ILKALNKKKF 300
ISQTYKNEYS SMEKLITHFK YWSEGFKIQS NWTYQAVESP KGEFGVTLVS 350
DGSNKPYRCK VRSPAYHHLQ VLPKMSKGHL LADLSALIGT IDIVFGEIDR 400
Length:400
Mass (Da):46,077
Last modified:April 1, 1990 - v1
Checksum:i1E66944DF516D4F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15917 Genomic DNA. Translation: CAA34042.1.
M26930 Genomic DNA. Translation: AAA79254.1.
PIRiS07733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15917 Genomic DNA. Translation: CAA34042.1 .
M26930 Genomic DNA. Translation: AAA79254.1 .
PIRi S07733.

3D structure databases

ProteinModelPortali P15689.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.645.10. 3 hits.
InterProi IPR001135. NADH_Q_OxRdtase_suD.
IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00346. Complex1_49kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
PROSITEi PS00535. COMPLEX1_49K. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Stock 51.
  2. "An unusual region of Paramecium mitochondrial DNA containing chloroplast-like genes."
    Pritchard A.E., Venuti S.E., Ghalambor M.A., Sable C.L., Cummings D.J.
    Gene 78:121-134(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiNDUS2_PARTE
AccessioniPrimary (citable) accession number: P15689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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