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P15689

- NDUS2_PARTE

UniProt

P15689 - NDUS2_PARTE

Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

NAD7

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    3. quinone binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    NADH dehydrogenase subunit 7
    Gene namesi
    Name:NAD7
    Encoded oniMitochondrion
    OrganismiParamecium tetraurelia
    Taxonomic identifieri5888 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400NADH-ubiquinone oxidoreductase 49 kDa subunitPRO_0000118590Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP15689.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 49 kDa subunit family.Curated

    Family and domain databases

    Gene3Di1.10.645.10. 3 hits.
    InterProiIPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00346. Complex1_49kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    PROSITEiPS00535. COMPLEX1_49K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15689-1 [UniParc]FASTAAdd to Basket

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    MKAICVNFGP QHPAAHGVLR LILQLNGEVV EKMDIHIGLL HRGSEKLMET    50
    KPYLQSMPYF DRLDYVSMMV QEHAYCLAIE ALLNTTNYTA NFVLVRTMFD 100
    ELTRILNHML AIACHALDIG SMSSIFWAFE EREKIMEFYE RVCGRRMHAA 150
    FYRPNEVNLN FLSVKLLTDI LEFNNNCLTT LSEMHNILTY NKIWKQRLVN 200
    IGSISYKDCL DFGLTGVMAR STGIKRDLRM DAFDTYANYY YLNFRSYTGQ 250
    AGDSYDRFLI RMNEMSESIN IISQAIFKLT TSKNTCSPAS ILKALNKKKF 300
    ISQTYKNEYS SMEKLITHFK YWSEGFKIQS NWTYQAVESP KGEFGVTLVS 350
    DGSNKPYRCK VRSPAYHHLQ VLPKMSKGHL LADLSALIGT IDIVFGEIDR 400
    Length:400
    Mass (Da):46,077
    Last modified:April 1, 1990 - v1
    Checksum:i1E66944DF516D4F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15917 Genomic DNA. Translation: CAA34042.1.
    M26930 Genomic DNA. Translation: AAA79254.1.
    PIRiS07733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15917 Genomic DNA. Translation: CAA34042.1 .
    M26930 Genomic DNA. Translation: AAA79254.1 .
    PIRi S07733.

    3D structure databases

    ProteinModelPortali P15689.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.645.10. 3 hits.
    InterProi IPR001135. NADH_Q_OxRdtase_suD.
    IPR014029. NADH_UbQ_OxRdtase_49kDa_CS.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00346. Complex1_49kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    PROSITEi PS00535. COMPLEX1_49K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Stock 51.
    2. "An unusual region of Paramecium mitochondrial DNA containing chloroplast-like genes."
      Pritchard A.E., Venuti S.E., Ghalambor M.A., Sable C.L., Cummings D.J.
      Gene 78:121-134(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiNDUS2_PARTE
    AccessioniPrimary (citable) accession number: P15689
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3