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Protein

NADH-ubiquinone oxidoreductase 49 kDa subunit

Gene

NAD7

Organism
Paramecium tetraurelia
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 49 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
NADH dehydrogenase subunit 7
Gene namesi
Name:NAD7
Encoded oniMitochondrion
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001185901 – 400NADH-ubiquinone oxidoreductase 49 kDa subunitAdd BLAST400

Structurei

3D structure databases

ProteinModelPortaliP15689
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 49 kDa subunit family.Curated

Family and domain databases

Gene3Di1.10.645.20, 1 hit
InterProiView protein in InterPro
IPR001135 NADH_Q_OxRdtase_suD
IPR038290 NADH_Q_OxRdtase_suD_sf
IPR014029 NADH_UbQ_OxRdtase_49kDa_CS
IPR029014 NiFe-Hase_large
PfamiView protein in Pfam
PF00346 Complex1_49kDa, 1 hit
SUPFAMiSSF56762 SSF56762, 1 hit
PROSITEiView protein in PROSITE
PS00535 COMPLEX1_49K, 1 hit

Sequencei

Sequence statusi: Complete.

P15689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAICVNFGP QHPAAHGVLR LILQLNGEVV EKMDIHIGLL HRGSEKLMET
60 70 80 90 100
KPYLQSMPYF DRLDYVSMMV QEHAYCLAIE ALLNTTNYTA NFVLVRTMFD
110 120 130 140 150
ELTRILNHML AIACHALDIG SMSSIFWAFE EREKIMEFYE RVCGRRMHAA
160 170 180 190 200
FYRPNEVNLN FLSVKLLTDI LEFNNNCLTT LSEMHNILTY NKIWKQRLVN
210 220 230 240 250
IGSISYKDCL DFGLTGVMAR STGIKRDLRM DAFDTYANYY YLNFRSYTGQ
260 270 280 290 300
AGDSYDRFLI RMNEMSESIN IISQAIFKLT TSKNTCSPAS ILKALNKKKF
310 320 330 340 350
ISQTYKNEYS SMEKLITHFK YWSEGFKIQS NWTYQAVESP KGEFGVTLVS
360 370 380 390 400
DGSNKPYRCK VRSPAYHHLQ VLPKMSKGHL LADLSALIGT IDIVFGEIDR
Length:400
Mass (Da):46,077
Last modified:April 1, 1990 - v1
Checksum:i1E66944DF516D4F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15917 Genomic DNA Translation: CAA34042.1
M26930 Genomic DNA Translation: AAA79254.1
PIRiS07733

Similar proteinsi

Entry informationi

Entry nameiNDUS2_PARTE
AccessioniPrimary (citable) accession number: P15689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health