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Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1UniRule annotation
Short name:
NSP1UniRule annotation
Alternative name(s):
NCVP2UniRule annotation
Non-structural RNA-binding protein 53UniRule annotation
Short name:
NS53UniRule annotation
OrganismiRotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
Taxonomic identifieri37137 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiMacaca mulatta (Rhesus macaque) [TaxID: 9544]
Proteomesi
  • UP000007180 Componenti: Genome

Subcellular locationi

  • host cytoskeleton UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001495581 – 495Non-structural protein 1Add BLAST495

Interactioni

Subunit structurei

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3.UniRule annotation

Structurei

3D structure databases

SMRiP15687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 81RNA-bindingUniRule annotationAdd BLAST81
Regioni42 – 79Zinc-binding domainUniRule annotationAdd BLAST38
Regioni82 – 177Important for cytoskeleton localizationUniRule annotationAdd BLAST96
Regioni320 – 495Interaction with host IRF3UniRule annotationAdd BLAST176

Domaini

The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3.UniRule annotation

Sequence similaritiesi

Belongs to the rotavirus NSP1 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG09000073

Family and domain databases

HAMAPiMF_04088 ROTA_NSP1, 1 hit
InterProiView protein in InterPro
IPR002148 Rotavirus_NSP1
PfamiView protein in Pfam
PF00981 Rota_NS53, 1 hit

Sequencei

Sequence statusi: Complete.

P15687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFKDACFH YRRLTALNRR LCNIGANSIC MPVPDEKIKG WCLECCQIAD
60 70 80 90 100
LTHCYGCSLP HVCKWCVQNR RCFLDNEPHL LKLRTVKHPI TKDKLQCIID
110 120 130 140 150
LYNIIFPIND KVIRKFERMI KQRKCRNQYK IEWYNHLLLP ITLNAAAFKF
160 170 180 190 200
DENNLYYVFG LYEKSVSDIY APYRIVNFIN EFDKLLLDDI NFTRMSNLPI
210 220 230 240 250
ELRTIMQEYF QLSRLPSSKL KQIYFSDFTK ETVIFNTYTK TPGRSIYRNV
260 270 280 290 300
TEFNWRDELE LYSDLKNDKN KLIAAMMTSK YTRFYAHDNN FGRLKMTIFE
310 320 330 340 350
LGHHCQPNYV ASNHPGNASD IQYCKWCNIK YFLSKIDWRI RDMYNLLMEF
360 370 380 390 400
IKDCYKSNVN VGHCSSVENI YPLIKRLIWS LFTNHMDQTI EEVFNHMSPV
410 420 430 440 450
SVEGTNVIML ILGLNISLYN EIKRTLNVDS IPMVLNLNEF SSIVKSISSK
460 470 480 490
WYNVDELDKL PMSIKSTEEL IEMKNSGTLT EEFELLISNS EDDNE
Length:495
Mass (Da):58,484
Last modified:April 1, 1990 - v1
Checksum:iD988A936CD1B534B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14914 Genomic RNA Translation: CAA33039.1
PIRiS08215 MNXRSA

Similar proteinsi

Entry informationi

Entry nameiNSP1_ROTS1
AccessioniPrimary (citable) accession number: P15687
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health