Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 5

Gene

Fgf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190372. FGFR3c ligand binding and activation.
R-MMU-190373. FGFR1c ligand binding and activation.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-5654219. Phospholipase C-mediated cascade: FGFR1.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654227. Phospholipase C-mediated cascade, FGFR3.
R-MMU-5654687. Downstream signaling of activated FGFR1.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 5
Short name:
FGF-5
Alternative name(s):
Heparin-binding growth factor 5
Short name:
HBGF-5
Gene namesi
Name:Fgf5
Synonyms:Fgf-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95519. Fgf5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000895921 – 264Fibroblast growth factor 5Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP15656.
PRIDEiP15656.

PTM databases

iPTMnetiP15656.
PhosphoSitePlusiP15656.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029337.
CleanExiMM_FGF5.
GenevisibleiP15656. MM.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031280.

Structurei

3D structure databases

ProteinModelPortaliP15656.
SMRiP15656.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 59Poly-Ser7

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP15656.
KOiK04358.
OMAiLSAWAHG.
OrthoDBiEOG091G0NAY.
PhylomeDBiP15656.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028240. FGF5.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF23. PTHR11486:SF23. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P15656-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSLLFLIF CSHLIHSAWA HGEKRLTPEG QPAPPRNPGD SSGSRGRSSA
60 70 80 90 100
TFSSSSASSP VAASPGSQGS GSEHSSFQWS PSGRRTGSLY CRVGIGFHLQ
110 120 130 140 150
IYPDGKVNGS HEASVLSILE IFAVSQGIVG IRGVFSNKFL AMSKKGKLHA
160 170 180 190 200
SAKFTDDCKF RERFQENSYN TYASAIHRTE KTGREWYVAL NKRGKAKRGC
210 220 230 240 250
SPRVKPQHVS THFLPRFKQS EQPELSFTVT VPEKKKPPVK PKVPLSQPRR
260
SPSPVKYRLK FRFG
Length:264
Mass (Da):29,103
Last modified:April 1, 1990 - v1
Checksum:iF6A9C8153EE923D1
GO
Isoform Short (identifier: P15656-2) [UniParc]FASTAAdd to basket
Also known as: FGF-5S

The sequence of this isoform differs from the canonical sequence as follows:
     118-121: ILEI → QIYG
     122-264: Missing.

Note: Seems to have an antagonistic effect compared to that of the isoform Long.
Show »
Length:121
Mass (Da):12,675
Checksum:iFB15B74A17652D8B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001520118 – 121ILEI → QIYG in isoform Short. 1 Publication4
Alternative sequenceiVSP_001521122 – 264Missing in isoform Short. 1 PublicationAdd BLAST143

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30643 mRNA. Translation: AAA96698.1.
M37823, M37821, M37822 Genomic DNA. Translation: AAB02660.1.
M37821 Genomic DNA. Translation: AAB02659.1. Sequence problems.
AB016516 mRNA. Translation: BAA33737.1.
AK028694 mRNA. Translation: BAC26069.1.
AK028894 mRNA. Translation: BAC26179.1.
BC071227 mRNA. Translation: AAH71227.1.
CCDSiCCDS19455.1. [P15656-1]
CCDS80344.1. [P15656-2]
PIRiA36207.
B36207.
RefSeqiNP_001264197.1. NM_001277268.1. [P15656-2]
NP_034333.1. NM_010203.5. [P15656-1]
UniGeneiMm.5055.

Genome annotation databases

EnsembliENSMUST00000031280; ENSMUSP00000031280; ENSMUSG00000029337. [P15656-1]
ENSMUST00000200059; ENSMUSP00000142420; ENSMUSG00000029337. [P15656-2]
GeneIDi14176.
KEGGimmu:14176.
UCSCiuc008ygc.2. mouse. [P15656-1]
uc008ygd.2. mouse. [P15656-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30643 mRNA. Translation: AAA96698.1.
M37823, M37821, M37822 Genomic DNA. Translation: AAB02660.1.
M37821 Genomic DNA. Translation: AAB02659.1. Sequence problems.
AB016516 mRNA. Translation: BAA33737.1.
AK028694 mRNA. Translation: BAC26069.1.
AK028894 mRNA. Translation: BAC26179.1.
BC071227 mRNA. Translation: AAH71227.1.
CCDSiCCDS19455.1. [P15656-1]
CCDS80344.1. [P15656-2]
PIRiA36207.
B36207.
RefSeqiNP_001264197.1. NM_001277268.1. [P15656-2]
NP_034333.1. NM_010203.5. [P15656-1]
UniGeneiMm.5055.

3D structure databases

ProteinModelPortaliP15656.
SMRiP15656.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031280.

PTM databases

iPTMnetiP15656.
PhosphoSitePlusiP15656.

Proteomic databases

PaxDbiP15656.
PRIDEiP15656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031280; ENSMUSP00000031280; ENSMUSG00000029337. [P15656-1]
ENSMUST00000200059; ENSMUSP00000142420; ENSMUSG00000029337. [P15656-2]
GeneIDi14176.
KEGGimmu:14176.
UCSCiuc008ygc.2. mouse. [P15656-1]
uc008ygd.2. mouse. [P15656-2]

Organism-specific databases

CTDi2250.
MGIiMGI:95519. Fgf5.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP15656.
KOiK04358.
OMAiLSAWAHG.
OrthoDBiEOG091G0NAY.
PhylomeDBiP15656.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190372. FGFR3c ligand binding and activation.
R-MMU-190373. FGFR1c ligand binding and activation.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-5654219. Phospholipase C-mediated cascade: FGFR1.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654227. Phospholipase C-mediated cascade, FGFR3.
R-MMU-5654687. Downstream signaling of activated FGFR1.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiP15656.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029337.
CleanExiMM_FGF5.
GenevisibleiP15656. MM.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028240. FGF5.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF23. PTHR11486:SF23. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF5_MOUSE
AccessioniPrimary (citable) accession number: P15656
Secondary accession number(s): O88825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.