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P15655

- FGF2_MOUSE

UniProt

P15655 - FGF2_MOUSE

Protein

Fibroblast growth factor 2

Gene

Fgf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351HeparinBy similarity

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. fibroblast growth factor receptor binding Source: MGI
    3. growth factor activity Source: MGI
    4. heparin binding Source: UniProtKB-KW
    5. ligand-dependent nuclear receptor transcription coactivator activity Source: Ensembl
    6. protein binding Source: MGI

    GO - Biological processi

    1. activation of MAPKK activity Source: MGI
    2. angiogenesis Source: MGI
    3. branching involved in ureteric bud morphogenesis Source: UniProtKB
    4. C21-steroid hormone biosynthetic process Source: Ensembl
    5. cardiac muscle cell proliferation Source: DFLAT
    6. cell migration involved in sprouting angiogenesis Source: Ensembl
    7. chondroblast differentiation Source: Ensembl
    8. corticotropin hormone secreting cell differentiation Source: MGI
    9. embryo development Source: Ensembl
    10. fibroblast growth factor receptor signaling pathway Source: MGI
    11. glial cell differentiation Source: MGI
    12. hyaluronan catabolic process Source: Ensembl
    13. inositol phosphate biosynthetic process Source: Ensembl
    14. lung development Source: MGI
    15. mammary gland epithelial cell differentiation Source: MGI
    16. MAPK import into nucleus Source: Ensembl
    17. negative regulation of blood vessel endothelial cell migration Source: Ensembl
    18. negative regulation of cell death Source: UniProtKB
    19. negative regulation of cell growth Source: Ensembl
    20. negative regulation of cell proliferation Source: MGI
    21. negative regulation of fibroblast migration Source: Ensembl
    22. negative regulation of transcription, DNA-templated Source: Ensembl
    23. negative regulation of wound healing Source: Ensembl
    24. organ induction Source: MGI
    25. phosphatidylinositol biosynthetic process Source: Ensembl
    26. positive regulation of angiogenesis Source: MGI
    27. positive regulation of blood vessel endothelial cell migration Source: Ensembl
    28. positive regulation of canonical Wnt signaling pathway Source: MGI
    29. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    30. positive regulation of cell differentiation Source: MGI
    31. positive regulation of cell division Source: UniProtKB-KW
    32. positive regulation of cell fate specification Source: MGI
    33. positive regulation of cell proliferation Source: MGI
    34. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
    35. positive regulation of endothelial cell migration Source: MGI
    36. positive regulation of endothelial cell proliferation Source: MGI
    37. positive regulation of epithelial cell proliferation Source: MGI
    38. positive regulation of ERK1 and ERK2 cascade Source: MGI
    39. positive regulation of gene expression Source: MGI
    40. positive regulation of osteoblast differentiation Source: MGI
    41. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
    42. positive regulation of phospholipase C activity Source: Ensembl
    43. positive regulation of protein kinase B signaling Source: MGI
    44. positive regulation of protein phosphorylation Source: MGI
    45. positive regulation of transcription, DNA-templated Source: DFLAT
    46. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    47. regulation of cell cycle Source: MGI
    48. regulation of retinal cell programmed cell death Source: MGI
    49. release of sequestered calcium ion into cytosol Source: Ensembl
    50. response to axon injury Source: MGI
    51. stem cell development Source: BHF-UCL
    52. substantia nigra development Source: MGI
    53. thyroid-stimulating hormone-secreting cell differentiation Source: MGI
    54. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Growth factor, Mitogen

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196538. Signaling by activated point mutants of FGFR1.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_196607. Non-integrin membrane-ECM interactions.
    REACT_196644. Syndecan interactions.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_220836. FGFR1b ligand binding and activation.
    REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
    REACT_223993. PI-3K cascade.
    REACT_225874. FGFR1c ligand binding and activation.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 2
    Short name:
    FGF-2
    Alternative name(s):
    Basic fibroblast growth factor
    Short name:
    bFGF
    Heparin-binding growth factor 2
    Short name:
    HBGF-2
    Gene namesi
    Name:Fgf2
    Synonyms:Fgf-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:95516. Fgf2.

    Subcellular locationi

    Secreted By similarity. Nucleus By similarity
    Note: Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane By similarity. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 By similarity.By similarity

    GO - Cellular componenti

    1. cytosol Source: MGI
    2. extracellular space Source: MGI
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 99PRO_0000008936
    Chaini10 – 154145Fibroblast growth factor 2PRO_0000008937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei81 – 811Phosphotyrosine; by TECBy similarity

    Post-translational modificationi

    Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP15655.

    PTM databases

    PhosphoSiteiP15655.

    Expressioni

    Gene expression databases

    BgeeiP15655.
    CleanExiMM_FGF2.
    GenevestigatoriP15655.

    Interactioni

    Subunit structurei

    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199647. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP15655.
    SMRiP15655. Positions 1-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 14317Heparin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG325757.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiP15655.
    KOiK04358.
    OMAiISAFEAW.
    OrthoDBiEOG7992S1.
    PhylomeDBiP15655.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028223. FGF2.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF68. PTHR11486:SF68. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15655-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASGITSLP ALPEDGGAAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG    50
    VREKSDPHVK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC 100
    FFFERLESNN YNTYRSRKYS SWYVALKRTG QYKLGSKTGP GQKAILFLPM 150
    SAKS 154
    Length:154
    Mass (Da):17,153
    Last modified:April 1, 1990 - v1
    Checksum:i689F677416274388
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30644 mRNA. Translation: AAA37621.1.
    AF065903 mRNA. Translation: AAC17503.1.
    AF065904 mRNA. Translation: AAC17504.1.
    AF065905 mRNA. Translation: AAC17505.1.
    CCDSiCCDS17320.1.
    PIRiC37360.
    RefSeqiNP_032032.1. NM_008006.2.
    UniGeneiMm.473689.

    Genome annotation databases

    EnsembliENSMUST00000038885; ENSMUSP00000037694; ENSMUSG00000037225.
    ENSMUST00000138563; ENSMUSP00000122227; ENSMUSG00000037225.
    GeneIDi14173.
    KEGGimmu:14173.
    UCSCiuc008pap.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30644 mRNA. Translation: AAA37621.1 .
    AF065903 mRNA. Translation: AAC17503.1 .
    AF065904 mRNA. Translation: AAC17504.1 .
    AF065905 mRNA. Translation: AAC17505.1 .
    CCDSi CCDS17320.1.
    PIRi C37360.
    RefSeqi NP_032032.1. NM_008006.2.
    UniGenei Mm.473689.

    3D structure databases

    ProteinModelPortali P15655.
    SMRi P15655. Positions 1-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199647. 3 interactions.

    PTM databases

    PhosphoSitei P15655.

    Proteomic databases

    PRIDEi P15655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038885 ; ENSMUSP00000037694 ; ENSMUSG00000037225 .
    ENSMUST00000138563 ; ENSMUSP00000122227 ; ENSMUSG00000037225 .
    GeneIDi 14173.
    KEGGi mmu:14173.
    UCSCi uc008pap.2. mouse.

    Organism-specific databases

    CTDi 2247.
    MGIi MGI:95516. Fgf2.

    Phylogenomic databases

    eggNOGi NOG325757.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi P15655.
    KOi K04358.
    OMAi ISAFEAW.
    OrthoDBi EOG7992S1.
    PhylomeDBi P15655.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196538. Signaling by activated point mutants of FGFR1.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_196607. Non-integrin membrane-ECM interactions.
    REACT_196644. Syndecan interactions.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_220836. FGFR1b ligand binding and activation.
    REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
    REACT_223993. PI-3K cascade.
    REACT_225874. FGFR1c ligand binding and activation.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 285342.
    PROi P15655.
    SOURCEi Search...

    Gene expression databases

    Bgeei P15655.
    CleanExi MM_FGF2.
    Genevestigatori P15655.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028223. FGF2.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF68. PTHR11486:SF68. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
      Hebert J.M., Basilico C., Goldfarb M., Haub O., Martin G.R.
      Dev. Biol. 138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Ma R.Z., Teuscher C.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: A/J, C57BL/6J and NOD/LtJ.
      Tissue: Spleen.
    3. "Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis."
      Kurtz A., Wang H.-L., Darwiche N., Harris V., Wellstein A.
      Oncogene 14:2671-2681(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGF2.

    Entry informationi

    Entry nameiFGF2_MOUSE
    AccessioniPrimary (citable) accession number: P15655
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3