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P15655

- FGF2_MOUSE

UniProt

P15655 - FGF2_MOUSE

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Protein

Fibroblast growth factor 2

Gene

Fgf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351HeparinBy similarity

GO - Molecular functioni

  1. fibroblast growth factor receptor binding Source: MGI
  2. growth factor activity Source: MGI
  3. heparin binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of MAPKK activity Source: MGI
  2. angiogenesis Source: MGI
  3. branching involved in ureteric bud morphogenesis Source: UniProtKB
  4. C21-steroid hormone biosynthetic process Source: Ensembl
  5. cardiac muscle cell proliferation Source: DFLAT
  6. corticotropin hormone secreting cell differentiation Source: MGI
  7. embryo development Source: Ensembl
  8. fibroblast growth factor receptor signaling pathway Source: MGI
  9. glial cell differentiation Source: MGI
  10. lung development Source: MGI
  11. mammary gland epithelial cell differentiation Source: MGI
  12. MAPK import into nucleus Source: Ensembl
  13. negative regulation of cell death Source: UniProtKB
  14. negative regulation of cell growth Source: Ensembl
  15. negative regulation of cell proliferation Source: MGI
  16. negative regulation of transcription, DNA-templated Source: Ensembl
  17. organ induction Source: MGI
  18. positive regulation of angiogenesis Source: MGI
  19. positive regulation of canonical Wnt signaling pathway Source: MGI
  20. positive regulation of cell differentiation Source: MGI
  21. positive regulation of cell division Source: UniProtKB-KW
  22. positive regulation of cell fate specification Source: MGI
  23. positive regulation of cell proliferation Source: MGI
  24. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
  25. positive regulation of endothelial cell migration Source: MGI
  26. positive regulation of endothelial cell proliferation Source: MGI
  27. positive regulation of epithelial cell proliferation Source: MGI
  28. positive regulation of ERK1 and ERK2 cascade Source: MGI
  29. positive regulation of gene expression Source: MGI
  30. positive regulation of osteoblast differentiation Source: MGI
  31. positive regulation of protein kinase B signaling Source: MGI
  32. positive regulation of protein phosphorylation Source: MGI
  33. positive regulation of transcription, DNA-templated Source: DFLAT
  34. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  35. regulation of cell cycle Source: MGI
  36. regulation of retinal cell programmed cell death Source: MGI
  37. response to axon injury Source: MGI
  38. stem cell development Source: BHF-UCL
  39. substantia nigra development Source: MGI
  40. thyroid-stimulating hormone-secreting cell differentiation Source: MGI
  41. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196536. Activated point mutants of FGFR2.
REACT_196538. Signaling by activated point mutants of FGFR1.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_196644. Syndecan interactions.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_220836. FGFR1b ligand binding and activation.
REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
REACT_223993. PI-3K cascade.
REACT_225874. FGFR1c ligand binding and activation.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 2
Short name:
FGF-2
Alternative name(s):
Basic fibroblast growth factor
Short name:
bFGF
Heparin-binding growth factor 2
Short name:
HBGF-2
Gene namesi
Name:Fgf2
Synonyms:Fgf-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:95516. Fgf2.

Subcellular locationi

Secreted By similarity. Nucleus By similarity
Note: Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity).By similarity

GO - Cellular componenti

  1. cytosol Source: MGI
  2. extracellular space Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 99PRO_0000008936
Chaini10 – 154145Fibroblast growth factor 2PRO_0000008937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811Phosphotyrosine; by TECBy similarity

Post-translational modificationi

Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15655.
PRIDEiP15655.

PTM databases

PhosphoSiteiP15655.

Expressioni

Gene expression databases

BgeeiP15655.
CleanExiMM_FGF2.
ExpressionAtlasiP15655. differential.
GenevestigatoriP15655.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199647. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP15655.
SMRiP15655. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG325757.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP15655.
KOiK18497.
OMAiISAFEAW.
OrthoDBiEOG7992S1.
PhylomeDBiP15655.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028223. FGF2.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF68. PTHR11486:SF68. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15655-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASGITSLP ALPEDGGAAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG
60 70 80 90 100
VREKSDPHVK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC
110 120 130 140 150
FFFERLESNN YNTYRSRKYS SWYVALKRTG QYKLGSKTGP GQKAILFLPM

SAKS
Length:154
Mass (Da):17,153
Last modified:April 1, 1990 - v1
Checksum:i689F677416274388
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30644 mRNA. Translation: AAA37621.1.
AF065903 mRNA. Translation: AAC17503.1.
AF065904 mRNA. Translation: AAC17504.1.
AF065905 mRNA. Translation: AAC17505.1.
CCDSiCCDS17320.1.
PIRiC37360.
RefSeqiNP_032032.1. NM_008006.2.
UniGeneiMm.473689.

Genome annotation databases

EnsembliENSMUST00000038885; ENSMUSP00000037694; ENSMUSG00000037225.
ENSMUST00000138563; ENSMUSP00000122227; ENSMUSG00000037225.
GeneIDi14173.
KEGGimmu:14173.
UCSCiuc008pap.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30644 mRNA. Translation: AAA37621.1 .
AF065903 mRNA. Translation: AAC17503.1 .
AF065904 mRNA. Translation: AAC17504.1 .
AF065905 mRNA. Translation: AAC17505.1 .
CCDSi CCDS17320.1.
PIRi C37360.
RefSeqi NP_032032.1. NM_008006.2.
UniGenei Mm.473689.

3D structure databases

ProteinModelPortali P15655.
SMRi P15655. Positions 1-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199647. 3 interactions.

PTM databases

PhosphoSitei P15655.

Proteomic databases

MaxQBi P15655.
PRIDEi P15655.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038885 ; ENSMUSP00000037694 ; ENSMUSG00000037225 .
ENSMUST00000138563 ; ENSMUSP00000122227 ; ENSMUSG00000037225 .
GeneIDi 14173.
KEGGi mmu:14173.
UCSCi uc008pap.2. mouse.

Organism-specific databases

CTDi 2247.
MGIi MGI:95516. Fgf2.

Phylogenomic databases

eggNOGi NOG325757.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi P15655.
KOi K18497.
OMAi ISAFEAW.
OrthoDBi EOG7992S1.
PhylomeDBi P15655.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196536. Activated point mutants of FGFR2.
REACT_196538. Signaling by activated point mutants of FGFR1.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_196644. Syndecan interactions.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_220836. FGFR1b ligand binding and activation.
REACT_220962. POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.
REACT_223993. PI-3K cascade.
REACT_225874. FGFR1c ligand binding and activation.
REACT_226341. PIP3 activates AKT signaling.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

NextBioi 285342.
PROi P15655.
SOURCEi Search...

Gene expression databases

Bgeei P15655.
CleanExi MM_FGF2.
ExpressionAtlasi P15655. differential.
Genevestigatori P15655.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028223. FGF2.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF68. PTHR11486:SF68. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
PROSITEi PS00247. HBGF_FGF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
    Hebert J.M., Basilico C., Goldfarb M., Haub O., Martin G.R.
    Dev. Biol. 138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Ma R.Z., Teuscher C.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A/J, C57BL/6J and NOD/LtJ.
    Tissue: Spleen.
  3. "Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis."
    Kurtz A., Wang H.-L., Darwiche N., Harris V., Wellstein A.
    Oncogene 14:2671-2681(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGF2.

Entry informationi

Entry nameiFGF2_MOUSE
AccessioniPrimary (citable) accession number: P15655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3