Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P15655 (FGF2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 2

Short name=FGF-2
Alternative name(s):
Basic fibroblast growth factor
Short name=bFGF
Heparin-binding growth factor 2
Short name=HBGF-2
Gene names
Name:Fgf2
Synonyms:Fgf-2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro By similarity.

Subunit structure

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2 By similarity. Ref.3

Subcellular location

Secreted By similarity. Nucleus By similarity. Note: Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane By similarity. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 By similarity.

Post-translational modification

Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion By similarity.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Biological processAngiogenesis
Differentiation
   Cellular componentNucleus
Secreted
   LigandHeparin-binding
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processC21-steroid hormone biosynthetic process

Inferred from electronic annotation. Source: Ensembl

MAPK import into nucleus

Inferred from electronic annotation. Source: Ensembl

activation of MAPKK activity

Inferred from direct assay PubMed 16339969. Source: MGI

angiogenesis

Inferred from direct assay PubMed 14702107PubMed 14998491. Source: MGI

branching involved in ureteric bud morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

cardiac muscle cell proliferation

Traceable author statement PubMed 20299672. Source: DFLAT

cell migration involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

chondroblast differentiation

Inferred from electronic annotation. Source: Ensembl

corticotropin hormone secreting cell differentiation

Inferred from direct assay PubMed 9463347. Source: MGI

embryo development

Inferred from electronic annotation. Source: Ensembl

fibroblast growth factor receptor signaling pathway

Inferred from genetic interaction PubMed 7494107. Source: MGI

glial cell differentiation

Inferred from mutant phenotype PubMed 12878680. Source: MGI

hyaluronan catabolic process

Inferred from electronic annotation. Source: Ensembl

inositol phosphate biosynthetic process

Inferred from electronic annotation. Source: Ensembl

lung development

Inferred from direct assay PubMed 15576401. Source: MGI

mammary gland epithelial cell differentiation

Inferred from direct assay PubMed 1376141. Source: MGI

negative regulation of blood vessel endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell death

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from genetic interaction PubMed 10027293PubMed 20570969. Source: MGI

negative regulation of fibroblast migration

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

negative regulation of wound healing

Inferred from electronic annotation. Source: Ensembl

organ induction

Inferred from direct assay PubMed 15576401. Source: MGI

phosphatidylinositol biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 16858399. Source: MGI

positive regulation of angiogenesis

Inferred from direct assay PubMed 16648142. Source: MGI

positive regulation of blood vessel endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of canonical Wnt signaling pathway

Inferred from direct assay PubMed 16858399. Source: MGI

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell differentiation

Inferred from direct assay PubMed 12417662PubMed 15781473. Source: MGI

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell fate specification

Inferred from sequence orthology PubMed 18635606. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 16141225PubMed 7494107PubMed 9463347. Source: MGI

positive regulation of cerebellar granule cell precursor proliferation

Inferred from direct assay PubMed 10027293. Source: MGI

positive regulation of endothelial cell migration

Inferred from direct assay PubMed 16291864. Source: MGI

positive regulation of endothelial cell proliferation

Inferred from direct assay PubMed 16291864. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from direct assay PubMed 17187775. Source: MGI

positive regulation of gene expression

Inferred from direct assay PubMed 9244299. Source: MGI

positive regulation of osteoblast differentiation

Inferred from genetic interaction PubMed 20570969. Source: MGI

positive regulation of phosphatidylinositol 3-kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of phospholipase C activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from direct assay PubMed 16858399. Source: MGI

positive regulation of protein phosphorylation

Inferred from direct assay PubMed 15608665. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10391928PubMed 9102311. Source: MGI

positive regulation of transcription, DNA-templated

Traceable author statement PubMed 20299672. Source: DFLAT

regulation of cell cycle

Inferred from direct assay PubMed 9463347. Source: MGI

regulation of retinal cell programmed cell death

Inferred from direct assay PubMed 11747369. Source: MGI

release of sequestered calcium ion into cytosol

Inferred from electronic annotation. Source: Ensembl

response to axon injury

Inferred from mutant phenotype PubMed 16009496. Source: MGI

stem cell development

Inferred from mutant phenotype PubMed 12843296. Source: BHF-UCL

substantia nigra development

Inferred from mutant phenotype PubMed 17234579. Source: MGI

thyroid-stimulating hormone-secreting cell differentiation

Inferred from direct assay PubMed 9463347. Source: MGI

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Inferred from direct assay PubMed 10644718. Source: MGI

extracellular space

Inferred from direct assay PubMed 12417662PubMed 15576401. Source: MGI

nucleus

Inferred from direct assay PubMed 10644718. Source: MGI

   Molecular_functionchemoattractant activity

Inferred from electronic annotation. Source: Ensembl

fibroblast growth factor receptor binding

Inferred from physical interaction PubMed 2161540. Source: MGI

growth factor activity

Inferred from direct assay PubMed 15608665. Source: MGI

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

ligand-dependent nuclear receptor transcription coactivator activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 12813049PubMed 8393815. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 99
PRO_0000008936
Chain10 – 154145Fibroblast growth factor 2
PRO_0000008937

Regions

Region127 – 14317Heparin-binding By similarity

Sites

Binding site351Heparin By similarity

Amino acid modifications

Modified residue811Phosphotyrosine; by TEC By similarity

Sequences

Sequence LengthMass (Da)Tools
P15655 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 689F677416274388

FASTA15417,153
        10         20         30         40         50         60 
MAASGITSLP ALPEDGGAAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHVK 

        70         80         90        100        110        120 
LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC FFFERLESNN YNTYRSRKYS 

       130        140        150 
SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS 

« Hide

References

[1]"Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
Hebert J.M., Basilico C., Goldfarb M., Haub O., Martin G.R.
Dev. Biol. 138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Ma R.Z., Teuscher C.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: A/J, C57BL/6J and NOD/LtJ.
Tissue: Spleen.
[3]"Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis."
Kurtz A., Wang H.-L., Darwiche N., Harris V., Wellstein A.
Oncogene 14:2671-2681(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGF2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M30644 mRNA. Translation: AAA37621.1.
AF065903 mRNA. Translation: AAC17503.1.
AF065904 mRNA. Translation: AAC17504.1.
AF065905 mRNA. Translation: AAC17505.1.
CCDSCCDS17320.1.
PIRC37360.
RefSeqNP_032032.1. NM_008006.2.
UniGeneMm.473689.

3D structure databases

ProteinModelPortalP15655.
SMRP15655. Positions 1-154.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199647. 3 interactions.

PTM databases

PhosphoSiteP15655.

Proteomic databases

PRIDEP15655.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038885; ENSMUSP00000037694; ENSMUSG00000037225.
ENSMUST00000138563; ENSMUSP00000122227; ENSMUSG00000037225.
GeneID14173.
KEGGmmu:14173.
UCSCuc008pap.2. mouse.

Organism-specific databases

CTD2247.
MGIMGI:95516. Fgf2.

Phylogenomic databases

eggNOGNOG325757.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP15655.
KOK04358.
OMAISAFEAW.
OrthoDBEOG7992S1.
PhylomeDBP15655.
TreeFamTF317805.

Gene expression databases

BgeeP15655.
CleanExMM_FGF2.
GenevestigatorP15655.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028223. FGF2.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF68. PTHR11486:SF68. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285342.
PROP15655.
SOURCESearch...

Entry information

Entry nameFGF2_MOUSE
AccessionPrimary (citable) accession number: P15655
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot