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Protein

Fibroblast growth factor 2

Gene

Fgf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351HeparinBy similarity

GO - Molecular functioni

  1. chemoattractant activity Source: MGI
  2. cytokine activity Source: MGI
  3. fibroblast growth factor receptor binding Source: MGI
  4. growth factor activity Source: MGI
  5. heparin binding Source: UniProtKB-KW
  6. ligand-dependent nuclear receptor transcription coactivator activity Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: MGI
  2. aging Source: Ensembl
  3. angiogenesis Source: MGI
  4. angiogenesis involved in coronary vascular morphogenesis Source: Ensembl
  5. branching involved in ureteric bud morphogenesis Source: UniProtKB
  6. cardiac muscle cell proliferation Source: DFLAT
  7. cell migration involved in sprouting angiogenesis Source: MGI
  8. chondroblast differentiation Source: MGI
  9. corticotropin hormone secreting cell differentiation Source: MGI
  10. embryo development ending in birth or egg hatching Source: Ensembl
  11. fibroblast growth factor receptor signaling pathway Source: MGI
  12. glial cell differentiation Source: MGI
  13. growth factor dependent regulation of skeletal muscle satellite cell proliferation Source: MGI
  14. hyaluronan catabolic process Source: MGI
  15. inositol phosphate biosynthetic process Source: MGI
  16. lung development Source: MGI
  17. mammary gland epithelial cell differentiation Source: MGI
  18. negative regulation of blood vessel endothelial cell migration Source: MGI
  19. negative regulation of cell death Source: UniProtKB
  20. negative regulation of cell proliferation Source: MGI
  21. negative regulation of fibroblast migration Source: MGI
  22. negative regulation of wound healing Source: MGI
  23. organ induction Source: MGI
  24. phosphatidylinositol biosynthetic process Source: MGI
  25. positive chemotaxis Source: MGI
  26. positive regulation of angiogenesis Source: MGI
  27. positive regulation of blood vessel endothelial cell migration Source: MGI
  28. positive regulation of canonical Wnt signaling pathway Source: MGI
  29. positive regulation of cardiac muscle cell proliferation Source: MGI
  30. positive regulation of cell differentiation Source: MGI
  31. positive regulation of cell division Source: UniProtKB-KW
  32. positive regulation of cell fate specification Source: MGI
  33. positive regulation of cell proliferation Source: MGI
  34. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
  35. positive regulation of endothelial cell chemotaxis to fibroblast growth factor Source: MGI
  36. positive regulation of endothelial cell migration Source: MGI
  37. positive regulation of endothelial cell proliferation Source: MGI
  38. positive regulation of epithelial cell proliferation Source: MGI
  39. positive regulation of ERK1 and ERK2 cascade Source: MGI
  40. positive regulation of gene expression Source: MGI
  41. positive regulation of MAP kinase activity Source: MGI
  42. positive regulation of osteoblast differentiation Source: MGI
  43. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  44. positive regulation of phospholipase C activity Source: MGI
  45. positive regulation of protein kinase B signaling Source: MGI
  46. positive regulation of protein phosphorylation Source: MGI
  47. positive regulation of smooth muscle cell proliferation Source: Ensembl
  48. positive regulation of sprouting angiogenesis Source: MGI
  49. positive regulation of transcription, DNA-templated Source: DFLAT
  50. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  51. regulation of cell cycle Source: MGI
  52. regulation of endothelial cell chemotaxis to fibroblast growth factor Source: MGI
  53. regulation of retinal cell programmed cell death Source: MGI
  54. release of sequestered calcium ion into cytosol Source: MGI
  55. response to axon injury Source: MGI
  56. stem cell development Source: BHF-UCL
  57. substantia nigra development Source: MGI
  58. thyroid-stimulating hormone-secreting cell differentiation Source: MGI
  59. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_275126. Signaling by activated point mutants of FGFR3.
REACT_276236. FGFR4 ligand binding and activation.
REACT_289551. FGFR1b ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_320075. Non-integrin membrane-ECM interactions.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_326610. Syndecan interactions.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333335. FGFR3c ligand binding and activation.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_338705. Signaling by FGFR3 mutants.
REACT_345290. Signaling by activated point mutants of FGFR1.
REACT_349060. Activated point mutants of FGFR2.
REACT_354830. FGFR1c ligand binding and activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 2
Short name:
FGF-2
Alternative name(s):
Basic fibroblast growth factor
Short name:
bFGF
Heparin-binding growth factor 2
Short name:
HBGF-2
Gene namesi
Name:Fgf2
Synonyms:Fgf-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95516. Fgf2.

Subcellular locationi

  1. Secreted By similarity
  2. Nucleus By similarity

  3. Note: Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: MGI
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 99PRO_0000008936
Chaini10 – 154145Fibroblast growth factor 2PRO_0000008937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811Phosphotyrosine; by TECBy similarity

Post-translational modificationi

Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP15655.
PRIDEiP15655.

PTM databases

PhosphoSiteiP15655.

Expressioni

Gene expression databases

BgeeiP15655.
CleanExiMM_FGF2.
ExpressionAtlasiP15655. baseline and differential.
GenevestigatoriP15655.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199647. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP15655.
SMRiP15655. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG325757.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP15655.
KOiK18497.
OMAiDAFPPGH.
OrthoDBiEOG7992S1.
PhylomeDBiP15655.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028223. FGF2.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF68. PTHR11486:SF68. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGITSLP ALPEDGGAAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG
60 70 80 90 100
VREKSDPHVK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC
110 120 130 140 150
FFFERLESNN YNTYRSRKYS SWYVALKRTG QYKLGSKTGP GQKAILFLPM

SAKS
Length:154
Mass (Da):17,153
Last modified:April 1, 1990 - v1
Checksum:i689F677416274388
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30644 mRNA. Translation: AAA37621.1.
AF065903 mRNA. Translation: AAC17503.1.
AF065904 mRNA. Translation: AAC17504.1.
AF065905 mRNA. Translation: AAC17505.1.
CCDSiCCDS17320.1.
PIRiC37360.
RefSeqiNP_032032.1. NM_008006.2.
UniGeneiMm.473689.

Genome annotation databases

EnsembliENSMUST00000038885; ENSMUSP00000037694; ENSMUSG00000037225.
ENSMUST00000138563; ENSMUSP00000122227; ENSMUSG00000037225.
GeneIDi14173.
KEGGimmu:14173.
UCSCiuc008pap.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30644 mRNA. Translation: AAA37621.1.
AF065903 mRNA. Translation: AAC17503.1.
AF065904 mRNA. Translation: AAC17504.1.
AF065905 mRNA. Translation: AAC17505.1.
CCDSiCCDS17320.1.
PIRiC37360.
RefSeqiNP_032032.1. NM_008006.2.
UniGeneiMm.473689.

3D structure databases

ProteinModelPortaliP15655.
SMRiP15655. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199647. 3 interactions.

PTM databases

PhosphoSiteiP15655.

Proteomic databases

MaxQBiP15655.
PRIDEiP15655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038885; ENSMUSP00000037694; ENSMUSG00000037225.
ENSMUST00000138563; ENSMUSP00000122227; ENSMUSG00000037225.
GeneIDi14173.
KEGGimmu:14173.
UCSCiuc008pap.2. mouse.

Organism-specific databases

CTDi2247.
MGIiMGI:95516. Fgf2.

Phylogenomic databases

eggNOGiNOG325757.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP15655.
KOiK18497.
OMAiDAFPPGH.
OrthoDBiEOG7992S1.
PhylomeDBiP15655.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_275126. Signaling by activated point mutants of FGFR3.
REACT_276236. FGFR4 ligand binding and activation.
REACT_289551. FGFR1b ligand binding and activation.
REACT_312401. FGFR2c ligand binding and activation.
REACT_320075. Non-integrin membrane-ECM interactions.
REACT_321421. SHC-mediated cascade.
REACT_323826. Phospholipase C-mediated cascade.
REACT_326306. Signaling by FGFR mutants.
REACT_326610. Syndecan interactions.
REACT_328674. Constitutive PI3K/AKT Signaling in Cancer.
REACT_332023. Negative regulation of FGFR signaling.
REACT_332809. FRS2-mediated cascade.
REACT_332866. PI3K Cascade.
REACT_333335. FGFR3c ligand binding and activation.
REACT_333474. PIP3 activates AKT signaling.
REACT_334662. PI-3K cascade.
REACT_338705. Signaling by FGFR3 mutants.
REACT_345290. Signaling by activated point mutants of FGFR1.
REACT_349060. Activated point mutants of FGFR2.
REACT_354830. FGFR1c ligand binding and activation.

Miscellaneous databases

NextBioi285342.
PROiP15655.
SOURCEiSearch...

Gene expression databases

BgeeiP15655.
CleanExiMM_FGF2.
ExpressionAtlasiP15655. baseline and differential.
GenevestigatoriP15655.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028223. FGF2.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF68. PTHR11486:SF68. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
    Hebert J.M., Basilico C., Goldfarb M., Haub O., Martin G.R.
    Dev. Biol. 138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Ma R.Z., Teuscher C.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: A/J, C57BL/6J and NOD/LtJ.
    Tissue: Spleen.
  3. "Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis."
    Kurtz A., Wang H.-L., Darwiche N., Harris V., Wellstein A.
    Oncogene 14:2671-2681(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGF2.

Entry informationi

Entry nameiFGF2_MOUSE
AccessioniPrimary (citable) accession number: P15655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 1, 2015
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.