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Protein

Long-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene

Acadl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Catalytic activityi

Long-chain-acyl-CoA + electron-transfer flavoprotein = long-chain-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: RGD
  • flavin adenine dinucleotide binding Source: RGD
  • long-chain-acyl-CoA dehydrogenase activity Source: RGD

GO - Biological processi

  • fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: RGD
  • long-chain fatty acid catabolic process Source: RGD
  • protein homotetramerization Source: RGD

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-RNO-77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA
R-RNO-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
SABIO-RKP15650
UniPathwayiUPA00660

Chemistry databases

SwissLipidsiSLP:000001586

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.8)
Short name:
LCAD
Gene namesi
Name:Acadl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2011 Acadl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176836

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionAdd BLAST30
ChainiPRO_000000051331 – 430Long-chain specific acyl-CoA dehydrogenase, mitochondrialAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-acetyllysineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei55PhosphoserineCombined sources1
Modified residuei66N6-acetyllysine; alternateBy similarity1
Modified residuei66N6-succinyllysine; alternateBy similarity1
Modified residuei81N6-acetyllysine; alternateBy similarity1
Modified residuei81N6-succinyllysine; alternateBy similarity1
Modified residuei92N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineBy similarity1
Modified residuei165N6-succinyllysineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei240N6-succinyllysineBy similarity1
Modified residuei254N6-acetyllysine; alternateBy similarity1
Modified residuei254N6-succinyllysine; alternateBy similarity1
Modified residuei279N6-acetyllysine; alternateBy similarity1
Modified residuei279N6-succinyllysine; alternateBy similarity1
Modified residuei318N6-acetyllysineBy similarity1
Modified residuei322N6-acetyllysine; alternateBy similarity1
Modified residuei322N6-succinyllysine; alternateBy similarity1
Modified residuei358N6-acetyllysineBy similarity1
Modified residuei362PhosphoserineBy similarity1

Post-translational modificationi

Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP15650
PRIDEiP15650

PTM databases

CarbonylDBiP15650
iPTMnetiP15650
PhosphoSitePlusiP15650

Expressioni

Gene expression databases

BgeeiENSRNOG00000012966
GenevisibleiP15650 RN

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi247326, 1 interactor
IntActiP15650, 1 interactor
STRINGi10116.ENSRNOP00000017686

Structurei

3D structure databases

ProteinModelPortaliP15650
SMRiP15650
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0141 Eukaryota
ENOG410XNMY LUCA
GeneTreeiENSGT00760000119007
HOGENOMiHOG000131659
HOVERGENiHBG104903
InParanoidiP15650
KOiK00255
OMAiQEEVIPH
OrthoDBiEOG091G092G
PhylomeDBiP15650
TreeFamiTF105054

Family and domain databases

CDDicd01160 LCAD, 1 hit
Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR006089 Acyl-CoA_DH_CS
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR013786 AcylCoA_DH/ox_N
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
IPR034179 LCAD
PfamiView protein in Pfam
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF02771 Acyl-CoA_dh_N, 1 hit
SUPFAMiSSF47203 SSF47203, 1 hit
SSF56645 SSF56645, 1 hit
PROSITEiView protein in PROSITE
PS00072 ACYL_COA_DH_1, 1 hit
PS00073 ACYL_COA_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARLLLRSL RVLSARSATL PPPSARCSHS GAEARLETPS AKKLTDIGIR
60 70 80 90 100
RIFSSEHDIF RESVRKFFQE EVIPYHEEWE KAGEVSRELW EKAGKQGLLG
110 120 130 140 150
INIAEKHGGI GGDLLSTAVT WEEQAYSNCT GPGFSLHSDI VMPYIANYGT
160 170 180 190 200
KEQIEQFIPQ MTAGKCIGAI AMTEPGAGSD LQGVRTNAKR SGSDWILNGS
210 220 230 240 250
KVFITNGWLS DLVIVVAVTN REARSPAHGI SLFLVENGMK GFIKGKKLHK
260 270 280 290 300
MGMKAQDTAE LFFEDVRLPA SALLGEENKG FYYLMQELPQ ERLLIADLAI
310 320 330 340 350
SACEFMFEET RNYVRQRKAF GKTVAHIQTV QHKLAELKTN ICVTRAFVDS
360 370 380 390 400
CLQLHETKRL DSASASMAKY WASELQNTVA YQCVQLHGGW GYMWEYPIAK
410 420 430
AYVDARVQPI YGGTNEIMKE LIARQIVSDS
Length:430
Mass (Da):47,873
Last modified:April 1, 1990 - v1
Checksum:iBEE1C7E0FDD84D2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05029 mRNA Translation: AAA40668.1
L11276 mRNA Translation: AAA41514.1
BC062006 mRNA Translation: AAH62006.1
PIRiA34252
RefSeqiNP_036951.1, NM_012819.1
UniGeneiRn.174

Genome annotation databases

EnsembliENSRNOT00000017686; ENSRNOP00000017686; ENSRNOG00000012966
GeneIDi25287
KEGGirno:25287
UCSCiRGD:2011 rat

Similar proteinsi

Entry informationi

Entry nameiACADL_RAT
AccessioniPrimary (citable) accession number: P15650
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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