##gff-version 3 P15646 UniProtKB Chain 1 327 . . . ID=PRO_0000148527;Note=RRNA 2'-O-methyltransferase fibrillarin P15646 UniProtKB Region 1 83 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P15646 UniProtKB Region 8 83 . . . Note=RGG-box P15646 UniProtKB Region 22 42 . . . Note=RNA-binding RGG-box;Ontology_term=ECO:0000250;evidence=ECO:0000250 P15646 UniProtKB Region 58 75 . . . Note=RNA-binding RGG-box;Ontology_term=ECO:0000250;evidence=ECO:0000250 P15646 UniProtKB Region 179 180 . . . Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Y9U3 P15646 UniProtKB Region 198 199 . . . Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22087 P15646 UniProtKB Region 223 224 . . . Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22087 P15646 UniProtKB Region 243 246 . . . Note=S-adenosyl-L-methionine binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P22087 P15646 UniProtKB Region 281 313 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P15646 UniProtKB Modified residue 8 8 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 8 8 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 12 12 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 12 12 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 16 16 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:33856219 P15646 UniProtKB Modified residue 16 16 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587 P15646 UniProtKB Modified residue 22 22 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 22 22 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587 P15646 UniProtKB Modified residue 26 26 . . . Note=Asymmetric dimethylarginine%3B by HMT1;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 30 30 . . . Note=Asymmetric dimethylarginine%3B by HMT1;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587 P15646 UniProtKB Modified residue 34 34 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587 P15646 UniProtKB Modified residue 34 34 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587 P15646 UniProtKB Modified residue 40 40 . . . Note=Omega-N-methylarginine%3B by HMT1;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587 P15646 UniProtKB Modified residue 48 48 . . . Note=Asymmetric dimethylarginine%3B by HMT1;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:26081071,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:26081071 P15646 UniProtKB Modified residue 52 52 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:26081071,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:26081071 P15646 UniProtKB Modified residue 52 52 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587 P15646 UniProtKB Modified residue 58 58 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 58 58 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:26081071,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:26081071 P15646 UniProtKB Modified residue 62 62 . . . Note=Asymmetric dimethylarginine%3B by HMT1;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 66 66 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 66 66 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:33856219 P15646 UniProtKB Modified residue 70 70 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:26081071,ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:26081071,PMID:33856219 P15646 UniProtKB Modified residue 70 70 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:26046779,ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:26046779,PMID:33856219 P15646 UniProtKB Modified residue 73 73 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:26081071,ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:26081071,PMID:33856219 P15646 UniProtKB Modified residue 73 73 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:26046779,ECO:0000269|PubMed:26081071,ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:26046779,PMID:26081071,PMID:33856219 P15646 UniProtKB Modified residue 81 81 . . . Note=Asymmetric dimethylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:33856219 P15646 UniProtKB Modified residue 81 81 . . . Note=Omega-N-methylarginine%3B by HMT1%3B alternate;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:23865587,ECO:0000269|PubMed:26046779,ECO:0000269|PubMed:26081071,ECO:0000269|PubMed:33856219,ECO:0000305|PubMed:12756332;Dbxref=PMID:12756332,PMID:23865587,PMID:26046779,PMID:26081071,PMID:33856219 P15646 UniProtKB Cross-link 150 150 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22106047;Dbxref=PMID:22106047 P15646 UniProtKB Mutagenesis 87 87 . . . Note=In nop1.3%3B thermosensitive allele showing a decrease in histone-glutamine N-methyltransferase activity upon shift to restrictive temperature%3B when associated with G-103%3B V-175 and S-219. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24352239;Dbxref=PMID:24352239 P15646 UniProtKB Mutagenesis 103 103 . . . Note=In nop1.3%3B thermosensitive allele showing a decrease in histone-glutamine N-methyltransferase activity upon shift to restrictive temperature%3B when associated with D-87%3B V-175 and S-219. E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24352239;Dbxref=PMID:24352239 P15646 UniProtKB Mutagenesis 175 175 . . . Note=In nop1.3%3B thermosensitive allele showing a decrease in histone-glutamine N-methyltransferase activity upon shift to restrictive temperature%3B when associated with D-87%3B G-103 and S-219. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24352239;Dbxref=PMID:24352239 P15646 UniProtKB Mutagenesis 219 219 . . . Note=In nop1.3%3B thermosensitive allele showing a decrease in histone-glutamine N-methyltransferase activity upon shift to restrictive temperature%3B when associated with D-87%3B G-103 and V-175. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24352239;Dbxref=PMID:24352239 P15646 UniProtKB Beta strand 87 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 96 109 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 117 119 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 122 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 138 143 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Helix 150 157 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 169 173 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Helix 179 188 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 193 198 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Helix 201 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 217 222 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Helix 227 233 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 237 242 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Helix 249 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 261 272 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Helix 273 275 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Helix 282 295 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 298 305 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Turn 307 309 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT P15646 UniProtKB Beta strand 310 320 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ZDT