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P15626

- GSTM2_MOUSE

UniProt

P15626 - GSTM2_MOUSE

Protein

Glutathione S-transferase Mu 2

Gene

Gstm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161SubstrateBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: MGI
    2. protein heterodimerization activity Source: MGI
    3. protein homodimerization activity Source: MGI

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_215316. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase Mu 2 (EC:2.5.1.18)
    Alternative name(s):
    GST 5-5
    GST class-mu 2
    Glutathione S-transferase pmGT2
    Gene namesi
    Name:Gstm2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:95861. Gstm2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 218217Glutathione S-transferase Mu 2PRO_0000185827Add
    BLAST

    Proteomic databases

    MaxQBiP15626.
    PaxDbiP15626.
    PRIDEiP15626.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00228820.
    P15626.
    SWISS-2DPAGEP15626.

    PTM databases

    PhosphoSiteiP15626.

    Expressioni

    Gene expression databases

    ArrayExpressiP15626.
    BgeeiP15626.
    CleanExiMM_GSTM2.
    GenevestigatoriP15626.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    IntActiP15626. 3 interactions.
    MINTiMINT-1869197.
    STRINGi10090.ENSMUSP00000012348.

    Structurei

    3D structure databases

    ProteinModelPortaliP15626.
    SMRiP15626. Positions 2-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 8887GST N-terminalAdd
    BLAST
    Domaini90 – 208119GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7 – 82Glutathione bindingBy similarity
    Regioni46 – 505Glutathione bindingBy similarity
    Regioni59 – 602Glutathione bindingBy similarity
    Regioni72 – 732Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Mu family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG300089.
    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115735.
    HOVERGENiHBG106842.
    InParanoidiP15626.
    KOiK00799.
    OMAiRITESWA.
    OrthoDBiEOG7KH9M3.
    PhylomeDBiP15626.
    TreeFamiTF353040.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01267. GSTRNSFRASEM.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P15626-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMTLGYWDI RGLAHAIRLL LEYTDTSYED KKYTMGDAPD YDRSQWLSEK    50
    FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHNLCGET EEERIRVDIL 100
    ENQAMDTRIQ LAMVCYSPDF EKKKPEYLEG LPEKMKLYSE FLGKQPWFAG 150
    NKVTYVDFLV YDVLDQHRIF EPKCLDAFPN LKDFMGRFEG LKKISDYMKS 200
    SRFLSKPIFA KMAFWNPK 218
    Length:218
    Mass (Da):25,717
    Last modified:January 23, 2007 - v2
    Checksum:i93D790DD75CBF51E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04696 mRNA. Translation: AAA37706.1.
    AF319526 Genomic DNA. Translation: AAK28508.1.
    BC037068 mRNA. Translation: AAH37068.1.
    CCDSiCCDS17746.1.
    PIRiB34159.
    RefSeqiNP_032209.1. NM_008183.3.
    UniGeneiMm.440086.

    Genome annotation databases

    EnsembliENSMUST00000012348; ENSMUSP00000012348; ENSMUSG00000040562.
    GeneIDi14863.
    KEGGimmu:14863.
    UCSCiuc008qxw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04696 mRNA. Translation: AAA37706.1 .
    AF319526 Genomic DNA. Translation: AAK28508.1 .
    BC037068 mRNA. Translation: AAH37068.1 .
    CCDSi CCDS17746.1.
    PIRi B34159.
    RefSeqi NP_032209.1. NM_008183.3.
    UniGenei Mm.440086.

    3D structure databases

    ProteinModelPortali P15626.
    SMRi P15626. Positions 2-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P15626. 3 interactions.
    MINTi MINT-1869197.
    STRINGi 10090.ENSMUSP00000012348.

    PTM databases

    PhosphoSitei P15626.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00228820.
    P15626.
    SWISS-2DPAGE P15626.

    Proteomic databases

    MaxQBi P15626.
    PaxDbi P15626.
    PRIDEi P15626.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000012348 ; ENSMUSP00000012348 ; ENSMUSG00000040562 .
    GeneIDi 14863.
    KEGGi mmu:14863.
    UCSCi uc008qxw.1. mouse.

    Organism-specific databases

    CTDi 2946.
    MGIi MGI:95861. Gstm2.

    Phylogenomic databases

    eggNOGi NOG300089.
    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115735.
    HOVERGENi HBG106842.
    InParanoidi P15626.
    KOi K00799.
    OMAi RITESWA.
    OrthoDBi EOG7KH9M3.
    PhylomeDBi P15626.
    TreeFami TF353040.

    Enzyme and pathway databases

    Reactomei REACT_215316. Glutathione conjugation.

    Miscellaneous databases

    NextBioi 287109.
    PROi P15626.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P15626.
    Bgeei P15626.
    CleanExi MM_GSTM2.
    Genevestigatori P15626.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01267. GSTRNSFRASEM.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2)."
      Townsend A.J., Goldsmith M.E., Pickett C.B., Cowan K.H.
      J. Biol. Chem. 264:21582-21590(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic organization and characterization of the promoter region of murine GSTM2 gene."
      Kumar A., Reddy E.P.
      Gene 270:221-229(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    4. "Purification and characterization of glutathione S-transferase of murine ovary and testis."
      Awasthi S., Singhal S.S., Srivastava S.K., Awasthi Y.C.
      Arch. Biochem. Biophys. 301:143-150(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-25.

    Entry informationi

    Entry nameiGSTM2_MOUSE
    AccessioniPrimary (citable) accession number: P15626
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3