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P15626

- GSTM2_MOUSE

UniProt

P15626 - GSTM2_MOUSE

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Protein
Glutathione S-transferase Mu 2
Gene
Gstm2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Substrate By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: MGI
  2. protein heterodimerization activity Source: MGI
  3. protein homodimerization activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 2 (EC:2.5.1.18)
Alternative name(s):
GST 5-5
GST class-mu 2
Glutathione S-transferase pmGT2
Gene namesi
Name:Gstm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:95861. Gstm2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 218217Glutathione S-transferase Mu 2
PRO_0000185827Add
BLAST

Proteomic databases

MaxQBiP15626.
PaxDbiP15626.
PRIDEiP15626.

2D gel databases

REPRODUCTION-2DPAGEIPI00228820.
P15626.
SWISS-2DPAGEP15626.

PTM databases

PhosphoSiteiP15626.

Expressioni

Gene expression databases

ArrayExpressiP15626.
BgeeiP15626.
CleanExiMM_GSTM2.
GenevestigatoriP15626.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP15626. 3 interactions.
MINTiMINT-1869197.
STRINGi10090.ENSMUSP00000012348.

Structurei

3D structure databases

ProteinModelPortaliP15626.
SMRiP15626. Positions 2-218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8887GST N-terminal
Add
BLAST
Domaini90 – 208119GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione binding By similarity
Regioni46 – 505Glutathione binding By similarity
Regioni59 – 602Glutathione binding By similarity
Regioni72 – 732Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.

Phylogenomic databases

eggNOGiNOG300089.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP15626.
KOiK00799.
OMAiRITESWA.
OrthoDBiEOG7KH9M3.
PhylomeDBiP15626.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15626-1 [UniParc]FASTAAdd to Basket

« Hide

MPMTLGYWDI RGLAHAIRLL LEYTDTSYED KKYTMGDAPD YDRSQWLSEK    50
FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHNLCGET EEERIRVDIL 100
ENQAMDTRIQ LAMVCYSPDF EKKKPEYLEG LPEKMKLYSE FLGKQPWFAG 150
NKVTYVDFLV YDVLDQHRIF EPKCLDAFPN LKDFMGRFEG LKKISDYMKS 200
SRFLSKPIFA KMAFWNPK 218
Length:218
Mass (Da):25,717
Last modified:January 23, 2007 - v2
Checksum:i93D790DD75CBF51E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04696 mRNA. Translation: AAA37706.1.
AF319526 Genomic DNA. Translation: AAK28508.1.
BC037068 mRNA. Translation: AAH37068.1.
CCDSiCCDS17746.1.
PIRiB34159.
RefSeqiNP_032209.1. NM_008183.3.
UniGeneiMm.440086.

Genome annotation databases

EnsembliENSMUST00000012348; ENSMUSP00000012348; ENSMUSG00000040562.
GeneIDi14863.
KEGGimmu:14863.
UCSCiuc008qxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04696 mRNA. Translation: AAA37706.1 .
AF319526 Genomic DNA. Translation: AAK28508.1 .
BC037068 mRNA. Translation: AAH37068.1 .
CCDSi CCDS17746.1.
PIRi B34159.
RefSeqi NP_032209.1. NM_008183.3.
UniGenei Mm.440086.

3D structure databases

ProteinModelPortali P15626.
SMRi P15626. Positions 2-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P15626. 3 interactions.
MINTi MINT-1869197.
STRINGi 10090.ENSMUSP00000012348.

PTM databases

PhosphoSitei P15626.

2D gel databases

REPRODUCTION-2DPAGE IPI00228820.
P15626.
SWISS-2DPAGE P15626.

Proteomic databases

MaxQBi P15626.
PaxDbi P15626.
PRIDEi P15626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000012348 ; ENSMUSP00000012348 ; ENSMUSG00000040562 .
GeneIDi 14863.
KEGGi mmu:14863.
UCSCi uc008qxw.1. mouse.

Organism-specific databases

CTDi 2946.
MGIi MGI:95861. Gstm2.

Phylogenomic databases

eggNOGi NOG300089.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.
InParanoidi P15626.
KOi K00799.
OMAi RITESWA.
OrthoDBi EOG7KH9M3.
PhylomeDBi P15626.
TreeFami TF353040.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 287109.
PROi P15626.
SOURCEi Search...

Gene expression databases

ArrayExpressi P15626.
Bgeei P15626.
CleanExi MM_GSTM2.
Genevestigatori P15626.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2)."
    Townsend A.J., Goldsmith M.E., Pickett C.B., Cowan K.H.
    J. Biol. Chem. 264:21582-21590(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic organization and characterization of the promoter region of murine GSTM2 gene."
    Kumar A., Reddy E.P.
    Gene 270:221-229(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. "Purification and characterization of glutathione S-transferase of murine ovary and testis."
    Awasthi S., Singhal S.S., Srivastava S.K., Awasthi Y.C.
    Arch. Biochem. Biophys. 301:143-150(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-25.

Entry informationi

Entry nameiGSTM2_MOUSE
AccessioniPrimary (citable) accession number: P15626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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