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P15626

- GSTM2_MOUSE

UniProt

P15626 - GSTM2_MOUSE

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Protein

Glutathione S-transferase Mu 2

Gene

Gstm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161SubstrateBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: MGI
  2. protein heterodimerization activity Source: MGI
  3. protein homodimerization activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 2 (EC:2.5.1.18)
Alternative name(s):
GST 5-5
GST class-mu 2
Glutathione S-transferase pmGT2
Gene namesi
Name:Gstm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:95861. Gstm2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 218217Glutathione S-transferase Mu 2PRO_0000185827Add
BLAST

Proteomic databases

MaxQBiP15626.
PaxDbiP15626.
PRIDEiP15626.

2D gel databases

REPRODUCTION-2DPAGEIPI00228820.
P15626.
SWISS-2DPAGEP15626.

PTM databases

PhosphoSiteiP15626.

Expressioni

Gene expression databases

BgeeiP15626.
CleanExiMM_GSTM2.
ExpressionAtlasiP15626. baseline and differential.
GenevestigatoriP15626.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiP15626. 3 interactions.
MINTiMINT-1869197.
STRINGi10090.ENSMUSP00000012348.

Structurei

3D structure databases

ProteinModelPortaliP15626.
SMRiP15626. Positions 2-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8887GST N-terminalAdd
BLAST
Domaini90 – 208119GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione bindingBy similarity
Regioni46 – 505Glutathione bindingBy similarity
Regioni59 – 602Glutathione bindingBy similarity
Regioni72 – 732Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG300089.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiP15626.
KOiK00799.
OMAiRITESWA.
OrthoDBiEOG7KH9M3.
PhylomeDBiP15626.
TreeFamiTF353040.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P15626-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMTLGYWDI RGLAHAIRLL LEYTDTSYED KKYTMGDAPD YDRSQWLSEK
60 70 80 90 100
FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHNLCGET EEERIRVDIL
110 120 130 140 150
ENQAMDTRIQ LAMVCYSPDF EKKKPEYLEG LPEKMKLYSE FLGKQPWFAG
160 170 180 190 200
NKVTYVDFLV YDVLDQHRIF EPKCLDAFPN LKDFMGRFEG LKKISDYMKS
210
SRFLSKPIFA KMAFWNPK
Length:218
Mass (Da):25,717
Last modified:January 23, 2007 - v2
Checksum:i93D790DD75CBF51E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04696 mRNA. Translation: AAA37706.1.
AF319526 Genomic DNA. Translation: AAK28508.1.
BC037068 mRNA. Translation: AAH37068.1.
CCDSiCCDS17746.1.
PIRiB34159.
RefSeqiNP_032209.1. NM_008183.3.
UniGeneiMm.440086.

Genome annotation databases

EnsembliENSMUST00000012348; ENSMUSP00000012348; ENSMUSG00000040562.
GeneIDi14863.
KEGGimmu:14863.
UCSCiuc008qxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04696 mRNA. Translation: AAA37706.1 .
AF319526 Genomic DNA. Translation: AAK28508.1 .
BC037068 mRNA. Translation: AAH37068.1 .
CCDSi CCDS17746.1.
PIRi B34159.
RefSeqi NP_032209.1. NM_008183.3.
UniGenei Mm.440086.

3D structure databases

ProteinModelPortali P15626.
SMRi P15626. Positions 2-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P15626. 3 interactions.
MINTi MINT-1869197.
STRINGi 10090.ENSMUSP00000012348.

PTM databases

PhosphoSitei P15626.

2D gel databases

REPRODUCTION-2DPAGE IPI00228820.
P15626.
SWISS-2DPAGE P15626.

Proteomic databases

MaxQBi P15626.
PaxDbi P15626.
PRIDEi P15626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000012348 ; ENSMUSP00000012348 ; ENSMUSG00000040562 .
GeneIDi 14863.
KEGGi mmu:14863.
UCSCi uc008qxw.1. mouse.

Organism-specific databases

CTDi 2946.
MGIi MGI:95861. Gstm2.

Phylogenomic databases

eggNOGi NOG300089.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.
InParanoidi P15626.
KOi K00799.
OMAi RITESWA.
OrthoDBi EOG7KH9M3.
PhylomeDBi P15626.
TreeFami TF353040.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

NextBioi 287109.
PROi P15626.
SOURCEi Search...

Gene expression databases

Bgeei P15626.
CleanExi MM_GSTM2.
ExpressionAtlasi P15626. baseline and differential.
Genevestigatori P15626.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2)."
    Townsend A.J., Goldsmith M.E., Pickett C.B., Cowan K.H.
    J. Biol. Chem. 264:21582-21590(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic organization and characterization of the promoter region of murine GSTM2 gene."
    Kumar A., Reddy E.P.
    Gene 270:221-229(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. "Purification and characterization of glutathione S-transferase of murine ovary and testis."
    Awasthi S., Singhal S.S., Srivastava S.K., Awasthi Y.C.
    Arch. Biochem. Biophys. 301:143-150(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-25.

Entry informationi

Entry nameiGSTM2_MOUSE
AccessioniPrimary (citable) accession number: P15626
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3