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P15623

- GLNA_BACFR

UniProt

P15623 - GLNA_BACFR

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Protein

Glutamine synthetase

Gene

glnA

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:BF1040
OrganismiBacteroides fragilis (strain YCH46)
Taxonomic identifieri295405 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
ProteomesiUP000002197: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Glutamine synthetasePRO_0000153277Add
BLAST

Interactioni

Subunit structurei

Homohexamer.

Protein-protein interaction databases

DIPiDIP-59116N.
STRINGi295405.BF1040.

Structurei

3D structure databases

ProteinModelPortaliP15623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3968.
HOGENOMiHOG000024492.
KOiK01915.
OMAiGQQLDDH.
OrthoDBiEOG6F2957.

Family and domain databases

Gene3Di3.30.590.10. 2 hits.
InterProiIPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR022147. GSIII_N.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF12437. GSIII_N. 1 hit.
[Graphical view]
PROSITEiPS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P15623-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKMRFFALQ ELSNRKPLEI TTPSNKLSDY YASHVFDRKK MQEYLPKEAY
60 70 80 90 100
KAVVDATEKG TPISREMADL IANGMKSWAK SLNVTHYTHW FQPLTDGTAE
110 120 130 140 150
KHDGFIEFGE DGEVIERFSG KLLIQQEPDA SSFPNGGIRN TFEARGYTAW
160 170 180 190 200
DVSSPAFVVD TTLCIPTIFI SYTGEALDYK TPLLKALAAV DKAATEVCQL
210 220 230 240 250
FDKNITRVFT NLGWEQEYFL VDTSLYNARP DLRLTGRTLM GHSSAKDQQL
260 270 280 290 300
EDHYFGSIPP RVTAFMKELE IECHKLGIPV KTRHNEVAPN QFELAPIFEN
310 320 330 340 350
CNLANDHNQL VMDLMKRIAR KHHFAVLFHE KPYNGVNGSG KHNNWSLCTD
360 370 380 390 400
TGINLFAPGK NPKGNMLFLT FLVNVLMMVH KNQDLLRASI MSAGNSHRLG
410 420 430 440 450
ANEAPPAILS IFLGSQLSAT LDEIVRQVTN SKMTPEEKTT LKLGIGRIPE
460 470 480 490 500
ILLDTTDRNR TSPFAFTGNR FEFRAAGSSA NCAAAMIAIN AAMANQLNEF
510 520 530 540 550
KASVDKLMEE GIGKDEAIFR ILKENIIASE PIRFEGDGYS EEWKQEAARR
560 570 580 590 600
GLTNICHVPE ALMHYTDNQS RAVLIGERIF NETELACRLE VELEKYTMKV
610 620 630 640 650
QIESRVLGDL AINHIVPIAV SYQNRLLENL CRMKEIFSEE EYEVMSADRK
660 670 680 690 700
ELIKEISHRV SAIKVLVRDM TEARKVANHK ENFKEKAFAY EETVRPYLES
710 720
IRDHIDHLEM EIDDEIWPLP KYRELLFTK
Length:729
Mass (Da):82,825
Last modified:November 23, 2004 - v2
Checksum:i1916071619EB9562
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521V → G in AAA62314. (PubMed:2576872)Curated
Sequence conflicti531 – 5311P → L in AAA62314. (PubMed:2576872)Curated
Sequence conflicti566 – 5661T → M in AAA62314. (PubMed:2576872)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28252 Genomic DNA. Translation: AAA62314.1.
AP006841 Genomic DNA. Translation: BAD47790.1.
PIRiA37191.
RefSeqiYP_098324.1. NC_006347.1.

Genome annotation databases

EnsemblBacteriaiBAD47790; BAD47790; BF1040.
GeneIDi3081476.
KEGGibfr:BF1040.
PATRICi21047818. VBIBacFra17906_1032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28252 Genomic DNA. Translation: AAA62314.1 .
AP006841 Genomic DNA. Translation: BAD47790.1 .
PIRi A37191.
RefSeqi YP_098324.1. NC_006347.1.

3D structure databases

ProteinModelPortali P15623.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59116N.
STRINGi 295405.BF1040.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD47790 ; BAD47790 ; BF1040 .
GeneIDi 3081476.
KEGGi bfr:BF1040.
PATRICi 21047818. VBIBacFra17906_1032.

Phylogenomic databases

eggNOGi COG3968.
HOGENOMi HOG000024492.
KOi K01915.
OMAi GQQLDDH.
OrthoDBi EOG6F2957.

Family and domain databases

Gene3Di 3.30.590.10. 2 hits.
InterProi IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR022147. GSIII_N.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF12437. GSIII_N. 1 hit.
[Graphical view ]
PROSITEi PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of a novel glutamine synthetase of the anaerobe Bacteroides fragilis."
    Hill R.T., Parker J.R., Goodman H.J.K., Jones D.T., Woods D.R.
    J. Gen. Microbiol. 135:3271-3279(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BF1.
  2. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
    Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
    Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YCH46.

Entry informationi

Entry nameiGLNA_BACFR
AccessioniPrimary (citable) accession number: P15623
Secondary accession number(s): Q64XI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3