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P15623

- GLNA_BACFR

UniProt

P15623 - GLNA_BACFR

Protein

Glutamine synthetase

Gene

glnA

Organism
Bacteroides fragilis (strain YCH46)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nitrogen compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Short name:
    GS
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:BF1040
    OrganismiBacteroides fragilis (strain YCH46)
    Taxonomic identifieri295405 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002197: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 729729Glutamine synthetasePRO_0000153277Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer.

    Protein-protein interaction databases

    DIPiDIP-59116N.
    STRINGi295405.BF1040.

    Structurei

    3D structure databases

    ProteinModelPortaliP15623.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3968.
    HOGENOMiHOG000024492.
    KOiK01915.
    OMAiGQQLDDH.
    OrthoDBiEOG6F2957.

    Family and domain databases

    Gene3Di3.30.590.10. 2 hits.
    InterProiIPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR022147. GSIII_N.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF12437. GSIII_N. 1 hit.
    [Graphical view]
    PROSITEiPS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P15623-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKMRFFALQ ELSNRKPLEI TTPSNKLSDY YASHVFDRKK MQEYLPKEAY    50
    KAVVDATEKG TPISREMADL IANGMKSWAK SLNVTHYTHW FQPLTDGTAE 100
    KHDGFIEFGE DGEVIERFSG KLLIQQEPDA SSFPNGGIRN TFEARGYTAW 150
    DVSSPAFVVD TTLCIPTIFI SYTGEALDYK TPLLKALAAV DKAATEVCQL 200
    FDKNITRVFT NLGWEQEYFL VDTSLYNARP DLRLTGRTLM GHSSAKDQQL 250
    EDHYFGSIPP RVTAFMKELE IECHKLGIPV KTRHNEVAPN QFELAPIFEN 300
    CNLANDHNQL VMDLMKRIAR KHHFAVLFHE KPYNGVNGSG KHNNWSLCTD 350
    TGINLFAPGK NPKGNMLFLT FLVNVLMMVH KNQDLLRASI MSAGNSHRLG 400
    ANEAPPAILS IFLGSQLSAT LDEIVRQVTN SKMTPEEKTT LKLGIGRIPE 450
    ILLDTTDRNR TSPFAFTGNR FEFRAAGSSA NCAAAMIAIN AAMANQLNEF 500
    KASVDKLMEE GIGKDEAIFR ILKENIIASE PIRFEGDGYS EEWKQEAARR 550
    GLTNICHVPE ALMHYTDNQS RAVLIGERIF NETELACRLE VELEKYTMKV 600
    QIESRVLGDL AINHIVPIAV SYQNRLLENL CRMKEIFSEE EYEVMSADRK 650
    ELIKEISHRV SAIKVLVRDM TEARKVANHK ENFKEKAFAY EETVRPYLES 700
    IRDHIDHLEM EIDDEIWPLP KYRELLFTK 729
    Length:729
    Mass (Da):82,825
    Last modified:November 23, 2004 - v2
    Checksum:i1916071619EB9562
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1521V → G in AAA62314. (PubMed:2576872)Curated
    Sequence conflicti531 – 5311P → L in AAA62314. (PubMed:2576872)Curated
    Sequence conflicti566 – 5661T → M in AAA62314. (PubMed:2576872)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28252 Genomic DNA. Translation: AAA62314.1.
    AP006841 Genomic DNA. Translation: BAD47790.1.
    PIRiA37191.
    RefSeqiYP_098324.1. NC_006347.1.

    Genome annotation databases

    EnsemblBacteriaiBAD47790; BAD47790; BF1040.
    GeneIDi3081476.
    KEGGibfr:BF1040.
    PATRICi21047818. VBIBacFra17906_1032.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28252 Genomic DNA. Translation: AAA62314.1 .
    AP006841 Genomic DNA. Translation: BAD47790.1 .
    PIRi A37191.
    RefSeqi YP_098324.1. NC_006347.1.

    3D structure databases

    ProteinModelPortali P15623.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59116N.
    STRINGi 295405.BF1040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD47790 ; BAD47790 ; BF1040 .
    GeneIDi 3081476.
    KEGGi bfr:BF1040.
    PATRICi 21047818. VBIBacFra17906_1032.

    Phylogenomic databases

    eggNOGi COG3968.
    HOGENOMi HOG000024492.
    KOi K01915.
    OMAi GQQLDDH.
    OrthoDBi EOG6F2957.

    Family and domain databases

    Gene3Di 3.30.590.10. 2 hits.
    InterProi IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR022147. GSIII_N.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF12437. GSIII_N. 1 hit.
    [Graphical view ]
    PROSITEi PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of a novel glutamine synthetase of the anaerobe Bacteroides fragilis."
      Hill R.T., Parker J.R., Goodman H.J.K., Jones D.T., Woods D.R.
      J. Gen. Microbiol. 135:3271-3279(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BF1.
    2. "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation."
      Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.
      Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YCH46.

    Entry informationi

    Entry nameiGLNA_BACFR
    AccessioniPrimary (citable) accession number: P15623
    Secondary accession number(s): Q64XI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3