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P15622

- ZN250_HUMAN

UniProt

P15622 - ZN250_HUMAN

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Protein
Zinc finger protein 250
Gene
ZNF250, ZNF647
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri199 – 22123C2H2-type 1
Add
BLAST
Zinc fingeri227 – 24923C2H2-type 2
Add
BLAST
Zinc fingeri255 – 27723C2H2-type 3
Add
BLAST
Zinc fingeri283 – 30523C2H2-type 4
Add
BLAST
Zinc fingeri311 – 33323C2H2-type 5
Add
BLAST
Zinc fingeri339 – 36123C2H2-type 6
Add
BLAST
Zinc fingeri367 – 38923C2H2-type 7
Add
BLAST
Zinc fingeri395 – 41723C2H2-type 8
Add
BLAST
Zinc fingeri423 – 44523C2H2-type 9
Add
BLAST
Zinc fingeri451 – 47323C2H2-type 10
Add
BLAST
Zinc fingeri479 – 50123C2H2-type 11
Add
BLAST
Zinc fingeri507 – 52923C2H2-type 12
Add
BLAST
Zinc fingeri535 – 55723C2H2-type 13
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: RefGenome
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 250
Alternative name(s):
Zinc finger protein 647
Gene namesi
Name:ZNF250
Synonyms:ZNF647
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:13044. ZNF250.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Zinc finger protein 250
PRO_0000047483Add
BLAST

Proteomic databases

MaxQBiP15622.
PaxDbiP15622.
PRIDEiP15622.

2D gel databases

REPRODUCTION-2DPAGEP15622.

PTM databases

PhosphoSiteiP15622.

Expressioni

Gene expression databases

ArrayExpressiP15622.
BgeeiP15622.
CleanExiHS_ZNF250.
GenevestigatoriP15622.

Organism-specific databases

HPAiHPA020853.

Interactioni

Protein-protein interaction databases

BioGridi121830. 16 interactions.
IntActiP15622. 16 interactions.
MINTiMINT-1438501.
STRINGi9606.ENSP00000292579.

Structurei

3D structure databases

ProteinModelPortaliP15622.
SMRiP15622. Positions 196-559.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9372KRAB
Add
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.
Contains 1 KRAB domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP15622.
KOiK09228.
OMAiNVMMETY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiP15622.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P15622-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAARLLPVP AGPQPLSFQA KLTFEDVAVL LSQDEWDRLC PAQRGLYRNV    50
MMETYGNVVS LGLPGSKPDI ISQLERGEDP WVLDRKGAKK SQGLWSDYSD 100
NLKYDHTTAC TQQDSLSCPW ECETKGESQN TDLSPKPLIS EQTVILGKTP 150
LGRIDQENNE TKQSFCLSPN SVDHREVQVL SQSMPLTPHQ AVPSGERPYM 200
CVECGKCFGR SSHLLQHQRI HTGEKPYVCS VCGKAFSQSS VLSKHRRIHT 250
GEKPYECNEC GKAFRVSSDL AQHHKIHTGE KPHECLECRK AFTQLSHLIQ 300
HQRIHTGERP YVCPLCGKAF NHSTVLRSHQ RVHTGEKPHR CNECGKTFSV 350
KRTLLQHQRI HTGEKPYTCS ECGKAFSDRS VLIQHHNVHT GEKPYECSEC 400
GKTFSHRSTL MNHERIHTEE KPYACYECGK AFVQHSHLIQ HQRVHTGEKP 450
YVCGECGHAF SARRSLIQHE RIHTGEKPFQ CTECGKAFSL KATLIVHLRT 500
HTGEKPYECN SCGKAFSQYS VLIQHQRIHT GEKPYECGEC GRAFNQHGHL 550
IQHQKVHRKL 560
Length:560
Mass (Da):63,468
Last modified:July 19, 2004 - v3
Checksum:i800170E1875D988C
GO
Isoform 2 (identifier: P15622-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: Missing.
     366-477: Missing.

Show »
Length:443
Mass (Da):50,022
Checksum:i5C51169876D5BBF5
GO
Isoform 3 (identifier: P15622-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: Missing.

Note: No experimental confirmation available.

Show »
Length:555
Mass (Da):62,895
Checksum:i28038298ED50A5B1
GO

Sequence cautioni

The sequence CAA34358.1 differs from that shown. Reason: Frameshift at positions 458 and 488.
The sequence BAD92047.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 195Missing in isoform 2 and isoform 3.
VSP_011039
Alternative sequencei366 – 477112Missing in isoform 2.
VSP_011040Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti515 – 5217AFSQYSV → PSASTQL1 Publication
Sequence conflicti542 – 5421R → G1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095705 mRNA. Translation: BAC04614.1.
AB208810 mRNA. Translation: BAD92047.1. Different initiation.
AF235103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82029.1.
CH471162 Genomic DNA. Translation: EAW82030.1.
BC017091 mRNA. Translation: AAH17091.2.
X16282 mRNA. Translation: CAA34358.1. Frameshift.
CCDSiCCDS34972.1. [P15622-1]
CCDS55282.1. [P15622-3]
PIRiS06781.
RefSeqiNP_001103159.1. NM_001109689.3. [P15622-3]
NP_066405.1. NM_021061.4. [P15622-1]
XP_005272384.1. XM_005272327.1. [P15622-3]
XP_005272385.1. XM_005272328.1. [P15622-3]
XP_006716675.1. XM_006716612.1. [P15622-1]
XP_006716676.1. XM_006716613.1. [P15622-1]
UniGeneiHs.532277.

Genome annotation databases

EnsembliENST00000292579; ENSP00000292579; ENSG00000196150. [P15622-1]
ENST00000417550; ENSP00000393442; ENSG00000196150. [P15622-3]
GeneIDi58500.
KEGGihsa:58500.
UCSCiuc003zeq.4. human. [P15622-1]
uc003zer.4. human.

Polymorphism databases

DMDMi50403721.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK095705 mRNA. Translation: BAC04614.1 .
AB208810 mRNA. Translation: BAD92047.1 . Different initiation.
AF235103 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82029.1 .
CH471162 Genomic DNA. Translation: EAW82030.1 .
BC017091 mRNA. Translation: AAH17091.2 .
X16282 mRNA. Translation: CAA34358.1 . Frameshift.
CCDSi CCDS34972.1. [P15622-1 ]
CCDS55282.1. [P15622-3 ]
PIRi S06781.
RefSeqi NP_001103159.1. NM_001109689.3. [P15622-3 ]
NP_066405.1. NM_021061.4. [P15622-1 ]
XP_005272384.1. XM_005272327.1. [P15622-3 ]
XP_005272385.1. XM_005272328.1. [P15622-3 ]
XP_006716675.1. XM_006716612.1. [P15622-1 ]
XP_006716676.1. XM_006716613.1. [P15622-1 ]
UniGenei Hs.532277.

3D structure databases

ProteinModelPortali P15622.
SMRi P15622. Positions 196-559.
ModBasei Search...

Protein-protein interaction databases

BioGridi 121830. 16 interactions.
IntActi P15622. 16 interactions.
MINTi MINT-1438501.
STRINGi 9606.ENSP00000292579.

PTM databases

PhosphoSitei P15622.

Polymorphism databases

DMDMi 50403721.

2D gel databases

REPRODUCTION-2DPAGE P15622.

Proteomic databases

MaxQBi P15622.
PaxDbi P15622.
PRIDEi P15622.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292579 ; ENSP00000292579 ; ENSG00000196150 . [P15622-1 ]
ENST00000417550 ; ENSP00000393442 ; ENSG00000196150 . [P15622-3 ]
GeneIDi 58500.
KEGGi hsa:58500.
UCSCi uc003zeq.4. human. [P15622-1 ]
uc003zer.4. human.

Organism-specific databases

CTDi 58500.
GeneCardsi GC08M146078.
HGNCi HGNC:13044. ZNF250.
HPAi HPA020853.
neXtProti NX_P15622.
PharmGKBi PA37622.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P15622.
KOi K09228.
OMAi NVMMETY.
OrthoDBi EOG7KSX7Q.
PhylomeDBi P15622.
TreeFami TF341817.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 58500.
NextBioi 65004.
PROi P15622.

Gene expression databases

ArrayExpressi P15622.
Bgeei P15622.
CleanExi HS_ZNF250.
Genevestigatori P15622.

Family and domain databases

Gene3Di 3.30.160.60. 13 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  6. Ammendola S., Ciliberto G.
    Submitted (AUG-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 250-560 (ISOFORM 1).

Entry informationi

Entry nameiZN250_HUMAN
AccessioniPrimary (citable) accession number: P15622
Secondary accession number(s): D3DWP1
, Q59HE9, Q8N942, Q96AH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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